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Visible interactions: all affected independent (normal) missing (in fusions) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)27
The number (and %) of the onco-proteins4 (14.81 %)
The number (and %) of the tumor suppressors1 (3.70 %)
Total number of binary PPIs (saturation %)49 (13.96 %)
The number (and %) of affected PPIs27 (55.10 %)
The number of possible different fusions3
PPI diameter2
PPI radius1
The average degree of PPI3.037
Assortativity coefficient-0.2922
The network average Clustering coefficient0.375
The number (and %) of a zero Clustering coefficients12 (44.44 %)
The number (and %) of a zero Betweenness Centrality17 (62.96 %)


List of the fusions

PPI for parental proteins: BEGAIN All fusions
: BF952154;
Proteins found in more fusions APP (see 4 fusions); BEGAIN (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 BEGAINparental protein270.046594.333Fez1 (PF06818): Fez1
BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2
DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472)
2 ABLIM1interactor30.6670.667LIM (PF00412, IPR001781, SM00132): LIM domain
VHP (PF02209, IPR003128, SM00153): Villin headpiece domain
zf-dskA_traR (PF01258, IPR000962): Prokaryotic dksA/traR C4-type zinc finger
DUF2175 (PF09943, IPR018686): Uncharacterized protein conserved in archaea (DUF2175)
AbLIM_anchor (PF16182, IPR032402): Putative adherens-junction anchoring region of AbLIM
3 APPprotein found in more fusions70.3339.667APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
4 ATP6AP2interactor200Phosphodiest (PF01663, IPR002591): Type I phosphodiesterase / nucleotide pyrophosphatase
Renin_r (PF07850, IPR012493): Renin receptor-like protein
5 BAHD1interactor100BAH (PF01426, IPR001025, SM00439): BAH domain
6 CATSPER1interactor200Ion_trans (PF00520, IPR005821): Ion transport protein
MMM1 (PF10296, IPR019411): Maintenance of mitochondrial morphology protein 1
7 CEP170interactor40.5003.000FHA (PF00498, IPR000253, SM00240): FHA domain
DUF4254 (PF14063, IPR025350): Protein of unknown function (DUF4254)
CEP170_C (PF15308, IPR029300): CEP170 C-terminus
8 CEP170P1interactor31.0000NA
9 DEF6interactor21.0000ArgK (PF03308, IPR005129): ArgK protein
HSP70 (PF00012, IPR013126): Hsp70 protein
PH (PF00169, IPR001849, SM00233): PH domain
zf-C4H2 (PF10146, IPR018482): Zinc finger-containing protein
EF-hand_6 (PF13405, IPR002048): EF-hand domain
10 DTNBinteractor200EF-hand_2 (PF09068, IPR015153): EF hand
EF-hand_3 (PF09069, IPR015154): EF-hand
Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain
Ax_dynein_light (PF10211, IPR019347): Axonemal dynein light chain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
SOGA (PF11365, IPR027881): Protein SOGA
11 ENKD1interactor30.6670.667Enkurin (PF13864, IPR027012): Calmodulin-binding
12 FAM107Ainteractor100DUF1151 (PF06625, IPR009533): Protein of unknown function (DUF1151)
13 GFI1Boncoprotein30.6671.000zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
14 HGSinteractor30.6671.000FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VHS (PF00790, IPR002014, SM00288): VHS domain
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate
PIEZO (PF15917, IPR031805): Piezo
15 HID1interactor100Hid1 (PF12722): High-temperature-induced dauer-formation protein
16 KIAA0408interactor100IncA (PF04156, IPR007285): IncA protein
DUF4482 (PF14818, IPR027882): Domain of unknown function (DUF4482)
17 QSOX1interactor100Evr1_Alr (PF04777, IPR017905): Erv1 / Alr family
Thioredoxin (PF00085, IPR013766): Thioredoxin
DUF35_N (PF12172, IPR022002): Rubredoxin-like zinc ribbon domain (DUF35_N)
Thioredoxin_2 (PF13098, IPR012336): Thioredoxin-like domain
18 RBL1suppressor100RB_A (PF01858, IPR002720): Retinoblastoma-associated protein A domain
RB_B (PF01857, IPR002719): Retinoblastoma-associated protein B domain
Rb_C (PF08934, IPR015030): Rb C-terminal domain
DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452)
19 RIBC2interactor100RIB43A (PF05914, IPR008805): RIB43A
20 SKA1interactor21.0000SKA1 (PF07160, IPR009829): Spindle and kinetochore-associated protein 1
21 TRIM27oncoprotein60.4006.000IncA (PF04156, IPR007285): IncA protein
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
22 USP2interactor30.6671.000UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
23 XPO1interactor40.5002.667CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
24 ZFP64oncoprotein100zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
zf-C2HE (PF16278, IPR032566): C2HE / C2H2 / C2HC zinc-binding finger
25 ZNF250interactor31.0000KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
26 ZNF417interactor21.0000A2L_zn_ribbon (PF08792, IPR014900): A2L zinc ribbon domain
C1_4 (PF07975, IPR004595, SM01047): TFIIH C1-like domain
KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
27 ZNF774interactor100zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
DUF3844 (PF12955, IPR024382): Domain of unknown function (DUF3844)
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain

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List of missing interactors (in fusions)

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 BEGAINparental proteinFez1 (PF06818): Fez1
BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2
DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472)
2 CEP170P1interactorNABF952154
3 FAM107AinteractorDUF1151 (PF06625, IPR009533): Protein of unknown function (DUF1151)BF952154

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