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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)142
The number (and %) of the onco-proteins36 (25.35 %)
The number (and %) of the tumor suppressors9 (6.34 %)
Total number of binary PPIs (saturation %)716 (7.15 %)
The number (and %) of affected PPIs142 (19.83 %)
The number of possible different fusions18
PPI diameter2
PPI radius1
The average degree of PPI9.225
Assortativity coefficient-0.2929
The network average Clustering coefficient0.391
The number (and %) of a zero Clustering coefficients11 (7.75 %)
The number (and %) of a zero Betweenness Centrality24 (16.90 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: AES All fusions
: AI358002; AA356820; BG774193;
Proteins found in more fusions AES (see 3 fusions); GFAP (see 3 fusions); U2AF2 (see 2 fusions); MLX (see 1 fusions); FRS3 (see 1 fusions); BCL6 (see 2 fusions); TRIM26 (see 1 fusions); SRPK2 (see 1 fusions); GRB2 (see 1 fusions); MAPK14 (see 1 fusions); RBPMS (see 2 fusions); RUNX1 (see 1 fusions); SOX5 (see 1 fusions); TMCC2 (see 3 fusions); ATN1 (see 1 fusions); FOXP2 (see 2 fusions); SMAD3 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 AESparental protein1420.05215434.192TLE_N (PF03920, IPR005617): Groucho/TLE N-terminal Q-rich domain
2 ABI2suppressor160.23855.355Abi_HHR (PF07815, IPR012849): Abl-interactor HHR
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
SH3_9 (PF14604, IPR001452): Variant SH3 domain
TMEM171 (PF15471, IPR029173): Transmembrane protein family 171
ATP-synt_ab_Xtn (PF16886, IPR031686): ATPsynthase alpha/beta subunit N-term extension
3 AENinteractor100.26719.108RNase_T (PF00929, IPR013520): Exonuclease
4 ARoncoprotein60.7001.833Androgen_recep (PF02166, IPR001103): Androgen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
5 ARHGAP32oncoprotein30.6670.400PX (PF00787, IPR001683, SM00312): PX domain
RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
RPEL (PF02755, IPR004018, SM00707): RPEL repeat
SH3_9 (PF14604, IPR001452): Variant SH3 domain
6 ATN1protein found in more fusions90.28618.000Atrophin-1 (PF03154, IPR002951): Atrophin-1 family
7 ATXN1Linteractor50.5002.333AXH (PF08517, IPR013723, SM00536): Ataxin-1 and HBP1 module (AXH)
8 BAHD1interactor70.3815.214BAH (PF01426, IPR001025, SM00439): BAH domain
9 BCL6oncoprotein60.4004.800BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
DZR (PF12773, IPR025874): Double zinc ribbon
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2HE (PF16278, IPR032566): C2HE / C2H2 / C2HC zinc-binding finger
10 BHLHE40interactor60.8000.833Hairy_orange (PF07527, IPR003650): Hairy Orange
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
11 BIRC7interactor40.6670.333BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
12 BYSLinteractor120.18229.528Bystin (PF05291, IPR007955): Bystin
MEA1 (PF06910, IPR009685): Male enhanced antigen 1 (MEA1)
13 C1orf109interactor180.18369.506CK2S (PF15011, IPR029159): Casein Kinase 2 substrate
14 C1orf216interactor80.25011.593DUF4653 (PF15546, IPR027812): Domain of unknown function (DUF4653)
15 C1orf94interactor150.17650.663DUF4688 (PF15752, IPR031496): Domain of unknown function (DUF4688)
16 CALCOCO2interactor140.20534.019bZIP_1 (PF00170, IPR004827): bZIP transcription factor
CALCOCO1 (PF07888, IPR012852): Calcium binding and coiled-coil domain (CALCOCO1) like
DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
zf-C2H2_4 (PF13894): C2H2-type zinc finger
17 CAPN1interactor100Calpain_III (PF01067, IPR022682, SM00720): Calpain large subunit, domain III
Peptidase_C2 (PF00648, IPR001300, SM00230): Calpain family cysteine protease
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
18 CARD9interactor110.37816.173CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
IncA (PF04156, IPR007285): IncA protein
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
19 CCDC57interactor70.3337.071CALCOCO1 (PF07888, IPR012852): Calcium binding and coiled-coil domain (CALCOCO1) like
DASH_Hsk3 (PF08227, IPR013183): DASH complex subunit Hsk3 like
DUF1003 (PF06210, IPR010406): Protein of unknown function (DUF1003)
Fez1 (PF06818): Fez1
Cnn_1N (PF07989, IPR012943): Centrosomin N-terminal motif 1
SlyX (PF04102, IPR007236): SlyX
