Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins BCL6 (from a repository: Thu Nov 10 14:59:26 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 111 The number (and %) of the onco-proteins 49 (44.14 %) The number (and %) of the tumor suppressors 6 (5.41 %) Total number of binary PPIs (saturation %) 432 (7.08 %) The number (and %) of affected PPIs 111 (25.69 %) The number of possible different fusions 22 PPI diameter 2 PPI radius 1 The average degree of PPI 7.027 Assortativity coefficient -0.3699 The network average Clustering coefficient 0.498 The number (and %) of a zero Clustering coefficients 29 (26.13 %) The number (and %) of a zero Betweenness Centrality 52 (46.85 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: BCL6	All fusions
Proteins found in more fusions	CREBBP (see 5 fusions); EBF1 (see 1 fusions); CTBP1 (see 2 fusions); AES (see 3 fusions); HSP90AA1 (see 2 fusions); EHMT1 (see 3 fusions); HDAC7 (see 1 fusions); CHD3 (see 1 fusions); HDAC5 (see 1 fusions); BCL6 (see 2 fusions); CUL3 (see 1 fusions); EP300 (see 1 fusions); HDAC4 (see 1 fusions); SIAH1 (see 1 fusions); PML (see 4 fusions); ZBTB16 (see 3 fusions); PRKCE (see 3 fusions); RUNX1T1 (see 1 fusions); YY1 (see 2 fusions); PLPP3 (see 3 fusions); TP53 (see 3 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	BCL6	parental protein	111	0.047	10050.765	BTB (PF00651, IPR013069, SM00225): BTB/POZ domain zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding DZR (PF12773, IPR025874): Double zinc ribbon zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2HE (PF16278, IPR032566): C2HE / C2H2 / C2HC zinc-binding finger
2	AES	protein found in more fusions	6	0.400	5.667	TLE_N (PF03920, IPR005617): Groucho/TLE N-terminal Q-rich domain
3	ARHGAP35	interactor	1	0	0	FF (PF01846, IPR002713, SM00441): FF domain Ras (PF00071, IPR001806, SM00173): Ras family RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain RhoGAP-FF1 (PF16512, IPR032835): p190-A and -B Rho GAPs FF domain
4	ARNT2	interactor	5	0.500	4.067	HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain PAS (PF00989, IPR013767, SM00091): PAS fold PAS_3 (PF08447, IPR013655): PAS fold PAP2 (PF01569, IPR000326, SM00014): PAP2 superfamily
5	ATF7	interactor	4	0.667	0.833	bZIP_1 (PF00170, IPR004827): bZIP transcription factor zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
6	BACH2	oncoprotein	3	0.667	1.000	BTB (PF00651, IPR013069, SM00225): BTB/POZ domain bZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor
7	BCL11A	oncoprotein	5	1.000	0	BSP_II (PF05432, IPR008412): Bone sialoprotein II (BSP-II) C1_4 (PF07975, IPR004595, SM01047): TFIIH C1-like domain zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-HIT (PF04438, IPR007529): HIT zinc finger zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain
8	BCL6B	suppressor	3	1.000	0	BTB (PF00651, IPR013069, SM00225): BTB/POZ domain zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain Lar_restr_allev (PF14354): Restriction alleviation protein Lar
9	BCOR	oncoprotein	9	0.536	6.648	Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) BCOR (PF15808, IPR031628): BCL-6 co-repressor, non-ankyrin-repeat region PUFD (PF16553, IPR032365): BCORL-PCGF1-binding domain
10	BLZF1	interactor	1	0	0	DASH_Hsk3 (PF08227, IPR013183): DASH complex subunit Hsk3 like DUF1178 (PF06676, IPR009562): Protein of unknown function (DUF1178) ZapB (PF06005, IPR009252): Cell division protein ZapB JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
11	CACNA1A	interactor	1	0	0	Ca_chan_IQ (PF08763, IPR014873, SM01062): Voltage gated calcium channel IQ domain GRP (PF07172, IPR010800): Glycine rich protein family Ion_trans (PF00520, IPR005821): Ion transport protein Roughex (PF06020, IPR009259): Drosophila roughex protein SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region GPHH (PF16905, IPR031649): Voltage-dependent L-type calcium channel, IQ-associated
