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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)87
The number (and %) of the onco-proteins27 (31.03 %)
The number (and %) of the tumor suppressors23 (26.44 %)
Total number of binary PPIs (saturation %)325 (8.69 %)
The number (and %) of affected PPIs87 (26.77 %)
The number of possible different fusions12
PPI diameter2
PPI radius1
The average degree of PPI6.460
Assortativity coefficient-0.3703
The network average Clustering coefficient0.617
The number (and %) of a zero Clustering coefficients10 (11.49 %)
The number (and %) of a zero Betweenness Centrality37 (42.53 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: BCL2L1 All fusions
Proteins found in more fusions MCL1 (see 2 fusions); ACTB (see 3 fusions); FKBP8 (see 1 fusions); BCL2L1 (see 1 fusions); CASP2 (see 3 fusions); MTOR (see 1 fusions); PINK1 (see 3 fusions); CLU (see 5 fusions); BCAP31 (see 3 fusions); TP53 (see 3 fusions); RTN4 (see 11 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BCL2L1parental protein870.0535538.405Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
BH4 (PF02180, IPR003093, SM00265): Bcl-2 homology region 4
2 ABL1oncoprotein70.4675.983Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
F_actin_bind (PF08919, IPR015015, SM00808): F-actin binding
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
FRG2 (PF15315, IPR026245): Facioscapulohumeral muscular dystrophy candidate 2
3 ACTBoncoprotein90.5717.036Actin (PF00022, IPR004000, SM00268): Actin
4 AKT1oncoprotein120.36425.133PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
5 APAF1suppressor60.4676.333CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
NB-ARC (PF00931, IPR002182): NB-ARC domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Cactin_mid (PF10312, IPR018816): Conserved mid region of cactin
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
Nbas_N (PF15492, IPR029145): Neuroblastoma-amplified sequence, N terminal
6 ATG5interactor100APG5 (PF04106, IPR007239): Autophagy protein Apg5
7 ATXN3interactor31.0000Josephin (PF02099, IPR006155): Josephin
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
8 AVENinteractor30.6670.500FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Tristanin_u2 (PF16638): Unstructured region on methyltransferase between zinc-fingers
9 BADoncoprotein80.5367.552Bcl-2_BAD (PF10514, IPR018868): Pro-apoptotic Bcl-2 protein, BAD
10 BAK1oncoprotein80.7621.783Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
11 BAXsuppressor220.271118.483Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
12 BBC3suppressor30.6670.133PUMA (PF15826, IPR031661): Bcl-2-binding component 3, p53 upregulated modulator of apoptosis
13 BCAP31protein found in more fusions70.6673.500Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like
DUF948 (PF06103, IPR009293): Bacterial protein of unknown function (DUF948)
14 BCL2oncoprotein420.115644.667Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
BH4 (PF02180, IPR003093, SM00265): Bcl-2 homology region 4
15 BCL2L11suppressor80.5715.933Bclx_interact (PF08945, IPR015040): Bcl-x interacting, BH3 domain
Bim_N (PF06773, IPR014771): Bim protein N-terminus
16 BCL2L14interactor100Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
CF222 (PF15661, IPR031362): C6orf222, uncharacterised family
17 BECN1suppressor80.4766.533APG6 (PF04111, IPR007243): Autophagy protein Apg6
Ima1_N (PF09779, IPR018617): Ima1 N-terminal domain
BH3 (PF15285, IPR029318): Beclin-1 BH3 domain, Bcl-2-interacting
18 BFARinteractor41.0000SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
DUF2231 (PF09990, IPR019251): Predicted membrane protein (DUF2231)
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
19 BIDoncoprotein110.44417.433BID (PF06393, IPR010479): BH3 interacting domain (BID)
20 BIKsuppressor40.5001.633bcl-2I13 (PF12201, IPR024579): Bcl2-interacting killer, BH3-domain containing
21 BLIDsuppressor31.0000NA
22 BLKoncoprotein21.0000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
23 BMFsuppressor50.6001.533BMF (PF15185, IPR028192): Bcl-2-modifying factor, apoptosis
24 BNIP1interactor30.6670.500DUF1537 (PF07005, IPR010737): Putative sugar-binding N-terminal domain
Sec20 (PF03908, IPR005606): Sec20
25 BNIP3oncoprotein50.6671.500BNIP3 (PF06553, IPR010548): BNIP3
26 BNIP3Lsuppressor41.0000BNIP3 (PF06553, IPR010548): BNIP3
27 BNIPLinteractor41.0000BNIP2 (PF12496, IPR022181): Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
