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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins ALDH7A1 (from a repository: Thu Nov 29 09:21:40 2018)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)38
The number (and %) of the onco-proteins8 (21.05 %)
The number (and %) of the tumor suppressors2 (5.26 %)
Total number of binary PPIs (saturation %)136 (19.35 %)
The number (and %) of affected PPIs37 (27.21 %)
The number of possible different fusions5
PPI diameter2
PPI radius1
The average degree of PPI6.526
Assortativity coefficient-0.3549
The network average Clustering coefficient0.509
The number (and %) of a zero Clustering coefficients9 (23.68 %)
The number (and %) of a zero Betweenness Centrality13 (34.21 %)

ACTIVE INTERACTORS


List of the fusions

Proteins found in more fusions EPS8 (see 1 fusions); APP (see 4 fusions); YWHAG (see 1 fusions); YWHAH (see 2 fusions); G6PD (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 ALDH7A1parental protein370.131967.419Aldedh (PF00171, IPR015590): Aldehyde dehydrogenase family
2 ABATinteractor21.0000Aminotran_3 (PF00202, IPR005814): Aminotransferase class-III
3 APPprotein found in more fusions80.38110.019APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
4 ASNSoncoprotein100.60011.200Asn_synthase (PF00733, IPR001962): Asparagine synthase
GATase_7 (PF13537, IPR000583): Glutamine amidotransferase domain
5 CAPN2interactor51.0000Calpain_III (PF01067, IPR022682, SM00720): Calpain large subunit, domain III
Peptidase_C2 (PF00648, IPR001300, SM00230): Calpain family cysteine protease
EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
6 CAPNS1interactor120.59113.352EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
7 CATsuppressor70.6004.733Catalase (PF00199, IPR011614, SM01060): Catalase
Catalase-rel (PF06628, IPR010582): Catalase-related immune-responsive
8 CPT2interactor100Carn_acyltransf (PF00755, IPR000542): Choline/Carnitine o-acyltransferase
9 DDA1interactor30.6670.333DDA1 (PF10172, IPR018276): Det1 complexing ubiquitin ligase
10 EIF5interactor120.45525.667CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Hist_rich_Ca-bd (PF10529, IPR019552): Histidine-rich Calcium-binding repeat region
eIF-5_eIF-2B (PF01873, IPR002735, SM00653): Domain found in IF2B/IF5
W2 (PF02020, IPR003307, SM00515): eIF4-gamma/eIF5/eIF2-epsilon
11 EPS8oncoprotein200DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
PTB (PF08416, IPR013625): Phosphotyrosine-binding domain
SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
12 ERP44interactor40.6670.800Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
13 FAHD2Ainteractor31.0000FAA_hydrolase (PF01557, IPR002529): Fumarylacetoacetate (FAA) hydrolase family
14 FERMT2interactor80.6795.333FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
15 G6PDprotein found in more fusions110.55613.119G6PD_C (PF02781, IPR022675): Glucose-6-phosphate dehydrogenase, C-terminal domain
G6PD_N (PF00479, IPR022674): Glucose-6-phosphate dehydrogenase, NAD binding domain
16 GLAinteractor40.8330.500Melibiase_2 (PF16499, IPR002241): Alpha galactosidase A
17 GOT1interactor100Aminotran_1_2 (PF00155, IPR004839): Aminotransferase class I and II
18 HIBCHinteractor100ECH_2 (PF16113, IPR032259): Enoyl-CoA hydratase/isomerase
19 HMGB3interactor31.0000HMG_box_2 (PF09011, IPR009071): HMG-box domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
20 KBTBD7interactor100BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_2 (PF07646, IPR011498): Kelch motif
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_4 (PF13418): Galactose oxidase, central domain
Kelch_6 (PF13964): Kelch motif
21 KIF2Ainteractor200Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
AAA_23 (PF13476): AAA domain
CREPT (PF16566, IPR032337): Cell-cycle alteration and expression-elevated protein in tumour
22 L3HYPDHinteractor100Pro_racemase (PF05544, IPR008794): Proline racemase
23 LDHBinteractor100.47215.667Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
24 PDIA4interactor90.6397.967Calsequestrin (PF01216, IPR001393): Calsequestrin
Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
FAM176 (PF14851): FAM176 family
25 PGDoncoprotein70.6674.8336PGD (PF00393, IPR006114): 6-phosphogluconate dehydrogenase, C-terminal domain
NAD_binding_2 (PF03446, IPR006115): NAD binding domain of 6-phosphogluconate dehydrogenase
26 PPIAinteractor30.6670.400Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
27 PPP1CAsuppressor70.7621.967Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
28 PRDX5interactor40.8330.400Redoxin (PF08534, IPR013740): Redoxin
NAD_binding_10 (PF13460, IPR016040): NAD(P)H-binding
29 SCPEP1interactor60.8670.667Peptidase_S10 (PF00450, IPR001563): Serine carboxypeptidase
30 SORDinteractor70.5336.333ADH_N (PF08240, IPR013154): Alcohol dehydrogenase GroES-like domain
ADH_zinc_N (PF00107, IPR013149): Zinc-binding dehydrogenase
ADH_zinc_N_2 (PF13602): Zinc-binding dehydrogenase
31 STK24interactor80.7142.300DUF1241 (PF06840, IPR009652): Protein of unknown function (DUF1241)
Pkinase (PF00069, IPR000719): Protein kinase domain
32 TBCBinteractor120.59114.833CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain
Ubiquitin_2 (PF14560, IPR027933): Ubiquitin-like domain
33 UBA5interactor200Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
ThiF (PF00899, IPR000594): ThiF family
34 XRCC4interactor200XRCC4 (PF06632, IPR010585): DNA double-strand break repair and V(D)J recombination protein XRCC4
35 YWHAEoncoprotein130.55119.71914-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
36 YWHAGprotein found in more fusions100.6117.90014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
37 YWHAHprotein found in more fusions130.56117.41914-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
38 YWHAQinteractor90.7225.11914-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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