12	CDK19	interactor	6	0.933	0.333	Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region Pkinase (PF00069, IPR000719): Protein kinase domain
13	CDK8	interactor	9	0.750	3.000	Pkinase (PF00069, IPR000719): Protein kinase domain
14	CHD3	oncoprotein	11	0.644	6.577	CHDCT2 (PF08074, IPR012957): CHDCT2 (NUC038) domain CHDNT (PF08073, IPR012958): CHDNT (NUC034) domain Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain DUF1086 (PF06461, IPR009462, SM01146): Domain of Unknown Function (DUF1086) DUF1087 (PF06465, IPR009463, SM01147): Domain of Unknown Function (DUF1087) DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid) PHD (PF00628, IPR019787, SM00249): PHD-finger Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein SMN (PF06003, IPR010304): Survival motor neuron protein (SMN) SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain DUF2956 (PF11169, IPR021339): Protein of unknown function (DUF2956) FAM176 (PF14851): FAM176 family
15	CREBBP	oncoprotein	23	0.325	110.774	Creb_binding (PF09030, IPR014744): Creb binding DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902) Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region KIX (PF02172, IPR003101): KIX domain MAS20 (PF02064, IPR002056): MAS20 protein import receptor TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2) zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26 HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729) DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
16	CSMD1	interactor	1	0	0	CUB (PF00431, IPR000859, SM00042): CUB domain Hep_core_N (PF08290, IPR013195): Hepatitis core protein, putative zinc finger Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat) DERM (PF14704): Dermatopontin
17	CTBP1	protein found in more fusions	18	0.390	50.286	2-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Cellsynth_D (PF03500, IPR022798): Cellulose synthase subunit D
18	CTNNB1	oncoprotein	12	0.470	19.492	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361) HEAT_EZ (PF13513): HEAT-like repeat
19	CUL3	protein found in more fusions	13	0.197	49.400	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
20	CUTC	interactor	2	0	0	CutC (PF03932, IPR005627): CutC family
21	DDX6	oncoprotein	4	0.500	3.000	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
22	DNAH9	interactor	1	0	0	AAA_5 (PF07728, IPR011704): AAA domain (dynein-related subfamily) DASH_Dad2 (PF08654, IPR013963): DASH complex subunit Dad2 DHC_N1 (PF08385, IPR013594): Dynein heavy chain, N-terminal region 1 DHC_N2 (PF08393, IPR013602): Dynein heavy chain, N-terminal region 2 Dynein_heavy (PF03028, IPR004273): Dynein heavy chain and region D6 of dynein motor Noelin-1 (PF12308, IPR022082): Neurogenesis glycoprotein AAA_6 (PF12774): Hydrolytic ATP binding site of dynein motor region D1 AAA_7 (PF12775): P-loop containing dynein motor region D3 MT (PF12777, IPR024743): Microtubule-binding stalk of dynein motor AAA_8 (PF12780, IPR024317): P-loop containing dynein motor region D4 AAA_9 (PF12781): ATP-binding dynein motor region D5
23	DROSHA	interactor	2	1.000	0	dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) Ribonuclease_3 (PF00636, IPR000999, SM00535): Ribonuclease III domain Ribonucleas_3_3 (PF14622, IPR000999): Ribonuclease-III-like DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614)
24	E2F3	oncoprotein	3	1.000	0	E2F_TDP (PF02319, IPR003316): E2F/DP family winged-helix DNA-binding domain TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain
25	EBF1	oncoprotein	3	1.000	0	TIG (PF01833, IPR002909): IPT/TIG domain COE1_DBD (PF16422, IPR032200): Transcription factor COE1 DNA-binding domain COE1_HLH (PF16423, IPR032201): Transcription factor COE1 helix-loop-helix domain