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
DUF3983 (PF13137, IPR025041): Protein of unknown function (DUF3983)
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
Cep57_CLD_2 (PF14197, IPR025925): Centrosome localisation domain of PPC89
TolA_bind_tri (PF16331, IPR032519): TolA binding protein trimerisation
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
20 CCNJLinteractor50.4003.686Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
21 CCNKinteractor80.39312.667Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387)
22 CFAP206interactor80.2868.521THP2 (PF09432, IPR018557): Tho complex subunit THP2
DUF3508 (PF12018, IPR021897): Domain of unknown function (DUF3508)
23 CIB3interactor21.0000EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
24 CPSF7interactor50.4004.333CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
PRIMA1 (PF16101): Proline-rich membrane anchor 1
25 CRACR2Ainteractor30.6671.000Ras (PF00071, IPR001806, SM00173): Ras family
TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
26 CRXinteractor60.3335.836TF_Otx (PF03529, IPR013851): Otx1 transcription factor
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
27 DDX6oncoprotein110.20025.676DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
28 DGCR6interactor170.17668.196DGCR6 (PF07324, IPR010849): DiGeorge syndrome critical region 6 (DGCR6) protein
29 DIP2Ainteractor21.0000AMP-binding (PF00501, IPR000873): AMP-binding enzyme
Cornifin (PF02389, IPR003302): Cornifin (SPRR) family
DMAP_binding (PF06464, IPR010506, SM01137): DMAP1-binding Domain
30 DNMT3Linteractor31.0000CEBP_ZZ (PF16366, IPR032296): Cytoplasmic polyadenylation element-binding protein ZZ domain
31 EAF1suppressor31.0000Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Peroxin-3 (PF04882, IPR006966): Peroxin-3
EAF (PF09816, IPR019194): RNA polymerase II transcription elongation factor
32 EIF4E2interactor140.20940.352IF4E (PF01652, IPR001040): Eukaryotic initiation factor 4E
33 ELAVL1oncoprotein180.162103.633RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
34 FAM124Ainteractor50.5005.000FAM124 (PF15067, IPR029380): FAM124 family
35 FAM124Binteractor120.30323.399FAM124 (PF15067, IPR029380): FAM124 family
36 FBF1interactor180.18386.079DUF737 (PF05300, IPR007964): Protein of unknown function (DUF737)
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Sacchrp_dh_NADP (PF03435, IPR005097): Saccharopine dehydrogenase NADP binding domain
Spc24 (PF08286, IPR013252): Spc24 subunit of Ndc80
Atg14 (PF10186, IPR018791): Vacuolar sorting 38 and autophagy-related subunit 14
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
YlqD (PF11068, IPR021297): YlqD protein
KfrA_N (PF11740, IPR021104): Plasmid replication region DNA-binding N-term
37 FGFR1OPoncoprotein41.0000FOP_dimer (PF09398, IPR018993): FOP N terminal dimerisation domain
38 FOXP2protein found in more fusions40.6671.000Auxin_repressed (PF05564, IPR008406): Dormancy/auxin associated protein
CDC45 (PF02724, IPR003874): CDC45-like protein
Plasmodium_Vir (PF05795, IPR008780): Plasmodium vivax Vir protein
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
Draxin (PF15550, IPR029094): Draxin
SPATA3 (PF15662, IPR026717): Spermatogenesis-associated protein 3 family
FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain
39 FRS3suppressor60.4002.883IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
40 FSD2interactor100Apolipoprotein (PF01442, IPR000074): Apolipoprotein A1/A4/E domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
REJ (PF02010, IPR002859): REJ domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
IZUMO (PF15005, IPR029389): Izumo sperm-egg fusion, Ig domain-associated
Sam68-YY (PF16568, IPR032335): Tyrosine-rich domain of Sam68
41 GFAPprotein found in more fusions110.35619.962Filament (PF00038, IPR001664): Intermediate filament protein
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
42 GFI1Boncoprotein50.5003.067zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
43 GOLGA2interactor270.108197.382ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
GOLGA2L5 (PF15070, IPR024858): Putative golgin subfamily A member 2-like protein 5
44 GORASP2interactor100.28922.884GRASP55_65 (PF04495, IPR024958): GRASP55/65 PDZ-like domain
