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Visible interactions: all affected independent (normal) missing (in fusions) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins AEBP1, PRAF2 (from a repository: Thu Feb 22 07:44:40 2018)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)14
The number (and %) of the onco-proteins2 (14.29 %)
The number (and %) of the tumor suppressors3 (21.43 %)
Total number of binary PPIs (saturation %)16 (17.58 %)
The number (and %) of affected PPIs12 (75.00 %)
The number of possible different fusions3
PPI diameter2
PPI radiusinf
The average degree of PPI2.000
Assortativity coefficient-0.3286
The network average Clustering coefficient0.193
The number (and %) of a zero Clustering coefficients10 (71.43 %)
The number (and %) of a zero Betweenness Centrality12 (85.71 %)

ACTIVE INTERACTORS
MISSING INTERACTORS (in fusions)


List of the fusions

PPI for parental proteins: AEBP1,PRAF2 All fusions
: CA436787;
Proteins found in more fusions GRB2 (see 1 fusions); RTN4 (see 11 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 AEBP1parental protein100GAGA_bind (PF06217, IPR010409): GAGA binding protein-like family
Peptidase_M14 (PF00246, IPR000834, SM00631): Zinc carboxypeptidase
Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
F5_F8_type_C (PF00754, IPR000421, SM00231): F5/8 type C domain
CarboxypepD_reg (PF13620): Carboxypeptidase regulatory-like domain
2 PRAF2parental protein110.036105.000PRA1 (PF03208, IPR004895): PRA1 family protein
3 DLK1suppressor100EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_2 (PF07974, IPR013111): EGF-like domain
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
4 FAM63Binteractor100DUF544 (PF04424, IPR007518): Protein of unknown function (DUF544)
Herpes_DNAp_acc (PF04929, IPR007013): Herpes DNA replication accessory factor
CCDC50_N (PF15295, IPR029311): Coiled-coil domain-containing protein 50 N-terminus
5 GRB2oncoprotein200SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
6 HMOX2interactor30.6671.000Heme_oxygenase (PF01126, IPR016053): Heme oxygenase
7 LPAR1oncoprotein1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
8 RP2interactor100NDK (PF00334, IPR001564, SM00562): Nucleoside diphosphate kinase
TBCC (PF07986, IPR012945): Tubulin binding cofactor C
9 RTN4suppressor200CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
Reticulon (PF02453, IPR003388): Reticulon
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
10 TCTN2interactor21.0000DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
11 TCTN3interactor21.0000DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
12 TNFRSF10Bsuppressor100Death (PF00531, IPR000488, SM00005): Death domain
RskA (PF10099, IPR018764): Anti-sigma-K factor rskA
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
13 TSPAN17interactor100Tetraspannin (PF00335, IPR018499): Tetraspanin family
14 TSPAN5interactor100Tetraspannin (PF00335, IPR018499): Tetraspanin family

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List of missing interactors (in fusions)

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 AEBP1parental proteinGAGA_bind (PF06217, IPR010409): GAGA binding protein-like family
Peptidase_M14 (PF00246, IPR000834, SM00631): Zinc carboxypeptidase
Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
F5_F8_type_C (PF00754, IPR000421, SM00231): F5/8 type C domain
CarboxypepD_reg (PF13620): Carboxypeptidase regulatory-like domain
CA436787
2 DLK1suppressorEGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_2 (PF07974, IPR013111): EGF-like domain
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
CA436787
3 FAM63BinteractorDUF544 (PF04424, IPR007518): Protein of unknown function (DUF544)
Herpes_DNAp_acc (PF04929, IPR007013): Herpes DNA replication accessory factor
CCDC50_N (PF15295, IPR029311): Coiled-coil domain-containing protein 50 N-terminus
CA436787
4 HMOX2interactorHeme_oxygenase (PF01126, IPR016053): Heme oxygenaseCA436787
5 LPAR1oncoprotein7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)CA436787
6 PRAF2parental proteinPRA1 (PF03208, IPR004895): PRA1 family proteinCA436787
7 RP2interactorNDK (PF00334, IPR001564, SM00562): Nucleoside diphosphate kinase
TBCC (PF07986, IPR012945): Tubulin binding cofactor C
CA436787
8 RTN4suppressorCENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
Reticulon (PF02453, IPR003388): Reticulon
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
CA436787
9 TCTN2interactorDUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)CA436787
10 TCTN3interactorDUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)CA436787
11 TNFRSF10BsuppressorDeath (PF00531, IPR000488, SM00005): Death domain
RskA (PF10099, IPR018764): Anti-sigma-K factor rskA
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
CA436787
12 TSPAN17interactorTetraspannin (PF00335, IPR018499): Tetraspanin familyCA436787
13 TSPAN5interactorTetraspannin (PF00335, IPR018499): Tetraspanin familyCA436787

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