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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)51
The number (and %) of the onco-proteins13 (25.49 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)162 (12.71 %)
The number (and %) of affected PPIs51 (31.48 %)
The number of possible different fusions7
PPI diameter2
PPI radius1
The average degree of PPI5.882
Assortativity coefficient-0.5076
The network average Clustering coefficient0.476
The number (and %) of a zero Clustering coefficients18 (35.29 %)
The number (and %) of a zero Betweenness Centrality26 (50.98 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: APOE All fusions
: AI680935;
Proteins found in more fusions CSNK2A1 (see 1 fusions); APOE (see 1 fusions); A2M (see 2 fusions); CDC37 (see 2 fusions); ACTG1 (see 4 fusions); MAPT (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 APOEparental protein510.0821981.428Apolipoprotein (PF01442, IPR000074): Apolipoprotein A1/A4/E domain
TipAS (PF07739, IPR012925): TipAS antibiotic-recognition domain
2 A2Mprotein found in more fusions210.35883.573A2M (PF00207, IPR001599): Alpha-2-macroglobulin family
A2M_comp (PF07678, IPR011626): A-macroglobulin complement component
A2M_N (PF01835, IPR002890): MG2 domain
A2M_N_2 (PF07703, IPR011625): Alpha-2-macroglobulin family N-terminal region
A2M_recep (PF07677, IPR009048): A-macroglobulin receptor
MP (PF01107, IPR028919): Viral movement protein (MP)
SVA (PF05326, IPR007990): Seminal vesicle autoantigen (SVA)
Thiol-ester_cl (PF10569, IPR019565): Alpha-macro-globulin thiol-ester bond-forming region
3 ACTG1protein found in more fusions200Actin (PF00022, IPR004000, SM00268): Actin
4 ALBinteractor40.5003.000Serum_albumin (PF00273, IPR014760, SM00103): Serum albumin family
5 ANKHinteractor100ANKH (PF07260, IPR009887): Progressive ankylosis protein (ANKH)
6 ARFGAP1interactor100ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf
7 C19orf52interactor100DUF2366 (PF10171, IPR019322): Uncharacterised conserved protein (DUF2366)
8 CDC37protein found in more fusions150.58213.448CDC37_C (PF08564, IPR013873, SM01069): Cdc37 C terminal domain
CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain
CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding
Rho_Binding (PF08912, IPR015008): Rho Binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
9 CSNK2A1oncoprotein50.6671.667Pkinase (PF00069, IPR000719): Protein kinase domain
10 CYP2C18interactor40.8330.167p450 (PF00067, IPR001128): Cytochrome P450
11 CYP2C8interactor80.8571.189p450 (PF00067, IPR001128): Cytochrome P450
12 ECSITinteractor180.51530.843ECSIT (PF06239, IPR010418): Evolutionarily conserved signalling intermediate in Toll pathway
ECSIT_C (PF14784, IPR029342): C-terminal domain of the ECSIT protein
13 ELAVL1oncoprotein70.4676.667RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
14 EPN2interactor100ENTH (PF01417, IPR001026, SM00273): ENTH domain
Pheromone (PF08015, IPR012597): Fungal mating-type pheromone
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
15 FARSAinteractor41.0000tRNA-synt_2d (PF01409, IPR002319): tRNA synthetases class II core domain (F)
MarR_2 (PF12802): MarR family
16 FBXL12interactor70.8570.543F-box-like (PF12937, IPR001810): F-box-like
17 FOXG1interactor100SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
SPX (PF03105, IPR004331): SPX domain
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
18 FXYD7interactor100ATP1G1_PLM_MAT8 (PF02038, IPR000272): ATP1G1/PLM/MAT8 family
19 GCDHinteractor80.8570.828Acyl-CoA_dh_1 (PF00441, IPR009075): Acyl-CoA dehydrogenase, C-terminal domain
Acyl-CoA_dh_M (PF02770, IPR006091): Acyl-CoA dehydrogenase, middle domain
Acyl-CoA_dh_N (PF02771, IPR013786): Acyl-CoA dehydrogenase, N-terminal domain
20 HLA-DPA1interactor100MHC_II_alpha (PF00993, IPR001003, SM00920): Class II histocompatibility antigen, alpha domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
C1-set_C (PF16196, IPR032431): C1-set C-terminal domain
21 HTRA1oncoprotein21.0000PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
IGFBP (PF00219, IPR000867, SM00121): Insulin-like growth factor binding protein
Kazal_2 (PF07648, IPR002350, SM00280): Kazal-type serine protease inhibitor domain
Trypsin_2 (PF13365): Trypsin-like peptidase domain
22 IFIT3interactor100.9170.725TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_10 (PF13374, IPR011990): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
23 IFIT5interactor100.7567.392TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
Sec16_C (PF12931, IPR024298): Sec23-binding domain of Sec16
TPR_6 (PF13174, IPR019734): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_15 (PF13429): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
24 IQSEC1interactor100Sec7 (PF01369, IPR000904, SM00222): Sec7 domain
IQ_SEC7_PH (PF16453, IPR001849): PH domain
25 LCATinteractor21.0000LCAT (PF02450, IPR003386): Lecithin:cholesterol acyltransferase
26 LONP1interactor100.8442.125AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
AAA_PrkA (PF08298, IPR013153, SM00763): PrkA AAA domain
LON_substr_bdg (PF02190, IPR003111, SM00464): ATP-dependent protease La (LON) substrate-binding domain
Lon_C (PF05362, IPR008269): Lon protease (S16) C-terminal proteolytic domain
RuvB_N (PF05496, IPR008824): Holliday junction DNA helicase ruvB N-terminus
AAA_23 (PF13476): AAA domain
27 LOXL4oncoprotein60.9330.154Lysyl_oxidase (PF01186, IPR001695): Lysyl oxidase