45 GRB2oncoprotein150.26444.860SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
46 GTF2E1interactor30.6670.500DUF1980 (PF09323, IPR015402): Domain of unknown function (DUF1980)
TF_Zn_Ribbon (PF08271, IPR013137): TFIIB zinc-binding
TFIIE_alpha (PF02002, IPR024550): TFIIE alpha subunit
TFIIE-A_C (PF11521, IPR021600): C-terminal general transcription factor TFIIE alpha
47 HGH1interactor30.6670.667Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
DUF383 (PF04063, IPR007205): Domain of unknown function (DUF383)
DUF384 (PF04064, IPR007206): Domain of unknown function (DUF384)
48 HGSinteractor170.16992.812FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VHS (PF00790, IPR002014, SM00288): VHS domain
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate
PIEZO (PF15917, IPR031805): Piezo
49 HMGB1oncoprotein60.4677.000HMG_box_2 (PF09011, IPR009071): HMG-box domain
NOA36 (PF06524, IPR010531): NOA36 protein
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
50 HNF1Aoncoprotein40.6671.000HNF-1_N (PF04814, IPR006899): Hepatocyte nuclear factor 1 (HNF-1), N terminus
HNF-1A_C (PF04813, IPR006898): Hepatocyte nuclear factor 1 (HNF-1), alpha isoform C terminus
HNF-1B_C (PF04812, IPR006897): Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
51 HNRNPABinteractor30.6670.667CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain
GRP (PF07172, IPR010800): Glycine rich protein family
NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DUF2462 (PF09495, IPR019034): Protein of unknown function (DUF2462)
52 HNRNPFinteractor70.33311.233RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Spot_14 (PF07084, IPR009786): Thyroid hormone-inducible hepatic protein Spot 14
zf-RNPHF (PF08080, IPR012996): RNPHF zinc finger
53 HOMEZinteractor80.2869.008Homeobox_KN (PF05920, IPR008422): Homeobox KN domain
Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
Homez (PF11569, IPR024578): Homeodomain leucine-zipper encoding, Homez
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
PRIMA1 (PF16101): Proline-rich membrane anchor 1
54 IKZF3oncoprotein180.16266.546C1_2 (PF03107, IPR004146): C1 domain
Desulfoferrod_N (PF06397, IPR004462): Desulfoferrodoxin, N-terminal domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies)
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
zf-C2H2_7 (PF15269): Zinc-finger
55 KANK2interactor80.4298.752KN_motif (PF12075, IPR021939): KN motif
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
NAM-associated (PF14303, IPR029466): No apical meristem-associated C-terminal domain
G_path_suppress (PF15991, IPR026094): G-protein pathway suppressor
56 KIFC3oncoprotein200.211105.817Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
57 KRT13interactor80.25011.886Filament (PF00038, IPR001664): Intermediate filament protein
FliD_N (PF02465, IPR003481): Flagellar hook-associated protein 2 N-terminus
Keratin_2_head (PF16208, IPR032444): Keratin type II head
58 KRT15interactor130.30834.205Filament (PF00038, IPR001664): Intermediate filament protein
Keratin_2_head (PF16208, IPR032444): Keratin type II head
59 KRT31interactor180.15776.993Filament (PF00038, IPR001664): Intermediate filament protein
60 KRT40interactor260.108165.976Filament (PF00038, IPR001664): Intermediate filament protein
UPF0184 (PF03670, IPR022788): Uncharacterised protein family (UPF0184)
61 KRTAP10-3interactor190.34049.833Keratin_B2 (PF01500, IPR002494): Keratin, high sulfur B2 protein
Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
62 KRTAP10-7interactor150.44022.893Keratin_B2 (PF01500, IPR002494): Keratin, high sulfur B2 protein
PMG (PF05287, IPR007951): PMG protein
DUF4106 (PF13388, IPR025179): Protein of unknown function (DUF4106)
Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
63 KRTAP10-8interactor150.45126.750Keratin_B2 (PF01500, IPR002494): Keratin, high sulfur B2 protein
PMG (PF05287, IPR007951): PMG protein
Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
64 KRTAP10-9interactor130.56114.502Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
65 L3MBTL2interactor100MBT (PF02820, IPR004092, SM00561): mbt repeat
66 LDOC1oncoprotein110.33316.367DUF4939 (PF16297, IPR032549): Domain of unknown function (DUF4939)
67 LINC00526interactor50.5002.722NA
