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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins ARIH2 (from a repository: Thu Nov 10 14:59:26 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)67
The number (and %) of the onco-proteins25 (37.31 %)
The number (and %) of the tumor suppressors1 (1.49 %)
Total number of binary PPIs (saturation %)219 (9.91 %)
The number (and %) of affected PPIs67 (30.59 %)
The number of possible different fusions18
PPI diameter2
PPI radius1
The average degree of PPI5.612
Assortativity coefficient-0.4267
The network average Clustering coefficient0.589
The number (and %) of a zero Clustering coefficients14 (20.90 %)
The number (and %) of a zero Betweenness Centrality36 (53.73 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: ARIH2 All fusions
: CK299468; AL162034;
Proteins found in more fusions UBE2R2 (see 1 fusions); UGP2 (see 1 fusions); KAT5 (see 3 fusions); EML4 (see 3 fusions); UBE2D2 (see 2 fusions); ARIH2 (see 2 fusions); UBE2L6 (see 2 fusions); EEF1G (see 1 fusions); UBE2E1 (see 2 fusions); UBC (see 1 fusions); UBE2E2 (see 1 fusions); BUB1 (see 1 fusions); PML (see 4 fusions); VCP (see 4 fusions); UBE2N (see 1 fusions); TP53 (see 3 fusions); TRIM27/MDM2 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 ARIH2parental protein670.0573493.502IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zinc_ribbon_12 (PF11331, IPR021480): Probable zinc-ribbon domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
PRAS (PF15798, IPR026682): Proline-rich AKT1 substrate 1
2 APEX1interactor70.33312.250Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family
3 ARAP1interactor21.0000ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf
PH (PF00169, IPR001849, SM00233): PH domain
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
4 ASB9interactor50.7002.500Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
SOCS_box (PF07525, IPR001496): SOCS box
5 BUB1oncoprotein200Mad3_BUB1_I (PF08311, IPR013212, SM00777): Mad3/BUB1 homology region 1
Pkinase (PF00069, IPR000719): Protein kinase domain
6 CBR3interactor21.0000adh_short (PF00106, IPR002198): short chain dehydrogenase
7 CCDC33interactor100C2 (PF00168, IPR000008, SM00239): C2 domain
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
SlyX (PF04102, IPR007236): SlyX
8 CEP126interactor21.0000Nop25 (PF09805, IPR019186): Nucleolar protein 12 (25kDa)
K1377 (PF15352, IPR028257): Susceptibility to monomelic amyotrophy
9 CUL5suppressor140.35243.886Cullin (PF00888, IPR001373, SM00182): Cullin family
GlutR_dimer (PF00745, IPR015896): Glutamyl-tRNAGlu reductase, dimerisation domain
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
10 DISC1interactor21.0000HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
Mnd1 (PF03962, IPR005647): Mnd1 family
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
Tropomyosin (PF00261, IPR000533): Tropomyosin
UVR (PF02151, IPR001943): UvrB/uvrC motif
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
11 DLSToncoprotein21.00002-oxoacid_dh (PF00198, IPR001078): 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
Biotin_lipoyl (PF00364, IPR000089): Biotin-requiring enzyme
DUF4106 (PF13388, IPR025179): Protein of unknown function (DUF4106)
12 EEF1A1oncoprotein90.5006.683GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
13 EEF1Gprotein found in more fusions60.8000.667EF1G (PF00647, IPR001662): Elongation factor 1 gamma, conserved domain
GST_C (PF00043, IPR004046): Glutathione S-transferase, C-terminal domain
GST_N (PF02798, IPR004045): Glutathione S-transferase, N-terminal domain
SAPS (PF04499, IPR007587): SIT4 phosphatase-associated protein
14 EHD1interactor50.6671.667Gp-FAR-1 (PF05823, IPR008632): Nematode fatty acid retinoid binding protein (Gp-FAR-1)
Gtr1_RagA (PF04670, IPR006762): Gtr1/RagA G protein conserved region
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
EHD_N (PF16880, IPR031692): N-terminal EH-domain containing protein
15 EML4oncoprotein31.0000HELP (PF03451, IPR005108): HELP motif
Ndc1_Nup (PF09531, IPR019049): Nucleoporin protein Ndc1-Nup
SlyX (PF04102, IPR007236): SlyX
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
16 ENSAinteractor100Endosulfine (PF04667, IPR006760): cAMP-regulated phosphoprotein/endosulfine conserved region
17 GFI1interactor100zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
18 HK2interactor40.6671.667Hexokinase_1 (PF00349, IPR022672): Hexokinase
Hexokinase_2 (PF03727, IPR022673): Hexokinase
19 IL4Roncoprotein21.0000fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
IL4Ra_N (PF09238, IPR015319): Interleukin-4 receptor alpha chain, N-terminal
20 KAT5oncoprotein80.6196.833MOZ_SAS (PF01853, IPR002717): MOZ/SAS family
Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain
21 KCNQ2interactor100Ion_trans (PF00520, IPR005821): Ion transport protein
KCNQ_channel (PF03520, IPR013821): KCNQ voltage-gated potassium channel
KCNQC3-Ank-G_bd (PF11956, IPR020969): Ankyrin-G binding motif of KCNQ2-3
KCNQ2_u3 (PF16642): Unstructured region on Potassium channel subunit alpha KvLQT2
22 LOC147791interactor100NA
23 MDM2oncoprotein190.29478.386Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region
Presenilin (PF01080, IPR001108): Presenilin
SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
24 NEDD8interactor110.42218.052ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
