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Visible interactions: all affected independent (normal) missing (in fusions) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)77
The number (and %) of the onco-proteins23 (29.87 %)
The number (and %) of the tumor suppressors13 (16.88 %)
Total number of binary PPIs (saturation %)259 (8.85 %)
The number (and %) of affected PPIs77 (29.73 %)
The number of possible different fusions17
PPI diameter2
PPI radius1
The average degree of PPI5.818
Assortativity coefficient-0.2759
The network average Clustering coefficient0.541
The number (and %) of a zero Clustering coefficients12 (15.58 %)
The number (and %) of a zero Betweenness Centrality27 (35.06 %)

ACTIVE INTERACTORS
MISSING INTERACTORS (in fusions)


List of the fusions

PPI for parental proteins: BECN1 All fusions
: AA158625;
Proteins found in more fusions RNF216 (see 1 fusions); TAB2 (see 1 fusions); TRAF6 (see 1 fusions); MCL1 (see 2 fusions); PRKDC (see 2 fusions); BCL2L1 (see 1 fusions); HSP90AA1 (see 6 fusions); ULK1 (see 2 fusions); S100A8 (see 3 fusions); BECN1 (see 1 fusions); UBC (see 7 fusions); DZIP3 (see 1 fusions); DAPK1 (see 1 fusions); DDB1 (see 4 fusions); PARK2 (see 1 fusions); NEDD4 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BECN1parental protein770.0524757.100APG6 (PF04111, IPR007243): Autophagy protein Apg6
Ima1_N (PF09779, IPR018617): Ima1 N-terminal domain
BH3 (PF15285, IPR029318): Beclin-1 BH3 domain, Bcl-2-interacting
2 AFG3L2interactor30.6671.000AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
FtsH_ext (PF06480, IPR011546): FtsH Extracellular
Peptidase_M41 (PF01434, IPR000642): Peptidase family M41
TniB (PF05621, IPR008868): Bacterial TniB protein
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
3 AMBRA1interactor140.30852.367Acyl_CoA_thio (PF02551, IPR025652): Acyl-CoA thioesterase
eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Spt20 (PF12090, IPR021950): Spt20 family
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
4 ATG14interactor110.34527.667Atg14 (PF10186, IPR018791): Vacuolar sorting 38 and autophagy-related subunit 14
5 ATG3interactor30.6670.500Autophagy_C (PF10381, IPR019461): Autophagocytosis associated protein C-terminal
Autophagy_N (PF03986, IPR007134): Autophagocytosis associated protein (Atg3), N-terminal domain
Autophagy_act_C (PF03987, IPR007135): Autophagocytosis associated protein, active-site domain
6 BCL2oncoprotein110.42218.300Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
BH4 (PF02180, IPR003093, SM00265): Bcl-2 homology region 4
7 BCL2L1oncoprotein80.4768.400Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
BH4 (PF02180, IPR003093, SM00265): Bcl-2 homology region 4
8 BIRC5interactor70.6003.667BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
9 BRCA1suppressor130.24244.500BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
10 BTKsuppressor40.6671.000BTK (PF00779, IPR001562, SM00107): BTK motif
PH (PF00169, IPR001849, SM00233): PH domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
11 CASP3interactor70.4006.400Peptidase_C14 (PF00656, IPR011600): Caspase domain
12 CDKN2Asuppressor50.5002.967Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
13 CHAF1Ainteractor40.6671.000CAF-1_p150 (PF11600): Chromatin assembly factor 1 complex p150 subunit, N-terminal
CAF1A (PF12253, IPR022043): Chromatin assembly factor 1 subunit A
CAF1-p150_C2 (PF15539, IPR029105): CAF1 complex subunit p150, region binding to CAF1-p60 at C-term
CAF1-p150_N (PF15557, IPR029091): CAF1 complex subunit p150, region binding to PCNA
14 DACT1suppressor31.0000Dapper (PF15268, IPR024843): Dapper
15 DAPK1suppressor40.6671.000ABC_tran (PF00005, IPR003439): ABC transporter
Death (PF00531, IPR000488, SM00005): Death domain
Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
Pkinase (PF00069, IPR000719): Protein kinase domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
