1 |
AHNAK | parental protein | 72 | 0.181 | 2124.130 | DUF945 (PF06097, IPR010352): Bacterial protein of unknown function (DUF945) ELFV_dehydrog_N (PF02812, IPR006097): Glu/Leu/Phe/Val dehydrogenase, dimerisation domain T2SSN (PF01203, IPR022792): Type II secretion system (T2SS), protein N PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) TT_ORF2a (PF08197, IPR013267): pORF2a truncated protein DUF2993 (PF11209, IPR021373): Protein of unknown function (DUF2993) DUF4097 (PF13349, IPR025164): Putative adhesin Ntox37 (PF15535, IPR029108): Bacterial toxin 37 |
2 |
ACTN4 | interactor | 17 | 0.382 | 34.212 | CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand Spectrin (PF00435, IPR002017): Spectrin repeat EF-hand_7 (PF13499, IPR011992): EF-hand domain pair Uds1 (PF15456, IPR029191): Up-regulated During Septation |
3 |
ARHGDIA | interactor | 13 | 0.348 | 17.673 | Rho_GDI (PF02115, IPR000406): RHO protein GDP dissociation inhibitor |
4 |
ASNS | oncoprotein | 4 | 0.500 | 0.804 | Asn_synthase (PF00733, IPR001962): Asparagine synthase GATase_7 (PF13537, IPR000583): Glutamine amidotransferase domain |
5 |
ATF2 | oncoprotein | 9 | 0.464 | 9.898 | bZIP_1 (PF00170, IPR004827): bZIP transcription factor zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type |
6 |
ATP4A | interactor | 2 | 0 | 0 | Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase H-K_ATPase_N (PF09040, IPR015127): Gastric H+/K+-ATPase, N terminal domain Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase HAD (PF12710): haloacid dehalogenase-like hydrolase Cation_ATPase (PF13246): Cation transport ATPase (P-type) |
7 |
BAG2 | protein found in more fusions | 14 | 0.615 | 9.904 | IncA (PF04156, IPR007285): IncA protein Mnd1 (PF03962, IPR005647): Mnd1 family ParD_antitoxin (PF03693, IPR022789): Bacterial antitoxin of ParD toxin-antitoxin type II system and RHH |
8 |
C14orf166 | interactor | 7 | 0.762 | 0.683 | RLL (PF10036, IPR019265): Putative carnitine deficiency-associated protein |
9 |
CAPZA2 | interactor | 11 | 0.745 | 3.685 | F-actin_cap_A (PF01267, IPR002189): F-actin capping protein alpha subunit |
10 |
CCDC8 | interactor | 21 | 0.379 | 43.327 | Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal PNMA (PF14893, IPR026523): PNMA |
11 |
CCT5 | interactor | 15 | 0.429 | 24.608 | Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family |
12 |
CDC42 | oncoprotein | 8 | 0.381 | 5.679 | Ras (PF00071, IPR001806, SM00173): Ras family |
13 |
CDC5L | interactor | 18 | 0.603 | 13.356 | OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain |
14 |
CDK2 | suppressor | 25 | 0.301 | 82.361 | Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase (PF00069, IPR000719): Protein kinase domain |
15 |
CUL7 | protein found in more fusions | 30 | 0.355 | 87.361 | ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10) Cullin (PF00888, IPR001373, SM00182): Cullin family DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918) Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7 |
16 |
DMD | suppressor | 2 | 1.000 | 0 | CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) EF-hand_2 (PF09068, IPR015153): EF hand EF-hand_3 (PF09069, IPR015154): EF-hand FliD_N (PF02465, IPR003481): Flagellar hook-associated protein 2 N-terminus IncA (PF04156, IPR007285): IncA protein Spectrin (PF00435, IPR002017): Spectrin repeat WW (PF00397, IPR001202, SM00456): WW domain Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1 ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type DinB_2 (PF12867, IPR024775): DinB superfamily CCDC-167 (PF15188, IPR028194): Coiled-coil domain-containing protein 167 |
