Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins ATR (from a repository: Mon Dec 5 06:01:19 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 99 The number (and %) of the onco-proteins 35 (35.35 %) The number (and %) of the tumor suppressors 20 (20.20 %) Total number of binary PPIs (saturation %) 588 (12.12 %) The number (and %) of affected PPIs 99 (16.84 %) The number of possible different fusions 17 PPI diameter 2 PPI radius 1 The average degree of PPI 11.172 Assortativity coefficient -0.2837 The network average Clustering coefficient 0.582 The number (and %) of a zero Clustering coefficients 4 (4.04 %) The number (and %) of a zero Betweenness Centrality 18 (18.18 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: ATR	All fusions
Proteins found in more fusions	MCM7 (see 2 fusions); HSP90AA1 (see 2 fusions); ATR (see 1 fusions); DCAF1 (see 1 fusions); CREB1 (see 2 fusions); TOPBP1 (see 2 fusions); EGFR (see 2 fusions); MCM2 (see 1 fusions); FANCA (see 1 fusions); EP300 (see 1 fusions); MSH2 (see 1 fusions); RPA1 (see 1 fusions); CHD4 (see 6 fusions); TP53 (see 3 fusions); SNW1 (see 1 fusions); CDK9 (see 2 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	ATR	parental protein	99	0.096	5679.086	FAT (PF02259, IPR003151): FAT domain FATC (PF02260, IPR003152): FATC domain HEAT (PF02985, IPR000357): HEAT repeat Mad3_BUB1_I (PF08311, IPR013212, SM00777): Mad3/BUB1 homology region 1 THP2 (PF09432, IPR018557): Tho complex subunit THP2 TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat UME (PF08064, IPR012993, SM00802): UME (NUC010) domain PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385) HEAT_EZ (PF13513): HEAT-like repeat SgrT (PF15894, IPR031767): Inhibitor of glucose uptake transporter SgrT
2	ABL1	oncoprotein	12	0.527	12.038	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain F_actin_bind (PF08919, IPR015015, SM00808): F-actin binding SH3_1 (PF00018, IPR001452, SM00326): SH3 domain FRG2 (PF15315, IPR026245): Facioscapulohumeral muscular dystrophy candidate 2
3	ALDH3A2	interactor	3	0.667	0.500	Aldedh (PF00171, IPR015590): Aldehyde dehydrogenase family
4	AP1B1	interactor	9	0.694	2.636	Adaptin_N (PF01602, IPR002553): Adaptin N terminal region Alpha_adaptinC2 (PF02883, IPR008152, SM00809): Adaptin C-terminal domain B2-adapt-app_C (PF09066, IPR015151, SM01020): Beta2-adaptin appendage, C-terminal sub-domain
5	AP3B1	interactor	4	0.667	1.167	Adaptin_N (PF01602, IPR002553): Adaptin N terminal region AP3B1_C (PF14796, IPR029390): Clathrin-adaptor complex-3 beta-1 subunit C-terminal SEEEED (PF14797, IPR029394): Serine-rich region of AP3B1, clathrin-adaptor complex
6	ARHGEF1	interactor	5	0.667	2.000	RGS-like (PF09128, IPR015212): Regulator of G protein signalling-like domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain Syntaxin_2 (PF14523): Syntaxin-like protein PH_13 (PF16652, IPR001849): Pleckstrin homology domain
7	ARRB1	interactor	7	0.524	5.658	Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
8	ATM	suppressor	51	0.177	726.933	FAT (PF02259, IPR003151): FAT domain FATC (PF02260, IPR003152): FATC domain HEAT (PF02985, IPR000357): HEAT repeat PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase TAN (PF11640, IPR021668): Telomere-length maintenance and DNA damage repair ANAPC5 (PF12862, IPR026000): Anaphase-promoting complex subunit 5
9	ATRIP	interactor	18	0.366	69.053	Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
10	BLM	suppressor	21	0.558	25.299	BDHCT (PF08072, IPR012532): BDHCT (NUC031) domain DEAD (PF00270, IPR011545): DEAD/DEAH box helicase HRDC (PF00570, IPR002121, SM00341): HRDC domain RQC (PF09382, IPR018982, SM00956): RQC domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain ALMT (PF11744, IPR020966): Aluminium activated malate transporter RecQ_Zn_bind (PF16124, IPR032284): RecQ zinc-binding BLM_N (PF16202, IPR032437): N-terminal region of Bloom syndrome protein BDHCT_assoc (PF16204, IPR032439): BDHCT-box associated domain on Bloom syndrome protein