SRCR (PF00530, IPR001190): Scavenger receptor cysteine-rich domain
28 LRP1interactor21.0000EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
SGL (PF08450, IPR013658): SMP-30/Gluconolaconase/LRE-like region
TadE (PF07811, IPR012495): TadE-like protein
Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A
Ldl_recept_b (PF00058, IPR000033, SM00135): Low-density lipoprotein receptor repeat class B
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
EGF_3 (PF12947, IPR024731): EGF domain
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
DUF5050 (PF16472, IPR032485): Domain of unknown function (DUF5050)
29 LRP2interactor100Arylesterase (PF01731, IPR002640): Arylesterase
EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
Form-deh_trans (PF09163, IPR015246): Formate dehydrogenase N, transmembrane
SGL (PF08450, IPR013658): SMP-30/Gluconolaconase/LRE-like region
Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A
Ldl_recept_b (PF00058, IPR000033, SM00135): Low-density lipoprotein receptor repeat class B
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
30 LRP8interactor21.0000EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A
Ldl_recept_b (PF00058, IPR000033, SM00135): Low-density lipoprotein receptor repeat class B
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
TMEM154 (PF15102, IPR028064): TMEM154 protein family
31 MAPTprotein found in more fusions40.6670.667Tubulin-binding (PF00418, IPR001084): Tau and MAP protein, tubulin-binding repeat
32 MAST1interactor140.56014.067DUF1908 (PF08926, IPR015022): Domain of unknown function (DUF1908)
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Pkinase (PF00069, IPR000719): Protein kinase domain
33 MID1IP1interactor100Spot_14 (PF07084, IPR009786): Thyroid hormone-inducible hepatic protein Spot 14
34 MMP3interactor100Peptidase_M10 (PF00413, IPR001818): Matrixin
PG_binding_1 (PF01471, IPR002477): Putative peptidoglycan binding domain
Hemopexin (PF00045, IPR018487, SM00120): Hemopexin
35 MMRN1interactor100C1q (PF00386, IPR001073, SM00110): C1q domain
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
EGF (PF00008, IPR000742, SM00181): EGF-like domain
EMI (PF07546, IPR011489): EMI domain
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
Occludin_ELL (PF07303, IPR010844): Occludin homology domain
RIH_assoc (PF08454, IPR013662): RyR and IP3R Homology associated
RPW8 (PF05659, IPR008808): Arabidopsis broad-spectrum mildew resistance protein RPW8
SlyX (PF04102, IPR007236): SlyX
Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain
Snapin_Pallidin (PF14712, IPR028119): Snapin/Pallidin
ABC_tran_CTD (PF16326, IPR032524): ABC transporter C-terminal domain
36 NEFMinteractor100ATP-synt_E (PF05680, IPR008386): ATP synthase E chain
FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Filament (PF00038, IPR001664): Intermediate filament protein
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
DUF3886 (PF13025, IPR024980): Protein of unknown function (DUF3886)
DUF4637 (PF15470, IPR029174): Domain of unknown function (DUF4637)
37 NOS3interactor110.51116.709FAD_binding_1 (PF00667, IPR003097): FAD binding domain
Flavodoxin_1 (PF00258, IPR008254): Flavodoxin
NAD_binding_1 (PF00175, IPR001433): Oxidoreductase NAD-binding domain
NO_synthase (PF02898, IPR004030): Nitric oxide synthase, oxygenase domain
HTH_15 (PF12324, IPR024259): Helix-turn-helix domain of alkylmercury lyase
38 PCMT1interactor21.0000PCMT (PF01135, IPR000682): Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
39 PDCD4oncoprotein40.6671.167Adhes-Ig_like (PF09085, IPR015169): Adhesion molecule, immunoglobulin-like
HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family
MA3 (PF02847, IPR003891, SM00544): MA3 domain
40 PLEKHA6interactor100FliJ (PF02050, IPR012823): Flagellar FliJ protein
PH (PF00169, IPR001849, SM00233): PH domain
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
Cep57_CLD_2 (PF14197, IPR025925): Centrosome localisation domain of PPC89
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
41 PLTPinteractor100LBP_BPI_CETP (PF01273, IPR017942, SM00328): LBP / BPI / CETP family, N-terminal domain
LBP_BPI_CETP_C (PF02886, IPR001124, SM00329): LBP / BPI / CETP family, C-terminal domain
42 PRAM1interactor60.8000.543hSH3 (PF14603, IPR029294): Helically-extended SH3 domain
43 PRDX2interactor90.6947.943AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
44 PSEN1oncoprotein160.34347.729Presenilin (PF01080, IPR001108): Presenilin
LRRC37AB_C (PF14914, IPR029423): LRRC37A/B like protein 1 C-terminal domain
45 RHEBoncoprotein40.8330.167Ras (PF00071, IPR001806, SM00173): Ras family
46 RNF32interactor180.55123.762IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
47 RPL4interactor100Ribosomal_L4 (PF00573, IPR002136): Ribosomal protein L4/L1 family
Ribos_L4_asso_C (PF14374, IPR025755): 60S ribosomal protein L4 C-terminal domain
48 ST13oncoprotein50.6003.500Hox9_act (PF04617, IPR006711): Hox9 activation region
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
RhoGEF67_u2 (PF16614): Unstructured region two on RhoGEF 6 and 7
49 TYRO3oncoprotein21.0000fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ig_3 (PF13927): Immunoglobulin domain
DUF4229 (PF14012, IPR025323): Protein of unknown function (DUF4229)
50 VDAC1interactor100Porin_3 (PF01459, IPR027246): Eukaryotic porin
51 ZNF558interactor21.0000KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain

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