26	EHMT1	oncoprotein	6	1.000	0	Pre-SET (PF05033, IPR007728): Pre-SET motif Ribosomal_L32p (PF01783, IPR002677): Ribosomal L32p protein family SET (PF00856, IPR001214, SM00317): SET domain XRCC4 (PF06632, IPR010585): DNA double-strand break repair and V(D)J recombination protein XRCC4 Zip (PF02535, IPR003689): ZIP Zinc transporter Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) DUF4551 (PF15087, IPR027878): Protein of unknown function (DUF4551)
27	EIF2AK3	interactor	3	0.667	1.000	OATP (PF03137, IPR004156): Organic Anion Transporter Polypeptide (OATP) family Pkinase (PF00069, IPR000719): Protein kinase domain PQQ_2 (PF13360, IPR002372): PQQ-like domain
28	EIF4ENIF1	interactor	2	1.000	0	EIF4E-T (PF10477, IPR018862): Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E DUF4718 (PF15842, IPR031695): Domain of unknown function (DUF4718)
29	EP300	oncoprotein	21	0.326	79.307	Creb_binding (PF09030, IPR014744): Creb binding DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902) Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region KIX (PF02172, IPR003101): KIX domain RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6 TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2) zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
30	EPHB6	oncoprotein	2	1.000	0	fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like Phage_holin_5_1 (PF06946, IPR009708): Bacteriophage A118-like holin, Hol118 Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) Ephrin_lbd (PF01404, IPR001090, SM00615): Ephrin receptor ligand binding domain hEGF (PF12661, IPR013032): Human growth factor-like EGF EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain IMUP (PF15761, IPR026621): Immortalisation up-regulated protein
31	ERCC5	interactor	1	0	0	5_3_exonuc (PF01367, IPR020045, SM00475): 5'-3' exonuclease, C-terminal SAM fold XPG_I (PF00867, IPR006086, SM00484): XPG I-region XPG_N (PF00752, IPR006085, SM00485): XPG N-terminal domain IZUMO (PF15005, IPR029389): Izumo sperm-egg fusion, Ig domain-associated Codanin-1_C (PF15296, IPR028171): Codanin-1 C-terminus EF-G-binding_N (PF07299): Elongation factor G-binding protein, N-terminal
32	FBXO11	oncoprotein	3	1.000	0	TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box) F-box-like (PF12937, IPR001810): F-box-like Beta_helix (PF13229): Right handed beta helix region
33	FOXM1	oncoprotein	3	0.667	0.500	EspF (PF04806, IPR006891): EspF protein repeat Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
34	HBEGF	interactor	2	1.000	0	EGF (PF00008, IPR000742, SM00181): EGF-like domain
35	HDAC1	suppressor	31	0.317	167.897	FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
36	HDAC2	oncoprotein	22	0.419	58.235	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
37	HDAC4	oncoprotein	15	0.429	25.995	Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
38	HDAC5	protein found in more fusions	16	0.448	33.723	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain NOA36 (PF06524, IPR010531): NOA36 protein Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3 HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
39	HDAC7	protein found in more fusions	11	0.733	3.004	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain PRIMA1 (PF16101): Proline-rich membrane anchor 1 CBP_BcsO (PF17037, IPR031484): Cellulose biosynthesis protein BcsO
40	HDAC9	interactor	10	0.667	3.056	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain SAE2 (PF08573, IPR013882): DNA repair protein endonuclease SAE2/CtIP C-terminus HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4 CEP19 (PF14933, IPR029412): CEP19-like protein
41	HELZ2	interactor	1	0	0	RNB (PF00773, SM00955): RNB domain zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding AAA_11 (PF13086): AAA domain AAA_12 (PF13087): AAA domain