17 |
EEF1A1 | suppressor | 28 | 0.368 | 100.086 | GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain |
18 |
EEF1B2 | interactor | 11 | 0.644 | 3.743 | EF1_GNE (PF00736, IPR014038, SM00888): EF-1 guanine nucleotide exchange domain EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region GST_C_6 (PF17171): Glutathione S-transferase, C-terminal domain |
19 |
EEF1D | protein found in more fusions | 15 | 0.451 | 19.206 | EF1_GNE (PF00736, IPR014038, SM00888): EF-1 guanine nucleotide exchange domain EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region |
20 |
EEF2 | interactor | 14 | 0.527 | 15.148 | EFG_C (PF00679, IPR000640, SM00838): Elongation factor G C-terminus EFG_IV (PF03764, IPR005517, SM00889): Elongation factor G, domain IV GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 EFG_II (PF14492, IPR009022): Elongation Factor G, domain II |
21 |
EGFR | oncoprotein | 23 | 0.355 | 59.816 | Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT) GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV |
22 |
ESR1 | suppressor | 18 | 0.316 | 38.097 | Oest_recep (PF02159, IPR001292): Oestrogen receptor zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal |
23 |
EZR | protein found in more fusions | 11 | 0.511 | 6.355 | DUF106 (PF01956, IPR002809): Integral membrane protein DUF106 ERM (PF00769, IPR011259): Ezrin/radixin/moesin family FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain FERM_M (PF00373, IPR019748): FERM central domain FERM_N (PF09379, IPR018979): FERM N-terminal domain |
24 |
FLNB | oncoprotein | 18 | 0.379 | 36.805 | CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain Filamin (PF00630, IPR017868): Filamin/ABP280 repeat PapC_N (PF13954, IPR025885): PapC N-terminal domain |
25 |
FMNL1 | protein found in more fusions | 6 | 0.600 | 0.682 | CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal Drf_FH3 (PF06367, IPR010472, SM01139): Diaphanous FH3 Domain Drf_GBD (PF06371, IPR010473, SM01140): Diaphanous GTPase-binding Domain Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator FH2 (PF02181, IPR015425, SM00498): Formin Homology 2 Domain SlyX (PF04102, IPR007236): SlyX FNIP_M (PF14637, IPR028085): Folliculin-interacting protein middle domain PRIMA1 (PF16101): Proline-rich membrane anchor 1 ABC_tran_CTD (PF16326, IPR032524): ABC transporter C-terminal domain |
26 |
FN1 | oncoprotein | 33 | 0.322 | 140.865 | fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369) |
27 |
GORASP2 | interactor | 2 | 1.000 | 0 | GRASP55_65 (PF04495, IPR024958): GRASP55/65 PDZ-like domain |
28 |
GRB2 | oncoprotein | 14 | 0.449 | 14.305 | SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093) |
29 |
GRPEL1 | interactor | 9 | 0.607 | 4.056 | GrpE (PF01025, IPR000740): GrpE |
30 |
HNRNPAB | interactor | 17 | 0.625 | 12.556 | CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain GRP (PF07172, IPR010800): Glycine rich protein family NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID) RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF2462 (PF09495, IPR019034): Protein of unknown function (DUF2462) |
31 |
HNRNPD | oncoprotein | 23 | 0.537 | 27.049 | CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID) RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Keratin_2_head (PF16208, IPR032444): Keratin type II head |
32 |
HNRNPDL | interactor | 15 | 0.686 | 6.119 | CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) |
33 |
HNRNPH1 | oncoprotein | 23 | 0.542 | 39.697 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-RNPHF (PF08080, IPR012996): RNPHF zinc finger |
