Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins ACTG1 (from a repository: Sun Dec 4 16:32:25 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 125 The number (and %) of the onco-proteins 41 (32.80 %) The number (and %) of the tumor suppressors 19 (15.20 %) Total number of binary PPIs (saturation %) 920 (11.87 %) The number (and %) of affected PPIs 125 (13.59 %) The number of possible different fusions 30 PPI diameter 2 PPI radius 1 The average degree of PPI 13.744 Assortativity coefficient -0.1628 The network average Clustering coefficient 0.522 The number (and %) of a zero Clustering coefficients 6 (4.80 %) The number (and %) of a zero Betweenness Centrality 18 (14.40 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: ACTG1	All fusions : BF082083; CB409249; CD240358; BQ431217;
Proteins found in more fusions	HSP90AA1 (see 2 fusions); EEF1A1 (see 1 fusions); SH3GL2 (see 1 fusions); ACTG1/ACTB (see 1 fusions); APOE (see 1 fusions); HSP90AB1 (see 1 fusions); SRPK2 (see 1 fusions); GRB2 (see 1 fusions); CTBP2 (see 2 fusions); BCAP31 (see 3 fusions); MYC (see 1 fusions); SP1 (see 1 fusions); ERBB3 (see 2 fusions); CDH1 (see 3 fusions); ACTB (see 3 fusions); TOPBP1 (see 2 fusions); ACTG1 (see 4 fusions); ACTG1/MEPCE (see 1 fusions); GAN (see 1 fusions); MCM2 (see 1 fusions); CTTN (see 1 fusions); KAT5 (see 3 fusions); VCL (see 2 fusions); CFL1/EED (see 1 fusions); SHC1 (see 1 fusions); EZH2 (see 1 fusions); LRRK2 (see 1 fusions); ERRFI1 (see 1 fusions); SUZ12 (see 2 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	ACTG1	parental protein	125	0.096	8979.590	Actin (PF00022, IPR004000, SM00268): Actin
2	ACTA1	interactor	31	0.222	234.175	Actin (PF00022, IPR004000, SM00268): Actin
3	ACTB	oncoprotein	53	0.198	692.501	Actin (PF00022, IPR004000, SM00268): Actin
4	ACTBL2	interactor	13	0.321	26.275	Actin (PF00022, IPR004000, SM00268): Actin
5	ADRB2	interactor	7	0.467	2.127	7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
6	AICDA	interactor	4	0.667	0.118	APOBEC_N (PF08210, IPR013158): APOBEC-like N-terminal domain
7	ANLN	oncoprotein	14	0.923	1.140	Anillin (PF08174, IPR012966): Cell division protein anillin PH (PF00169, IPR001849, SM00233): PH domain Anillin_N (PF16018, IPR031970): Anillin N-terminus
8	APOE	protein found in more fusions	2	0	0	Apolipoprotein (PF01442, IPR000074): Apolipoprotein A1/A4/E domain TipAS (PF07739, IPR012925): TipAS antibiotic-recognition domain
9	BCAP31	protein found in more fusions	5	0.667	0.722	Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like DUF948 (PF06103, IPR009293): Bacterial protein of unknown function (DUF948)
10	BMI1	oncoprotein	12	0.382	18.399	zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
11	BRCA1	suppressor	18	0.375	46.644	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
12	BRK1	interactor	5	0.900	0.500	DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
13	CAD	oncoprotein	17	0.471	23.738	Amidohydro_1 (PF01979, IPR006680): Amidohydrolase family CPSase_L_D2 (PF02786, IPR005479): Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_D3 (PF02787, IPR005480, SM01096): Carbamoyl-phosphate synthetase large chain, oligomerisation domain CPSase_sm_chain (PF00988, IPR002474, SM01097): Carbamoyl-phosphate synthase small chain, CPSase domain GATase (PF00117, IPR017926): Glutamine amidotransferase class-I MGS (PF02142, IPR011607, SM00851): MGS-like domain OTCace (PF00185, IPR006131): Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain OTCace_N (PF02729, IPR006132): Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain ATPgrasp_Ter (PF15632, IPR011226): ATP-grasp in the biosynthetic pathway with Ter operon
14	CAP1	interactor	12	0.400	19.948	CAP_C (PF08603, IPR013912): Adenylate cyclase associated (CAP) C terminal CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
15	CAP2	interactor	7	0.600	4.167	CAP_C (PF08603, IPR013912): Adenylate cyclase associated (CAP) C terminal CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
16	CAPZA2	interactor	24	0.551	52.230	F-actin_cap_A (PF01267, IPR002189): F-actin capping protein alpha subunit