42	HNF1A	oncoprotein	5	0.667	2.000	HNF-1_N (PF04814, IPR006899): Hepatocyte nuclear factor 1 (HNF-1), N terminus HNF-1A_C (PF04813, IPR006898): Hepatocyte nuclear factor 1 (HNF-1), alpha isoform C terminus HNF-1B_C (PF04812, IPR006897): Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
43	HSF4	interactor	2	1.000	0	Vert_HS_TF (PF06546, IPR010542): Vertebrate heat shock transcription factor HSF_DNA-bind (PF00447, IPR000232, SM00415): HSF-type DNA-binding
44	HSP90AA1	oncoprotein	15	0.209	64.467	HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein
45	IDI2	interactor	1	0	0	NUDIX (PF00293, IPR000086): NUDIX domain
46	IL32	interactor	4	1.000	0	IL32 (PF15225, IPR028067): Interleukin 32
47	IRF4	oncoprotein	2	1.000	0	IRF (PF00605, IPR001346, SM00348): Interferon regulatory factor transcription factor IRF-3 (PF10401, IPR019471): Interferon-regulatory factor 3
48	JUN	oncoprotein	18	0.324	60.027	bZIP_1 (PF00170, IPR004827): bZIP transcription factor Jun (PF03957, IPR005643): Jun-like transcription factor
49	JUNB	oncoprotein	5	0.800	0.583	bZIP_1 (PF00170, IPR004827): bZIP transcription factor Jun (PF03957, IPR005643): Jun-like transcription factor
50	JUND	oncoprotein	4	0.833	0.333	bZIP_1 (PF00170, IPR004827): bZIP transcription factor Jun (PF03957, IPR005643): Jun-like transcription factor
51	KDM2A	interactor	1	0	0	JmjC (PF02373, IPR003347, SM00558): JmjC domain, hydroxylase Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein zf-CXXC (PF02008, IPR002857): CXXC zinc finger domain F-box (PF00646, IPR001810, SM00256): F-box domain DZR (PF12773, IPR025874): Double zinc ribbon LRR_6 (PF13516, IPR001611): Leucine Rich repeat LRR_8 (PF13855, IPR001611): Leucine rich repeat PHD_4 (PF16866, IPR019787): PHD-finger
52	KIF13B	interactor	2	1.000	0	CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain DUF342 (PF03961, IPR005646): Protein of unknown function (DUF342) FHA (PF00498, IPR000253, SM00240): FHA domain Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain KIF1B (PF12423, IPR022140): Kinesin protein 1B DUF3694 (PF12473, IPR022164): Kinesin protein NCKAP5 (PF15246, IPR032769): Nck-associated protein 5, Peripheral clock protein Kinesin_assoc (PF16183, IPR032405): Kinesin-associated
53	KIFC3	oncoprotein	5	0.500	2.667	Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein KxDL (PF10241, IPR019371): Uncharacterized conserved protein Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200) HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
54	KMT2B	oncoprotein	2	1.000	0	FLO_LFY (PF01698, IPR002910): Floricaula / Leafy protein FYRC (PF05965, IPR003889, SM00542): F/Y rich C-terminus FYRN (PF05964, IPR003888, SM00541): F/Y-rich N-terminus GRP (PF07172, IPR010800): Glycine rich protein family PHD (PF00628, IPR019787, SM00249): PHD-finger SET (PF00856, IPR001214, SM00317): SET domain zf-CXXC (PF02008, IPR002857): CXXC zinc finger domain Bromodomain (PF00439, IPR001487, SM00297): Bromodomain Fer4_2 (PF12797, IPR001450): 4Fe-4S binding domain zf-HC5HC2H (PF13771): PHD-like zinc-binding domain FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 AIM3 (PF17096, IPR031370): Altered inheritance of mitochondria protein 3
55	LIMS3	interactor	1	0	0	CagZ (PF09053, IPR015139): CagZ LIM (PF00412, IPR001781, SM00132): LIM domain TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region zf-RRN7 (PF11781, IPR021752): Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 zf-C4pol (PF14260, IPR025687): C4-type zinc-finger of DNA polymerase delta
56	LPAR2	interactor	1	0	0	7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srt (PF10321, IPR019425): Serpentine type 7TM GPCR chemoreceptor Srt
57	LPAR4	interactor	1	0	0	7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family) EVC2_like (PF12297, IPR022076): Ellis van Creveld protein 2 like protein
58	LSM1	interactor	2	1.000	0	LSM (PF01423, IPR001163): LSM domain
