Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins AHCYL1 (from a repository: Thu Nov 10 14:59:26 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 141 The number (and %) of the onco-proteins 36 (25.53 %) The number (and %) of the tumor suppressors 9 (6.38 %) Total number of binary PPIs (saturation %) 792 (8.02 %) The number (and %) of affected PPIs 141 (17.80 %) The number of possible different fusions 23 PPI diameter 2 PPI radius 1 The average degree of PPI 10.582 Assortativity coefficient -0.2879 The network average Clustering coefficient 0.421 The number (and %) of a zero Clustering coefficients 14 (9.93 %) The number (and %) of a zero Betweenness Centrality 26 (18.44 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: AHCYL1	All fusions : AI800578;
Proteins found in more fusions	TPM1 (see 2 fusions); TKT (see 5 fusions); TPM2/TPM3 (see 1 fusions); UBE2C (see 1 fusions); TPM2/TPM1 (see 1 fusions); SRPK2 (see 1 fusions); VPS26A (see 1 fusions); PSME3 (see 2 fusions); UBQLN1 (see 2 fusions); TPM2 (see 1 fusions); UBE2D2 (see 2 fusions); DHX8/SRPK2 (see 1 fusions); AHCYL1 (see 3 fusions); STUB1 (see 1 fusions); SRSF1 (see 1 fusions); HSPA5/UBL7 (see 1 fusions); ECHS1 (see 1 fusions); SOD1/TAGLN2 (see 1 fusions); CDC37 (see 2 fusions); DHX8 (see 1 fusions); TPD52L2 (see 2 fusions); CSNK1E (see 1 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	AHCYL1	parental protein	141	0.062	14445.511	AdoHcyase (PF05221, IPR000043, SM00996): S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD (PF00670, IPR015878, SM00997): S-adenosyl-L-homocysteine hydrolase, NAD binding domain DUF515 (PF04415, IPR007509): Protein of unknown function (DUF515) Big_3_5 (PF16640, IPR032109): Bacterial Ig-like domain (group 3)
2	AHCY	interactor	3	1.000	0	AdoHcyase (PF05221, IPR000043, SM00996): S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD (PF00670, IPR015878, SM00997): S-adenosyl-L-homocysteine hydrolase, NAD binding domain
3	ANP32A	oncoprotein	7	0.571	7.400	SDA1 (PF05285, IPR007949): SDA1 LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_9 (PF14580): Leucine-rich repeat
4	ANP32B	oncoprotein	6	0.667	4.400	FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide SDA1 (PF05285, IPR007949): SDA1 LRR_9 (PF14580): Leucine-rich repeat
5	ANP32E	interactor	3	1.000	0	BUD22 (PF09073, IPR015158): BUD22 LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_9 (PF14580): Leucine-rich repeat
6	ATP6V1B2	interactor	16	0.367	37.488	ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain DUF2481 (PF10654, IPR018916): Protein of unknown function (DUF2481)
7	BID	oncoprotein	5	0.500	1.595	BID (PF06393, IPR010479): BH3 interacting domain (BID)
8	C11orf58	interactor	3	0.667	1.000	DUF3408 (PF11888, IPR021823): Protein of unknown function (DUF3408) SMAP (PF15477, IPR028124): Small acidic protein family
9	C1QBP	interactor	5	0.400	3.900	MAM33 (PF02330, IPR003428): Mitochondrial glycoprotein DUF3053 (PF11254, IPR021413): Protein of unknown function (DUF3053)
10	CCT5	interactor	5	0.400	5.067	Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
11	CD2BP2	interactor	7	0.381	10.262	GYF (PF02213, IPR003169, SM00444): GYF domain EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region Hist_rich_Ca-bd (PF10529, IPR019552): Histidine-rich Calcium-binding repeat region
12	CDC37	protein found in more fusions	9	0.500	8.281	CDC37_C (PF08564, IPR013873, SM01069): Cdc37 C terminal domain CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding Rho_Binding (PF08912, IPR015008): Rho Binding TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
13	CDKN2C	oncoprotein	2	1.000	0	Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_5 (PF13857): Ankyrin repeats (many copies)
