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Visible interactions: all affected independent (normal) missing (in fusions) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins ANKHD1-EIF4EBP3, TAGLN (from a repository: Sun May 7 20:23:35 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)61
The number (and %) of the onco-proteins11 (18.03 %)
The number (and %) of the tumor suppressors4 (6.56 %)
Total number of binary PPIs (saturation %)263 (14.37 %)
The number (and %) of affected PPIs59 (22.43 %)
The number of possible different fusions6
PPI diameter5
PPI radius3
The average degree of PPI8.066
Assortativity coefficient-0.1749
The network average Clustering coefficient0.499
The number (and %) of a zero Clustering coefficients9 (14.75 %)
The number (and %) of a zero Betweenness Centrality17 (27.87 %)

ACTIVE INTERACTORS
MISSING INTERACTORS (in fusions)


List of the fusions

PPI for parental proteins: ANKHD1-EIF4EBP3,TAGLN All fusions
: AW998109; AW998111;
Proteins found in more fusions SF1 (see 1 fusions); YWHAG (see 1 fusions); BAG3 (see 4 fusions); JAK1 (see 1 fusions); HINT1 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 ANKHD1-EIF4EBP3parental protein90.111473.257DUF572 (PF04502, IPR007590): Family of unknown function (DUF572)
Eapp_C (PF10238, IPR019370): E2F-associated phosphoprotein
KH_1 (PF00013, IPR004088, SM00322): KH domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
AAA_23 (PF13476): AAA domain
DUF4746 (PF15928, IPR031827): Domain of unknown function (DUF4746)
2 TAGLNparental protein500.1371985.935Calponin (PF00402, IPR000557): Calponin family repeat
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
3 ACAA2interactor80.6436.488Thiolase_C (PF02803, IPR020617): Thiolase, C-terminal domain
Thiolase_N (PF00108, IPR020616): Thiolase, N-terminal domain
4 ACDinteractor70.66745.292TPP1 (PF10341, IPR019437): Shelterin complex subunit, TPP1/ACD
5 ACTA1interactor31.0000Actin (PF00022, IPR004000, SM00268): Actin
6 ALDOAinteractor120.58211.289Glycolytic (PF00274, IPR000741): Fructose-bisphosphate aldolase class-I
7 ALDOCinteractor110.364149.659Glycolytic (PF00274, IPR000741): Fructose-bisphosphate aldolase class-I
8 BAG3oncoprotein140.244216.708BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
9 CFL1interactor100.42221.912Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
10 DUSP6suppressor100DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain
11 EEF2interactor50.7001.605EFG_C (PF00679, IPR000640, SM00838): Elongation factor G C-terminus
EFG_IV (PF03764, IPR005517, SM00889): Elongation factor G, domain IV
GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
EFG_II (PF14492, IPR009022): Elongation Factor G, domain II
12 ENO1oncoprotein190.51541.834Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain
Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
13 ENO2interactor200.50072.846Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain
Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
14 ENO3interactor150.7338.658Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain
Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
15 FABP3suppressor31.0000Lipocalin (PF00061, IPR000566): Lipocalin / cytosolic fatty-acid binding protein family
16 FABP5interactor130.57720.390Lipocalin (PF00061, IPR000566): Lipocalin / cytosolic fatty-acid binding protein family
17 FABP7interactor21.0000Lipocalin (PF00061, IPR000566): Lipocalin / cytosolic fatty-acid binding protein family
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
18 FGFR1OPoncoprotein31.0000FOP_dimer (PF09398, IPR018993): FOP N terminal dimerisation domain
19 FKBP1Ainteractor170.54245.996FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
Hemopexin (PF00045, IPR018487, SM00120): Hemopexin
20 FKBP1Binteractor100.7117.833FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
21 FKBP2interactor150.60024.908FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
22 GIPC1interactor100PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
23 GPX4interactor140.61514.985GSHPx (PF00255, IPR000889): Glutathione peroxidase
24 GSTO1interactor40.5004.265GST_N_3 (PF13417, IPR004045): Glutathione S-transferase, N-terminal domain
GST_C_3 (PF14497, IPR004046): Glutathione S-transferase, C-terminal domain
25 HINT1suppressor190.51655.050HIT (PF01230, IPR001310): HIT domain
26 HOXC4interactor100Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
27 HSD17B10interactor160.55025.431adh_short (PF00106, IPR002198): short chain dehydrogenase
28 HSPE1interactor130.51322.200Cpn10 (PF00166, IPR020818, SM00883): Chaperonin 10 Kd subunit
29 ISG15suppressor90.38928.313ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
30 JAK1oncoprotein200FERM_M (PF00373, IPR019748): FERM central domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
31 MAGEA1interactor100MAGE (PF01454, IPR002190): MAGE family
MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
32 MOV10interactor60.133246.262AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
33 MRPL53interactor50.6005.369MRP_L53 (PF10780, IPR019716): 39S ribosomal protein L53/MRP-L53
34 NCF1interactor200p47_phox_C (PF08944, IPR015039): NADPH oxidase subunit p47Phox, C terminal domain