68 LMO1oncoprotein100.24416.117LIM (PF00412, IPR001781, SM00132): LIM domain
Vps39_2 (PF10367, IPR019453): Vacuolar sorting protein 39 domain 2
69 LMO2oncoprotein190.19679.132CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
LIM (PF00412, IPR001781, SM00132): LIM domain
70 LMO4interactor100.22217.067LIM (PF00412, IPR001781, SM00132): LIM domain
zf-dskA_traR (PF01258, IPR000962): Prokaryotic dksA/traR C4-type zinc finger
71 LSM2interactor30.6670.500LSM (PF01423, IPR001163): LSM domain
72 MAGOHBinteractor70.2863.648Mago_nashi (PF02792, IPR004023): Mago nashi protein
73 MAPK14oncoprotein40.6670.667Pkinase (PF00069, IPR000719): Protein kinase domain
74 MBNL1interactor30.6671.000zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
zf-CCCH_3 (PF15663): Zinc-finger containing family
75 MED31interactor40.5002.333Med31 (PF05669, IPR008831): SOH1
76 MED4interactor90.27823.133Med4 (PF10018, IPR019258): Vitamin-D-receptor interacting Mediator subunit 4
77 MFAP1interactor90.33312.478MFAP1 (PF06991, IPR009730): Microfibril-associated/Pre-mRNA processing
DUF3464 (PF11947, IPR021855): Protein of unknown function (DUF3464)
SIR4_SID (PF16991, IPR031556): Sir4 SID domain
78 MIA2suppressor30.6670.222NESP55 (PF06390, IPR009434): Neuroendocrine-specific golgi protein P55 (NESP55)
SH3_2 (PF07653, IPR011511): Variant SH3 domain
Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
79 MLXprotein found in more fusions200HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
DUF3322 (PF11795, IPR024537): Uncharacterized protein conserved in bacteria N-term (DUF3322)
80 MORF4L2interactor21.0000MRG (PF05712, IPR026541): MRG
81 MOV10interactor120.19744.850AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
82 MTUS2suppressor120.20018.793DUF496 (PF04363, IPR007458): Protein of unknown function (DUF496)
RNA_pol_Rpb1_R (PF05001, IPR000684): RNA polymerase Rpb1 C-terminal repeat
FAM184 (PF15665): Family with sequence similarity 184, A and B
83 MVPoncoprotein150.19844.935Vault (PF01505, IPR002499): Major Vault Protein repeat
DUF2543 (PF10820, IPR020251): Protein of unknown function (DUF2543)
MVP_shoulder (PF11978, IPR021870): Shoulder domain
84 MYO15Binteractor21.0000FERM_M (PF00373, IPR019748): FERM central domain
MyTH4 (PF00784, IPR000857, SM00139): MyTH4 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
SH3_9 (PF14604, IPR001452): Variant SH3 domain
BLOC1S3 (PF15753, IPR017245): Biogenesis of lysosome-related organelles complex 1 subunit 3
85 NAB2oncoprotein90.5007.719NCD1 (PF04904, IPR006988): NAB conserved region 1 (NCD1)
NCD2 (PF04905, IPR006989): NAB conserved region 2 (NCD2)
86 NCDNinteractor100Neurochondrin (PF05536, IPR008709): Neurochondrin
87 NEK6interactor70.3332.347Pkinase (PF00069, IPR000719): Protein kinase domain
88 NOTCH2NLinteractor210.276100.194EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
89 NUDT22interactor100NA
90 OLIG3interactor30.6671.000HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
91 OSGIN1suppressor50.4001.982Pyr_redox_2 (PF07992, IPR023753): Pyridine nucleotide-disulphide oxidoreductase
Pyr_redox_3 (PF13738): Pyridine nucleotide-disulphide oxidoreductase
92 PARVGinteractor21.0000CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
93 PPP1R16Ainteractor31.0000Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
94 PRKAA1suppressor180.17688.164Pkinase (PF00069, IPR000719): Protein kinase domain
AdenylateSensor (PF16579, IPR032270): Adenylate sensor of SNF1-like protein kinase
95 PRKAA2suppressor120.31826.100Pkinase (PF00069, IPR000719): Protein kinase domain
AdenylateSensor (PF16579, IPR032270): Adenylate sensor of SNF1-like protein kinase
96 PRPF31interactor170.19256.381Nop (PF01798, IPR002687): snoRNA binding domain, fibrillarin
Cytokin_check_N (PF10407, IPR018844): Cdc14 phosphatase binding protein N-terminus
Prp31_C (PF09785, IPR019175): Prp31 C terminal domain
97 PRR3interactor30.6671.000zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
98 PTRH2interactor100PTH2 (PF01981, IPR002833): Peptidyl-tRNA hydrolase PTH2
99 QARSinteractor50.4004.567tRNA-synt_1c (PF00749, IPR020058): tRNA synthetases class I (E and Q), catalytic domain
tRNA-synt_1c_C (PF03950, IPR020059): tRNA synthetases class I (E and Q), anti-codon binding domain