14	CEP128	interactor	4	0.500	1.567	DUF1129 (PF06570, IPR009214): Protein of unknown function (DUF1129) DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) ERM (PF00769, IPR011259): Ezrin/radixin/moesin family Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein SpoOE-like (PF09388, IPR018540): Spo0E like sporulation regulatory protein DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968) TraF_2 (PF13729, IPR032811): F plasmid transfer operon, TraF, protein GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200) DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404) HAUS6_N (PF14661, IPR028163): HAUS augmin-like complex subunit 6 N-terminus HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
15	CSNK1E	protein found in more fusions	7	0.467	6.083	APH (PF01636, IPR002575): Phosphotransferase enzyme family Pkinase (PF00069, IPR000719): Protein kinase domain
16	DACH1	suppressor	3	1.000	0	DUF508 (PF04370, IPR007465): Domain of unknown function (DUF508) Pap_E4 (PF02711, IPR003861): E4 protein Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein Secretin_N_2 (PF07655, IPR011514): Secretin N-terminal domain Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family Macoilin (PF09726, IPR019130): Transmembrane protein SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
17	DHX8	protein found in more fusions	6	0.600	1.662	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2) S1 (PF00575, IPR003029, SM00316): S1 RNA binding domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
18	DOK4	interactor	2	1.000	0	IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type) PH (PF00169, IPR001849, SM00233): PH domain
19	ECHS1	protein found in more fusions	6	0.600	1.995	ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
20	ECT2	oncoprotein	7	0.381	9.500	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain PTCB-BRCT (PF12738, IPR001357): twin BRCT domain PGBA_C (PF15437, IPR032737): Plasminogen-binding protein pgbA C-terminal
21	EDA	interactor	2	1.000	0	Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies) TNF (PF00229, IPR006052, SM00207): TNF(Tumour Necrosis Factor) family
22	EIF3M	interactor	3	0.667	0.667	Death (PF00531, IPR000488, SM00005): Death domain PCI (PF01399, IPR000717, SM00088): PCI domain
23	ELAVL1	oncoprotein	31	0.136	315.001	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
24	FAM13C	interactor	3	1.000	0	Mnd1 (PF03962, IPR005647): Mnd1 family SlyX (PF04102, IPR007236): SlyX MRI (PF15325, IPR028278): Modulator of retrovirus infection Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
25	FBXL7	oncoprotein	4	0.500	2.500	LRR_1 (PF00560, IPR001611): Leucine Rich Repeat LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) F-box-like (PF12937, IPR001810): F-box-like LRR_6 (PF13516, IPR001611): Leucine Rich repeat
26	GEM	interactor	1	0	0	Ras (PF00071, IPR001806, SM00173): Ras family AAA_22 (PF13401, IPR003593): AAA domain
27	GINS4	interactor	4	0.500	3.000	Sld5 (PF05916, IPR021151): GINS complex protein SLD5_C (PF16922, IPR031633): DNA replication complex GINS protein SLD5 C-terminus
28	HGS	interactor	10	0.356	18.395	FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif VHS (PF00790, IPR002014, SM00288): VHS domain EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate PIEZO (PF15917, IPR031805): Piezo
29	HOXC9	interactor	1	0	0	Hox9_act (PF04617, IPR006711): Hox9 activation region Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
30	HSPA5	oncoprotein	17	0.300	56.367	HSP70 (PF00012, IPR013126): Hsp70 protein
31	ITPR1	interactor	1	0	0	Ins145_P3_rec (PF08709, IPR014821): Inositol 1,4,5-trisphosphate/ryanodine receptor Ion_trans (PF00520, IPR005821): Ion transport protein MIR (PF02815, IPR016093, SM00472): MIR domain RIH_assoc (PF08454, IPR013662): RyR and IP3R Homology associated RYDR_ITPR (PF01365, IPR000699): RIH domain CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit
