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Visible interactions: all affected independent (normal) missing (in fusions) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins ARSA (from a repository: Thu Dec 15 09:10:12 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)15
The number (and %) of the onco-proteins2 (13.33 %)
The number (and %) of the tumor suppressors1 (6.67 %)
Total number of binary PPIs (saturation %)20 (19.05 %)
The number (and %) of affected PPIs15 (75.00 %)
The number of possible different fusions2
PPI diameter2
PPI radius1
The average degree of PPI2.267
Assortativity coefficient-0.5694
The network average Clustering coefficient0.224
The number (and %) of a zero Clustering coefficients10 (66.67 %)
The number (and %) of a zero Betweenness Centrality12 (80.00 %)

ACTIVE INTERACTORS
MISSING INTERACTORS (in fusions)


List of the fusions

PPI for parental proteins: ARSA All fusions
: BF932162;
Proteins found in more fusions ARSA (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 ARSAparental protein150.033174.000Sulfatase (PF00884, IPR000917): Sulfatase
Sulfatase_C (PF14707): C-terminal region of aryl-sulfatase
DUF4976 (PF16347, IPR032506): Domain of unknown function (DUF4976)
2 CETN2interactor100EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
3 CLEC4Ginteractor100ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
4 GALNSoncoprotein30.6671.000Sulfatase (PF00884, IPR000917): Sulfatase
Sulfatase_C (PF14707): C-terminal region of aryl-sulfatase
5 GFPT2interactor100SIS (PF01380, IPR001347): SIS domain
GATase_6 (PF13522): Glutamine amidotransferase domain
6 MESDC2interactor100Mesd (PF10185, IPR019330): Chaperone for wingless signalling and trafficking of LDL receptor
7 PDIA5interactor100Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
8 PLAURoncoprotein30.6671.000Toxin_1 (PF00087, IPR003571): Snake toxin
UPAR_LY6 (PF00021, IPR001526): u-PAR/Ly-6 domain
9 PPICinteractor100Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
10 PPOXinteractor21.0000Amino_oxidase (PF01593, IPR002937): Flavin containing amine oxidoreductase
11 PTPRKsuppressor21.0000fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
MAM (PF00629, IPR000998, SM00137): MAM domain, meprin/A5/mu
Protocadherin (PF08374, IPR013585): Protocadherin
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
12 SUMF1interactor100FGE-sulfatase (PF03781, IPR005532): Sulfatase-modifying factor enzyme 1
DNA_ligase_IV (PF11411, IPR021536): DNA ligase IV
13 TMEM25interactor100C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
DUF4674 (PF15719, IPR029779): Domain of unknown function (DUF4674)
14 TRIP13interactor200AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
15 ZBTB43interactor200BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
DUF2256 (PF10013, IPR017136): Uncharacterized protein conserved in bacteria (DUF2256)
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_8 (PF15909, IPR031799): C2H2-type zinc ribbon

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List of missing interactors (in fusions)

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ARSAparental proteinSulfatase (PF00884, IPR000917): Sulfatase
Sulfatase_C (PF14707): C-terminal region of aryl-sulfatase
DUF4976 (PF16347, IPR032506): Domain of unknown function (DUF4976)
BF932162

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