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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins ARIH1 (from a repository: Sat Nov 12 09:37:31 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)42
The number (and %) of the onco-proteins13 (30.95 %)
The number (and %) of the tumor suppressors5 (11.90 %)
Total number of binary PPIs (saturation %)133 (15.45 %)
The number (and %) of affected PPIs42 (31.58 %)
The number of possible different fusions13
PPI diameter2
PPI radius1
The average degree of PPI5.381
Assortativity coefficient-0.3665
The network average Clustering coefficient0.580
The number (and %) of a zero Clustering coefficients5 (11.90 %)
The number (and %) of a zero Betweenness Centrality16 (38.10 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: ARIH1 All fusions
: BE000781; BM462307; BG282810; DB350003;
Proteins found in more fusions HSPB1 (see 3 fusions); ARIH1 (see 4 fusions); CUL1 (see 3 fusions); CUL3 (see 1 fusions); UBE2L6 (see 2 fusions); CUL4A (see 4 fusions); GOPC (see 2 fusions); UBE2E2 (see 1 fusions); DHPS (see 1 fusions); VCP (see 4 fusions); SNCAIP (see 1 fusions); UBE2N (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 ARIH1parental protein420.0881296.236CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
Med14 (PF08638, IPR013947): Mediator complex subunit MED14
zinc_ribbon_2 (PF13240, IPR026870): zinc-ribbon domain
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
2 ANKMY2interactor30.6671.000zf-MYND (PF01753, IPR002893): MYND finger
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_3 (PF13606, IPR002110): Ankyrin repeat
zf-C6H2 (PF15801, IPR031615): zf-MYND-like zinc finger, mRNA-binding
3 BTF3L4interactor31.0000NAC (PF01849, IPR002715): NAC domain
4 BTRConcoprotein120.40025.050WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
5 CASKinteractor21.0000L27 (PF02828, IPR014775, SM00569): L27 domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Pkinase (PF00069, IPR000719): Protein kinase domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
6 CTSCinteractor40.5002.667CathepsinC_exc (PF08773, IPR014882): Cathepsin C exclusion domain
Peptidase_C1 (PF00112, IPR000668, SM00645): Papain family cysteine protease
Propeptide_C1 (PF08127, IPR012599): Peptidase family C1 propeptide
7 CUL1suppressor110.51114.836Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
8 CUL2suppressor50.7001.250Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
9 CUL3protein found in more fusions110.40019.250Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
10 CUL4Aprotein found in more fusions70.8670.536Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
11 DHPSprotein found in more fusions31.0000DS (PF01916, IPR002773): Deoxyhypusine synthase
12 DR1interactor31.0000CBFD_NFYB_HMF (PF00808, IPR003958): Histone-like transcription factor (CBF/NF-Y) and archaeal histone
SLED (PF12140, IPR021987): SLED domain
13 EIF4E2interactor30.6671.000IF4E (PF01652, IPR001040): Eukaryotic initiation factor 4E
14 ELAC2oncoprotein31.0000Synthase_beta (PF11421, IPR020971): ATP synthase F1 beta subunit
Lactamase_B_2 (PF12706, IPR001279): Beta-lactamase superfamily domain
Lactamase_B_4 (PF13691, IPR027794): tRNase Z endonuclease
15 EPN3interactor100ENTH (PF01417, IPR001026, SM00273): ENTH domain
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
16 FBXL15interactor21.0000LRV (PF01816, IPR004830): Leucine rich repeat variant
F-box (PF00646, IPR001810, SM00256): F-box domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
17 FBXO6interactor60.4675.917FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
18 FBXW11interactor90.5369.817WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
19 GOPConcoprotein50.6672.000DUF903 (PF06004, IPR010305): Bacterial protein of unknown function (DUF903)
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
DUF3209 (PF11483, IPR021577): Protein of unknown function (DUF3209)
20 HAUS7interactor100M3 (PF09213, IPR015296): M3
Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein
21 HSPB1oncoprotein70.4676.286HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
22 NEDD8interactor110.44416.986ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
23 NOTCH1suppressor31.0000Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_2 (PF07974, IPR013111): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
NOD (PF06816, IPR010660): NOTCH protein
NODP (PF07684, IPR011656): NOTCH protein
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
Notch (PF00066, IPR000800, SM00004): LNR domain
DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454)
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
24 P3H1interactor60.4007.400TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
YfiO (PF13525): Outer membrane lipoprotein
2OG-FeII_Oxy_3 (PF13640, IPR005123): 2OG-Fe(II) oxygenase superfamily
MCM_N (PF14551, IPR027925): MCM N-terminal domain
Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
25 PARK2suppressor120.20041.900IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
26 SIM2interactor21.0000HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_3 (PF08447, IPR013655): PAS fold
SIM_C (PF06621, IPR010578): Single-minded protein C-terminus
27 SNCAIPprotein found in more fusions31.0000Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
SNCAIP_SNCA_bd (PF16700, IPR032027): Synphilin-1 alpha-Synuclein-binding domain
28 SPANXN3interactor31.0000SPAN-X (PF07458, IPR010007): Sperm protein associated with nucleus, mapped to X chromosome
29 UBA2interactor50.4005.167ThiF (PF00899, IPR000594): ThiF family
UAE_UbL (PF14732, IPR028077): Ubiquitin/SUMO-activating enzyme ubiquitin-like domain
UBA2_C (PF16195, IPR032426): SUMO-activating enzyme subunit 2 C-terminus
30 UBE2D1interactor70.4006.786UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
31 UBE2D3interactor60.7001.667UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
32 UBE2E2protein found in more fusions40.6670.500UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
33 UBE2L3interactor50.5003.000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
34 UBE2L6protein found in more fusions31.0000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
35 UBE2Nprotein found in more fusions40.6670.667UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
36 VAV2oncoprotein100PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
CAMSAP_CH (PF11971, IPR022613): CAMSAP CH domain
CotJB (PF12652, IPR024207): CotJB protein
37 VCPprotein found in more fusions110.46713.752AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
38 WDR4interactor50.6003.167WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
39 XPO5suppressor50.6003.667IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
40 ZFP41interactor100zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
41 ZNF501interactor100zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_11 (PF16622, IPR007087): zinc-finger C2H2-type
42 ZPR1interactor50.4005.500zf-ZPR1 (PF03367, IPR004457, SM00709): ZPR1 zinc-finger domain

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