32	JOSD2	interactor	2	1.000	0	Josephin (PF02099, IPR006155): Josephin
33	LAGE3	interactor	6	0.400	6.633	Pcc1 (PF09341, IPR015419): Transcription factor Pcc1
34	MAB21L3	interactor	1	0	0	Mab-21 (PF03281, IPR024810): Mab-21 protein
35	MEOX2	interactor	4	0.500	3.000	Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
36	MOV10	interactor	23	0.126	140.671	AAA_12 (PF13087): AAA domain AAA_30 (PF13604): AAA domain
37	MYL6	interactor	3	1.000	0	EF-hand_1 (PF00036, IPR002048, SM00054): EF hand EF-hand_6 (PF13405, IPR002048): EF-hand domain EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
38	NXF1	interactor	30	0.123	259.671	NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain LRR_8 (PF13855, IPR001611): Leucine rich repeat
39	PDCD6IP	interactor	8	0.524	7.167	BRO1 (PF03097, IPR004328, SM01041): BRO1-like domain MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c ALIX_LYPXL_bnd (PF13949, IPR025304): ALIX V-shaped domain binding to HIV
40	PITX2	interactor	2	0	0	OAR (PF03826, IPR003654): OAR domain XRCC4 (PF06632, IPR010585): DNA double-strand break repair and V(D)J recombination protein XRCC4 Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
41	POC1A	interactor	3	0.667	1.000	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
42	PPIL3	interactor	11	0.309	30.900	Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
43	PPL	interactor	1	0	0	ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) Cortex-I_coil (PF09304, IPR015383): Cortexillin I, coiled coil DivIC (PF04977, IPR007060): Septum formation initiator MCU (PF04678, IPR006769): Mitochondrial calcium uniporter ZapB (PF06005, IPR009252): Cell division protein ZapB Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family FliT (PF05400, IPR008622): Flagellar protein FliT M (PF02370, IPR003345): M protein repeat Mnd1 (PF03962, IPR005647): Mnd1 family Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain Spectrin (PF00435, IPR002017): Spectrin repeat Plectin (PF00681, IPR001101, SM00250): Plectin repeat TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140) DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472)
44	PPM1G	interactor	18	0.203	92.576	Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510) PP2C (PF00481, IPR001932): Protein phosphatase 2C DUF4820 (PF16091, IPR032150): Domain of unknown function (DUF4820)
45	PPP2CA	suppressor	5	0.400	5.167	Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
46	PSAT1	interactor	8	0.286	13.100	Aminotran_5 (PF00266, IPR000192): Aminotransferase class-V
47	PSMD12	interactor	7	0.600	4.667	Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain PCI (PF01399, IPR000717, SM00088): PCI domain
48	PSMD4	interactor	14	0.275	50.719	UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain
49	PSMD6	interactor	5	0.800	1.333	RPN7 (PF10602, IPR019585): 26S proteasome subunit RPN7 PCI (PF01399, IPR000717, SM00088): PCI domain
50	PSMD9	interactor	7	0.476	10.000	Remorin_C (PF03763, IPR005516): Remorin, C-terminal region DUF2046 (PF09755, IPR019152): Uncharacterized conserved protein H4 (DUF2046) PDZ_2 (PF13180, IPR001478): PDZ domain
51	PSME3	protein found in more fusions	9	0.357	13.662	PA28_alpha (PF02251, IPR003185): Proteasome activator pa28 alpha subunit PA28_beta (PF02252, IPR003186): Proteasome activator pa28 beta subunit
52	PTGES3	interactor	7	0.467	5.567	CS (PF04969, IPR007052): CS domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
53	PTS	interactor	2	0	0	PTPS (PF01242, IPR007115): 6-pyruvoyl tetrahydropterin synthase
54	RPL37A	interactor	1	0	0	Ribosomal_L37ae (PF01780, IPR002674): Ribosomal L37ae protein family