17	CCDC22	interactor	2	1.000	0	DUF812 (PF05667, IPR008530): Protein of unknown function (DUF812) HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate
18	CCDC8	interactor	18	0.419	28.939	Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal PNMA (PF14893, IPR026523): PNMA
19	CDH1	suppressor	9	0.464	7.926	Cadherin_C (PF01049, IPR000233): Cadherin cytoplasmic region Cadherin_pro (PF08758, IPR014868, SM01055): Cadherin prodomain like Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
20	CDK2	suppressor	31	0.391	99.015	Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase (PF00069, IPR000719): Protein kinase domain
21	CDKN2A	suppressor	21	0.333	74.371	Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_5 (PF13857): Ankyrin repeats (many copies)
22	CFL1	protein found in more fusions	29	0.404	120.714	Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
23	CFL2	interactor	16	0.790	8.621	Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
24	CORO1B	interactor	16	0.750	9.606	DUF1899 (PF08953, IPR015048, SM01166): Domain of unknown function (DUF1899) Trimer_CC (PF08954, IPR015049, SM01167): Trimerisation motif WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain WD40_4 (PF16300): Type of WD40 repeat
25	CORO1C	oncoprotein	20	0.642	20.152	DUF1899 (PF08953, IPR015048, SM01166): Domain of unknown function (DUF1899) WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat WD40_4 (PF16300): Type of WD40 repeat
26	COTL1	oncoprotein	5	0.800	0.206	Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
27	CTBP2	protein found in more fusions	3	1.000	0	2-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
28	CTNND1	suppressor	7	0.333	6.586	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat Ebp2 (PF05890, IPR008610): Eukaryotic rRNA processing protein EBP2 Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
29	CTTN	oncoprotein	18	0.515	40.714	FadA (PF09403, IPR018543): Adhesion protein FadA HS1_rep (PF02218, IPR003134): Repeat in HS1/Cortactin SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
30	DBN1	oncoprotein	31	0.391	133.907	Pinin_SDK_memA (PF04696, IPR006786): pinin/SDK/memA/ protein conserved region Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein CAF-1_p150 (PF11600): Chromatin assembly factor 1 complex p150 subunit, N-terminal MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
31	DISC1	interactor	5	0.400	5.400	HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper Mnd1 (PF03962, IPR005647): Mnd1 family TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein Tropomyosin (PF00261, IPR000533): Tropomyosin UVR (PF02151, IPR001943): UvrB/uvrC motif CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
32	DMAP1	interactor	11	0.745	4.791	DMAP1 (PF05499, IPR008468): DNA methyltransferase 1-associated protein 1 (DMAP1) SANT_DAMP1_like (PF16282, IPR032563): SANT/Myb-like domain of DAMP1
33	DSTN	interactor	11	0.709	3.672	Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
34	EED	suppressor	20	0.333	54.290	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
35	EEF1A1	suppressor	32	0.232	211.153	GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
36	EEF1A2	oncoprotein	6	0.467	3.452	GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
37	EHHADH	interactor	2	1.000	0	2-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH (PF00725, IPR006108): 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 3HCDH_N (PF02737, IPR006176): 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
38	EIF6	interactor	6	0.467	3.375	eIF-6 (PF01912, IPR002769, SM00654): eIF-6 family
39	EPS8L1	interactor	2	1.000	0	PTB (PF08416, IPR013625): Phosphotyrosine-binding domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain PRIMA1 (PF16101): Proline-rich membrane anchor 1 TetR_C_11 (PF16859, IPR011075): Bacterial transcriptional repressor C-terminal
40	EPS8L2	interactor	1	0	0	PTB (PF08416, IPR013625): Phosphotyrosine-binding domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
41	ERBB3	oncoprotein	12	0.491	14.280	Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
42	ERRFI1	suppressor	10	0.556	6.139	GTPase_binding (PF09027, IPR015116): GTPase binding Inhibitor_Mig-6 (PF11555, IPR021619): EGFR receptor inhibitor Mig-6
