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Visible interactions: all affected independent (normal) missing (in fusions) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins ASIC3 (from a repository: Sat Mar 10 16:16:11 2018)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)8
The number (and %) of the onco-proteins3 (37.50 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)12 (42.86 %)
The number (and %) of affected PPIs7 (58.33 %)
The number of possible different fusions4
PPI diameter2
PPI radius1
The average degree of PPI2.250
Assortativity coefficient-0.3780
The network average Clustering coefficient0.512
The number (and %) of a zero Clustering coefficients3 (37.50 %)
The number (and %) of a zero Betweenness Centrality7 (87.50 %)


List of the fusions

PPI for parental proteins: ASIC3 All fusions
: AA429417;
Proteins found in more fusions DLG4 (see 1 fusions); STOM (see 1 fusions); GOPC (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 ASIC3parental protein70.09538.000ASC (PF00858, IPR001873): Amiloride-sensitive sodium channel
2 ASIC2interactor21.0000ASC (PF00858, IPR001873): Amiloride-sensitive sodium channel
3 DLG4protein found in more fusions31.0000L27_1 (PF09058, IPR015143): L27_1
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
MAGUK_N_PEST (PF10608, IPR019590): Polyubiquitination (PEST) N-terminal domain of MAGUK
PDZ_assoc (PF10600, IPR019583): PDZ-associated domain of NMDA receptors
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
4 GOPConcoprotein200DUF903 (PF06004, IPR010305): Bacterial protein of unknown function (DUF903)
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
DUF3209 (PF11483, IPR021577): Protein of unknown function (DUF3209)
5 LIN7Binteractor21.0000L27 (PF02828, IPR014775, SM00569): L27 domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
6 MAGI1interactor100PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Peptidase_C58 (PF03543, IPR006473): Yersinia/Haemophilus virulence surface antigen
Serglycin (PF04360, IPR007455): Serglycin
WW (PF00397, IPR001202, SM00456): WW domain
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
Med3 (PF11593, IPR020998): Mediator complex subunit 3 fungal
PDZ_2 (PF13180, IPR001478): PDZ domain
DUF4578 (PF15147, IPR028106): Domain of unknown function (DUF4578)
DUF4770 (PF15994, IPR031935): Domain of unknown function (DUF4770)
MAGI_u1 (PF16663): Unstructured region on MAGI
MAGI_u5 (PF16666): Unstructured region on MAGI
7 PRKACAinteractor100Pkinase (PF00069, IPR000719): Protein kinase domain
8 STOMprotein found in more fusions31.0000Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family

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List of missing interactors (in fusions)

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ASIC2interactorASC (PF00858, IPR001873): Amiloride-sensitive sodium channelAA429417
2 ASIC3parental proteinASC (PF00858, IPR001873): Amiloride-sensitive sodium channelAA429417

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