11	BRCA1	suppressor	34	0.303	191.778	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
12	BRCA2	suppressor	10	0.600	8.329	BRCA-2_helical (PF09169, IPR015252): BRCA2, helical BRCA-2_OB1 (PF09103, IPR015187): BRCA2, oligonucleotide/oligosaccharide-binding, domain 1 BRCA-2_OB3 (PF09104, IPR015188): BRCA2, oligonucleotide/oligosaccharide-binding, domain 3 BRCA2 (PF00634, IPR002093): BRCA2 repeat Tower (PF09121, IPR015205): Tower
13	BSG	interactor	4	0.667	1.333	Ig_2 (PF13895, IPR007110): Immunoglobulin domain Ig_3 (PF13927): Immunoglobulin domain Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
14	CA14	interactor	2	1.000	0	Carb_anhydrase (PF00194, IPR001148, SM01057): Eukaryotic-type carbonic anhydrase NicO (PF03824, IPR011541): High-affinity nickel-transport protein
15	CCNB2	interactor	2	1.000	0	Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
16	CD274	oncoprotein	3	1.000	0	C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E V-set (PF07686, IPR013106): Immunoglobulin V-set domain
17	CDC5L	interactor	23	0.364	76.824	OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
18	CDC6	oncoprotein	7	0.571	6.575	Cdc6_C (PF09079, IPR015163, SM01074): CDC6, C terminal winged helix domain AAA_22 (PF13401, IPR003593): AAA domain ORC5_C (PF14630, IPR020796): Origin recognition complex (ORC) subunit 5 C-terminus
19	CDK9	protein found in more fusions	12	0.564	9.044	Pkinase (PF00069, IPR000719): Protein kinase domain
20	CDKN2A	suppressor	14	0.374	34.084	Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_5 (PF13857): Ankyrin repeats (many copies)
21	CDKN2C	suppressor	3	1.000	0	Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_5 (PF13857): Ankyrin repeats (many copies)
22	CEACAM21	interactor	1	0	0	V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_2 (PF13895, IPR007110): Immunoglobulin domain
23	CEP164	interactor	2	1.000	0	DUF883 (PF05957, IPR010279): Bacterial protein of unknown function (DUF883) DUF948 (PF06103, IPR009293): Bacterial protein of unknown function (DUF948) TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP) WW (PF00397, IPR001202, SM00456): WW domain KxDL (PF10241, IPR019371): Uncharacterized conserved protein XhlA (PF10779, IPR019715): Haemolysin XhlA KfrA_N (PF11740, IPR021104): Plasmid replication region DNA-binding N-term DUF3807 (PF12720, IPR024526): Protein of unknown function (DUF3807)
24	CHD4	oncoprotein	12	0.491	15.614	CDC27 (PF09507, IPR019038): DNA polymerase subunit Cdc27 CHDCT2 (PF08074, IPR012957): CHDCT2 (NUC038) domain CHDNT (PF08073, IPR012958): CHDNT (NUC034) domain Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain DTHCT (PF08070, IPR012542): DTHCT (NUC029) region DUF1086 (PF06461, IPR009462, SM01146): Domain of Unknown Function (DUF1086) DUF1087 (PF06465, IPR009463, SM01147): Domain of Unknown Function (DUF1087) PHD (PF00628, IPR019787, SM00249): PHD-finger Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain FAM176 (PF14851): FAM176 family Coilin_N (PF15862, IPR031722): Coilin N-terminus
25	CHEK1	suppressor	15	0.533	18.550	Pkinase (PF00069, IPR000719): Protein kinase domain
26	CHEK2	suppressor	8	0.714	5.250	FHA (PF00498, IPR000253, SM00240): FHA domain Pkinase (PF00069, IPR000719): Protein kinase domain
27	CINP	interactor	2	1.000	0	Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
28	CLK2	interactor	9	0.500	9.567	DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764) Pkinase (PF00069, IPR000719): Protein kinase domain zf-met (PF12874): Zinc-finger of C2H2 type