AAA_23 (PF13476): AAA domain
Ank_5 (PF13857): Ankyrin repeats (many copies)
COR (PF16095, IPR032171): C-terminal of Roc, COR, domain
16 DDB1protein found in more fusions60.8001.067CPSF_A (PF03178, IPR004871): CPSF A subunit region
MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
17 DYNC1I1interactor31.0000CDC45 (PF02724, IPR003874): CDC45-like protein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Dynein_IC2 (PF11540, IPR025956): Cytoplasmic dynein 1 intermediate chain 2
AviRa (PF11599, IPR024268): RRNA methyltransferase AviRa
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated
18 DYNLL1interactor60.7002.167Dynein_light (PF01221, IPR001372): Dynein light chain type 1
19 DZIP3protein found in more fusions31.0000DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
SlyX (PF04102, IPR007236): SlyX
zf-RING-like (PF08746, IPR014857): RING-like domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
20 EXOC2interactor80.50010.400PhzC-PhzF (PF02567, IPR003719): Phenazine biosynthesis-like protein
TIG (PF01833, IPR002909): IPT/TIG domain
Sec5 (PF15469): Exocyst complex component Sec5
21 EXOC4oncoprotein31.0000DUF948 (PF06103, IPR009293): Bacterial protein of unknown function (DUF948)
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
Sec8_exocyst (PF04048, IPR007191): Sec8 exocyst complex component specific domain
Vps51 (PF08700): Vps51/Vps67
22 EXOC8interactor70.6194.733K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
PH (PF00169, IPR001849, SM00233): PH domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Vps51 (PF08700): Vps51/Vps67
Syntaxin_2 (PF14523): Syntaxin-like protein
Exo84_C (PF16528, IPR032403): Exocyst component 84 C-terminal
23 FRS2interactor100IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
24 GFI1Boncoprotein21.0000zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
25 GOPConcoprotein200DUF903 (PF06004, IPR010305): Bacterial protein of unknown function (DUF903)
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
DUF3209 (PF11483, IPR021577): Protein of unknown function (DUF3209)
26 GSPT1oncoprotein21.0000GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
PAM2 (PF07145, IPR009818): Ataxin-2 C-terminal region
27 HERC5interactor200Peptidase_S51 (PF03575, IPR005320): Peptidase family S51
RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
28 HSP90AA1oncoprotein180.22890.600HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
29 HSPA1Ainteractor60.7332.133HSP70 (PF00012, IPR013126): Hsp70 protein
30 IRGMinteractor50.6671.000IIGP (PF05049, IPR007743): Interferon-inducible GTPase (IIGP)
31 ITCHinteractor50.6672.000C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
32 LSM3interactor100LSM (PF01423, IPR001163): LSM domain
33 MCL1oncoprotein70.4675.833Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
34 MDN1interactor21.0000AAA_5 (PF07728, IPR011704): AAA domain (dynein-related subfamily)
DNA_pol_phi (PF04931, IPR007015): DNA polymerase phi
DnaB_C (PF03796, IPR007694): DnaB-like helicase C terminal domain
AAA_16 (PF13191): AAA ATPase domain
Sigma54_activ_2 (PF14532, IPR002078): Sigma-54 interaction domain
35 MEFVinteractor30.6671.0007TMR-HDED (PF07697, IPR011624): 7TM-HD extracellular
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
36 NEDD4suppressor50.5002.667Rota_NS26 (PF01525, IPR002512): Rotavirus NS26
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
37 NGDNinteractor21.0000Sas10_Utp3 (PF04000, IPR007146): Sas10/Utp3/C1D family
FAM176 (PF14851): FAM176 family
TMEM247 (PF15444, IPR029200): Transmembrane protein 247
38 NLRP2oncoprotein40.5002.667LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
NACHT (PF05729): NACHT domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
AAA_16 (PF13191): AAA ATPase domain
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
39 NLRP5interactor21.0000NACHT (PF05729): NACHT domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
