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Visible interactions: all affected independent (normal) nothing (blank)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)70
The number (and %) of the onco-proteins14 (20.00 %)
The number (and %) of the tumor suppressors6 (8.57 %)
Total number of binary PPIs (saturation %)303 (12.55 %)
The number (and %) of affected PPIs70 (23.10 %)
The number of possible different fusions8
PPI diameter2
PPI radius1
The average degree of PPI8.000
Assortativity coefficient-0.2455
The network average Clustering coefficient0.552
The number (and %) of a zero Clustering coefficients4 (5.71 %)
The number (and %) of a zero Betweenness Centrality16 (22.86 %)


List of the fusions

PPI for parental proteins: BCAP31 All fusions
: BE742553; BE077216; BF934379;
Proteins found in more fusions TPM2 (see 1 fusions); APP (see 4 fusions); BCL2L1 (see 1 fusions); ACTG1 (see 4 fusions); TPM2/MYH9 (see 1 fusions); RPA1 (see 1 fusions); BCAP31 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 BCAP31parental protein700.0903412.998Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like
DUF948 (PF06103, IPR009293): Bacterial protein of unknown function (DUF948)
2 ACTG1protein found in more fusions50.6672.000Actin (PF00022, IPR004000, SM00268): Actin
3 APPprotein found in more fusions150.23157.300APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
4 ATF2oncoprotein100.50010.183bZIP_1 (PF00170, IPR004827): bZIP transcription factor
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
5 ATP4Ainteractor70.4005.400Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
H-K_ATPase_N (PF09040, IPR015127): Gastric H+/K+-ATPase, N terminal domain
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
HAD (PF12710): haloacid dehalogenase-like hydrolase
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
6 BCAP29interactor60.7331.900Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like
ZapB (PF06005, IPR009252): Cell division protein ZapB
7 BCL2oncoprotein60.8001.333Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
BH4 (PF02180, IPR003093, SM00265): Bcl-2 homology region 4
8 BCL2L1oncoprotein70.6673.667Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
BH4 (PF02180, IPR003093, SM00265): Bcl-2 homology region 4
9 BFARinteractor41.0000SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
DUF2231 (PF09990, IPR019251): Predicted membrane protein (DUF2231)
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
10 CANXinteractor180.27585.162Calreticulin (PF00262, IPR001580): Calreticulin family
DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit
11 CASP1oncoprotein41.0000CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
12 CASP8suppressor70.6005.333DED (PF01335, IPR001875, SM00031): Death effector domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
13 CEP290interactor21.0000ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
DivIC (PF04977, IPR007060): Septum formation initiator
DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
Fez1 (PF06818): Fez1
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
HemY_N (PF07219, IPR010817): HemY protein N-terminus
Cnn_1N (PF07989, IPR012943): Centrosomin N-terminal motif 1
Mnd1 (PF03962, IPR005647): Mnd1 family
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
Rho_Binding (PF08912, IPR015008): Rho Binding
Sec20 (PF03908, IPR005606): Sec20
Sec2p (PF06428, IPR009449): GDP/GTP exchange factor Sec2p
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Swi5 (PF07061, IPR010760): Swi5
TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
LIDHydrolase (PF10230, IPR019363): Lipid-droplet associated hydrolase
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
FAM76 (PF16046, IPR032017): FAM76 protein
TolA_bind_tri (PF16331, IPR032519): TolA binding protein trimerisation
CEP209_CC5 (PF16574, IPR032321): Coiled-coil region of centrosome protein CE290
14 CFTRsuppressor80.42910.167ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Rotamase_2 (PF13145, IPR000297): PPIC-type PPIASE domain
CFTR_R (PF14396, IPR025837): Cystic fibrosis TM conductance regulator (CFTR), regulator domain
15 CISD1interactor51.0000zf-CDGSH (PF09360, IPR018967, SM00704): Iron-binding zinc finger CDGSH type
MitoNEET_N (PF10660, IPR019610): Iron-containing outer mitochondrial membrane protein N-terminus
16 COX4I1interactor110.52717.167COX4 (PF02936, IPR004203): Cytochrome c oxidase subunit IV
17 DERL1interactor90.50010.333DER1 (PF04511, IPR007599): Der1-like family
18 ENO1oncoprotein50.6002.952Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain
Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
19 EPCAMoncoprotein31.0000Asp_protease (PF09668, IPR019103): Aspartyl protease
DAG1 (PF05454, IPR008465): Dystroglycan (Dystrophin-associated glycoprotein 1)
Thyroglobulin_1 (PF00086, IPR000716, SM00211): Thyroglobulin type-1 repeat
20 EVC2interactor100HBS1_N (PF08938, IPR015033): HBS1 N-terminus
DUF342 (PF03961, IPR005646): Protein of unknown function (DUF342)
Histone_HNS (PF00816, IPR001801): H-NS histone family
EVC2_like (PF12297, IPR022076): Ellis van Creveld protein 2 like protein
21 FIS1interactor40.6671.000Fis1_TPR_N (PF14852, IPR028058): Fis1 N-terminal tetratricopeptide repeat
Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
22 GOLT1Binteractor100.33324.233Got1 (PF04178, IPR007305): Got1/Sft2-like family
23 GPRIN2interactor100GRIN_C (PF15235, IPR032745): G protein-regulated inducer of neurite outgrowth C-terminus
24 HACD2interactor30.6670.333DHHA1 (PF02272, IPR003156): DHHA1 domain
PTPLA (PF04387, IPR007482): Protein tyrosine phosphatase-like protein, PTPLA
