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Visible interactions: all affected independent (normal) missing (in fusions) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)46
The number (and %) of the onco-proteins8 (17.39 %)
The number (and %) of the tumor suppressors4 (8.70 %)
Total number of binary PPIs (saturation %)68 (6.57 %)
The number (and %) of affected PPIs46 (67.65 %)
The number of possible different fusions4
PPI diameter2
PPI radius1
The average degree of PPI2.565
Assortativity coefficient-0.4548
The network average Clustering coefficient0.219
The number (and %) of a zero Clustering coefficients32 (69.57 %)
The number (and %) of a zero Betweenness Centrality38 (82.61 %)


List of the fusions

PPI for parental proteins: ALAS1 All fusions
: CN258752;
Proteins found in more fusions USP20 (see 1 fusions); ALAS1 (see 1 fusions); VHL (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 ALAS1parental protein460.0141932.500Aminotran_1_2 (PF00155, IPR004839): Aminotransferase class I and II
Preseq_ALAS (PF09029, IPR015118): 5-aminolevulinate synthase presequence
2 BCL7Asuppressor100BCL_N (PF04714, IPR006804): BCL7, N-terminal conserver region
DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754)
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
UPF0561 (PF10573, IPR018888): Uncharacterised protein family UPF0561
3 C2orf42interactor100zf-tcix (PF14952, IPR029269): Putative treble-clef, zinc-finger, Zn-binding
4 C8orf33interactor30.6670.500DUF4615 (PF15393, IPR029274): Domain of unknown function (DUF4615)
5 CCHCR1interactor200HCR (PF07111, IPR009800): Alpha helical coiled-coil rod protein (HCR)
6 CDC73suppressor100CDC73_C (PF05179, IPR007852): RNA pol II accessory factor, Cdc73 family, C-terminal
CDC73_N (PF16050, IPR032041): Paf1 complex subunit CDC73 N-terminal
7 CDK5oncoprotein31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
8 CDKN1Asuppressor40.6672.000CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor
9 CERKinteractor100DAGK_cat (PF00781, IPR001206, SM00046): Diacylglycerol kinase catalytic domain
10 DUSP19interactor100DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
11 EP400oncoprotein100FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
DDHD (PF02862, IPR004177, SM01127): DDHD domain
GN3L_Grn1 (PF08701, IPR014813): GNL3L/Grn1 putative GTPase
HSA (PF07529, IPR014012, SM00573): HSA
Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
EPL1 (PF10513, IPR019542): Enhancer of polycomb-like
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
DUF3304 (PF11745, IPR021733): Protein of unknown function (DUF3304)
DUF3381 (PF11861, IPR024576): Domain of unknown function (DUF3381)
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
DUF3484 (PF11983, IPR021873): Membrane-attachment and polymerisation-promoting switch
DUF3573 (PF12097, IPR021956): Protein of unknown function (DUF3573)
Myb_DNA-bind_4 (PF13837): Myb/SANT-like DNA-binding domain
EP400_N (PF15790, IPR031575): E1A-binding protein p400, N-terminal
12 FAM127Cinteractor100DUF4939 (PF16297, IPR032549): Domain of unknown function (DUF4939)
13 GNL3Linteractor100DUF258 (PF03193, IPR004881): Protein of unknown function, DUF258
GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
MMR_HSR1 (PF01926, IPR006073): 50S ribosome-binding GTPase
SPT16 (PF08644, IPR013953): FACT complex subunit (SPT16/CDC68)
14 HMGCLinteractor100HMGL-like (PF00682, IPR000891): HMGL-like
15 KLHL35interactor100BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_5 (PF13854): Kelch motif
Kelch_6 (PF13964): Kelch motif
16 LONRF1interactor200LON_substr_bdg (PF02190, IPR003111, SM00464): ATP-dependent protease La (LON) substrate-binding domain
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
DZR (PF12773, IPR025874): Double zinc ribbon
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_14 (PF13428): Tetratricopeptide repeat
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
TPR_19 (PF14559): Tetratricopeptide repeat
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
17 MOV10interactor60.3339.000AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
18 MTFR2interactor100Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
19 NUDT3interactor30.6670.500NUDIX (PF00293, IPR000086): NUDIX domain
20 NXF1interactor60.4005.000NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
21 OXLD1interactor100Oxidored-like (PF09791, IPR019180): Oxidoreductase-like protein, N-terminal
22 PIK3CBoncoprotein100PI3K_C2 (PF00792, IPR002420, SM00142): Phosphoinositide 3-kinase C2
PI3K_p85B (PF02192, IPR003113, SM00143): PI3-kinase family, p85-binding domain
PI3K_rbd (PF00794, IPR000341, SM00144): PI3-kinase family, ras-binding domain
PI3Ka (PF00613, IPR001263, SM00145): Phosphoinositide 3-kinase family, accessory domain (PIK domain)
RWD (PF05773, IPR006575, SM00591): RWD domain
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