PX (PF00787, IPR001683, SM00312): PX domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
NECFESHC (PF16621, IPR032136): SH3 terminal domain of 2nd SH3 on Neutrophil cytosol factor 1
35 NDUFA7interactor40.6671.333CI-B14_5a (PF07347, IPR009947): NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a)
36 NINLinteractor21.0000PD40 (PF07676, IPR011659): WD40-like Beta Propeller Repeat
TBCA (PF02970, IPR004226): Tubulin binding cofactor A
DUF2389 (PF09493, IPR012663): Tryptophan-rich protein (DUF2389)
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein
FAM184 (PF15665): Family with sequence similarity 184, A and B
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
37 NME1-NME2interactor130.56424.472NDK (PF00334, IPR001564, SM00562): Nucleoside diphosphate kinase
38 NME2interactor120.7644.139NDK (PF00334, IPR001564, SM00562): Nucleoside diphosphate kinase
39 NUTF2interactor70.40090.363NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
40 NXF1interactor70.133170.703NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
41 PGDoncoprotein90.194162.7736PGD (PF00393, IPR006114): 6-phosphogluconate dehydrogenase, C-terminal domain
NAD_binding_2 (PF03446, IPR006115): NAD binding domain of 6-phosphogluconate dehydrogenase
42 PIK3CDoncoprotein100PI3K_C2 (PF00792, IPR002420, SM00142): Phosphoinositide 3-kinase C2
PI3K_p85B (PF02192, IPR003113, SM00143): PI3-kinase family, p85-binding domain
PI3K_rbd (PF00794, IPR000341, SM00144): PI3-kinase family, ras-binding domain
PI3Ka (PF00613, IPR001263, SM00145): Phosphoinositide 3-kinase family, accessory domain (PIK domain)
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
43 PLS3interactor60.5335.500CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
EF-hand_5 (PF13202, IPR002048): EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
44 POT1interactor100.500107.064POT1 (PF02765, IPR011564, SM00976): Telomeric single stranded DNA binding POT1/CDC13
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
POT1PC (PF16686, IPR032042): ssDNA-binding domain of telomere protection protein
45 PPIBinteractor140.484171.237Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
46 RBM27interactor30.6670.500DUF342 (PF03961, IPR005646): Protein of unknown function (DUF342)
Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
PWI (PF01480, IPR002483, SM00311): PWI domain
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
DUF2203 (PF09969, IPR018699): Uncharacterized conserved protein (DUF2203)
DUF2408 (PF10303, IPR018810): Protein of unknown function (DUF2408)
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
Nup35_RRM_2 (PF14605): Nup53/35/40-type RNA recognition motif
47 RNF14interactor200IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
RWD (PF05773, IPR006575, SM00591): RWD domain
T5orf172 (PF10544, IPR018306, SM00974): T5orf172 domain
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
zf-RING_11 (PF17123, IPR001841): RING-like zinc finger
48 S100A9oncoprotein200S_100 (PF01023, IPR013787): S-100/ICaBP type calcium binding domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
49 SARNPoncoprotein21.0000SAP (PF02037, IPR003034, SM00513): SAP domain
HTH_Tnp_IS630 (PF01710, IPR002622): Transposase
Prok-E2_A (PF14457, IPR032865): Prokaryotic E2 family A
50 SF1protein found in more fusions40.6673.208UPF0181 (PF03701, IPR005371): Uncharacterised protein family (UPF0181)
zf-CCHC (PF00098, IPR001878): Zinc knuckle
KH_1 (PF00013, IPR004088, SM00322): KH domain
RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
PRIMA1 (PF16101): Proline-rich membrane anchor 1
SF1-HH (PF16275, IPR032570): Splicing factor 1 helix-hairpin domain
51 SNX12interactor21.0000PX (PF00787, IPR001683, SM00312): PX domain
52 SNX3interactor70.42910.333PX (PF00787, IPR001683, SM00312): PX domain
53 SRPRBinteractor50.5005.000MHYT (PF03707, IPR005330): Bacterial signalling protein N terminal repeat
SRPRB (PF09439, IPR019009): Signal recognition particle receptor beta subunit
54 STIP1interactor140.51629.360TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
Wtap (PF17098, IPR029732): Pre-mRNA-splicing regulator WTAP
55 SUGP1interactor60.6007.939G-patch (PF01585, IPR000467, SM00443): G-patch domain
Herpes_DNAp_acc (PF04929, IPR007013): Herpes DNA replication accessory factor
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
OrfB_IS605 (PF01385, IPR001959): Probable transposase
RtcB (PF01139, IPR001233): tRNA-splicing ligase RtcB
Surp (PF01805, IPR000061, SM00648): Surp module
G-patch_2 (PF12656, IPR026822): DExH-box splicing factor binding site
56 TINF2interactor70.73331.399TINF2_N (PF14973, IPR029400): TERF1-interacting nuclear factor 2 N-terminus
57 UCHL3interactor120.54516.604Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
58 YKT6interactor31.0000Synaptobrevin (PF00957, IPR001388): Synaptobrevin
Longin (PF13774, IPR010908): Regulated-SNARE-like domain
59 YWHAEoncoprotein50.60090.94314-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
60 YWHAGprotein found in more fusions70.400120.24514-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
61 ZC3H3interactor30.6670.400zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
CCDC24 (PF15669, IPR031367): Coiled-coil domain-containing protein 24 family

