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Visible interactions: all affected independent (normal) missing (in fusions) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins ARMC9 (from a repository: Thu Feb 21 08:35:38 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)9
The number (and %) of the onco-proteins2 (22.22 %)
The number (and %) of the tumor suppressors2 (22.22 %)
Total number of binary PPIs (saturation %)11 (30.56 %)
The number (and %) of affected PPIs8 (72.73 %)
The number of possible different fusions4
PPI diameter2
PPI radius1
The average degree of PPI1.778
Assortativity coefficient0
The network average Clustering coefficient0.000
The number (and %) of a zero Clustering coefficients9 (100.00 %)
The number (and %) of a zero Betweenness Centrality8 (88.89 %)

ACTIVE INTERACTORS
MISSING INTERACTORS (in fusions)


List of the fusions

PPI for parental proteins: ARMC9 All fusions
: BF064081;
Proteins found in more fusions PRPS2 (see 2 fusions); APP (see 4 fusions); SIAH1 (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 ARMC9parental protein8056.000CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
FOP_dimer (PF09398, IPR018993): FOP N terminal dimerisation domain
AP3D1 (PF06375): AP-3 complex subunit delta-1
2 APPprotein found in more fusions200APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
3 CMTM5suppressor100MARVEL (PF01284, IPR008253): Membrane-associating domain
DUF2207 (PF09972, IPR018702): Predicted membrane protein (DUF2207)
4 CRTAPinteractor100Whi5 (PF08528, IPR013734): Whi5 like
YfiO (PF13525): Outer membrane lipoprotein
Stomagen (PF16851, IPR031753): Stomagen
5 CTSCinteractor100CathepsinC_exc (PF08773, IPR014882): Cathepsin C exclusion domain
Peptidase_C1 (PF00112, IPR000668, SM00645): Papain family cysteine protease
Propeptide_C1 (PF08127, IPR012599): Peptidase family C1 propeptide
6 DPP8interactor100DPPIV_N (PF00930, IPR002469): Dipeptidyl peptidase IV (DPP IV) N-terminal region
Peptidase_S15 (PF02129, IPR000383): X-Pro dipeptidyl-peptidase (S15 family)
Peptidase_S9 (PF00326, IPR001375): Prolyl oligopeptidase family
7 NPLOC4interactor100NPL4 (PF05021, IPR007717): NPL4 family
zf-NPL4 (PF05020, IPR007716): NPL4 family, putative zinc binding region
UN_NPL4 (PF11543, IPR024682): Nuclear pore localisation protein NPL4
8 PRPS2protein found in more fusions200Pribosyltran (PF00156, IPR000836): Phosphoribosyl transferase domain
Pribosyltran_N (PF13793, IPR029099): N-terminal domain of ribose phosphate pyrophosphokinase
Pribosyl_synth (PF14572, IPR005946): Phosphoribosyl synthetase-associated domain
9 SIAH1suppressor200Sina (PF03145, IPR018121): Seven in absentia protein family

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List of missing interactors (in fusions)

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ARMC9parental proteinCENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
FOP_dimer (PF09398, IPR018993): FOP N terminal dimerisation domain
AP3D1 (PF06375): AP-3 complex subunit delta-1
BF064081
2 CMTM5suppressorMARVEL (PF01284, IPR008253): Membrane-associating domain
DUF2207 (PF09972, IPR018702): Predicted membrane protein (DUF2207)
BF064081
3 CRTAPinteractorWhi5 (PF08528, IPR013734): Whi5 like
YfiO (PF13525): Outer membrane lipoprotein
Stomagen (PF16851, IPR031753): Stomagen
BF064081
4 CTSCinteractorCathepsinC_exc (PF08773, IPR014882): Cathepsin C exclusion domain
Peptidase_C1 (PF00112, IPR000668, SM00645): Papain family cysteine protease
Propeptide_C1 (PF08127, IPR012599): Peptidase family C1 propeptide
BF064081
5 DPP8interactorDPPIV_N (PF00930, IPR002469): Dipeptidyl peptidase IV (DPP IV) N-terminal region
Peptidase_S15 (PF02129, IPR000383): X-Pro dipeptidyl-peptidase (S15 family)
Peptidase_S9 (PF00326, IPR001375): Prolyl oligopeptidase family
BF064081
6 NPLOC4interactorNPL4 (PF05021, IPR007717): NPL4 family
zf-NPL4 (PF05020, IPR007716): NPL4 family, putative zinc binding region
UN_NPL4 (PF11543, IPR024682): Nuclear pore localisation protein NPL4
BF064081
7 PRPS2interactorPribosyltran (PF00156, IPR000836): Phosphoribosyl transferase domain
Pribosyltran_N (PF13793, IPR029099): N-terminal domain of ribose phosphate pyrophosphokinase
Pribosyl_synth (PF14572, IPR005946): Phosphoribosyl synthetase-associated domain
BF064081
8 SIAH1suppressorSina (PF03145, IPR018121): Seven in absentia protein familyBF064081

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