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Visible interactions: all affected independent (normal) missing (in fusions) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins SLC6A1, ARHGAP35 (from a repository: Sat Jan 18 10:20:35 2020)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)15
The number (and %) of the onco-proteins6 (40.00 %)
The number (and %) of the tumor suppressors2 (13.33 %)
Total number of binary PPIs (saturation %)25 (23.81 %)
The number (and %) of affected PPIs13 (52.00 %)
The number of possible different fusions4
PPI diameter2
PPI radiusinf
The average degree of PPI2.533
Assortativity coefficient-0.2524
The network average Clustering coefficient0.302
The number (and %) of a zero Clustering coefficients9 (60.00 %)
The number (and %) of a zero Betweenness Centrality12 (80.00 %)

ACTIVE INTERACTORS
MISSING INTERACTORS (in fusions)


List of the fusions

PPI for parental proteins: ARHGAP35,SLC6A1 All fusions
: BQ300148;
Proteins found in more fusions GRB2 (see 1 fusions); RAC1 (see 1 fusions); BCL6 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 ARHGAP35parental protein120.091115.667FF (PF01846, IPR002713, SM00441): FF domain
Ras (PF00071, IPR001806, SM00173): Ras family
RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
RhoGAP-FF1 (PF16512, IPR032835): p190-A and -B Rho GAPs FF domain
2 SLC6A1parental protein100SNF (PF00209, IPR000175): Sodium:neurotransmitter symporter family
3 BCL6oncoprotein200BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
DZR (PF12773, IPR025874): Double zinc ribbon
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2HE (PF16278, IPR032566): C2HE / C2H2 / C2HC zinc-binding finger
4 CDC42oncoprotein31.0000Ras (PF00071, IPR001806, SM00173): Ras family
5 GRB2oncoprotein60.6003.667SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
6 KRT31interactor100Filament (PF00038, IPR001664): Intermediate filament protein
7 NTRK1oncoprotein50.8330.667I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
8 RAC1oncoprotein200Ras (PF00071, IPR001806, SM00173): Ras family
9 RASA1oncoprotein31.0000C2 (PF00168, IPR000008, SM00239): C2 domain
PH (PF00169, IPR001849, SM00233): PH domain
RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
10 RHOAsuppressor100Ras (PF00071, IPR001806, SM00173): Ras family
11 RND1interactor100Ras (PF00071, IPR001806, SM00173): Ras family
12 RND2interactor100Ras (PF00071, IPR001806, SM00173): Ras family
13 RND3suppressor100Ras (PF00071, IPR001806, SM00173): Ras family
14 STX1Ainteractor200Syntaxin (PF00804, IPR006011, SM00503): Syntaxin
SNARE (PF05739, IPR000727, SM00397): SNARE domain
4HB_MCP_1 (PF12729, IPR024478): Four helix bundle sensory module for signal transduction
15 TCERG1interactor31.0000FF (PF01846, IPR002713, SM00441): FF domain
WW (PF00397, IPR001202, SM00456): WW domain
Folliculin (PF11704, IPR021713): Vesicle coat protein involved in Golgi to plasma membrane transport
DUF3807 (PF12720, IPR024526): Protein of unknown function (DUF3807)
DUF3886 (PF13025, IPR024980): Protein of unknown function (DUF3886)
Spore_coat_CotO (PF14153, IPR025439): Spore coat protein CotO
FAM150 (PF15129, IPR029364): FAM150 family

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List of missing interactors (in fusions)

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ARHGAP35parental proteinFF (PF01846, IPR002713, SM00441): FF domain
Ras (PF00071, IPR001806, SM00173): Ras family
RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
RhoGAP-FF1 (PF16512, IPR032835): p190-A and -B Rho GAPs FF domain
BQ300148
2 BCL6oncoproteinBTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
DZR (PF12773, IPR025874): Double zinc ribbon
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2HE (PF16278, IPR032566): C2HE / C2H2 / C2HC zinc-binding finger
BQ300148
3 CDC42oncoproteinRas (PF00071, IPR001806, SM00173): Ras familyBQ300148
4 GRB2oncoproteinSH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
BQ300148
5 KRT31interactorFilament (PF00038, IPR001664): Intermediate filament proteinBQ300148
6 NTRK1oncoproteinI-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
BQ300148
7 RAC1oncoproteinRas (PF00071, IPR001806, SM00173): Ras familyBQ300148
8 RASA1oncoproteinC2 (PF00168, IPR000008, SM00239): C2 domain
PH (PF00169, IPR001849, SM00233): PH domain
RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
BQ300148
9 RHOAsuppressorRas (PF00071, IPR001806, SM00173): Ras familyBQ300148
10 RND1interactorRas (PF00071, IPR001806, SM00173): Ras familyBQ300148
11 RND2interactorRas (PF00071, IPR001806, SM00173): Ras familyBQ300148
12 RND3suppressorRas (PF00071, IPR001806, SM00173): Ras familyBQ300148
13 SLC6A1parental proteinSNF (PF00209, IPR000175): Sodium:neurotransmitter symporter familyBQ300148
14 TCERG1interactorFF (PF01846, IPR002713, SM00441): FF domain
WW (PF00397, IPR001202, SM00456): WW domain
Folliculin (PF11704, IPR021713): Vesicle coat protein involved in Golgi to plasma membrane transport
DUF3807 (PF12720, IPR024526): Protein of unknown function (DUF3807)
DUF3886 (PF13025, IPR024980): Protein of unknown function (DUF3886)
Spore_coat_CotO (PF14153, IPR025439): Spore coat protein CotO
FAM150 (PF15129, IPR029364): FAM150 family
BQ300148

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