tRNA_synt_1c_R1 (PF04558, IPR007639): Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1
tRNA_synt_1c_R2 (PF04557, IPR007638): Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2
100 RBM10interactor70.4007.667G-patch (PF01585, IPR000467, SM00443): G-patch domain
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
GSIII_N (PF12437, IPR022147): Glutamine synthetase type III N terminal
G-patch_2 (PF12656, IPR026822): DExH-box splicing factor binding site
zf-C2H2_4 (PF13894): C2H2-type zinc finger
DUF4337 (PF14235, IPR025570): Domain of unknown function (DUF4337)
FAM176 (PF14851): FAM176 family
101 RBPMSprotein found in more fusions170.20071.638RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
102 RELoncoprotein190.129106.102RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
103 RELAoncoprotein110.35624.348DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
104 RFX6interactor90.25016.571RFX_DNA_binding (PF02257, IPR003150): RFX DNA-binding domain
SapB_1 (PF05184, IPR007856): Saposin-like type B, region 1
105 RHOXF2interactor80.5247.119DUF367 (PF04034, IPR007177): Domain of unknown function (DUF367)
GRP (PF07172, IPR010800): Glycine rich protein family
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
106 RIMBP3interactor40.5000.908fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
tRNA-synt_1c (PF00749, IPR020058): tRNA synthetases class I (E and Q), catalytic domain
G-gamma (PF00631, IPR015898, SM00224): GGL domain
Alanine_zipper (PF11839, IPR021793): Alanine-zipper, major outer membrane lipoprotein
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
SH3_9 (PF14604, IPR001452): Variant SH3 domain
GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
107 RNF31interactor80.38111.833Auto_anti-p27 (PF06677, IPR009563): Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27)
IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
PUB (PF09409, IPR018997): PUB domain
TF_Zn_Ribbon (PF08271, IPR013137): TFIIB zinc-binding
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
HOIP-UBA (PF16678, IPR032065): UB-associated-like domain of HOIP or E3 ubiquitin-protein ligase
108 RUNX1oncoprotein50.5002.333Runt (PF00853, IPR013524): Runt domain
RunxI (PF08504, IPR013711): Runx inhibition domain
DUF3037 (PF11236, IPR021398): Protein of unknown function (DUF3037)
109 SCNM1interactor120.37922.544zf-SCNM1 (PF15803, IPR031622): Zinc-finger of sodium channel modifier 1
SCNM1_acidic (PF15805, IPR031625): Acidic C-terminal region of sodium channel modifier 1 SCNM1
110 SDCBPinteractor170.19181.021PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
111 SH3GL3interactor200BAR (PF03114, IPR004148, SM00721): BAR domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
112 SIX1interactor100KilA-N (PF04383, IPR018004): KilA-N domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
SIX1_SD (PF16878, IPR031701): Transcriptional regulator, SIX1, N-terminal SD domain
113 SIX3interactor21.0000Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
SIX1_SD (PF16878, IPR031701): Transcriptional regulator, SIX1, N-terminal SD domain
114 SIX6interactor21.0000Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
FAM199X (PF15814, IPR029672): Protein family FAM199X
SIX1_SD (PF16878, IPR031701): Transcriptional regulator, SIX1, N-terminal SD domain
115 SKILoncoprotein50.5001.952c-SKI_SMAD_bind (PF08782, IPR014890, SM01046): c-SKI Smad4 binding domain
DUF489 (PF04356, IPR007451): Protein of unknown function (DUF489)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family
DUF2115 (PF09888, IPR019215): Uncharacterized protein conserved in archaea (DUF2115)
116 SMAD3oncoprotein120.21839.333MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
117 SNRPCinteractor90.25020.217zf-U1 (PF06220, IPR013085, SM00451): U1 zinc finger
118 SOX5oncoprotein60.4003.186HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
SOAR (PF16533, IPR032393): STIM1 Orai1-activating region
MPS2 (PF17060, IPR031433): Monopolar spindle protein 2
119 SRPK2oncoprotein100.22222.633DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Pkinase (PF00069, IPR000719): Protein kinase domain
S-antigen (PF05756, IPR008825): S-antigen protein
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
