Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins BRAF (from a repository: Thu Nov 10 14:59:26 2016)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)42
The number (and %) of the onco-proteins23 (54.76 %)
The number (and %) of the tumor suppressors7 (16.67 %)
Total number of binary PPIs (saturation %)238 (27.64 %)
The number (and %) of affected PPIs42 (17.65 %)
The number of possible different fusions15
PPI diameter2
PPI radius1
The average degree of PPI10.190
Assortativity coefficient-0.3021
The network average Clustering coefficient0.569
The number (and %) of a zero Clustering coefficients4 (9.52 %)
The number (and %) of a zero Betweenness Centrality7 (16.67 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: BRAF All fusions
: BE083400;
Proteins found in more fusions NEDD4L (see 3 fusions); KSR1 (see 1 fusions); HSP90AB1 (see 1 fusions); PAK2 (see 2 fusions); CCDC88A (see 3 fusions); CDC37 (see 2 fusions); YWHAG (see 1 fusions); PRKCE (see 3 fusions); HSP90AA1 (see 2 fusions); MAPK1 (see 1 fusions); YWHAZ (see 1 fusions); LIMK1 (see 1 fusions); BRAF (see 3 fusions); YWHAH (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BRAFparental protein420.211765.634Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
2 AKT1oncoprotein160.49525.471PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
3 ARAFoncoprotein130.57712.324Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
4 BADoncoprotein130.66711.217Bcl-2_BAD (PF10514, IPR018868): Pro-apoptotic Bcl-2 protein, BAD
5 BRAPinteractor60.9000.500BRAP2 (PF07576, IPR011422): BRCA1-associated protein 2
DUF87 (PF01935, IPR002789): Domain of unknown function DUF87
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
KASH_CCD (PF14662, IPR028168): Coiled-coil region of CCDC155 or KASH
6 CCDC88Aprotein found in more fusions50.8330.286bZIP_1 (PF00170, IPR004827): bZIP transcription factor
ZapB (PF06005, IPR009252): Cell division protein ZapB
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
HOOK (PF05622, IPR008636): HOOK protein
Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein
BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472)
TolA_bind_tri (PF16331, IPR032519): TolA binding protein trimerisation
APC_N_CC (PF16689, IPR032038): Coiled-coil N-terminus of APC, dimerisation domain
7 CDC37protein found in more fusions140.62810.064CDC37_C (PF08564, IPR013873, SM01069): Cdc37 C terminal domain
CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain
CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding
Rho_Binding (PF08912, IPR015008): Rho Binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
8 FBXW7suppressor40.6670.667Mem_trans (PF03547, IPR004776): Membrane transport protein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
F-box-like (PF12937, IPR001810): F-box-like
9 HRASoncoprotein41.0000Ras (PF00071, IPR001806, SM00173): Ras family
10 HSP90AA1oncoprotein170.40045.598HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
11 HSP90AB1oncoprotein140.56413.671HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
12 HSPA1Ainteractor100.6674.623HSP70 (PF00012, IPR013126): Hsp70 protein
13 HSPA5oncoprotein140.56413.879HSP70 (PF00012, IPR013126): Hsp70 protein
14 HSPA8oncoprotein130.6419.744HSP70 (PF00012, IPR013126): Hsp70 protein
15 HSPA9oncoprotein60.7331.155HSP70 (PF00012, IPR013126): Hsp70 protein
16 IQGAP1interactor110.40019.802CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
DUF87 (PF01935, IPR002789): Domain of unknown function DUF87
IDEAL (PF08858, IPR014957, SM00914): IDEAL domain
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase
RasGAP_C (PF03836, IPR000593): RasGAP C-terminus
WW (PF00397, IPR001202, SM00456): WW domain
17 KSR1oncoprotein80.7142.556Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
KSR1-SAM (PF13543, IPR025561): SAM like domain present in kinase suppressor RAS 1
18 LIMK1oncoprotein50.6670.667LIM (PF00412, IPR001781, SM00132): LIM domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
19 LIPFinteractor100Abhydro_lipase (PF04083, IPR006693): Partial alpha/beta-hydrolase lipase region
Abhydrolase_1 (PF00561, IPR000073): alpha/beta hydrolase fold
20 MAP2K1oncoprotein160.42935.397Pkinase (PF00069, IPR000719): Protein kinase domain
DUF3216 (PF11505, IPR023108): Protein of unknown function (DUF3216)
21 MAP2K2interactor90.7143.443Pkinase (PF00069, IPR000719): Protein kinase domain
CAMSAP_CC1 (PF17095, IPR031372): Spectrin-binding region of Ca2+-Calmodulin
22 MAPK1oncoprotein80.7622.556Pkinase (PF00069, IPR000719): Protein kinase domain
23 MAPK3oncoprotein90.5718.844Pkinase (PF00069, IPR000719): Protein kinase domain
24 MRASoncoprotein21.0000Ras (PF00071, IPR001806, SM00173): Ras family
25 MUS81suppressor100ERCC4 (PF02732, IPR006166, SM00891): ERCC4 domain
MutL (PF13941, IPR006230): MutL protein
HHH_8 (PF14716, IPR010996): Helix-hairpin-helix domain
26 NEDD4Lsuppressor100.8062.211WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
27 PAK2protein found in more fusions100.6115.786PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
Pkinase (PF00069, IPR000719): Protein kinase domain
28 PHKBinteractor100Glyco_hydro_15 (PF00723, IPR011613): Glycosyl hydrolases family 15
29 PRKCEsuppressor90.5365.978C2 (PF00168, IPR000008, SM00239): C2 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
30 RAF1oncoprotein260.330132.725Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
31 RAP1Asuppressor40.5002.222Ras (PF00071, IPR001806, SM00173): Ras family
32 RAP1GAPsuppressor21.0000GoLoco (PF02188, IPR003109, SM00390): GoLoco motif
Rap_GAP (PF02145, IPR000331): Rap/ran-GAP
33 RNF149interactor100PA (PF02225, IPR003137): PA domain
UPF0233 (PF06781, IPR009619): Uncharacterised protein family (UPF0233)
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
Zn_ribbon_17 (PF17120): Zinc-ribbon, C4HC2 type
34 RPS6KB2interactor130.50018.255Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
35 SFNsuppressor120.6735.35514-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
36 TERF1interactor60.7000.869TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
37 YWHABinteractor160.54222.39014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
Virulence_fact (PF13769, IPR025989): Virulence factor
38 YWHAEoncoprotein180.51632.30314-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
39 YWHAGprotein found in more fusions170.54227.85114-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
40 YWHAHprotein found in more fusions140.65412.19614-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
41 YWHAQinteractor150.60015.64314-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
42 YWHAZprotein found in more fusions170.58322.12114-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

B a c k    t o    T o p ⇑