34 |
HSPA5 | oncoprotein | 30 | 0.433 | 96.099 | HSP70 (PF00012, IPR013126): Hsp70 protein |
35 |
HSPA9 | oncoprotein | 19 | 0.386 | 41.600 | HSP70 (PF00012, IPR013126): Hsp70 protein |
36 |
HSPB1 | oncoprotein | 33 | 0.319 | 164.173 | HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family |
37 |
ISG15 | suppressor | 9 | 0.444 | 5.642 | ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family |
38 |
JSRP1 | interactor | 1 | 0 | 0 | SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal JSRP (PF15312, IPR026178): Junctional sarcoplasmic reticulum protein PRIMA1 (PF16101): Proline-rich membrane anchor 1 |
39 |
KLHL40 | interactor | 1 | 0 | 0 | BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch BTB (PF00651, IPR013069, SM00225): BTB/POZ domain Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif Kelch_3 (PF13415): Galactose oxidase, central domain Kelch_6 (PF13964): Kelch motif |
40 |
LASP1 | oncoprotein | 7 | 0.333 | 4.058 | LIM (PF00412, IPR001781, SM00132): LIM domain Nebulin (PF00880, IPR000900, SM00227): Nebulin repeat SH3_9 (PF14604, IPR001452): Variant SH3 domain |
41 |
LIMA1 | suppressor | 19 | 0.374 | 45.687 | LIM (PF00412, IPR001781, SM00132): LIM domain ROKNT (PF08067, IPR012987): ROKNT (NUC014) domain |
42 |
MCM2 | oncoprotein | 38 | 0.320 | 200.610 | AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA) MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2 MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain |
43 |
MED4 | interactor | 7 | 0.476 | 3.940 | Med4 (PF10018, IPR019258): Vitamin-D-receptor interacting Mediator subunit 4 |
44 |
MYH9 | suppressor | 23 | 0.391 | 69.301 | IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain Myosin_tail_1 (PF01576, IPR002928): Myosin tail Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain) |
45 |
MYL6 | interactor | 8 | 0.607 | 3.972 | EF-hand_1 (PF00036, IPR002048, SM00054): EF hand EF-hand_6 (PF13405, IPR002048): EF-hand domain EF-hand_8 (PF13833, IPR002048): EF-hand domain pair |
46 |
MYO19 | interactor | 8 | 0.714 | 2.625 | IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain) |
47 |
NOL9 | interactor | 3 | 0.667 | 0.667 | SP2 (PF03014, IPR004261): Structural protein 2 CLP1_P (PF16575, IPR032319): mRNA cleavage and polyadenylation factor CLP1 P-loop |
48 |
NXF1 | interactor | 18 | 0.324 | 41.642 | NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain LRR_8 (PF13855, IPR001611): Leucine rich repeat |
49 |
OBSL1 | protein found in more fusions | 26 | 0.427 | 55.769 | BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E I-set (PF07679, IPR013098): Immunoglobulin I-set domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain |
50 |
OXCT1 | interactor | 3 | 1.000 | 0 | CoA_trans (PF01144, IPR004165, SM00882): Coenzyme A transferase |
51 |
POT1 | interactor | 7 | 0.333 | 3.224 | POT1 (PF02765, IPR011564, SM00976): Telomeric single stranded DNA binding POT1/CDC13 tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain POT1PC (PF16686, IPR032042): ssDNA-binding domain of telomere protection protein |
52 |
PSME3 | protein found in more fusions | 6 | 0.700 | 0.952 | PA28_alpha (PF02251, IPR003185): Proteasome activator pa28 alpha subunit PA28_beta (PF02252, IPR003186): Proteasome activator pa28 beta subunit |
53 |
RPA1 | suppressor | 27 | 0.492 | 50.163 | Rep-A_N (PF04057, IPR007199): Replication factor-A protein 1, N-terminal domain Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain REPA_OB_2 (PF16900, IPR031657): Replication protein A OB domain |
54 |