59	MAPK8IP3	interactor	2	1.000	0	Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP) Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1 Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion UPF0449 (PF15136, IPR028227): Uncharacterised protein family UPF0449 JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
60	MBD3	interactor	13	0.545	16.075	DUF2201_N (PF13203, IPR025154): Putative metallopeptidase domain
61	MED17	oncoprotein	8	0.679	5.067	Med17 (PF10156, IPR019313): Subunit 17 of Mediator complex
62	MED23	interactor	8	0.607	7.500	Med23 (PF11573, IPR021629): Mediator complex subunit 23
63	MED6	interactor	6	0.933	0.333	Med6 (PF04934, IPR007018): MED6 mediator sub complex component Peptidase_M15 (PF01427, IPR000755): D-ala-D-ala dipeptidase
64	MTA3	oncoprotein	7	0.857	1.150	BAH (PF01426, IPR001025, SM00439): BAH domain ELM2 (PF01448, IPR000949): ELM2 domain Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain GATA (PF00320, IPR000679, SM00401): GATA zinc finger
65	NACC1	interactor	6	0.500	2.383	BTB (PF00651, IPR013069, SM00225): BTB/POZ domain BEN (PF10523, IPR018379, SM01025): BEN domain
66	NCOR1	oncoprotein	16	0.533	17.784	BES1_N (PF05687, IPR008540): BES1/BZR1 plant transcription factor, N-terminal Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp) MAS20 (PF02064, IPR002056): MAS20 protein import receptor Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region Eapp_C (PF10238, IPR019370): E2F-associated phosphoprotein Hid1 (PF12722): High-temperature-induced dauer-formation protein Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) GPS2_interact (PF15784, IPR031557): G-protein pathway suppressor 2-interacting domain DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834) RBR (PF17208): RNA binding Region
67	NCOR2	oncoprotein	19	0.491	40.561	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal MAS20 (PF02064, IPR002056): MAS20 protein import receptor OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain PSK (PF06404, IPR009438): Phytosulfokine precursor protein (PSK) SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360) Gti1_Pac2 (PF09729, IPR018608): Gti1/Pac2 family PRCC (PF10253, IPR018800): Mitotic checkpoint regulator, MAD2B-interacting Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain Spt20 (PF12090, IPR021950): Spt20 family DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) DUF4518 (PF15008, IPR026698): Domain of unknown function (DUF4518) GPS2_interact (PF15784, IPR031557): G-protein pathway suppressor 2-interacting domain DUF4820 (PF16091, IPR032150): Domain of unknown function (DUF4820)
68	NKRF	interactor	3	0.667	0.667	dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif G-patch (PF01585, IPR000467, SM00443): G-patch domain R3H (PF01424, IPR001374, SM00393): R3H domain XTBD (PF11952, IPR021859): XRN-Two Binding Domain, XTBD
69	OLA1	interactor	1	0	0	Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 (PF01926, IPR006073): 50S ribosome-binding GTPase YchF-GTPase_C (PF06071, IPR013029): Protein of unknown function (DUF933)
70	OSBPL1A	interactor	1	0	0	DinB (PF05163, IPR007837): DinB family Oxysterol_BP (PF01237, IPR000648): Oxysterol-binding protein Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_5 (PF13857): Ankyrin repeats (many copies) DUF4298 (PF14131, IPR025384): Domain of unknown function (DUF4298) PH_11 (PF15413): Pleckstrin homology domain
71	PANX3	interactor	1	0	0	Innexin (PF00876, IPR000990): Innexin VirB3 (PF05101, IPR007792): Type IV secretory pathway, VirB3-like protein
72	PARP12	interactor	1	0	0	PARP (PF00644, IPR012317): Poly(ADP-ribose) polymerase catalytic domain WWE (PF02825, IPR004170, SM00678): WWE domain zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger Torus (PF16131, IPR032297): Torus domain
