Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins ARIH2 (from a repository: Thu Nov 10 14:59:26 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 67 The number (and %) of the onco-proteins 25 (37.31 %) The number (and %) of the tumor suppressors 1 (1.49 %) Total number of binary PPIs (saturation %) 219 (9.91 %) The number (and %) of affected PPIs 67 (30.59 %) The number of possible different fusions 18 PPI diameter 2 PPI radius 1 The average degree of PPI 5.612 Assortativity coefficient -0.4267 The network average Clustering coefficient 0.589 The number (and %) of a zero Clustering coefficients 14 (20.90 %) The number (and %) of a zero Betweenness Centrality 36 (53.73 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: ARIH2	All fusions : CK299468; AL162034;
Proteins found in more fusions	UBE2R2 (see 1 fusions); UGP2 (see 1 fusions); KAT5 (see 3 fusions); EML4 (see 3 fusions); UBE2D2 (see 2 fusions); ARIH2 (see 2 fusions); UBE2L6 (see 2 fusions); EEF1G (see 1 fusions); UBE2E1 (see 2 fusions); UBC (see 1 fusions); UBE2E2 (see 1 fusions); BUB1 (see 1 fusions); PML (see 4 fusions); VCP (see 4 fusions); UBE2N (see 1 fusions); TP53 (see 3 fusions); TRIM27/MDM2 (see 1 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	ARIH2	parental protein	67	0.057	3493.502	IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) zinc_ribbon_12 (PF11331, IPR021480): Probable zinc-ribbon domain zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING PRAS (PF15798, IPR026682): Proline-rich AKT1 substrate 1
2	APEX1	interactor	7	0.333	12.250	Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family
3	ARAP1	interactor	2	1.000	0	ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf PH (PF00169, IPR001849, SM00233): PH domain RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
4	ASB9	interactor	5	0.700	2.500	Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_5 (PF13857): Ankyrin repeats (many copies) SOCS_box (PF07525, IPR001496): SOCS box
5	BUB1	oncoprotein	2	0	0	Mad3_BUB1_I (PF08311, IPR013212, SM00777): Mad3/BUB1 homology region 1 Pkinase (PF00069, IPR000719): Protein kinase domain
6	CBR3	interactor	2	1.000	0	adh_short (PF00106, IPR002198): short chain dehydrogenase
7	CCDC33	interactor	1	0	0	C2 (PF00168, IPR000008, SM00239): C2 domain DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat SlyX (PF04102, IPR007236): SlyX
8	CEP126	interactor	2	1.000	0	Nop25 (PF09805, IPR019186): Nucleolar protein 12 (25kDa) K1377 (PF15352, IPR028257): Susceptibility to monomelic amyotrophy
9	CUL5	suppressor	14	0.352	43.886	Cullin (PF00888, IPR001373, SM00182): Cullin family GlutR_dimer (PF00745, IPR015896): Glutamyl-tRNAGlu reductase, dimerisation domain Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
10	DISC1	interactor	2	1.000	0	HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper Mnd1 (PF03962, IPR005647): Mnd1 family TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein Tropomyosin (PF00261, IPR000533): Tropomyosin UVR (PF02151, IPR001943): UvrB/uvrC motif CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
11	DLST	oncoprotein	2	1.000	0	2-oxoacid_dh (PF00198, IPR001078): 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl (PF00364, IPR000089): Biotin-requiring enzyme DUF4106 (PF13388, IPR025179): Protein of unknown function (DUF4106)
12	EEF1A1	oncoprotein	9	0.500	6.683	GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
13	EEF1G	protein found in more fusions	6	0.800	0.667	EF1G (PF00647, IPR001662): Elongation factor 1 gamma, conserved domain GST_C (PF00043, IPR004046): Glutathione S-transferase, C-terminal domain GST_N (PF02798, IPR004045): Glutathione S-transferase, N-terminal domain SAPS (PF04499, IPR007587): SIT4 phosphatase-associated protein
14	EHD1	interactor	5	0.667	1.667	Gp-FAR-1 (PF05823, IPR008632): Nematode fatty acid retinoid binding protein (Gp-FAR-1) Gtr1_RagA (PF04670, IPR006762): Gtr1/RagA G protein conserved region Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand EHD_N (PF16880, IPR031692): N-terminal EH-domain containing protein