55	SEC24A	interactor	18	0.150	82.614	Gelsolin (PF00626, IPR007123): Gelsolin repeat Sec23_BS (PF08033, IPR012990): Sec23/Sec24 beta-sandwich domain Sec23_helical (PF04815, IPR006900): Sec23/Sec24 helical domain Sec23_trunk (PF04811, IPR006896): Sec23/Sec24 trunk domain zf-Sec23_Sec24 (PF04810, IPR006895): Sec23/Sec24 zinc finger
56	SEC24C	interactor	11	0.345	20.222	Gelsolin (PF00626, IPR007123): Gelsolin repeat Sec23_BS (PF08033, IPR012990): Sec23/Sec24 beta-sandwich domain Sec23_helical (PF04815, IPR006900): Sec23/Sec24 helical domain Sec23_trunk (PF04811, IPR006896): Sec23/Sec24 trunk domain zf-Sec23_Sec24 (PF04810, IPR006895): Sec23/Sec24 zinc finger
57	SEPHS1	interactor	7	0.600	4.400	AIRS (PF00586, IPR000728): AIR synthase related protein, N-terminal domain AIRS_C (PF02769, IPR010918): AIR synthase related protein, C-terminal domain
58	SERPINH1	interactor	10	0.267	20.139	Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
59	SGTA	interactor	5	0.500	3.400	TOM20_plant (PF06552, IPR010547): Plant specific mitochondrial import receptor subunit TOM20 TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat XPC-binding (PF09280, IPR015360): XPC-binding domain TPR_17 (PF13431): Tetratricopeptide repeat SGTA_dimer (PF16546, IPR032374): Homodimerisation domain of SGTA
60	SH3BGRL3	interactor	1	0	0	SH3BGR (PF04908, IPR006993): SH3-binding, glutamic acid-rich protein
61	SHTN1	interactor	7	0.333	5.289	Asp-B-Hydro_N (PF05279, IPR007943): Aspartyl beta-hydroxylase N-terminal region VIT1 (PF01988, IPR008217): VIT family Pinin_SDK_memA (PF04696, IPR006786): pinin/SDK/memA/ protein conserved region Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2 Atg14 (PF10186, IPR018791): Vacuolar sorting 38 and autophagy-related subunit 14 DUF3484 (PF11983, IPR021873): Membrane-attachment and polymerisation-promoting switch Dscam_C (PF12355, IPR021012): Down syndrome cell adhesion molecule C terminal PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain PRIMA1 (PF16101): Proline-rich membrane anchor 1
62	SIN3A	oncoprotein	8	0.250	17.567	Sin3_corepress (PF08295, IPR013194, SM00761): Sin3 family co-repressor PAH (PF02671, IPR003822, SM00309): Paired amphipathic helix repeat Sin3a_C (PF16879, IPR031693): C-terminal domain of Sin3a protein
63	SKP1	oncoprotein	9	0.278	17.651	Skp1 (PF01466, IPR016072, SM00512): Skp1 family, dimerisation domain Skp1_POZ (PF03931, IPR016073): Skp1 family, tetramerisation domain
64	SLC23A1	interactor	1	0	0	Xan_ur_permease (PF00860, IPR006043): Permease family
65	SNCG	oncoprotein	3	1.000	0	Synuclein (PF01387, IPR001058): Synuclein
66	SNRPA	interactor	4	0.667	0.500	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
67	SNX12	interactor	6	0.400	4.600	PX (PF00787, IPR001683, SM00312): PX domain
68	SNX3	interactor	9	0.333	14.789	PX (PF00787, IPR001683, SM00312): PX domain
69	SOD1	protein found in more fusions	17	0.333	52.557	Sod_Cu (PF00080, IPR001424): Copper/zinc superoxide dismutase (SODC)
70	SOX2	oncoprotein	11	0.356	24.333	HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box SOXp (PF12336, IPR022097): SOX transcription factor
71	SOX30	interactor	1	0	0	HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
72	SP100	suppressor	5	0.500	1.429	Pap_E4 (PF02711, IPR003861): E4 protein PHD (PF00628, IPR019787, SM00249): PHD-finger SAND (PF01342, IPR000770, SM00258): SAND domain HSR (PF03172, IPR004865): HSR domain; Sp100 domain Bromodomain (PF00439, IPR001487, SM00297): Bromodomain FRG2 (PF15315, IPR026245): Facioscapulohumeral muscular dystrophy candidate 2
73	SPR	interactor	9	0.528	11.967	adh_short (PF00106, IPR002198): short chain dehydrogenase
74	SRPK1	interactor	10	0.333	23.622	FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid) Pkinase (PF00069, IPR000719): Protein kinase domain NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