25 NOTCH1oncoprotein50.6671.000Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_2 (PF07974, IPR013111): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
NOD (PF06816, IPR010660): NOTCH protein
NODP (PF07684, IPR011656): NOTCH protein
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
Notch (PF00066, IPR000800, SM00004): LNR domain
DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454)
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
26 NTRK1oncoprotein180.21393.219I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
27 NUBP1interactor40.6671.667DUF258 (PF03193, IPR004881): Protein of unknown function, DUF258
ParA (PF10609, IPR019591): NUBPL iron-transfer P-loop NTPase
28 PABPN1interactor41.0000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain
Shadoo (PF14999, IPR029238): Shadow of prion protein, neuroprotective
29 PAPSS2interactor21.0000APS_kinase (PF01583, IPR002891): Adenylylsulphate kinase
ATP-sulfurylase (PF01747, IPR024951): ATP-sulfurylase
DUF258 (PF03193, IPR004881): Protein of unknown function, DUF258
YscJ_FliF (PF01514, IPR006182): Secretory protein of YscJ/FliF family
PUA_2 (PF14306, IPR025980): PUA-like domain
30 PARP6interactor100PARP (PF00644, IPR012317): Poly(ADP-ribose) polymerase catalytic domain
31 PDLIM1interactor41.0000LIM (PF00412, IPR001781, SM00132): LIM domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
DUF4749 (PF15936, IPR031847): Domain of unknown function (DUF4749)
32 PHF7interactor30.6670.667zf-Sec23_Sec24 (PF04810, IPR006895): Sec23/Sec24 zinc finger
zf-HC5HC2H (PF13771): PHD-like zinc-binding domain
33 PMLoncoprotein70.7332.083zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
DUF3583 (PF12126, IPR021978): Protein of unknown function (DUF3583)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
34 PPP2R1Aoncoprotein80.5368.369TAF6_C (PF07571, IPR011442): TAF6 C-terminal HEAT repeat domain
HEAT (PF02985, IPR000357): HEAT repeat
HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
35 PTNoncoprotein200PTN_MK_C (PF01091, IPR020090): PTN/MK heparin-binding protein family, C-terminal domain
PTN_MK_N (PF05196, IPR020089): PTN/MK heparin-binding protein family, N-terminal domain
36 RAB40Aoncoprotein31.0000Ras (PF00071, IPR001806, SM00173): Ras family
SOCS_box (PF07525, IPR001496): SOCS box
37 RELinteractor100RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
38 RHEBinteractor100Ras (PF00071, IPR001806, SM00173): Ras family
39 RPL8interactor60.6002.483Ribosomal_L2 (PF00181, IPR022666): Ribosomal Proteins L2, RNA binding domain
Ribosomal_L2_C (PF03947, IPR022669): Ribosomal Proteins L2, C-terminal domain
40 SCAMP2interactor100SCAMP (PF04144, IPR007273): SCAMP family
KfrA_N (PF11740, IPR021104): Plasmid replication region DNA-binding N-term
41 SGCEinteractor100Sarcoglycan_2 (PF05510, IPR008908): Sarcoglycan alpha/epsilon
42 SLC1A6interactor100SDF (PF00375, IPR001991): Sodium:dicarboxylate symporter family
43 SOCS6interactor50.7001.733SH2 (PF00017, IPR000980, SM00252): SH2 domain
SOCS_box (PF07525, IPR001496): SOCS box
44 TCEB1interactor80.5369.733Skp1_POZ (PF03931, IPR016073): Skp1 family, tetramerisation domain
45 TCEB2interactor60.8001.400ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
46 TP53oncoprotein140.38532.486DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
47 TRIM27oncoprotein180.28775.667IncA (PF04156, IPR007285): IncA protein
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
48 TWF2interactor21.0000Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
49 UBCprotein found in more fusions220.262123.617ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
50 UBE2D1interactor70.7333.333UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
51 UBE2D2oncoprotein110.44416.867UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
52 UBE2D3interactor60.8000.800UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
53 UBE2D4interactor40.6670.667UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
54 UBE2E1protein found in more fusions31.0000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
55 UBE2E2protein found in more fusions41.0000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
56 UBE2E3interactor51.0000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
57 UBE2L3interactor51.0000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
58 UBE2L6protein found in more fusions31.0000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
59 UBE2Nprotein found in more fusions70.8001.667UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
60 UBE2R2protein found in more fusions41.0000NOA36 (PF06524, IPR010531): NOA36 protein
UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
61 UBE2Tinteractor41.0000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
62 UBE2V1interactor40.8330.400UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
63 UGP2protein found in more fusions31.0000UDPGP (PF01704, IPR002618): UTP--glucose-1-phosphate uridylyltransferase
64 UTP14Ainteractor21.0000Utp14 (PF04615, IPR006709): Utp14 protein
65 VCPprotein found in more fusions80.7142.050AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
66 WDR91interactor21.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
WIYLD (PF10440, IPR018848): Ubiquitin-binding WIYLD domain
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
67 ZFP41interactor100zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain

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