73	PATZ1	oncoprotein	4	0.667	1.000	AT_hook (PF02178, IPR017956, SM00384): AT hook motif BTB (PF00651, IPR013069, SM00225): BTB/POZ domain zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger zf-C2H2_assoc3 (PF16637): Putative zinc-finger between two C2H2 zinc-fingers on Patz
74	PCDH9	interactor	1	0	0	Cadherin_2 (PF08266, IPR013164): Cadherin-like Protocadherin (PF08374, IPR013585): Protocadherin Cadherin (PF00028, IPR002126, SM00112): Cadherin domain Cadherin_3 (PF16184): Cadherin-like
75	PELI1	interactor	1	0	0	Pellino (PF04710, IPR006800): Pellino
76	PIKFYVE	interactor	1	0	0	Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger PIP5K (PF01504, IPR002498): Phosphatidylinositol-4-phosphate 5-Kinase
77	PIN1	suppressor	11	0.400	25.965	Rotamase (PF00639, IPR000297): PPIC-type PPIASE domain WW (PF00397, IPR001202, SM00456): WW domain
78	PLPP3	oncoprotein	2	0	0	YhhN (PF07947, IPR012506): YhhN-like protein PAP2 (PF01569, IPR000326, SM00014): PAP2 superfamily C1-set_C (PF16196, IPR032431): C1-set C-terminal domain
79	PML	oncoprotein	20	0.421	56.686	zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger DUF3583 (PF12126, IPR021978): Protein of unknown function (DUF3583) zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
80	POU2F3	suppressor	2	1.000	0	Pou (PF00157, IPR000327, SM00352): Pou domain - N-terminal to homeobox domain Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
81	PPARGC1A	interactor	6	0.733	1.515	Pap_E4 (PF02711, IPR003861): E4 protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RSRP (PF17069): Arginine/Serine-Rich protein 1
82	PRKCE	suppressor	6	0.600	3.400	C2 (PF00168, IPR000008, SM00239): C2 domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
83	PRKD3	interactor	2	1.000	0	PH (PF00169, IPR001849, SM00233): PH domain Pkinase (PF00069, IPR000719): Protein kinase domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
84	RAF1	oncoprotein	7	0.400	7.400	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
85	RUNX1T1	oncoprotein	8	0.905	0.315	NHR2 (PF08788, IPR014896): NHR2 domain like TAFH (PF07531, IPR003894, SM00549): NHR1 homology to TAF zf-MYND (PF01753, IPR002893): MYND finger DUF3731 (PF12531, IPR021030): DNA-K related protein
86	SAE1	interactor	1	0	0	ThiF (PF00899, IPR000594): ThiF family
87	SENP7	interactor	1	0	0	Peptidase_C48 (PF02902, IPR003653): Ulp1 protease family, C-terminal catalytic domain TMEM215 (PF15746, IPR031486): TMEM215 family
88	SIAH1	suppressor	6	0.500	5.000	Sina (PF03145, IPR018121): Seven in absentia protein family
89	SIN3A	oncoprotein	19	0.462	43.589	Sin3_corepress (PF08295, IPR013194, SM00761): Sin3 family co-repressor PAH (PF02671, IPR003822, SM00309): Paired amphipathic helix repeat Sin3a_C (PF16879, IPR031693): C-terminal domain of Sin3a protein
90	SMARCA4	oncoprotein	20	0.353	89.941	DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840) HSA (PF07529, IPR014012, SM00573): HSA QLQ (PF08880, IPR014978, SM00951): QLQ SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain BRK (PF07533, IPR006576, SM00592): BRK domain Bromodomain (PF00439, IPR001487, SM00297): Bromodomain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal DUF4065 (PF13274, IPR025272): Protein of unknown function (DUF4065) SnAC (PF14619, IPR029295): Snf2-ATP coupling, chromatin remodelling complex WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
91	SMO	interactor	1	0	0	Frizzled (PF01534, IPR000539): Frizzled/Smoothened family membrane region Fz (PF01392, IPR020067, SM00063): Fz domain
92	SPI1	oncoprotein	6	0.667	4.200	Ets (PF00178, IPR000418, SM00413): Ets-domain p47_phox_C (PF08944, IPR015039): NADPH oxidase subunit p47Phox, C terminal domain
93	SPTLC2	interactor	1	0	0	Aminotran_1_2 (PF00155, IPR004839): Aminotransferase class I and II
94	TNFRSF8	oncoprotein	3	1.000	0	c-SKI_SMAD_bind (PF08782, IPR014890, SM01046): c-SKI Smad4 binding domain Rib_recp_KP_reg (PF05104, IPR007794): Ribosome receptor lysine/proline rich region TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