29	CLSPN	interactor	7	0.571	3.928	Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754) NinG (PF05766, IPR008713): Bacteriophage Lambda NinG protein Presenilin (PF01080, IPR001108): Presenilin PTS_IIB (PF02302, IPR003501): PTS system, Lactose/Cellobiose specific IIB subunit XAP5 (PF04921, IPR007005): XAP5, circadian clock regulator Adaptin_binding (PF10199, IPR019341): Alpha and gamma adaptin binding protein p34 Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
30	CLTC	oncoprotein	11	0.436	16.208	Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker Clathrin_propel (PF01394, IPR022365): Clathrin propeller repeat Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS Clathrin_H_link (PF13838): Clathrin-H-link
31	CREB1	oncoprotein	9	0.786	1.875	bZIP_1 (PF00170, IPR004827): bZIP transcription factor pKID (PF02173, IPR003102): pKID domain DUF4988 (PF16378, IPR032149): Domain of unknown function
32	DCAF1	protein found in more fusions	9	0.500	8.222	DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913) LisH (PF08513, IPR013720, SM00667): LisH ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated
33	DCLRE1C	interactor	7	0.810	0.619	DRMBL (PF07522, IPR011084): DNA repair metallo-beta-lactamase DUF3290 (PF11694, IPR021707): Protein of unknown function (DUF3290) Lactamase_B_2 (PF12706, IPR001279): Beta-lactamase superfamily domain
34	DTL	interactor	5	1.000	0	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
35	E2F1	suppressor	8	0.607	4.193	Cellsynth_D (PF03500, IPR022798): Cellulose synthase subunit D E2F_TDP (PF02319, IPR003316): E2F/DP family winged-helix DNA-binding domain E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain
36	E4F1	interactor	6	0.733	2.556	FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain zf-C2H2_11 (PF16622, IPR007087): zinc-finger C2H2-type
37	EGFR	oncoprotein	21	0.311	84.220	Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT) GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
38	EP300	oncoprotein	19	0.327	60.085	Creb_binding (PF09030, IPR014744): Creb binding DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902) Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region KIX (PF02172, IPR003101): KIX domain RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6 TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2) zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
39	ETV1	oncoprotein	5	0.800	1.333	Ets (PF00178, IPR000418, SM00413): Ets-domain ETS_PEA3_N (PF04621, IPR006715): PEA3 subfamily ETS-domain transcription factor N terminal domain
40	FAAP24	interactor	5	0.500	3.233	Rad10 (PF03834, IPR004579): Binding domain of DNA repair protein Ercc1 (rad10/Swi10) HHH_2 (PF12826): Helix-hairpin-helix motif
41	FAM133B	interactor	1	0	0	BRF1 (PF07741, IPR011665): Brf1-like TBP-binding domain DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755) TSGP1 (PF07771, IPR011694): Tick salivary peptide group 1 NuDC (PF16273, IPR032572): Nuclear distribution C domain
42	FANCA	oncoprotein	10	0.444	14.444	Fanconi_A (PF03511, IPR003516): Fanconi anaemia group A protein Fanconi_A_N (PF15865, IPR031729): Fanconi anaemia group A protein N terminus
43	FANCD2	oncoprotein	13	0.423	33.457	FancD2 (PF14631, IPR029448): Fanconi anaemia protein FancD2 nuclease
44	H2AFX	suppressor	18	0.438	38.996	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4 Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
45	HDAC1	suppressor	19	0.366	61.986	FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
46	HDAC2	suppressor	13	0.500	17.036	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
47	HSP90AA1	oncoprotein	20	0.363	55.047	HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein
48	HSPA4	interactor	16	0.342	44.465	Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region HSP70 (PF00012, IPR013126): Hsp70 protein TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