43	EZH2	suppressor	12	0.418	18.467	CDC45 (PF02724, IPR003874): CDC45-like protein TCR (PF03638, IPR005172, SM01114): Tesmin/TSO1-like CXC domain, cysteine-rich domain SET (PF00856, IPR001214, SM00317): SET domain EZH2_WD-Binding (PF11616, IPR021654): WD repeat binding protein EZH2 Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
44	FAF2	interactor	8	0.429	7.510	DUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682) UBX (PF00789, IPR001012, SM00166): UBX domain Thioredoxin_7 (PF13899): Thioredoxin-like UBA_4 (PF14555): UBA-like domain
45	FBXO25	suppressor	16	0.433	29.917	Elongin_A (PF06881, IPR010684): RNA polymerase II transcription factor SIII (Elongin) subunit A
46	FBXO6	interactor	14	0.396	20.477	FBA (PF04300, IPR007397): F-box associated region F-box-like (PF12937, IPR001810): F-box-like
47	FEZ1	interactor	3	1.000	0	FEZ (PF07763, IPR011680): FEZ-like protein DUF5102 (PF17104, IPR031355): Domain of unknown function (DUF5102)
48	FHOD1	interactor	6	0.600	2.567	Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator FH2 (PF02181, IPR015425, SM00498): Formin Homology 2 Domain
49	FLNA	suppressor	35	0.398	167.252	CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain Filamin (PF00630, IPR017868): Filamin/ABP280 repeat
50	FN1	oncoprotein	28	0.370	104.593	fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
51	GAN	protein found in more fusions	9	0.286	11.372	BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch BTB (PF00651, IPR013069, SM00225): BTB/POZ domain Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif Kelch_3 (PF13415): Galactose oxidase, central domain Kelch_5 (PF13854): Kelch motif
52	GIT2	interactor	2	0	0	ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf Sen15 (PF09631, IPR018593): Sen15 protein GIT_SHD (PF08518, IPR013724, SM00555): Spa2 homology domain (SHD) of GIT GIT1_C (PF12205, IPR022018): G protein-coupled receptor kinase-interacting protein 1 C term Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) DUF4482 (PF14818, IPR027882): Domain of unknown function (DUF4482) GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
53	GRB2	oncoprotein	29	0.354	132.648	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
54	GZMA	interactor	3	1.000	0	Trypsin (PF00089, IPR001254, SM00020): Trypsin
55	GZMK	interactor	2	1.000	0	Trypsin (PF00089, IPR001254, SM00020): Trypsin
56	HIST1H3E	interactor	11	0.436	10.252	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
57	HSP90AA1	oncoprotein	33	0.254	200.517	HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein
58	HSP90AB1	oncoprotein	31	0.294	141.420	HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein
59	HSPA5	oncoprotein	35	0.280	214.657	HSP70 (PF00012, IPR013126): Hsp70 protein
60	HSPB2	interactor	7	0.467	3.349	Crystallin (PF00525, IPR003090): Alpha crystallin A chain, N terminal HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
61	ILF3	oncoprotein	23	0.308	74.861	dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif DZF (PF07528, IPR006561, SM00572): DZF domain
62	IQGAP1	interactor	39	0.377	180.219	CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain DUF87 (PF01935, IPR002789): Domain of unknown function DUF87 IDEAL (PF08858, IPR014957, SM00914): IDEAL domain IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase RasGAP_C (PF03836, IPR000593): RasGAP C-terminus WW (PF00397, IPR001202, SM00456): WW domain
63	ITGA4	interactor	20	0.462	32.792	FG-GAP (PF01839, IPR013517): FG-GAP repeat Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
64	KAT5	suppressor	16	0.552	18.897	MOZ_SAS (PF01853, IPR002717): MOZ/SAS family Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain
65	LGR4	interactor	9	0.536	3.794	7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family) LRR_1 (PF00560, IPR001611): Leucine Rich Repeat LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_8 (PF13855, IPR001611): Leucine rich repeat
66	LIG4	interactor	6	0.400	5.536	APG17 (PF04108, IPR007240): Autophagy protein Apg17 BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain DNA_ligase_A_C (PF04679, IPR012309): ATP dependent DNA ligase C terminal region DNA_ligase_A_M (PF01068, IPR012310): ATP dependent DNA ligase domain DNA_ligase_A_N (PF04675, IPR012308): DNA ligase N terminus DNA_ligase_IV (PF11411, IPR021536): DNA ligase IV RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