15	EML4	oncoprotein	3	1.000	0	HELP (PF03451, IPR005108): HELP motif Ndc1_Nup (PF09531, IPR019049): Nucleoporin protein Ndc1-Nup SlyX (PF04102, IPR007236): SlyX WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360) ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
16	ENSA	interactor	1	0	0	Endosulfine (PF04667, IPR006760): cAMP-regulated phosphoprotein/endosulfine conserved region
17	GFI1	interactor	1	0	0	zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger
18	HK2	interactor	4	0.667	1.667	Hexokinase_1 (PF00349, IPR022672): Hexokinase Hexokinase_2 (PF03727, IPR022673): Hexokinase
19	IL4R	oncoprotein	2	1.000	0	fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain IL4Ra_N (PF09238, IPR015319): Interleukin-4 receptor alpha chain, N-terminal
20	KAT5	oncoprotein	8	0.619	6.833	MOZ_SAS (PF01853, IPR002717): MOZ/SAS family Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain
21	KCNQ2	interactor	1	0	0	Ion_trans (PF00520, IPR005821): Ion transport protein KCNQ_channel (PF03520, IPR013821): KCNQ voltage-gated potassium channel KCNQC3-Ank-G_bd (PF11956, IPR020969): Ankyrin-G binding motif of KCNQ2-3 KCNQ2_u3 (PF16642): Unstructured region on Potassium channel subunit alpha KvLQT2
22	LOC147791	interactor	1	0	0	NA
23	MDM2	oncoprotein	19	0.294	78.386	Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region Presenilin (PF01080, IPR001108): Presenilin SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
24	NEDD8	interactor	11	0.422	18.052	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
25	NOTCH1	oncoprotein	5	0.667	1.000	Ank (PF00023, IPR002110, SM00248): Ankyrin repeat EGF (PF00008, IPR000742, SM00181): EGF-like domain EGF_2 (PF07974, IPR013111): EGF-like domain EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain NOD (PF06816, IPR010660): NOTCH protein NODP (PF07684, IPR011656): NOTCH protein TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit Notch (PF00066, IPR000800, SM00004): LNR domain DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454) hEGF (PF12661, IPR013032): Human growth factor-like EGF cEGF (PF12662, IPR026823): Complement Clr-like EGF-like Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
26	NTRK1	oncoprotein	18	0.213	93.219	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
27	NUBP1	interactor	4	0.667	1.667	DUF258 (PF03193, IPR004881): Protein of unknown function, DUF258 ParA (PF10609, IPR019591): NUBPL iron-transfer P-loop NTPase
28	PABPN1	interactor	4	1.000	0	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain Shadoo (PF14999, IPR029238): Shadow of prion protein, neuroprotective
29	PAPSS2	interactor	2	1.000	0	APS_kinase (PF01583, IPR002891): Adenylylsulphate kinase ATP-sulfurylase (PF01747, IPR024951): ATP-sulfurylase DUF258 (PF03193, IPR004881): Protein of unknown function, DUF258 YscJ_FliF (PF01514, IPR006182): Secretory protein of YscJ/FliF family PUA_2 (PF14306, IPR025980): PUA-like domain
30	PARP6	interactor	1	0	0	PARP (PF00644, IPR012317): Poly(ADP-ribose) polymerase catalytic domain
31	PDLIM1	interactor	4	1.000	0	LIM (PF00412, IPR001781, SM00132): LIM domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) DUF4749 (PF15936, IPR031847): Domain of unknown function (DUF4749)
32	PHF7	interactor	3	0.667	0.667	zf-Sec23_Sec24 (PF04810, IPR006895): Sec23/Sec24 zinc finger zf-HC5HC2H (PF13771): PHD-like zinc-binding domain
33	PML	oncoprotein	7	0.733	2.083	zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger DUF3583 (PF12126, IPR021978): Protein of unknown function (DUF3583) zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
34	PPP2R1A	oncoprotein	8	0.536	8.369	TAF6_C (PF07571, IPR011442): TAF6 C-terminal HEAT repeat domain HEAT (PF02985, IPR000357): HEAT repeat HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat HEAT_2 (PF13646): HEAT repeats