49	HTR6	interactor	5	0.700	1.619	7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
50	HUS1	oncoprotein	10	0.556	10.217	Hus1 (PF04005, IPR007150): Hus1-like protein
51	IKBKG	interactor	10	0.444	9.335	CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H) DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725) NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
52	LIG4	interactor	4	0.667	1.000	APG17 (PF04108, IPR007240): Autophagy protein Apg17 BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain DNA_ligase_A_C (PF04679, IPR012309): ATP dependent DNA ligase C terminal region DNA_ligase_A_M (PF01068, IPR012310): ATP dependent DNA ligase domain DNA_ligase_A_N (PF04675, IPR012308): DNA ligase N terminus DNA_ligase_IV (PF11411, IPR021536): DNA ligase IV RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
53	LYPD3	oncoprotein	2	1.000	0	DUF753 (PF05444, IPR008472): Protein of unknown function (DUF753) UPAR_LY6 (PF00021, IPR001526): u-PAR/Ly-6 domain
54	MCM2	oncoprotein	20	0.322	74.210	AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA) MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2 MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain
55	MCM7	protein found in more fusions	8	0.619	3.205	MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain
56	MCPH1	suppressor	10	0.533	7.743	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain MSP (PF01716, IPR002628): Manganese-stabilising protein / photosystem II polypeptide Spectrin (PF00435, IPR002017): Spectrin repeat Microcephalin (PF12258, IPR022047): Microcephalin protein PTCB-BRCT (PF12738, IPR001357): twin BRCT domain BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
57	MRE11A	oncoprotein	19	0.523	33.566	APG6 (PF04111, IPR007243): Autophagy protein Apg6 Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase Mre11_DNA_bind (PF04152, IPR007281): Mre11 DNA-binding presumed domain
58	MSH2	suppressor	27	0.412	89.103	MutS_I (PF01624, IPR007695): MutS domain I MutS_II (PF05188, IPR007860): MutS domain II MutS_V (PF00488, IPR000432, SM00534): MutS domain V MutS_III (PF05192, IPR007696, SM00533): MutS domain III AAA_27 (PF13514): AAA domain
59	MSH6	oncoprotein	22	0.411	62.726	MutS_I (PF01624, IPR007695): MutS domain I MutS_II (PF05188, IPR007860): MutS domain II PWWP (PF00855, IPR000313, SM00293): PWWP domain MutS_V (PF00488, IPR000432, SM00534): MutS domain V MutS_III (PF05192, IPR007696, SM00533): MutS domain III UPF0524 (PF15823, IPR029670): UPF0524 of C3orf70
60	MTA1	oncoprotein	7	0.810	1.408	BAH (PF01426, IPR001025, SM00439): BAH domain ELM2 (PF01448, IPR000949): ELM2 domain Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain GATA (PF00320, IPR000679, SM00401): GATA zinc finger
61	MTA2	interactor	7	0.857	0.889	BAH (PF01426, IPR001025, SM00439): BAH domain ELM2 (PF01448, IPR000949): ELM2 domain Resolvase (PF00239, IPR006119, SM00857): Resolvase, N terminal domain DDA1 (PF10172, IPR018276): Det1 complexing ubiquitin ligase Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain GATA (PF00320, IPR000679, SM00401): GATA zinc finger
62	NBN	suppressor	23	0.470	49.826	FHA (PF00498, IPR000253, SM00240): FHA domain Nbs1_C (PF08599, IPR013908): DNA damage repair protein Nbs1 NIBRIN_BRCT_II (PF16508, IPR032429): Second BRCT domain on Nijmegen syndrome breakage protein RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
63	NCOA2	oncoprotein	6	0.800	1.125	DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518) HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Nuc_rec_co-act (PF08815, IPR014920): Nuclear receptor coactivator PAS (PF00989, IPR013767, SM00091): PAS fold PAS_3 (PF08447, IPR013655): PAS fold SRC-1 (PF08832, IPR014935): Steroid receptor coactivator PAS_11 (PF14598): PAS domain DUF4927 (PF16279, IPR032565): Domain of unknown function (DUF4927) NCOA_u2 (PF16665): Unstructured region on nuclear receptor coactivator protein
