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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins APEH (from a repository: Thu Nov 10 14:59:26 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)39
The number (and %) of the onco-proteins11 (28.21 %)
The number (and %) of the tumor suppressors2 (5.13 %)
Total number of binary PPIs (saturation %)158 (21.32 %)
The number (and %) of affected PPIs39 (24.68 %)
The number of possible different fusions8
PPI diameter2
PPI radius1
The average degree of PPI7.231
Assortativity coefficient-0.3007
The network average Clustering coefficient0.531
The number (and %) of a zero Clustering coefficients7 (17.95 %)
The number (and %) of a zero Betweenness Centrality11 (28.21 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: APEH All fusions
: AA639921;
Proteins found in more fusions PFKL (see 2 fusions); PFKM (see 1 fusions); APEH (see 1 fusions); VPS26A (see 1 fusions); LAMP2 (see 1 fusions); STAT1 (see 1 fusions); CTTN (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 APEHparental protein390.147854.452Peptidase_S9 (PF00326, IPR001375): Prolyl oligopeptidase family
2 CAND1interactor180.36856.819Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981)
HEAT (PF02985, IPR000357): HEAT repeat
TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20)
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
3 CARSoncoprotein100.6008.733tRNA-synt_1e (PF01406, IPR024909): tRNA synthetases class I (C) catalytic domain
4 CNOT7interactor100CAF1 (PF04857, IPR006941): CAF1 family ribonuclease
5 CTTNoncoprotein70.8001.067FadA (PF09403, IPR018543): Adhesion protein FadA
HS1_rep (PF02218, IPR003134): Repeat in HS1/Cortactin
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
6 CYHR1interactor80.5717.733Sina (PF03145, IPR018121): Seven in absentia protein family
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
7 DNM1Linteractor70.7331.767Dynamin_M (PF01031, IPR000375): Dynamin central region
GED (PF02212, IPR003130, SM00302): Dynamin GTPase effector domain
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
AAA_16 (PF13191): AAA ATPase domain
8 GARSinteractor100.48914.300HGTP_anticodon (PF03129, IPR004154): Anticodon binding domain
tRNA-synt_2b (PF00587, IPR002314): tRNA synthetase class II core domain (G, H, P, S and T)
WHEP-TRS (PF00458, IPR000738, SM00991): WHEP-TRS domain
9 H1FXinteractor80.6076.033IGPS (PF00218, IPR013798): Indole-3-glycerol phosphate synthase
10 HIST1H1Concoprotein50.8001.000Amelin (PF05111, IPR007798, SM00817): Ameloblastin precursor (Amelin)
Linker_histone (PF00538, IPR005818, SM00526): linker histone H1 and H5 family
DUF4349 (PF14257, IPR025645): Domain of unknown function (DUF4349)
11 HSPA4Linteractor60.6672.300HSP70 (PF00012, IPR013126): Hsp70 protein
12 IPO7interactor60.7331.733Cse1 (PF08506, IPR013713): Cse1
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
RIX1 (PF08167, IPR012583): rRNA processing/ribosome biogenesis
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457)
DUF3730 (PF12530, IPR022542): Protein of unknown function (DUF3730)
13 IST1interactor100Ist1 (PF03398, IPR005061): Regulator of Vps4 activity in the MVB pathway
14 JMJD6interactor130.43626.019AF-4 (PF05110, IPR007797): AF-4 proto-oncoprotein
JmjC (PF02373, IPR003347, SM00558): JmjC domain, hydroxylase
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
15 KARSinteractor70.7621.786tRNA-synt_2 (PF00152, IPR004364): tRNA synthetases class II (D, K and N)
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
16 LAMP2protein found in more fusions200Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp)
17 LGALS8interactor100Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
18 MOV10interactor50.7001.367AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
19 NMIinteractor80.5716.067IFP_35_N (PF07334, IPR009938): Interferon-induced 35 kDa protein (IFP 35) N-terminus
NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID)
20 NTRK1oncoprotein220.276111.452I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
21 NXF1interactor50.6671.167NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
22 PAWRoncoprotein90.6945.319ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
23 PFKLprotein found in more fusions41.0000PFK (PF00365, IPR000023): Phosphofructokinase
24 PFKMprotein found in more fusions60.6002.833PFK (PF00365, IPR000023): Phosphofructokinase
25 PPM1Ginteractor80.7143.400Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein
DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
PP2C (PF00481, IPR001932): Protein phosphatase 2C
DUF4820 (PF16091, IPR032150): Domain of unknown function (DUF4820)
26 PREPLinteractor200Peptidase_S9 (PF00326, IPR001375): Prolyl oligopeptidase family
Peptidase_S9_N (PF02897, IPR023302): Prolyl oligopeptidase, N-terminal beta-propeller domain
27 SERPINE2interactor100Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
28 SHBGoncoprotein200Laminin_G_1 (PF00054, IPR001791): Laminin G domain
Laminin_G_2 (PF02210, IPR001791): Laminin G domain
29 SHMT1interactor90.6434.919SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
30 SHMT2interactor120.47024.033SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
31 SNX6interactor51.0000PX (PF00787, IPR001683, SM00312): PX domain
Vps5 (PF09325, IPR015404): Vps5 C terminal like
32 STAT1suppressor150.42933.833SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
STAT1_TAZ2bind (PF12162, IPR022752): STAT1 TAZ2 binding domain
33 TARSinteractor60.5335.667HGTP_anticodon (PF03129, IPR004154): Anticodon binding domain
TGS (PF02824, IPR004095): TGS domain
tRNA-synt_2b (PF00587, IPR002314): tRNA synthetase class II core domain (G, H, P, S and T)
tRNA_SAD (PF07973, IPR012947, SM00863): Threonyl and Alanyl tRNA synthetase second additional domain
34 TBCDinteractor50.7001.567HEAT (PF02985, IPR000357): HEAT repeat
HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat
TFCD_C (PF12612, IPR022577): Tubulin folding cofactor D C terminal
HEAT_EZ (PF13513): HEAT-like repeat
35 TOLLIPinteractor41.0000C2 (PF00168, IPR000008, SM00239): C2 domain
CUE (PF02845, IPR003892, SM00546): CUE domain
36 UBA5interactor40.6670.667Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
ThiF (PF00899, IPR000594): ThiF family
37 USP39oncoprotein31.0000UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
38 VPS26Aprotein found in more fusions110.51113.467Vps26 (PF03643, IPR005377): Vacuolar protein sorting-associated protein 26
39 ZYXsuppressor40.8330.500DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
LIM (PF00412, IPR001781, SM00132): LIM domain
DUF2757 (PF10955, IPR020115): Protein of unknown function (DUF2757)

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