Toxin_12 (PF07740, IPR011696): Ion channel inhibitory toxin
Toxin_23 (PF08093, IPR012628): Magi 5 toxic peptide family
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
AAA_16 (PF13191): AAA ATPase domain
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
40 NRBF2interactor41.0000NRBF2 (PF08961, IPR015056): Nuclear receptor-binding factor 2, autophagy regulator
NRBF2_MIT (PF17169): MIT domain of nuclear receptor-binding factor 2
41 PARK2suppressor110.48914.867IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
42 PIK3C3interactor150.33356.033PI3K_C2 (PF00792, IPR002420, SM00142): Phosphoinositide 3-kinase C2
PI3Ka (PF00613, IPR001263, SM00145): Phosphoinositide 3-kinase family, accessory domain (PIK domain)
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
43 PIK3CGoncoprotein100Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
PI3K_C2 (PF00792, IPR002420, SM00142): Phosphoinositide 3-kinase C2
PI3K_rbd (PF00794, IPR000341, SM00144): PI3-kinase family, ras-binding domain
PI3Ka (PF00613, IPR001263, SM00145): Phosphoinositide 3-kinase family, accessory domain (PIK domain)
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
DUF3244 (PF11589, IPR021638): Domain of unknown function (DUF3244)
DUF4135 (PF13575, IPR025410): Domain of unknown function (DUF4135)
44 PIK3R4interactor70.6194.967HEAT (PF02985, IPR000357): HEAT repeat
Pkinase (PF00069, IPR000719): Protein kinase domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
45 PRKDCprotein found in more fusions70.5335.833FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
NUC194 (PF08163, IPR012582): NUC194 domain
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
46 PTOV1interactor21.0000Med25 (PF11232, IPR021394): Mediator complex subunit 25 PTOV activation and synapsin 2
47 PYCARDsuppressor50.5002.667CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
48 RNF2interactor140.20555.900zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
49 RNF216oncoprotein40.6670.667DUF226 (PF02890, IPR004180): Borrelia family of unknown function DUF226
IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
DUF4645 (PF15488, IPR027891): Domain of unknown function (DUF4645)
50 RUBCNinteractor60.7332.333RUN (PF02759, IPR004012, SM00593): RUN domain
zf-RING_9 (PF13901, IPR025258): Putative zinc-RING and/or ribbon
51 RUBCNLinteractor100zf-RING_9 (PF13901, IPR025258): Putative zinc-RING and/or ribbon
52 S100A8oncoprotein200S_100 (PF01023, IPR013787): S-100/ICaBP type calcium binding domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
53 SEH1Linteractor100WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
Ge1_WD40 (PF16529, IPR032401): WD40 region of Ge1, enhancer of mRNA-decapping protein
54 SHDinteractor100SH2 (PF00017, IPR000980, SM00252): SH2 domain
55 SLC27A4interactor100AMP-binding (PF00501, IPR000873): AMP-binding enzyme
AMP-binding_C (PF13193, IPR025110): AMP-binding enzyme C-terminal domain
56 SMC1Aoncoprotein50.8330.400SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
57 SMC3oncoprotein40.8330.400SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
58 TAB2oncoprotein80.4768.733CUE (PF02845, IPR003892, SM00546): CUE domain
DivIC (PF04977, IPR007060): Septum formation initiator
Mnd1 (PF03962, IPR005647): Mnd1 family
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
59 TAB3oncoprotein51.0000CUE (PF02845, IPR003892, SM00546): CUE domain
Tmemb_cc2 (PF10267, IPR019394): Predicted transmembrane and coiled-coil 2 protein
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
60 TBC1D7interactor30.6671.000RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain
61 TCOF1interactor21.0000CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755)
Gal-3-0_sulfotr (PF06990, IPR009729): Galactose-3-O-sulfotransferase
Treacle (PF03546, IPR003993): Treacher Collins syndrome protein Treacle
IMUP (PF15761, IPR026621): Immortalisation up-regulated protein