CRAL_TRIO_2 (PF13716, IPR001251): Divergent CRAL/TRIO domain
28 CASP1oncoprotein41.0000CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
29 CASP2suppressor70.8001.300CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
30 CASP8suppressor180.30974.517DED (PF01335, IPR001875, SM00031): Death effector domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
31 CASP8AP2interactor31.0000CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
IncA (PF04156, IPR007285): IncA protein
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
DUF3304 (PF11745, IPR021733): Protein of unknown function (DUF3304)
PNISR (PF15996, IPR031937): Arginine/serine-rich protein PNISR
32 CASP9oncoprotein80.5369.333CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
33 CDKN2Asuppressor60.6003.067Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
34 CFLARoncoprotein50.6670.900DED (PF01335, IPR001875, SM00031): Death effector domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
35 CLUsuppressor31.0000Clusterin (PF01093, IPR000753): Clusterin
36 CREB3interactor50.5002.000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
37 CRYAAoncoprotein41.0000Crystallin (PF00525, IPR003090): Alpha crystallin A chain, N terminal
HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
38 CRYABoncoprotein90.6795.300Crystallin (PF00525, IPR003090): Alpha crystallin A chain, N terminal
HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
39 CYCSinteractor50.7002.167Cytochrom_C (PF00034, IPR003088): Cytochrome c
40 DOCK7interactor21.0000DHR-2 (PF06920, IPR010703): Dock homology region 2
DUF3398 (PF11878, IPR021816): Domain of unknown function (DUF3398)
DOCK-C2 (PF14429, IPR027007): C2 domain in Dock180 and Zizimin proteins
DOCK_N (PF16172, IPR032376): DOCK N-terminus
41 DYNLL1interactor70.5334.900Dynein_light (PF01221, IPR001372): Dynein light chain type 1
42 EDRF1oncoprotein21.0000TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
DUF2315 (PF10231, IPR018796): Uncharacterised conserved protein (DUF2315)
43 FBP1suppressor31.0000FBPase (PF00316, IPR000146): Fructose-1-6-bisphosphatase, N-terminal domain
44 FKBP8protein found in more fusions50.6671.333FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
45 GIMAP5interactor60.8001.200AIG1 (PF04548, IPR006703): AIG1 family
KapB (PF08810, IPR014916): Kinase associated protein B
46 GLOD4interactor100Glyoxalase (PF00903, IPR004360): Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
47 HNRNPA1interactor70.4677.250RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
48 HRKinteractor30.6670.133Harakiri (PF15196, IPR017249): Activator of apoptosis harakiri
49 IKZF3suppressor200C1_2 (PF03107, IPR004146): C1 domain
Desulfoferrod_N (PF06397, IPR004462): Desulfoferrodoxin, N-terminal domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies)
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
zf-C2H2_7 (PF15269): Zinc-finger
50 IRS1interactor50.8000.619CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
PH (PF00169, IPR001849, SM00233): PH domain
51 LARP1interactor21.0000La (PF05383, IPR006630, SM00715): La domain
Pox_Ag35 (PF03286, IPR004966): Pox virus Ag35 surface protein
FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
52 MAPK8oncoprotein140.34636.821DUF530 (PF04409, IPR007503): Protein of unknown function (DUF530)
Pkinase (PF00069, IPR000719): Protein kinase domain
53 MCL1oncoprotein190.21682.667Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
54 METTL23interactor100Methyltransf_16 (PF10294, IPR019410): Lysine methyltransferase
55 MOAP1interactor41.0000PNMA (PF14893, IPR026523): PNMA
56 MTORoncoprotein90.46410.202DUF1104 (PF06518, IPR009488): Protein of unknown function (DUF1104)
EPSP_synthase (PF00275, IPR001986): EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
HEAT (PF02985, IPR000357): HEAT repeat
FRB_dom (PF08771, IPR009076): FKBP12-rapamycin binding domain
V-ATPase_H_N (PF03224, IPR004908): V-ATPase subunit H
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
TPR_19 (PF14559): Tetratricopeptide repeat
57 PARK2suppressor160.21970.500IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
58 PARK7suppressor70.6003.650DJ-1_PfpI (PF01965, IPR002818): DJ-1/PfpI family
59 PDIA4interactor21.0000Calsequestrin (PF01216, IPR001393): Calsequestrin
Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
FAM176 (PF14851): FAM176 family
60 PDS5Ainteractor100HEAT (PF02985, IPR000357): HEAT repeat
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
HEAT_EZ (PF13513): HEAT-like repeat