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List of missing interactors (in fusions)

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ANKHD1-EIF4EBP3parental proteinDUF572 (PF04502, IPR007590): Family of unknown function (DUF572)
Eapp_C (PF10238, IPR019370): E2F-associated phosphoprotein
KH_1 (PF00013, IPR004088, SM00322): KH domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
AAA_23 (PF13476): AAA domain
DUF4746 (PF15928, IPR031827): Domain of unknown function (DUF4746)
AW998109, AW998111
2 FGFR1OPoncoproteinFOP_dimer (PF09398, IPR018993): FOP N terminal dimerisation domainAW998109, AW998111
3 HOXC4interactorHomeobox (PF00046, IPR001356, SM00389): Homeobox domainAW998109, AW998111
4 MAGEA1interactorMAGE (PF01454, IPR002190): MAGE family
MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
AW998109, AW998111
5 MOV10interactorAAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
AW998109, AW998111
6 NINLinteractorPD40 (PF07676, IPR011659): WD40-like Beta Propeller Repeat
TBCA (PF02970, IPR004226): Tubulin binding cofactor A
DUF2389 (PF09493, IPR012663): Tryptophan-rich protein (DUF2389)
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein
FAM184 (PF15665): Family with sequence similarity 184, A and B
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
AW998109, AW998111
7 TAGLNparental proteinCalponin (PF00402, IPR000557): Calponin family repeat
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
AW998109, AW998111
8 YWHAEoncoprotein14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 proteinAW998109, AW998111
9 YWHAGinteractor14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 proteinAW998109, AW998111
10 ZC3H3interactorzf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
CCDC24 (PF15669, IPR031367): Coiled-coil domain-containing protein 24 family
AW998109, AW998111

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