75	SRPK2	oncoprotein	12	0.364	27.256	DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387) Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator Pkinase (PF00069, IPR000719): Protein kinase domain S-antigen (PF05756, IPR008825): S-antigen protein DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
76	SRSF1	protein found in more fusions	10	0.389	13.312	Corona_nucleoca (PF00937, IPR001218): Coronavirus nucleocapsid protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
77	SRXN1	interactor	25	0.247	137.914	ParBc (PF02195, IPR003115): ParB-like nuclease domain
78	STAM	interactor	16	0.308	49.636	GAT (PF03127, IPR004152): GAT domain UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif VHS (PF00790, IPR002014, SM00288): VHS domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
79	STAT6	oncoprotein	5	0.500	1.868	SH2 (PF00017, IPR000980, SM00252): SH2 domain STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain STAT6_C (PF14596, IPR028187): STAT6 C-terminal
80	STIP1	interactor	11	0.364	21.622	TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat TPR_11 (PF13414, IPR011990): TPR repeat TPR_12 (PF13424): Tetratricopeptide repeat TPR_17 (PF13431): Tetratricopeptide repeat Wtap (PF17098, IPR029732): Pre-mRNA-splicing regulator WTAP
81	STMN1	interactor	10	0.333	23.086	Stathmin (PF00836, IPR000956): Stathmin family
82	STMN2	interactor	6	0.600	1.663	Stathmin (PF00836, IPR000956): Stathmin family
83	STUB1	suppressor	22	0.229	107.696	U-box (PF04564, IPR003613, SM00504): U-box domain ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 (PF13414, IPR011990): TPR repeat TPR_20 (PF14561): Tetratricopeptide repeat
84	SUGT1	interactor	6	0.400	8.333	CheC (PF04509, IPR007597): CheC-like family CS (PF04969, IPR007052): CS domain SGS (PF05002, IPR007699): SGS domain TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat TPR_16 (PF13432): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat
85	SULT1A1	interactor	27	0.279	149.699	Sulfotransfer_1 (PF00685, IPR000863): Sulfotransferase domain
86	SUMO2	interactor	6	0.400	4.667	Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
87	TACC3	oncoprotein	4	0.667	0.404	TACC (PF05010, IPR007707): Transforming acidic coiled-coil-containing protein (TACC) bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
88	TAGLN2	protein found in more fusions	17	0.279	66.004	Calponin (PF00402, IPR000557): Calponin family repeat CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
89	TARDBP	interactor	9	0.357	9.145	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
90	TBCA	interactor	1	0	0	TBCA (PF02970, IPR004226): Tubulin binding cofactor A
91	TES	suppressor	7	0.333	7.262	LIM (PF00412, IPR001781, SM00132): LIM domain PET (PF06297, IPR010442): PET Domain PSCyt3 (PF07627, IPR013039): Protein of unknown function (DUF1588) Ig_Tie2_1 (PF10430, IPR018941): Tie-2 Ig-like domain 1
92	THADA	oncoprotein	9	0.333	14.492	HEAT (PF02985, IPR000357): HEAT repeat UME (PF08064, IPR012993, SM00802): UME (NUC010) domain DUF2428 (PF10350, IPR019442): Putative death-receptor fusion protein (DUF2428)
93	TKT	protein found in more fusions	11	0.533	13.486	Transket_pyr (PF02779, IPR005475, SM00861): Transketolase, pyrimidine binding domain Transketolase_C (PF02780, IPR005476): Transketolase, C-terminal domain Transketolase_N (PF00456, IPR005474): Transketolase, thiamine diphosphate binding domain
94	TLE3	interactor	8	0.429	6.795	TLE_N (PF03920, IPR005617): Groucho/TLE N-terminal Q-rich domain WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
95	TMEM17	interactor	5	0.600	2.786	Transmemb_17 (PF09799, IPR019184): Predicted membrane protein DUF3043 (PF11241, IPR021403): Protein of unknown function (DUF3043)
