Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins AMBP (from a repository: Thu Feb 9 00:41:20 2017)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)13
The number (and %) of the onco-proteins6 (46.15 %)
The number (and %) of the tumor suppressors1 (7.69 %)
Total number of binary PPIs (saturation %)26 (33.33 %)
The number (and %) of affected PPIs13 (50.00 %)
The number of possible different fusions5
PPI diameter2
PPI radius1
The average degree of PPI3.231
Assortativity coefficient-0.6256
The network average Clustering coefficient0.534
The number (and %) of a zero Clustering coefficients4 (30.77 %)
The number (and %) of a zero Betweenness Centrality9 (69.23 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: AMBP All fusions
Proteins found in more fusions GRB2 (see 1 fusions); STAT3 (see 2 fusions); A2M (see 2 fusions); AMBP (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 AMBPparental protein130.136102.000Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
Lipocalin (PF00061, IPR000566): Lipocalin / cytosolic fatty-acid binding protein family
2 A2Mprotein found in more fusions31.0000A2M (PF00207, IPR001599): Alpha-2-macroglobulin family
A2M_comp (PF07678, IPR011626): A-macroglobulin complement component
A2M_N (PF01835, IPR002890): MG2 domain
A2M_N_2 (PF07703, IPR011625): Alpha-2-macroglobulin family N-terminal region
A2M_recep (PF07677, IPR009048): A-macroglobulin receptor
MP (PF01107, IPR028919): Viral movement protein (MP)
SVA (PF05326, IPR007990): Seminal vesicle autoantigen (SVA)
Thiol-ester_cl (PF10569, IPR019565): Alpha-macro-globulin thiol-ester bond-forming region
3 ALBinteractor21.0000Serum_albumin (PF00273, IPR014760, SM00103): Serum albumin family
4 CD79Aoncoprotein100ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
5 COX8Ainteractor100COX8 (PF02285, IPR003205): Cytochrome oxidase c subunit VIII
6 DAAM1interactor100APG6 (PF04111, IPR007243): Autophagy protein Apg6
Drf_FH3 (PF06367, IPR010472, SM01139): Diaphanous FH3 Domain
Drf_GBD (PF06371, IPR010473, SM01140): Diaphanous GTPase-binding Domain
FH2 (PF02181, IPR015425, SM00498): Formin Homology 2 Domain
Phage_GPO (PF05929, IPR009228): Phage capsid scaffolding protein (GPO) serine peptidase
7 ENO1oncoprotein31.0000Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain
Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
8 FHL3interactor200LIM (PF00412, IPR001781, SM00132): LIM domain
Med27 (PF11571, IPR021627): Mediator complex subunit 27
9 FN1oncoprotein40.6672.000fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
10 GRB2oncoprotein70.4678.000SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
11 PIK3CAoncoprotein31.0000PI3K_C2 (PF00792, IPR002420, SM00142): Phosphoinositide 3-kinase C2
PI3K_p85B (PF02192, IPR003113, SM00143): PI3-kinase family, p85-binding domain
PI3K_rbd (PF00794, IPR000341, SM00144): PI3-kinase family, ras-binding domain
PI3Ka (PF00613, IPR001263, SM00145): Phosphoinositide 3-kinase family, accessory domain (PIK domain)
DUF2321 (PF10083, IPR016891): Uncharacterized protein conserved in bacteria (DUF2321)
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
12 PIK3R3interactor40.6672.000SH2 (PF00017, IPR000980, SM00252): SH2 domain
PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
13 STAT3suppressor31.0000SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain

B a c k    t o    T o p ⇑