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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins APH1A (from a repository: Sun Nov 13 19:41:10 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)20
The number (and %) of the onco-proteins7 (35.00 %)
The number (and %) of the tumor suppressors1 (5.00 %)
Total number of binary PPIs (saturation %)53 (27.89 %)
The number (and %) of affected PPIs20 (37.74 %)
The number of possible different fusions3
PPI diameter2
PPI radius1
The average degree of PPI4.300
Assortativity coefficient-0.3812
The network average Clustering coefficient0.688
The number (and %) of a zero Clustering coefficients2 (10.00 %)
The number (and %) of a zero Betweenness Centrality8 (40.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: APH1A All fusions
: BG982667; BG982654;
Proteins found in more fusions RBFOX2 (see 2 fusions); APH1A (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 APH1Aparental protein200.140260.400Aph-1 (PF06105, IPR009294): Aph-1 protein
2 ATF4oncoprotein50.6672.000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
3 BHLHE40interactor40.6671.000Hairy_orange (PF07527, IPR003650): Hairy Orange
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
4 CREB3interactor50.6672.000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
5 ELAVL1oncoprotein90.32118.400RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
6 ERLIN2interactor50.8001.000Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
DUF4346 (PF14251, IPR025595): Domain of unknown function (DUF4346)
7 GLP1Rinteractor1007tm_2 (PF00002, IPR000832): 7 transmembrane receptor (Secretin family)
HRM (PF02793, IPR001879, SM00008): Hormone receptor domain
8 GPATCH8interactor21.0000G-patch (PF01585, IPR000467, SM00443): G-patch domain
Peptidase_S64 (PF08192, IPR012985): Peptidase family S64
SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
Use1 (PF09753, IPR019150): Membrane fusion protein Use1
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
SOBP (PF15279, IPR026092): Sine oculis-binding protein
CCDC106 (PF15794, IPR031591): Coiled-coil domain-containing protein 106
9 HES1oncoprotein30.6671.000Hairy_orange (PF07527, IPR003650): Hairy Orange
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
10 HIVEP1suppressor21.0000PHD (PF00628, IPR019787, SM00249): PHD-finger
PyrI_C (PF02748, IPR020542): Aspartate carbamoyltransferase regulatory chain, metal binding domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies)
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain
zf-C2H2_7 (PF15269): Zinc-finger
11 KLF11interactor21.0000zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
12 MOV10interactor31.0000AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
13 NCSTNinteractor60.8001.400Nicastrin (PF05450, IPR008710): Nicastrin
Ost4 (PF10215, IPR018943): Oligosaccaryltransferase
14 NXF1interactor31.0000NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
15 PSEN1oncoprotein60.9000.400Presenilin (PF01080, IPR001108): Presenilin
LRRC37AB_C (PF14914, IPR029423): LRRC37A/B like protein 1 C-terminal domain
16 PSEN2oncoprotein60.8001.000Herpes_LMP1 (PF05297, IPR007961): Herpesvirus latent membrane protein 1 (LMP1)
Presenilin (PF01080, IPR001108): Presenilin
17 PSENENinteractor60.6674.400PEN-2 (PF10251, IPR019379): Presenilin enhancer-2 subunit of gamma secretase
18 RBFOX2protein found in more fusions40.6671.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Fox-1_C (PF12414, IPR025670): Calcitonin gene-related peptide regulator C terminal
19 THPOoncoprotein100EPO_TPO (PF00758, IPR001323): Erythropoietin/thrombopoietin
CYTL1 (PF15153, IPR029253): Cytokine-like protein 1
20 TLE1interactor31.0000TLE_N (PF03920, IPR005617): Groucho/TLE N-terminal Q-rich domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain

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