95	TP53	oncoprotein	28	0.299	160.268	DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
96	TRAF1	oncoprotein	8	0.333	13.167	HypA (PF01155, IPR000688): Hydrogenase/urease nickel incorporation, metallochaperone, hypA SlyX (PF04102, IPR007236): SlyX TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
97	TRAF3IP3	interactor	1	0	0	ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) FUSC (PF04632, IPR006726): Fusaric acid resistance protein family HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
98	TRIB3	interactor	2	1.000	0	Pkinase (PF00069, IPR000719): Protein kinase domain
99	TWIST1	oncoprotein	6	0.800	0.956	ACC_epsilon (PF13822, IPR032716): Acyl-CoA carboxylase epsilon subunit PRR20 (PF15708, IPR031439): Proline-rich protein family 20 FXR_C1 (PF16096, IPR032172): Fragile X-related 1 protein C-terminal region 2
100	USP7	oncoprotein	10	0.306	16.489	MATH (PF00917, IPR002083, SM00061): MATH domain UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase USP7_ICP0_bdg (PF12436, IPR024729): ICP0-binding domain of Ubiquitin-specific protease 7 USP7_C2 (PF14533, IPR029346): Ubiquitin-specific protease C-terminal
101	UTP6	interactor	1	0	0	NRDE-2 (PF08424, IPR013633): NRDE-2, necessary for RNA interference Mad3_BUB1_I (PF08311, IPR013212, SM00777): Mad3/BUB1 homology region 1 U3_assoc_6 (PF08640, IPR013949): U3 small nucleolar RNA-associated protein 6 TPR_14 (PF13428): Tetratricopeptide repeat
102	WDR35	interactor	2	1.000	0	A2L_zn_ribbon (PF08792, IPR014900): A2L zinc ribbon domain Coatomer_WDAD (PF04053, IPR006692): Coatomer WD associated region WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
103	WNK4	interactor	3	1.000	0	Pkinase (PF00069, IPR000719): Protein kinase domain OSR1_C (PF12202, IPR024678): Oxidative-stress-responsive kinase 1 C terminal
104	WNT16	interactor	1	0	0	wnt (PF00110, IPR005817, SM00097): wnt family
105	YY1	protein found in more fusions	14	0.385	32.287	zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger Keratin_2_tail (PF16210, IPR032449): Keratin type II cytoskeletal 1 tail
106	ZBTB16	oncoprotein	18	0.463	49.841	BTB (PF00651, IPR013069, SM00225): BTB/POZ domain zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
107	ZBTB17	interactor	5	0.833	0.500	BTB (PF00651, IPR013069, SM00225): BTB/POZ domain C1_4 (PF07975, IPR004595, SM01047): TFIIH C1-like domain Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6 zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger
108	ZBTB7A	interactor	10	0.667	4.402	BTB (PF00651, IPR013069, SM00225): BTB/POZ domain GAGA (PF09237, IPR015318): GAGA factor zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger
109	ZBTB7B	interactor	6	0.600	1.639	BTB (PF00651, IPR013069, SM00225): BTB/POZ domain CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal GAGA (PF09237, IPR015318): GAGA factor SMN (PF06003, IPR010304): Survival motor neuron protein (SMN) zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
110	ZMYND8	oncoprotein	8	0.643	5.283	DUF1640 (PF07798, IPR024461): Protein of unknown function (DUF1640) Mucin (PF01456, IPR000458): Mucin-like glycoprotein PHD (PF00628, IPR019787, SM00249): PHD-finger PWWP (PF00855, IPR000313, SM00293): PWWP domain RNA_pol_Rbc25 (PF08292, IPR013238): RNA polymerase III subunit Rpc25 TCP (PF03634, IPR005333): TCP family transcription factor zf-MYND (PF01753, IPR002893): MYND finger Bromodomain (PF00439, IPR001487, SM00297): Bromodomain DUF3544 (PF12064, IPR021931): Domain of unknown function (DUF3544) CAML (PF14963, IPR016719): Calcium signal-modulating cyclophilin ligand
111	ZNF443	interactor	1	0	0	KRAB (PF01352, IPR001909, SM00349): KRAB box zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger YhfH (PF14149, IPR025432): YhfH-like protein

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