Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins AFF1 (from a repository: Sun Nov 13 16:15:09 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 32 The number (and %) of the onco-proteins 16 (50.00 %) The number (and %) of the tumor suppressors 4 (12.50 %) Total number of binary PPIs (saturation %) 125 (25.20 %) The number (and %) of affected PPIs 32 (25.60 %) The number of possible different fusions 11 PPI diameter 2 PPI radius 1 The average degree of PPI 7.062 Assortativity coefficient -0.3625 The network average Clustering coefficient 0.554 The number (and %) of a zero Clustering coefficients 6 (18.75 %) The number (and %) of a zero Betweenness Centrality 9 (28.12 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: AFF1	All fusions
Proteins found in more fusions	AFF1 (see 1 fusions); KMT2A (see 16 fusions); POLR2A (see 2 fusions); SIAH2 (see 1 fusions); AFF1/KMT2A (see 113 fusions); SIAH1 (see 1 fusions); NPM1 (see 1 fusions); CDK9 (see 2 fusions); MLLT1/KMT2A (see 19 fusions); MLLT3/KMT2A (see 19 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	AFF1	parental protein	32	0.176	593.002	AF-4 (PF05110, IPR007797): AF-4 proto-oncoprotein
2	AFF4	oncoprotein	12	0.636	13.302	AF-4 (PF05110, IPR007797): AF-4 proto-oncoprotein
3	BRD4	oncoprotein	5	0.900	0.400	Caldesmon (PF02029, IPR006018): Caldesmon Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region Stm1_N (PF09598, IPR019084): Stm1 SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain NAM-associated (PF14303, IPR029466): No apical meristem-associated C-terminal domain BET (PF17035, IPR027353): Bromodomain extra-terminal - transcription regulation BRD4_CDT (PF17105, IPR031354): C-terminal domain of bromodomain protein 4
4	CARM1	oncoprotein	2	1.000	0	K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain PRMT5 (PF05185, IPR025799): PRMT5 arginine-N-methyltransferase CBP_GIL (PF10995, IPR017745): GGDEF I-site like or GIL domain CARM1 (PF11531, IPR020989): Coactivator-associated arginine methyltransferase 1 N terminal
5	CCNT1	oncoprotein	14	0.577	16.619	Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region RP-C_C (PF11800, IPR021760): Replication protein C C-terminal region CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit MDFI (PF15316, IPR026134): MyoD family inhibitor
6	CDK9	protein found in more fusions	15	0.549	22.869	Pkinase (PF00069, IPR000719): Protein kinase domain
7	DDX6	oncoprotein	1	0	0	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
8	DOT1L	oncoprotein	7	0.667	4.833	AT_hook (PF02178, IPR017956, SM00384): AT hook motif DivIC (PF04977, IPR007060): Septum formation initiator DOT1 (PF08123, IPR013110): Histone methylation protein DOT1 ZapB (PF06005, IPR009252): Cell division protein ZapB HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper TraV (PF09676, IPR014118): Type IV conjugative transfer system lipoprotein (TraV)
9	EAF1	suppressor	8	0.893	1.000	Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator Peroxin-3 (PF04882, IPR006966): Peroxin-3 EAF (PF09816, IPR019194): RNA polymerase II transcription elongation factor
10	ELL2	interactor	9	0.806	4.250	Occludin_ELL (PF07303, IPR010844): Occludin homology domain Wbp11 (PF09429, IPR019007): WW domain binding protein 11 ELL (PF10390, IPR019464): RNA polymerase II elongation factor ELL
11	ELL3	interactor	6	0.933	0.250	Occludin_ELL (PF07303, IPR010844): Occludin homology domain ELL (PF10390, IPR019464): RNA polymerase II elongation factor ELL TEX19 (PF15553, IPR029093): Testis-expressed protein 19
12	HDAC1	suppressor	8	0.524	6.567	FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
13	HEXIM1	oncoprotein	8	0.607	6.300	APG6 (PF04111, IPR007243): Autophagy protein Apg6 DivIC (PF04977, IPR007060): Septum formation initiator Shugoshin_N (PF07558, IPR011516): Shugoshin N-terminal coiled-coil region HEXIM (PF15313, IPR024872): Hexamethylene bis-acetamide-inducible protein
14	HIST3H3	interactor	7	0.571	6.000	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
15	KMT2A	oncoprotein	11	0.600	10.233	AT_hook (PF02178, IPR017956, SM00384): AT hook motif DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) FYRC (PF05965, IPR003889, SM00542): F/Y rich C-terminus FYRN (PF05964, IPR003888, SM00541): F/Y-rich N-terminus Peptidase_S49_N (PF08496, IPR013703): Peptidase family S49 N-terminal PHD (PF00628, IPR019787, SM00249): PHD-finger Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4 SET (PF00856, IPR001214, SM00317): SET domain zf-CXXC (PF02008, IPR002857): CXXC zinc finger domain SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain zf-HC5HC2H (PF13771): PHD-like zinc-binding domain DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