AP3D1 (PF06375): AP-3 complex subunit delta-1
62 TNFAIP3suppressor50.6670.733OTU (PF02338, IPR003323): OTU-like cysteine protease
zf-A20 (PF01754, IPR002653, SM00259): A20-like zinc finger
Thioredoxin_3 (PF13192, IPR012336): Thioredoxin domain
63 TP53BP2suppressor40.6672.000ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
Erp_C (PF06780, IPR009618): Erp protein C-terminus
SlyX (PF04102, IPR007236): SlyX
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
64 TRABDinteractor21.0000TraB (PF01963, IPR002816): TraB family
65 TRAF6protein found in more fusions130.31835.000SlyX (PF04102, IPR007236): SlyX
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
66 TRIB1interactor100Pkinase (PF00069, IPR000719): Protein kinase domain
67 TRIM21interactor50.5002.500DUF313 (PF03754, IPR005508): Domain of unknown function (DUF313)
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
Prok-RING_1 (PF14446): Prokaryotic RING finger family 1
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
68 TSC1suppressor40.6671.000Bcr-Abl_Oligo (PF09036, IPR015123): Bcr-Abl oncoprotein oligomerisation domain
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
Hamartin (PF04388, IPR007483): Hamartin protein
69 UBCprotein found in more fusions180.20694.467ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
70 ULK1protein found in more fusions90.35715.333Pkinase (PF00069, IPR000719): Protein kinase domain
DUF3543 (PF12063, IPR022708): Domain of unknown function (DUF3543)
RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
71 USP18interactor50.6002.833TAFII55_N (PF04658, IPR006751): TAFII55 protein conserved region
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
72 USP33suppressor40.6671.667UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
DUSP (PF06337, IPR006615, SM00695): DUSP domain
73 UVRAGsuppressor60.6672.900C2 (PF00168, IPR000008, SM00239): C2 domain
HTH_1 (PF00126, IPR000847): Bacterial regulatory helix-turn-helix protein, lysR family
Atg14 (PF10186, IPR018791): Vacuolar sorting 38 and autophagy-related subunit 14
74 WASHC1interactor21.0000WASH_WAHD (PF11945, IPR021854): WAHD domain of WASH complex
PRIMA1 (PF16101): Proline-rich membrane anchor 1
75 XPO1interactor110.23637.567CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
76 YES1oncoprotein40.5002.067Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
YdjC (PF04794, IPR006879): YdjC-like protein
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
77 ZWINTinteractor200Zwint (PF15556, IPR029092): ZW10 interactor

B a c k    t o    T o p ⇑


List of missing interactors (in fusions)

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 AFG3L2interactorAAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
FtsH_ext (PF06480, IPR011546): FtsH Extracellular
Peptidase_M41 (PF01434, IPR000642): Peptidase family M41
TniB (PF05621, IPR008868): Bacterial TniB protein
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
AA158625
2 AMBRA1interactorAcyl_CoA_thio (PF02551, IPR025652): Acyl-CoA thioesterase
eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Spt20 (PF12090, IPR021950): Spt20 family
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
AA158625
3 ATG14interactorAtg14 (PF10186, IPR018791): Vacuolar sorting 38 and autophagy-related subunit 14AA158625
4 ATG3interactorAutophagy_C (PF10381, IPR019461): Autophagocytosis associated protein C-terminal
Autophagy_N (PF03986, IPR007134): Autophagocytosis associated protein (Atg3), N-terminal domain
Autophagy_act_C (PF03987, IPR007135): Autophagocytosis associated protein, active-site domain
AA158625
5 BCL2oncoproteinBcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
BH4 (PF02180, IPR003093, SM00265): Bcl-2 homology region 4
AA158625
6 BCL2L1oncoproteinBcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
BH4 (PF02180, IPR003093, SM00265): Bcl-2 homology region 4
AA158625