Tom37_C (PF11801, IPR019564): Tom37 C-terminal domain
DUF4381 (PF14316, IPR025489): Domain of unknown function (DUF4381)
23 PLAUinteractor100EGF (PF00008, IPR000742, SM00181): EGF-like domain
Kringle (PF00051, IPR000001): Kringle domain
Trypsin (PF00089, IPR001254, SM00020): Trypsin
24 POLDIP2interactor30.6670.500DUF525 (PF04379, IPR007474): Protein of unknown function (DUF525)
YccV-like (PF08755, IPR011722, SM00992): Hemimethylated DNA-binding protein YccV like
25 PPLinteractor100ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
Cortex-I_coil (PF09304, IPR015383): Cortexillin I, coiled coil
DivIC (PF04977, IPR007060): Septum formation initiator
MCU (PF04678, IPR006769): Mitochondrial calcium uniporter
ZapB (PF06005, IPR009252): Cell division protein ZapB
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
FliT (PF05400, IPR008622): Flagellar protein FliT
M (PF02370, IPR003345): M protein repeat
Mnd1 (PF03962, IPR005647): Mnd1 family
Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain
Spectrin (PF00435, IPR002017): Spectrin repeat
Plectin (PF00681, IPR001101, SM00250): Plectin repeat
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit
DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140)
DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472)
26 RAP1Boncoprotein21.0000Ras (PF00071, IPR001806, SM00173): Ras family
27 SH2D4Ainteractor21.0000Cytochrom_NNT (PF03264, IPR005126): NapC/NirT cytochrome c family, N-terminal region
Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1
Peptidase_S49_N (PF08496, IPR013703): Peptidase family S49 N-terminal
SH2 (PF00017, IPR000980, SM00252): SH2 domain
DUF2039 (PF10217, IPR019351): Uncharacterized conserved protein (DUF2039)
28 SNX20interactor100PX (PF00787, IPR001683, SM00312): PX domain
TPR_12 (PF13424): Tetratricopeptide repeat
29 STAMBPinteractor100USP8_dimer (PF08969, IPR015063): USP8 dimerisation domain
JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
DUF3526 (PF12040, IPR021913): Domain of unknown function (DUF3526)
30 SUMO2interactor200Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
31 TCEA2interactor100Med26 (PF08711, IPR017923): TFIIS helical bundle-like domain
TFIIS_C (PF01096, IPR001222): Transcription factor S-II (TFIIS)
TFIIS_M (PF07500, IPR003618): Transcription factor S-II (TFIIS), central domain
DUF4423 (PF14394, IPR025537): Domain of unknown function (DUF4423)
32 TEKT4interactor100Tektin (PF03148, IPR000435): Tektin family
33 TK1oncoprotein50.6672.000TK (PF00265, IPR001267, SM00203): Thymidine kinase
34 TMSB10oncoprotein100CheR (PF01739, IPR022642): CheR methyltransferase, SAM binding domain
35 TMSB4Xinteractor31.0000Thymosin (PF01290, IPR001152, SM00152): Thymosin beta-4 family
36 TMSB4XP1interactor100NA
37 TMSB4XP2interactor100NA
38 TMSB4XP6interactor100NA
39 TTC23interactor100DUF3856 (PF12968, IPR024552): Domain of Unknown Function (DUF3856)
TPR_12 (PF13424): Tetratricopeptide repeat
40 USP20protein found in more fusions31.0000UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
DUSP (PF06337, IPR006615, SM00695): DUSP domain
41 VHLsuppressor31.0000Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
VHL (PF01847, IPR022772): von Hippel-Lindau disease tumour suppressor protein
VHL_C (PF17211): VHL box domain
42 WIPF1interactor100CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
GRP (PF07172, IPR010800): Glycine rich protein family
WH2 (PF02205, IPR003124, SM00246): WH2 motif
43 ZFYVE26oncoprotein100FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
MerR-DNA-bind (PF09278, IPR015358): MerR, DNA binding
FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_14 (PF13428): Tetratricopeptide repeat
44 ZMAT1interactor100DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
zf-U11-48K (PF05253, IPR022776): U11-48K-like CHHC zinc finger
UPF0239 (PF06783, IPR009621): Uncharacterised protein family (UPF0239)
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-met (PF12874): Zinc-finger of C2H2 type
YqzE (PF14038, IPR025622): YqzE-like protein
NYD-SP28_assoc (PF14775, IPR029440): Sperm tail C-terminal domain
45 ZNF175interactor100Zn-ribbon_8 (PF09723, IPR013429, SM00834): Zinc ribbon domain
KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
46 ZNF564interactor100FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
KRAB (PF01352, IPR001909, SM00349): KRAB box
TF_Zn_Ribbon (PF08271, IPR013137): TFIIB zinc-binding
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger

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List of missing interactors (in fusions)

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ALAS1parental proteinAminotran_1_2 (PF00155, IPR004839): Aminotransferase class I and II
Preseq_ALAS (PF09029, IPR015118): 5-aminolevulinate synthase presequence
2 TMSB4XP1interactorNACN258752
3 TMSB4XP2interactorNACN258752
4 TMSB4XP6interactorNACN258752

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