64	NOSIP	interactor	2	1.000	0	Rtf2 (PF04641, IPR027799): Rtf2 RING-finger U-box (PF04564, IPR003613, SM00504): U-box domain zf-NOSIP (PF15906, IPR031790): Zinc-finger of nitric oxide synthase-interacting protein
65	NT5E	interactor	1	0	0	5_nucleotid_C (PF02872, IPR008334): 5'-nucleotidase, C-terminal domain Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
66	PA2G4	interactor	7	0.476	6.833	Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24 Ribosomal_S25 (PF03297, IPR004977): S25 ribosomal protein TraC (PF07820, IPR012930): TraC-like protein
67	PABPN1	interactor	2	1.000	0	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain Shadoo (PF14999, IPR029238): Shadow of prion protein, neuroprotective
68	PIK3CA	oncoprotein	3	0.667	1.000	PI3K_C2 (PF00792, IPR002420, SM00142): Phosphoinositide 3-kinase C2 PI3K_p85B (PF02192, IPR003113, SM00143): PI3-kinase family, p85-binding domain PI3K_rbd (PF00794, IPR000341, SM00144): PI3-kinase family, ras-binding domain PI3Ka (PF00613, IPR001263, SM00145): Phosphoinositide 3-kinase family, accessory domain (PIK domain) DUF2321 (PF10083, IPR016891): Uncharacterized protein conserved in bacteria (DUF2321) PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
69	PMS1	oncoprotein	7	0.667	1.772	DNA_mis_repair (PF01119, IPR013507): DNA mismatch repair protein, C-terminal domain HTH_Tnp_IS630 (PF01710, IPR002622): Transposase HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box MRP-L46 (PF11788, IPR021757): 39S mitochondrial ribosomal protein L46 HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
70	POLD1	interactor	7	0.762	2.169	DNA_pol_B (PF00136, IPR006134): DNA polymerase family B DNA_pol_B_exo1 (PF03104, IPR006133): DNA polymerase family B, exonuclease domain zf-C4pol (PF14260, IPR025687): C4-type zinc-finger of DNA polymerase delta
71	POLN	interactor	3	0.667	0.400	DNA_pol_A (PF00476, IPR001098, SM00482): DNA polymerase family A
72	POU5F1	oncoprotein	12	0.345	25.039	Pou (PF00157, IPR000327, SM00352): Pou domain - N-terminal to homeobox domain Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
73	PPP2R3A	interactor	4	0.500	2.667	EF-hand_1 (PF00036, IPR002048, SM00054): EF hand DUF3924 (PF13062, IPR025038): Protein of unknown function (DUF3924) DUF4116 (PF13475, IPR025197): Domain of unknown function (DUF4116) EF-hand_7 (PF13499, IPR011992): EF-hand domain pair DUF4187 (PF13821, IPR025239): Domain of unknown function (DUF4187)
74	RAD1	interactor	8	0.786	1.812	Pro_3_hydrox_C (PF05373, IPR008035): L-proline 3-hydroxylase, C-terminal Rad1 (PF02144, IPR003021): Repair protein Rad1/Rec1/Rad17
75	RAD17	interactor	7	0.524	5.806	Mvb12 (PF09452, IPR019014): ESCRT-I subunit Mvb12 Rad17 (PF03215): Rad17 cell cycle checkpoint protein
76	RAD9A	oncoprotein	12	0.485	15.807	Rad9 (PF04139, IPR007268): Rad9
77	RASSF1	suppressor	4	1.000	0	RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) Nore1-SARAH (PF16517, IPR011524): Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
78	RHEB	oncoprotein	2	1.000	0	Ras (PF00071, IPR001806, SM00173): Ras family
79	RPA1	suppressor	33	0.335	155.780	Rep-A_N (PF04057, IPR007199): Replication factor-A protein 1, N-terminal domain Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain REPA_OB_2 (PF16900, IPR031657): Replication protein A OB domain
80	RPA2	oncoprotein	25	0.397	71.773	RPA_C (PF08784, IPR014892): Replication protein A C terminal tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain RMI2 (PF16100, IPR032245): RecQ-mediated genome instability protein 2
81	RPA3	interactor	19	0.503	24.359	Rep_fac-A_3 (PF08661, IPR013970): Replication factor A protein 3