7 BECN1parental proteinAPG6 (PF04111, IPR007243): Autophagy protein Apg6
Ima1_N (PF09779, IPR018617): Ima1 N-terminal domain
BH3 (PF15285, IPR029318): Beclin-1 BH3 domain, Bcl-2-interacting
AA158625
8 BIRC5interactorBIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domainAA158625
9 BRCA1suppressorBRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
AA158625
10 BTKsuppressorBTK (PF00779, IPR001562, SM00107): BTK motif
PH (PF00169, IPR001849, SM00233): PH domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
AA158625
11 CASP3interactorPeptidase_C14 (PF00656, IPR011600): Caspase domainAA158625
12 CDKN2AsuppressorAnk_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
AA158625
13 CHAF1AinteractorCAF-1_p150 (PF11600): Chromatin assembly factor 1 complex p150 subunit, N-terminal
CAF1A (PF12253, IPR022043): Chromatin assembly factor 1 subunit A
CAF1-p150_C2 (PF15539, IPR029105): CAF1 complex subunit p150, region binding to CAF1-p60 at C-term
CAF1-p150_N (PF15557, IPR029091): CAF1 complex subunit p150, region binding to PCNA
AA158625
14 DACT1suppressorDapper (PF15268, IPR024843): DapperAA158625
15 DAPK1suppressorABC_tran (PF00005, IPR003439): ABC transporter
Death (PF00531, IPR000488, SM00005): Death domain
Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
Pkinase (PF00069, IPR000719): Protein kinase domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
AAA_23 (PF13476): AAA domain
Ank_5 (PF13857): Ankyrin repeats (many copies)
COR (PF16095, IPR032171): C-terminal of Roc, COR, domain
AA158625
16 DDB1interactorCPSF_A (PF03178, IPR004871): CPSF A subunit region
MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
AA158625
17 DYNC1I1interactorCDC45 (PF02724, IPR003874): CDC45-like protein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Dynein_IC2 (PF11540, IPR025956): Cytoplasmic dynein 1 intermediate chain 2
AviRa (PF11599, IPR024268): RRNA methyltransferase AviRa
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated
AA158625
18 DYNLL1interactorDynein_light (PF01221, IPR001372): Dynein light chain type 1AA158625
19 DZIP3interactorDUF16 (PF01519, IPR002862): Protein of unknown function DUF16
SlyX (PF04102, IPR007236): SlyX
zf-RING-like (PF08746, IPR014857): RING-like domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
AA158625
20 EXOC2interactorPhzC-PhzF (PF02567, IPR003719): Phenazine biosynthesis-like protein
TIG (PF01833, IPR002909): IPT/TIG domain
Sec5 (PF15469): Exocyst complex component Sec5
AA158625
21 EXOC4oncoproteinDUF948 (PF06103, IPR009293): Bacterial protein of unknown function (DUF948)
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
Sec8_exocyst (PF04048, IPR007191): Sec8 exocyst complex component specific domain
Vps51 (PF08700): Vps51/Vps67
AA158625
22 EXOC8interactorK_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
PH (PF00169, IPR001849, SM00233): PH domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Vps51 (PF08700): Vps51/Vps67
Syntaxin_2 (PF14523): Syntaxin-like protein
Exo84_C (PF16528, IPR032403): Exocyst component 84 C-terminal
AA158625
23 FRS2interactorIRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)AA158625
24 GFI1Boncoproteinzf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
AA158625
25 GOPConcoproteinDUF903 (PF06004, IPR010305): Bacterial protein of unknown function (DUF903)
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
DUF3209 (PF11483, IPR021577): Protein of unknown function (DUF3209)
AA158625
26 GSPT1oncoproteinGTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
PAM2 (PF07145, IPR009818): Ataxin-2 C-terminal region
AA158625
27 HERC5interactorPeptidase_S51 (PF03575, IPR005320): Peptidase family S51
RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
AA158625
28 HSP90AA1oncoproteinHATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
AA158625
29 HSPA1AinteractorHSP70 (PF00012, IPR013126): Hsp70 proteinAA158625