61 PGAM5interactor31.0000His_Phos_1 (PF00300, IPR013078, SM00855): Histidine phosphatase superfamily (branch 1)
62 PINK1protein found in more fusions70.5334.900Pkinase (PF00069, IPR000719): Protein kinase domain
63 PLD3interactor100PLDc_2 (PF13091, IPR025202): PLD-like domain
PLDc_3 (PF13918, IPR032803): PLD-like domain
64 PMAIP1interactor40.8330.133PMAIP1 (PF15150, IPR024140): Phorbol-12-myristate-13-acetate-induced
65 PPHLN1interactor31.0000Lge1 (PF11488): Transcriptional regulatory protein LGE1
HERV-K_REC (PF15695): Rec (regulator of expression encoded by corf) of HERV-K-113
66 PPP1CAsuppressor90.55610.438Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
67 PPP1CConcoprotein100.53312.838Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
68 PSEN1oncoprotein40.6671.000Presenilin (PF01080, IPR001108): Presenilin
LRRC37AB_C (PF14914, IPR029423): LRRC37A/B like protein 1 C-terminal domain
69 PSEN2oncoprotein31.0000Herpes_LMP1 (PF05297, IPR007961): Herpesvirus latent membrane protein 1 (LMP1)
Presenilin (PF01080, IPR001108): Presenilin
70 PTNoncoprotein31.0000PTN_MK_C (PF01091, IPR020090): PTN/MK heparin-binding protein family, C-terminal domain
PTN_MK_N (PF05196, IPR020089): PTN/MK heparin-binding protein family, N-terminal domain
71 RAD9Aoncoprotein30.6670.500Rad9 (PF04139, IPR007268): Rad9
72 RAF1oncoprotein90.5008.752Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
73 RBM5suppressor100DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
G-patch (PF01585, IPR000467, SM00443): G-patch domain
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
GSIII_N (PF12437, IPR022147): Glutamine synthetase type III N terminal
PHM7_cyt (PF14703, IPR027815): Cytosolic domain of 10TM putative phosphate transporter
zf-C2HE (PF16278, IPR032566): C2HE / C2H2 / C2HC zinc-binding finger
74 RTN1interactor21.0000Reticulon (PF02453, IPR003388): Reticulon
75 RTN4suppressor40.6671.000CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
Reticulon (PF02453, IPR003388): Reticulon
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
76 SPNS1interactor21.0000MFS_1 (PF07690, IPR011701): Major Facilitator Superfamily
OATP (PF03137, IPR004156): Organic Anion Transporter Polypeptide (OATP) family
77 TLE1interactor31.0000TLE_N (PF03920, IPR005617): Groucho/TLE N-terminal Q-rich domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
78 TP53suppressor230.229142.033DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
79 TP53BP2suppressor80.53610.567ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
Erp_C (PF06780, IPR009618): Erp protein C-terminus
SlyX (PF04102, IPR007236): SlyX
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
80 TPT1interactor31.0000TCTP (PF00838, IPR018105): Translationally controlled tumour protein
81 UBR1interactor21.0000ATPase_2 (PF01637, IPR011579): ATPase domain predominantly from Archaea
ClpS (PF02617, IPR003769): ATP-dependent Clp protease adaptor protein ClpS
zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box)
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
82 UHRF2suppressor51.0000PHD (PF00628, IPR019787, SM00249): PHD-finger
SAD_SRA (PF02182, IPR003105, SM00466): SAD/SRA domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
TTD (PF12148, IPR021991): Tandem tudor domain within UHRF1
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
UBA2_C (PF16195, IPR032426): SUMO-activating enzyme subunit 2 C-terminus
83 USP14interactor100UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
84 VDAC1interactor90.50011.867Porin_3 (PF01459, IPR027246): Eukaryotic porin
85 ZFYVE1interactor100DUF429 (PF04250, IPR007362): Protein of unknown function (DUF429)
FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
GBP (PF02263, IPR015894): Guanylate-binding protein, N-terminal domain
Eapp_C (PF10238, IPR019370): E2F-associated phosphoprotein
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
DZR (PF12773, IPR025874): Double zinc ribbon
zinc_ribbon_4 (PF13717): zinc-ribbon domain
86 ZHX1interactor60.4003.536Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
Homez (PF11569, IPR024578): Homeodomain leucine-zipper encoding, Homez
zf-C2H2_4 (PF13894): C2H2-type zinc finger
TerB_C (PF15615, IPR028932): TerB-C domain
87 ZNF219interactor21.0000Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zinc_ribbon_10 (PF10058, IPR019273): Predicted integral membrane zinc-ribbon metal-binding protein
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1

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