82	SCARA3	interactor	1	0	0	Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies) Filament (PF00038, IPR001664): Intermediate filament protein Flagellin_C (PF00700, IPR001029): Bacterial flagellin C-terminal helical region Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding zf-C2H2_10 (PF16588, IPR001878): C2H2 zinc-finger
83	SCN2B	interactor	4	0.667	1.250	DUF1191 (PF06697, IPR010605): Protein of unknown function (DUF1191) V-set (PF07686, IPR013106): Immunoglobulin V-set domain
84	SMC1A	oncoprotein	13	0.530	10.003	SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
85	SNIP1	interactor	4	0.667	1.333	FHA (PF00498, IPR000253, SM00240): FHA domain MIP-T3 (PF10243): Microtubule-binding protein MIP-T3 FAM176 (PF14851): FAM176 family
86	SNW1	protein found in more fusions	27	0.298	145.221	SKIP_SNW (PF02731, IPR004015): SKIP/SNW domain PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term SIR4_SID (PF16991, IPR031556): Sir4 SID domain
87	SOCS1	suppressor	5	0.900	0.143	SH2 (PF00017, IPR000980, SM00252): SH2 domain SOCS_box (PF07525, IPR001496): SOCS box
88	TELO2	interactor	7	0.619	4.865	Telomere_reg-2 (PF10193, IPR019337): Telomere length regulation protein HEAT_2 (PF13646): HEAT repeats
89	TERT	oncoprotein	8	0.464	10.598	RVT_1 (PF00078, IPR000477): Reverse transcriptase (RNA-dependent DNA polymerase) Telomerase_RBD (PF12009, IPR021891, SM00975): Telomerase ribonucleoprotein complex - RNA binding domain
90	TOPBP1	protein found in more fusions	15	0.495	20.455	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain PTCB-BRCT (PF12738, IPR001357): twin BRCT domain RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
91	TP53	suppressor	38	0.246	306.328	DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
92	TTI1	interactor	10	0.378	22.448	Dopey_N (PF04118, IPR007249): Dopey, N-terminal HEAT (PF02985, IPR000357): HEAT repeat VHS (PF00790, IPR002014, SM00288): VHS domain CLASP_N (PF12348, IPR024395): CLASP N terminal
93	UPF1	interactor	5	0.800	1.000	UPF1_Zn_bind (PF09416, IPR018999): RNA helicase (UPF2 interacting domain) AAA_11 (PF13086): AAA domain AAA_12 (PF13087): AAA domain
94	VSIG2	interactor	2	1.000	0	V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain
95	WRN	oncoprotein	13	0.682	5.430	DNA_pol_A_exo1 (PF01612, IPR002562, SM00474): 3'-5' exonuclease DEAD (PF00270, IPR011545): DEAD/DEAH box helicase HRDC (PF00570, IPR002121, SM00341): HRDC domain Laminin_II (PF06009, IPR010307): Laminin Domain II RQC (PF09382, IPR018982, SM00956): RQC domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain HTH_40 (PF14493, IPR029491): Helix-turn-helix domain RecQ_Zn_bind (PF16124, IPR032284): RecQ zinc-binding
96	XPA	oncoprotein	7	0.714	1.854	XPA_C (PF05181, IPR022656): XPA protein C-terminus XPA_N (PF01286, IPR022652): XPA protein N-terminal MscS_TM (PF12794, IPR025692): Mechanosensitive ion channel inner membrane domain 1 zinc_ribbon_2 (PF13240, IPR026870): zinc-ribbon domain
97	XPC	oncoprotein	8	0.643	4.227	Rad4 (PF03835, IPR018325): Rad4 transglutaminase-like domain BHD_1 (PF10403, IPR018326, SM01030): Rad4 beta-hairpin domain 1 BHD_2 (PF10404, IPR018327, SM01031): Rad4 beta-hairpin domain 2 BHD_3 (PF10405, IPR018328, SM01032): Rad4 beta-hairpin domain 3 Macoilin (PF09726, IPR019130): Transmembrane protein SOG2 (PF10428, IPR019487): RAM signalling pathway protein Abdominal-A (PF12407, IPR022132): Homeobox protein DUF4820 (PF16091, IPR032150): Domain of unknown function (DUF4820)
98	XRCC5	suppressor	20	0.415	46.436	Ku (PF02735, IPR006164, SM00559): Ku70/Ku80 beta-barrel domain Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm Ku_N (PF03731, IPR005161): Ku70/Ku80 N-terminal alpha/beta domain Ku_PK_bind (PF08785, IPR014893): Ku C terminal domain like
99	YBX3	interactor	2	1.000	0	CSD (PF00313, IPR002059): 'Cold-shock' DNA-binding domain Herpes_LMP1 (PF05297, IPR007961): Herpesvirus latent membrane protein 1 (LMP1)

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