96	TMOD3	interactor	7	0.429	8.467	Tropomodulin (PF03250, IPR004934): Tropomodulin Usher (PF00577, IPR000015): Outer membrane usher protein LRR_6 (PF13516, IPR001611): Leucine Rich repeat
97	TOM1L2	suppressor	8	0.357	11.100	GAT (PF03127, IPR004152): GAT domain VHS (PF00790, IPR002014, SM00288): VHS domain
98	TPD52L2	protein found in more fusions	9	0.321	14.429	TPD52 (PF04201, IPR007327): Tumour protein D52 family
99	TPM1	protein found in more fusions	11	0.378	19.319	Tropomyosin (PF00261, IPR000533): Tropomyosin Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
100	TPM2	protein found in more fusions	9	0.500	9.867	DASH_Spc19 (PF08287, IPR013251): Spc19 Tropomyosin (PF00261, IPR000533): Tropomyosin Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
101	TPM3	oncoprotein	9	0.393	9.134	Tropomyosin (PF00261, IPR000533): Tropomyosin Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
102	TPM3P4	interactor	2	1.000	0	NA
103	TRIP6	interactor	17	0.228	66.911	DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region LIM (PF00412, IPR001781, SM00132): LIM domain
104	TTC1	interactor	16	0.375	32.684	TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
105	TTC9C	interactor	20	0.289	69.811	TPR_17 (PF13431): Tetratricopeptide repeat TPR_16 (PF13432): Tetratricopeptide repeat
106	TTLL12	interactor	15	0.448	25.266	TTL (PF03133, IPR004344): Tubulin-tyrosine ligase family
107	TUBB6	interactor	8	0.286	10.294	Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
108	TXN	oncoprotein	10	0.422	16.771	Thioredoxin (PF00085, IPR013766): Thioredoxin
109	TYMS	interactor	10	0.489	10.278	Thymidylat_synt (PF00303, IPR000398): Thymidylate synthase
110	UBA2	interactor	19	0.287	73.090	ThiF (PF00899, IPR000594): ThiF family UAE_UbL (PF14732, IPR028077): Ubiquitin/SUMO-activating enzyme ubiquitin-like domain UBA2_C (PF16195, IPR032426): SUMO-activating enzyme subunit 2 C-terminus
111	UBA52	interactor	7	0.714	1.680	Ribosomal_L40e (PF01020, IPR001975): Ribosomal L40e family VWC (PF00093, IPR001007, SM00214): von Willebrand factor type C domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
112	UBA6	interactor	8	0.607	5.387	ThiF (PF00899, IPR000594): ThiF family E1_UFD (PF09358, IPR018965, SM00985): Ubiquitin fold domain UBA_e1_thiolCys (PF10585, IPR019572): Ubiquitin-activating enzyme active site
113	UBE2B	interactor	22	0.324	62.962	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
114	UBE2C	oncoprotein	23	0.364	59.322	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
115	UBE2D1	interactor	18	0.434	33.888	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
116	UBE2D2	oncoprotein	14	0.500	16.633	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
117	UBE2L3	interactor	18	0.404	39.847	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
118	UBE2V1	interactor	16	0.383	37.339	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
119	UBE4B	suppressor	27	0.397	80.206	DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180) NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region Ufd2P_core (PF10408, IPR019474): Ubiquitin elongating factor core U-box (PF04564, IPR003613, SM00504): U-box domain DUF4568 (PF15132, IPR027919): Domain of unknown function (DUF4568)
120	UBL7	oncoprotein	12	0.561	10.975	UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
121	UBQLN1	protein found in more fusions	23	0.351	84.137	Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain XPC-binding (PF09280, IPR015360): XPC-binding domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B FAM199X (PF15814, IPR029672): Protein family FAM199X
