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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)11
The number (and %) of the onco-proteins4 (36.36 %)
The number (and %) of the tumor suppressors3 (27.27 %)
Total number of binary PPIs (saturation %)26 (47.27 %)
The number (and %) of affected PPIs11 (42.31 %)
The number of possible different fusions5
PPI diameter2
PPI radius1
The average degree of PPI3.091
Assortativity coefficient-0.3008
The network average Clustering coefficient0.599
The number (and %) of a zero Clustering coefficients3 (27.27 %)
The number (and %) of a zero Betweenness Centrality8 (72.73 %)


List of the fusions

PPI for parental proteins: AREL1 All fusions
: BE048757;
Proteins found in more fusions HSP90AA1 (see 2 fusions); UBC (see 1 fusions); UBE2D2 (see 2 fusions); AREL1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 AREL1parental protein110.15671.667Filamin (PF00630, IPR017868): Filamin/ABP280 repeat
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
2 CRKLoncoprotein100SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
3 DIABLOsuppressor31.0000Smac_DIABLO (PF09057, IPR015142): Second Mitochondria-derived Activator of Caspases
4 HSP90AA1oncoprotein200HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
5 HTRA2suppressor31.0000Peptidase_S32 (PF05579, IPR008760): Equine arteritis virus serine endopeptidase S32
PDZ_2 (PF13180, IPR001478): PDZ domain
Trypsin_2 (PF13365): Trypsin-like peptidase domain
6 SEPT4suppressor100Septin (PF00735, IPR000038): Septin
7 UBCprotein found in more fusions60.6003.667ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
8 UBE2D1interactor41.0000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
9 UBE2D2oncoprotein50.8330.667UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
10 UBE2D3interactor31.0000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
11 UBE2L3interactor41.0000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme

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