16	LARP7	interactor	5	0.800	0.900	Agouti (PF05039, IPR007733, SM00792): Agouti protein DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754) La (PF05383, IPR006630, SM00715): La domain RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 (PF08777, IPR014886): RNA binding motif
17	MED26	interactor	9	0.861	1.817	Med26 (PF08711, IPR017923): TFIIS helical bundle-like domain Med26_C (PF15693, IPR031416): Mediator complex subunit 26 C-terminal Med26_M (PF15694, IPR031417): Mediator complex subunit 26 middle domain
18	MLLT1	oncoprotein	15	0.514	30.802	DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510) Peptidase_S64 (PF08192, IPR012985): Peptidase family S64 YEATS (PF03366, IPR005033): YEATS family DDRGK (PF09756, IPR019153, SM01128): DDRGK domain
19	MLLT10	oncoprotein	6	0.700	3.000	SpoIIIAH (PF12685, IPR024232): SpoIIIAH-like protein CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal PHD_2 (PF13831): PHD-finger zf-HC5HC2H_2 (PF13832): PHD-zinc-finger like domain Tnp_zf-ribbon_2 (PF13842, IPR032718): DDE_Tnp_1-like zinc-ribbon CCDC106 (PF15794, IPR031591): Coiled-coil domain-containing protein 106 DUF4718 (PF15842, IPR031695): Domain of unknown function (DUF4718) DUF4887 (PF16228, IPR032615): Domain of unknown function (DUF4887) AP3D1 (PF06375): AP-3 complex subunit delta-1
20	MLLT3	oncoprotein	12	0.652	12.002	Peptidase_S64 (PF08192, IPR012985): Peptidase family S64 YEATS (PF03366, IPR005033): YEATS family DUF3446 (PF11928, IPR021849): Domain of unknown function (DUF3446) Sox_N (PF12444, IPR022151): Sox developmental protein N terminal PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal NKAP (PF15692): NF-kappa-B-activating protein BET (PF17035, IPR027353): Bromodomain extra-terminal - transcription regulation
21	MYH7	interactor	1	0	0	IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain Myosin_tail_1 (PF01576, IPR002928): Myosin tail Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
22	NPM1	suppressor	7	0.533	6.000	Nucleoplasmin (PF03066): Nucleoplasmin SDA1 (PF05285, IPR007949): SDA1 NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
23	NSD1	oncoprotein	4	0.667	1.000	PHD (PF00628, IPR019787, SM00249): PHD-finger PWWP (PF00855, IPR000313, SM00293): PWWP domain SET (PF00856, IPR001214, SM00317): SET domain zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
24	NT5E	interactor	1	0	0	5_nucleotid_C (PF02872, IPR008334): 5'-nucleotidase, C-terminal domain Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
25	PCSK1	interactor	1	0	0	P_proprotein (PF01483, IPR002884): Proprotein convertase P-domain Peptidase_S8 (PF00082, IPR000209): Subtilase family Proho_convert (PF12177, IPR022005): Prohormone convertase enzyme Peptidase_S8_N (PF16361, IPR032304): N-terminal of Subtilase family S8_pro-domain (PF16470, IPR032815): Peptidase S8 pro-domain
26	POLR2A	protein found in more fusions	9	0.643	6.619	RNA_pol_Rpb1_1 (PF04997, IPR007080): RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_2 (PF00623, IPR000722): RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 (PF04983, IPR007066): RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 (PF05000, IPR007083): RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_5 (PF04998, IPR007081): RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_R (PF05001, IPR000684): RNA polymerase Rpb1 C-terminal repeat
27	RELA	oncoprotein	9	0.429	13.233	DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
28	SIAH1	suppressor	6	0.500	5.000	Sina (PF03145, IPR018121): Seven in absentia protein family
29	SIAH2	oncoprotein	3	1.000	0	Sina (PF03145, IPR018121): Seven in absentia protein family zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
30	SLC16A6	interactor	1	0	0	CBM_10 (PF02013, IPR002883, SM01064): Cellulose or protein binding domain MFS_1 (PF07690, IPR011701): Major Facilitator Superfamily
31	SMAD9	interactor	2	0	0	MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain
32	ZNF526	interactor	2	1.000	0	Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid) zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zinc_ribbon_10 (PF10058, IPR019273): Predicted integral membrane zinc-ribbon metal-binding protein Zn_Tnp_IS1595 (PF12760, IPR024442): Transposase zinc-ribbon domain zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger

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