120 STK16interactor160.23848.222Pkinase (PF00069, IPR000719): Protein kinase domain
121 STX11interactor110.28922.360KxDL (PF10241, IPR019371): Uncharacterized conserved protein
Syntaxin (PF00804, IPR006011, SM00503): Syntaxin
SNARE (PF05739, IPR000727, SM00397): SNARE domain
122 STYXL1interactor100DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain
123 TBX3oncoprotein31.0000T-box (PF00907, IPR001699, SM00425): T-box
TBX (PF12598, IPR022582): T-box transcription factor
124 TCF4suppressor210.110122.022CDC45 (PF02724, IPR003874): CDC45-like protein
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
125 TLE1interactor90.32118.333TLE_N (PF03920, IPR005617): Groucho/TLE N-terminal Q-rich domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
126 TLE3interactor200TLE_N (PF03920, IPR005617): Groucho/TLE N-terminal Q-rich domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
127 TMCC2protein found in more fusions90.28614.105Tmemb_cc2 (PF10267, IPR019394): Predicted transmembrane and coiled-coil 2 protein
MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
128 TRAF1oncoprotein130.25837.367HypA (PF01155, IPR000688): Hydrogenase/urease nickel incorporation, metallochaperone, hypA
SlyX (PF04102, IPR007236): SlyX
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
129 TRAF2interactor150.24254.708MATH (PF00917, IPR002083, SM00061): MATH domain
Sina (PF03145, IPR018121): Seven in absentia protein family
SlyX (PF04102, IPR007236): SlyX
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
130 TRIM26protein found in more fusions40.6671.000Nop14 (PF04147, IPR007276): Nop14-like family
SPRY (PF00622, IPR003877, SM00449): SPRY domain
IFT57 (PF10498, IPR019530): Intra-flagellar transport protein 57
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
131 TRIM27oncoprotein240.142119.142IncA (PF04156, IPR007285): IncA protein
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
132 TRIM41interactor90.32116.900BUD22 (PF09073, IPR015158): BUD22
Fer2 (PF00111, IPR001041): 2Fe-2S iron-sulfur cluster binding domain
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
RecR (PF02132, IPR023628): RecR protein
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
DUF3631 (PF12307, IPR022081): Protein of unknown function (DUF3631)
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
133 TSC22D4interactor100.35621.237AflR (PF08493, IPR013700): Aflatoxin regulatory protein
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
134 TSGA10interactor50.5001.238Bcr-Abl_Oligo (PF09036, IPR015123): Bcr-Abl oncoprotein oligomerisation domain
SKA1 (PF07160, IPR009829): Spindle and kinetochore-associated protein 1
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Pox_A3L (PF05288, IPR007952): Poxvirus A3L Protein
DUF4201 (PF13870, IPR025254): Domain of unknown function (DUF4201)
PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
135 TSSK3interactor50.4001.214Pkinase (PF00069, IPR000719): Protein kinase domain
136 U2AF2protein found in more fusions110.24429.167RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Transformer (PF06495, IPR010519): Fruit fly transformer protein
137 UBXN11interactor70.3338.652DivIC (PF04977, IPR007060): Septum formation initiator
SEP (PF08059, IPR012989, SM00553): SEP domain
UBX (PF00789, IPR001012, SM00166): UBX domain
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
TRPM_tetra (PF16519, IPR032415): Tetramerisation domain of TRPM
138 VPS37Binteractor50.4003.619Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein
139 VPS37Cinteractor60.4004.233Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein
140 ZBTB24interactor100.37818.457AT_hook (PF02178, IPR017956, SM00384): AT hook motif
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zinc_ribbon_4 (PF13717): zinc-ribbon domain
141 ZGPATinteractor90.3898.791Agenet (PF05641, IPR008395, SM00743): Agenet domain
G-patch (PF01585, IPR000467, SM00443): G-patch domain
Laminin_I (PF06008, IPR009254): Laminin Domain I
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
CCDC-167 (PF15188, IPR028194): Coiled-coil domain-containing protein 167
142 ZNF576interactor21.0000Opy2 (PF09463, IPR018571): Opy2 protein
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger

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