25 HLA-Aoncoprotein70.4768.833DUF202 (PF02656, IPR003807): Domain of unknown function (DUF202)
MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
MHC_I_C (PF06623, IPR010579): MHC_I C-terminus
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
26 ITGAMinteractor100FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
VWA (PF00092, IPR002035, SM00327): von Willebrand factor type A domain
VCBS (PF13517): Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
FG-GAP_2 (PF14312, IPR013517): FG-GAP repeat
27 KLK10suppressor100Trypsin (PF00089, IPR001254, SM00020): Trypsin
28 LMAN1interactor120.30331.083Lectin_leg-like (PF03388, IPR005052): Legume-like lectin family
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
29 MOV10interactor100.35616.857AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
30 MT-CO2interactor70.7622.550NA
31 MYH10interactor60.8670.571IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
32 MYH9suppressor90.58311.638IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
33 NDUFB10interactor21.0000NDUFB10 (PF10249, IPR019377): NADH-ubiquinone oxidoreductase subunit 10
34 NTRK1oncoprotein190.25593.369I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
35 NXF1interactor70.3336.619NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
36 OLA1interactor31.0000Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
MMR_HSR1 (PF01926, IPR006073): 50S ribosome-binding GTPase
YchF-GTPase_C (PF06071, IPR013029): Protein of unknown function (DUF933)
37 PGRMC1interactor70.6672.619Cyt-b5 (PF00173, IPR001199, SM01117): Cytochrome b5-like Heme/Steroid binding domain
SlyX (PF04102, IPR007236): SlyX
SCNM1_acidic (PF15805, IPR031625): Acidic C-terminal region of sodium channel modifier 1 SCNM1
38 PHBsuppressor160.37548.286Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
DUF4290 (PF14123, IPR025632): Domain of unknown function (DUF4290)
39 RAB1Aoncoprotein130.41028.536Ras (PF00071, IPR001806, SM00173): Ras family
40 RAB2Aoncoprotein130.37239.383Ras (PF00071, IPR001806, SM00173): Ras family
41 RBM8Ainteractor40.6670.667RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
42 RDXinteractor31.0000ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
43 RER1interactor80.3939.719Rer1 (PF03248, IPR004932): Rer1 family
44 RNF185interactor90.46410.733zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
45 RNF5interactor51.0000zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
46 RPA1suppressor140.53815.643Rep-A_N (PF04057, IPR007199): Replication factor-A protein 1, N-terminal domain
Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
REPA_OB_2 (PF16900, IPR031657): Replication protein A OB domain
47 RPA2oncoprotein130.48719.671RPA_C (PF08784, IPR014892): Replication protein A C terminal
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
RMI2 (PF16100, IPR032245): RecQ-mediated genome instability protein 2
48 RPA3interactor130.54512.938Rep_fac-A_3 (PF08661, IPR013970): Replication factor A protein 3
49 SCAMP2interactor50.4003.133SCAMP (PF04144, IPR007273): SCAMP family
KfrA_N (PF11740, IPR021104): Plasmid replication region DNA-binding N-term
50 SCAMP3interactor80.4299.471SCAMP (PF04144, IPR007273): SCAMP family
51 SEC61A1interactor70.3819.400DUF1430 (PF07242, IPR006541): Protein of unknown function (DUF1430)
SecY (PF00344, IPR002208): SecY translocase
Plug_translocon (PF10559, IPR019561): Plug domain of Sec61p
52 SEC61Binteractor50.6671.000Sec61_beta (PF03911, IPR016482): Sec61beta family
53 SERPINF2interactor21.0000Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
54 TCTN1interactor31.0000DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
55 TCTN2interactor80.39311.100DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
56 TCTN3interactor130.21845.505DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
57 TMEM17interactor100.24425.933Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
DUF3043 (PF11241, IPR021403): Protein of unknown function (DUF3043)
58 TMEM216interactor70.4296.867Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
59 TMEM237interactor30.6671.000TMEM237 (PF15383, IPR029409): Transmembrane protein 237
60 TMEM67interactor21.0000Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like
NCD3G (PF07562, IPR011500): Nine Cysteines Domain of family 3 GPCR
Tme5_EGF_like (PF09064, IPR015149): Thrombomodulin like fifth domain, EGF-like
Meckelin (PF09773, IPR019170): Meckelin (Transmembrane protein 67)
hEGF (PF12661, IPR013032): Human growth factor-like EGF
61 TPM2protein found in more fusions80.5718.667DASH_Spc19 (PF08287, IPR013251): Spc19
Tropomyosin (PF00261, IPR000533): Tropomyosin
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
62 TRAM1interactor60.5335.167TRAM1 (PF08390, IPR013599): TRAM1-like protein
TRAM_LAG1_CLN8 (PF03798, IPR006634): TLC domain
DUF3382 (PF11862, IPR021807): Domain of unknown function (DUF3382)
DUF3671 (PF12420, IPR022139): Protein of unknown function
63 UBL4Ainteractor120.27334.521ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
64 VAMP2interactor60.6002.767Synaptobrevin (PF00957, IPR001388): Synaptobrevin
PRIMA1 (PF16101): Proline-rich membrane anchor 1
65 VAMP3interactor70.5245.267Synaptobrevin (PF00957, IPR001388): Synaptobrevin
66 VDAC1interactor160.36757.552Porin_3 (PF01459, IPR027246): Eukaryotic porin
67 VDAC2interactor130.48722.986Porin_3 (PF01459, IPR027246): Eukaryotic porin
68 VDAC3interactor90.7503.486Porin_3 (PF01459, IPR027246): Eukaryotic porin
69 VKORC1interactor50.5002.667VKOR (PF07884, IPR012932, SM00756): Vitamin K epoxide reductase family
70 YWHAQinteractor50.7002.33314-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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