30 IRGMinteractorIIGP (PF05049, IPR007743): Interferon-inducible GTPase (IIGP)AA158625
31 ITCHinteractorC2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
AA158625
32 LSM3interactorLSM (PF01423, IPR001163): LSM domainAA158625
33 MCL1oncoproteinBcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 familyAA158625
34 MDN1interactorAAA_5 (PF07728, IPR011704): AAA domain (dynein-related subfamily)
DNA_pol_phi (PF04931, IPR007015): DNA polymerase phi
DnaB_C (PF03796, IPR007694): DnaB-like helicase C terminal domain
AAA_16 (PF13191): AAA ATPase domain
Sigma54_activ_2 (PF14532, IPR002078): Sigma-54 interaction domain
AA158625
35 MEFVinteractor7TMR-HDED (PF07697, IPR011624): 7TM-HD extracellular
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
AA158625
36 NEDD4suppressorRota_NS26 (PF01525, IPR002512): Rotavirus NS26
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
AA158625
37 NGDNinteractorSas10_Utp3 (PF04000, IPR007146): Sas10/Utp3/C1D family
FAM176 (PF14851): FAM176 family
TMEM247 (PF15444, IPR029200): Transmembrane protein 247
AA158625
38 NLRP2oncoproteinLRR_1 (PF00560, IPR001611): Leucine Rich Repeat
NACHT (PF05729): NACHT domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
AAA_16 (PF13191): AAA ATPase domain
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
AA158625
39 NLRP5interactorNACHT (PF05729): NACHT domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
Toxin_12 (PF07740, IPR011696): Ion channel inhibitory toxin
Toxin_23 (PF08093, IPR012628): Magi 5 toxic peptide family
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
AAA_16 (PF13191): AAA ATPase domain
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
AA158625
40 NRBF2interactorNRBF2 (PF08961, IPR015056): Nuclear receptor-binding factor 2, autophagy regulator
NRBF2_MIT (PF17169): MIT domain of nuclear receptor-binding factor 2
AA158625
41 PARK2suppressorIBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
AA158625
42 PIK3C3interactorPI3K_C2 (PF00792, IPR002420, SM00142): Phosphoinositide 3-kinase C2
PI3Ka (PF00613, IPR001263, SM00145): Phosphoinositide 3-kinase family, accessory domain (PIK domain)
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
AA158625
43 PIK3CGoncoproteinMyc-LZ (PF02344, IPR003327): Myc leucine zipper domain
PI3K_C2 (PF00792, IPR002420, SM00142): Phosphoinositide 3-kinase C2
PI3K_rbd (PF00794, IPR000341, SM00144): PI3-kinase family, ras-binding domain
PI3Ka (PF00613, IPR001263, SM00145): Phosphoinositide 3-kinase family, accessory domain (PIK domain)
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
DUF3244 (PF11589, IPR021638): Domain of unknown function (DUF3244)
DUF4135 (PF13575, IPR025410): Domain of unknown function (DUF4135)
AA158625
44 PIK3R4interactorHEAT (PF02985, IPR000357): HEAT repeat
Pkinase (PF00069, IPR000719): Protein kinase domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
AA158625
45 PRKDCinteractorFAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
NUC194 (PF08163, IPR012582): NUC194 domain
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
AA158625
46 PTOV1interactorMed25 (PF11232, IPR021394): Mediator complex subunit 25 PTOV activation and synapsin 2AA158625
47 PYCARDsuppressorCARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
AA158625
48 RNF2interactorzf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
AA158625
49 RNF216oncoproteinDUF226 (PF02890, IPR004180): Borrelia family of unknown function DUF226
IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
DUF4645 (PF15488, IPR027891): Domain of unknown function (DUF4645)
AA158625
50 RUBCNinteractorRUN (PF02759, IPR004012, SM00593): RUN domain
zf-RING_9 (PF13901, IPR025258): Putative zinc-RING and/or ribbon
AA158625
51 RUBCNLinteractorzf-RING_9 (PF13901, IPR025258): Putative zinc-RING and/or ribbonAA158625
52 S100A8oncoproteinS_100 (PF01023, IPR013787): S-100/ICaBP type calcium binding domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