RPA2 | oncoprotein | 21 | 0.562 | 24.713 | RPA_C (PF08784, IPR014892): Replication protein A C terminal tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain RMI2 (PF16100, IPR032245): RecQ-mediated genome instability protein 2 |
55 |
RPA3 | interactor | 22 | 0.505 | 31.849 | Rep_fac-A_3 (PF08661, IPR013970): Replication factor A protein 3 |
56 |
RUVBL1 | oncoprotein | 14 | 0.449 | 18.374 | TIP49 (PF06068, IPR010339): TIP49 C-terminus |
57 |
S100A10 | oncoprotein | 3 | 1.000 | 0 | S_100 (PF01023, IPR013787): S-100/ICaBP type calcium binding domain EF-hand_7 (PF13499, IPR011992): EF-hand domain pair |
58 |
S100B | oncoprotein | 2 | 0 | 0 | S_100 (PF01023, IPR013787): S-100/ICaBP type calcium binding domain |
59 |
SEC16A | interactor | 9 | 0.639 | 3.509 | APC_r (PF05923): APC repeat Sec16_C (PF12931, IPR024298): Sec23-binding domain of Sec16 Sec16 (PF12932, IPR024340): Vesicle coat trafficking protein Sec16 mid-region |
60 |
SIRT7 | interactor | 16 | 0.317 | 41.670 | DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563) SIR2 (PF02146, IPR003000): Sir2 family |
61 |
SKI | oncoprotein | 6 | 0.500 | 1.091 | c-SKI_SMAD_bind (PF08782, IPR014890, SM01046): c-SKI Smad4 binding domain Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family SlyX (PF04102, IPR007236): SlyX HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1 |
62 |
SNW1 | protein found in more fusions | 21 | 0.511 | 32.133 | SKIP_SNW (PF02731, IPR004015): SKIP/SNW domain PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term SIR4_SID (PF16991, IPR031556): Sir4 SID domain |
63 |
STIP1 | interactor | 17 | 0.412 | 34.055 | TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat TPR_11 (PF13414, IPR011990): TPR repeat TPR_12 (PF13424): Tetratricopeptide repeat TPR_17 (PF13431): Tetratricopeptide repeat Wtap (PF17098, IPR029732): Pre-mRNA-splicing regulator WTAP |
64 |
STMN1 | interactor | 11 | 0.509 | 11.657 | Stathmin (PF00836, IPR000956): Stathmin family |
65 |
STRN | oncoprotein | 4 | 0.500 | 0.682 | CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H) Nucleoporin_N (PF08801, IPR014908): Nup133 N terminal like Striatin (PF08232, IPR013258): Striatin family WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain |
66 |
SUMO2 | interactor | 7 | 0.467 | 4.446 | Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like |
67 |
TARDBP | interactor | 21 | 0.600 | 17.630 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) |
68 |
TARS | interactor | 11 | 0.564 | 6.097 | HGTP_anticodon (PF03129, IPR004154): Anticodon binding domain TGS (PF02824, IPR004095): TGS domain tRNA-synt_2b (PF00587, IPR002314): tRNA synthetase class II core domain (G, H, P, S and T) tRNA_SAD (PF07973, IPR012947, SM00863): Threonyl and Alanyl tRNA synthetase second additional domain |
69 |
TUBA1C | interactor | 15 | 0.486 | 15.175 | Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain |
70 |
U2AF2 | protein found in more fusions | 24 | 0.435 | 46.443 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Transformer (PF06495, IPR010519): Fruit fly transformer protein |
71 |
VARS | interactor | 9 | 0.583 | 3.767 | Anticodon_1 (PF08264, IPR013155): Anticodon-binding domain of tRNA GST_C (PF00043, IPR004046): Glutathione S-transferase, C-terminal domain tRNA-synt_1 (PF00133, IPR002300): tRNA synthetases class I (I, L, M and V) Val_tRNA-synt_C (PF10458, IPR019499): Valyl tRNA synthetase tRNA binding arm SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3 |
72 |
YARS | interactor | 8 | 0.607 | 2.322 | tRNA-synt_1b (PF00579, IPR002305): tRNA synthetases class I (W and Y) tRNA_bind (PF01588, IPR002547): Putative tRNA binding domain |