122	UBQLN4	interactor	22	0.329	79.475	CRF (PF00473, IPR000187, SM00039): Corticotropin-releasing factor family DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180) Arm_2 (PF04826, IPR006911): Armadillo-like NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain XPC-binding (PF09280, IPR015360): XPC-binding domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B partial_CstF (PF15861, IPR031721): Partial cleavage stimulation factor domain
123	UBXN1	interactor	20	0.427	46.262	Selenoprotein_S (PF06936, IPR009703): Selenoprotein S (SelS) UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain UBX (PF00789, IPR001012, SM00166): UBX domain
124	UCHL3	interactor	19	0.418	39.700	Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
125	UFC1	interactor	16	0.400	36.871	UFC1 (PF08694, IPR014806): Ubiquitin-fold modifier-conjugating enzyme 1
126	UFM1	interactor	21	0.395	65.695	Ufm1 (PF03671, IPR005375): Ubiquitin fold modifier 1 protein
127	USP34	interactor	27	0.336	112.294	Secretin_N_2 (PF07655, IPR011514): Secretin N-terminal domain UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase DUF3517 (PF12030, IPR021905): Domain of unknown function (DUF3517)
128	USP42	interactor	1	0	0	TFIIF_alpha (PF05793, IPR008851): Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase Med19 (PF10278, IPR019403): Mediator of RNA pol II transcription subunit 19 AP3D1 (PF06375): AP-3 complex subunit delta-1
129	USP9X	interactor	26	0.338	114.599	DUF1722 (PF08349, IPR013560): Protein of unknown function (DUF1722) UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase Utp13 (PF08625, IPR013934): Utp13 specific WD40 associated domain
130	VPS26A	protein found in more fusions	9	0.607	4.417	Vps26 (PF03643, IPR005377): Vacuolar protein sorting-associated protein 26
131	VPS4B	interactor	16	0.433	31.319	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) AAA_2 (PF07724, IPR013093): AAA domain (Cdc48 subfamily) MIT (PF04212, IPR007330, SM00745): MIT (microtubule interacting and transport) domain MMR_HSR1 (PF01926, IPR006073): 50S ribosome-binding GTPase TIP49 (PF06068, IPR010339): TIP49 C-terminus Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
132	WDR48	suppressor	4	0.500	3.000	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat DUF3337 (PF11816, IPR021772): Domain of unknown function (DUF3337)
133	XPO1	interactor	19	0.234	98.194	CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
134	YAP1	oncoprotein	18	0.386	35.863	Bindin (PF02084, IPR000775): Bindin WW (PF00397, IPR001202, SM00456): WW domain GspL_C (PF12693, IPR025691): GspL periplasmic domain FAM181 (PF15238, IPR029359): FAM181
135	ZC3H3	interactor	3	0.667	0.095	zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar) MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c CCDC24 (PF15669, IPR031367): Coiled-coil domain-containing protein 24 family
136	ZFYVE19	interactor	23	0.411	62.058	Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein DUF1690 (PF07956, IPR012471): Protein of Unknown function (DUF1690) FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger Rpr2 (PF04032, IPR007175): RNAse P Rpr2/Rpp21/SNM1 subunit domain zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
137	ZNF165	interactor	1	0	0	SCAN (PF02023, IPR003309, SM00431): SCAN domain zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
138	ZNF444	interactor	2	1.000	0	FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
139	ZPR1	interactor	20	0.337	55.421	zf-ZPR1 (PF03367, IPR004457, SM00709): ZPR1 zinc-finger domain
140	ZRANB2	interactor	19	0.368	61.726	RRN3 (PF05327, IPR007991): RNA polymerase I specific transcription initiation factor RRN3 zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
141	ZYX	suppressor	14	0.352	31.539	DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180) LIM (PF00412, IPR001781, SM00132): LIM domain DUF2757 (PF10955, IPR020115): Protein of unknown function (DUF2757)

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