35	PTN	oncoprotein	2	0	0	PTN_MK_C (PF01091, IPR020090): PTN/MK heparin-binding protein family, C-terminal domain PTN_MK_N (PF05196, IPR020089): PTN/MK heparin-binding protein family, N-terminal domain
36	RAB40A	oncoprotein	3	1.000	0	Ras (PF00071, IPR001806, SM00173): Ras family SOCS_box (PF07525, IPR001496): SOCS box
37	REL	interactor	1	0	0	RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
38	RHEB	interactor	1	0	0	Ras (PF00071, IPR001806, SM00173): Ras family
39	RPL8	interactor	6	0.600	2.483	Ribosomal_L2 (PF00181, IPR022666): Ribosomal Proteins L2, RNA binding domain Ribosomal_L2_C (PF03947, IPR022669): Ribosomal Proteins L2, C-terminal domain
40	SCAMP2	interactor	1	0	0	SCAMP (PF04144, IPR007273): SCAMP family KfrA_N (PF11740, IPR021104): Plasmid replication region DNA-binding N-term
41	SGCE	interactor	1	0	0	Sarcoglycan_2 (PF05510, IPR008908): Sarcoglycan alpha/epsilon
42	SLC1A6	interactor	1	0	0	SDF (PF00375, IPR001991): Sodium:dicarboxylate symporter family
43	SOCS6	interactor	5	0.700	1.733	SH2 (PF00017, IPR000980, SM00252): SH2 domain SOCS_box (PF07525, IPR001496): SOCS box
44	TCEB1	interactor	8	0.536	9.733	Skp1_POZ (PF03931, IPR016073): Skp1 family, tetramerisation domain
45	TCEB2	interactor	6	0.800	1.400	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
46	TP53	oncoprotein	14	0.385	32.486	DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
47	TRIM27	oncoprotein	18	0.287	75.667	IncA (PF04156, IPR007285): IncA protein SPRY (PF00622, IPR003877, SM00449): SPRY domain zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger PRY (PF13765, IPR006574, SM00589): SPRY-associated domain zf-C2H2_4 (PF13894): C2H2-type zinc finger zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
48	TWF2	interactor	2	1.000	0	Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
49	UBC	protein found in more fusions	22	0.262	123.617	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
50	UBE2D1	interactor	7	0.733	3.333	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
51	UBE2D2	oncoprotein	11	0.444	16.867	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
52	UBE2D3	interactor	6	0.800	0.800	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
53	UBE2D4	interactor	4	0.667	0.667	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
54	UBE2E1	protein found in more fusions	3	1.000	0	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
55	UBE2E2	protein found in more fusions	4	1.000	0	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
56	UBE2E3	interactor	5	1.000	0	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
57	UBE2L3	interactor	5	1.000	0	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
58	UBE2L6	protein found in more fusions	3	1.000	0	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
59	UBE2N	protein found in more fusions	7	0.800	1.667	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
60	UBE2R2	protein found in more fusions	4	1.000	0	NOA36 (PF06524, IPR010531): NOA36 protein UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
61	UBE2T	interactor	4	1.000	0	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
62	UBE2V1	interactor	4	0.833	0.400	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
63	UGP2	protein found in more fusions	3	1.000	0	UDPGP (PF01704, IPR002618): UTP--glucose-1-phosphate uridylyltransferase
64	UTP14A	interactor	2	1.000	0	Utp14 (PF04615, IPR006709): Utp14 protein
65	VCP	protein found in more fusions	8	0.714	2.050	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2 CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain TniB (PF05621, IPR008868): Bacterial TniB protein Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
66	WDR91	interactor	2	1.000	0	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat WIYLD (PF10440, IPR018848): Ubiquitin-binding WIYLD domain ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
67	ZFP41	interactor	1	0	0	zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain

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