AA158625
53 SEH1LinteractorWD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
Ge1_WD40 (PF16529, IPR032401): WD40 region of Ge1, enhancer of mRNA-decapping protein
AA158625
54 SHDinteractorSH2 (PF00017, IPR000980, SM00252): SH2 domainAA158625
55 SLC27A4interactorAMP-binding (PF00501, IPR000873): AMP-binding enzyme
AMP-binding_C (PF13193, IPR025110): AMP-binding enzyme C-terminal domain
AA158625
56 SMC1AoncoproteinSMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domainAA158625
57 SMC3oncoproteinSMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domainAA158625
58 TAB2oncoproteinCUE (PF02845, IPR003892, SM00546): CUE domain
DivIC (PF04977, IPR007060): Septum formation initiator
Mnd1 (PF03962, IPR005647): Mnd1 family
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
AA158625
59 TAB3oncoproteinCUE (PF02845, IPR003892, SM00546): CUE domain
Tmemb_cc2 (PF10267, IPR019394): Predicted transmembrane and coiled-coil 2 protein
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
AA158625
60 TBC1D7interactorRabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domainAA158625
61 TCOF1interactorCENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755)
Gal-3-0_sulfotr (PF06990, IPR009729): Galactose-3-O-sulfotransferase
Treacle (PF03546, IPR003993): Treacher Collins syndrome protein Treacle
IMUP (PF15761, IPR026621): Immortalisation up-regulated protein
AP3D1 (PF06375): AP-3 complex subunit delta-1
AA158625
62 TNFAIP3suppressorOTU (PF02338, IPR003323): OTU-like cysteine protease
zf-A20 (PF01754, IPR002653, SM00259): A20-like zinc finger
Thioredoxin_3 (PF13192, IPR012336): Thioredoxin domain
AA158625
63 TP53BP2suppressorATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
Erp_C (PF06780, IPR009618): Erp protein C-terminus
SlyX (PF04102, IPR007236): SlyX
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
AA158625
64 TRABDinteractorTraB (PF01963, IPR002816): TraB familyAA158625
65 TRAF6interactorSlyX (PF04102, IPR007236): SlyX
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
AA158625
66 TRIB1interactorPkinase (PF00069, IPR000719): Protein kinase domainAA158625
67 TRIM21interactorDUF313 (PF03754, IPR005508): Domain of unknown function (DUF313)
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
Prok-RING_1 (PF14446): Prokaryotic RING finger family 1
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
AA158625
68 TSC1suppressorBcr-Abl_Oligo (PF09036, IPR015123): Bcr-Abl oncoprotein oligomerisation domain
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
Hamartin (PF04388, IPR007483): Hamartin protein
AA158625
69 UBCinteractorubiquitin (PF00240, IPR000626, SM00213): Ubiquitin familyAA158625
70 ULK1interactorPkinase (PF00069, IPR000719): Protein kinase domain
DUF3543 (PF12063, IPR022708): Domain of unknown function (DUF3543)
RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
AA158625
71 USP18interactorTAFII55_N (PF04658, IPR006751): TAFII55 protein conserved region
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
AA158625
72 USP33suppressorUCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
DUSP (PF06337, IPR006615, SM00695): DUSP domain
AA158625
73 UVRAGsuppressorC2 (PF00168, IPR000008, SM00239): C2 domain
HTH_1 (PF00126, IPR000847): Bacterial regulatory helix-turn-helix protein, lysR family
Atg14 (PF10186, IPR018791): Vacuolar sorting 38 and autophagy-related subunit 14
AA158625
74 WASHC1interactorWASH_WAHD (PF11945, IPR021854): WAHD domain of WASH complex
PRIMA1 (PF16101): Proline-rich membrane anchor 1
AA158625
75 XPO1interactorCRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
AA158625
76 YES1oncoproteinPkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
YdjC (PF04794, IPR006879): YdjC-like protein
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
AA158625
77 ZWINTinteractorZwint (PF15556, IPR029092): ZW10 interactorAA158625

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