67	LIMA1	suppressor	29	0.458	89.624	LIM (PF00412, IPR001781, SM00132): LIM domain ROKNT (PF08067, IPR012987): ROKNT (NUC014) domain
68	LRRK2	oncoprotein	15	0.385	26.720	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain DUF1043 (PF06295, IPR009386): Protein of unknown function (DUF1043) T2SSE (PF00437, IPR001482): Type II/IV secretion system protein Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase Pkinase (PF00069, IPR000719): Protein kinase domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) PQQ_2 (PF13360, IPR002372): PQQ-like domain LRR_8 (PF13855, IPR001611): Leucine rich repeat COR (PF16095, IPR032171): C-terminal of Roc, COR, domain
69	MAPK6	oncoprotein	8	0.429	8.079	Pkinase (PF00069, IPR000719): Protein kinase domain
70	MCM2	oncoprotein	32	0.316	167.730	AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA) MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2 MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain
71	MDK	oncoprotein	3	0.667	1.000	PTN_MK_C (PF01091, IPR020090): PTN/MK heparin-binding protein family, C-terminal domain PTN_MK_N (PF05196, IPR020089): PTN/MK heparin-binding protein family, N-terminal domain
72	MEPCE	protein found in more fusions	8	0.571	3.050	Bin3 (PF06859, IPR010675): Bicoid-interacting protein 3 (Bin3) Methyltransf_23 (PF13489): Methyltransferase domain FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 DLEU7 (PF15760, IPR031510): Leukemia-associated protein 7
73	MLH1	suppressor	9	0.417	14.217	DNA_mis_repair (PF01119, IPR013507): DNA mismatch repair protein, C-terminal domain HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Mlh1_C (PF16413, IPR032189): DNA mismatch repair protein Mlh1 C-terminus
74	MORF4L1	interactor	11	0.822	2.037	MRG (PF05712, IPR026541): MRG Fmp27_WPPW (PF10359, IPR019449): RNA pol II promoter Fmp27 protein domain Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain
75	MORF4L2	interactor	10	0.822	2.037	MRG (PF05712, IPR026541): MRG
76	MRGBP	interactor	9	0.917	0.567	Eaf7 (PF07904, IPR012423): Chromatin modification-related protein EAF7
77	MYC	oncoprotein	19	0.405	45.068	HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain Myc_N (PF01056, IPR012682): Myc amino-terminal region
78	MYH9	suppressor	41	0.363	231.455	IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain Myosin_tail_1 (PF01576, IPR002928): Myosin tail Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
79	MYO18A	interactor	23	0.644	32.847	Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1 IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif Myosin_tail_1 (PF01576, IPR002928): Myosin tail PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain) BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
80	MYO19	interactor	19	0.766	8.363	IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
81	MYO1C	interactor	28	0.418	93.339	IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif Myosin_TH1 (PF06017, IPR010926): Unconventional myosin tail, actin- and lipid-binding Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
82	MYO5C	interactor	16	0.725	10.339	DIL (PF01843, IPR018444, SM01132): DIL domain DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) ERM (PF00769, IPR011259): Ezrin/radixin/moesin family IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain Pilus_CpaD (PF09476, IPR019027): Pilus biogenesis CpaD protein (pilus_cpaD) Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain) YtxH (PF12732, IPR024623): YtxH-like protein Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
83	MYOC	interactor	6	0.800	0.667	IncA (PF04156, IPR007285): IncA protein OLF (PF02191, IPR003112, SM00284): Olfactomedin-like domain
84	NCKAP1	interactor	6	0.533	4.472	Nckap1 (PF09735, IPR019137): Membrane-associated apoptosis protein
85	NDRG1	suppressor	10	0.489	15.640	Ndr (PF03096, IPR004142): Ndr family
86	PDLIM7	interactor	9	0.694	4.367	LIM (PF00412, IPR001781, SM00132): LIM domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) zinc_ribbon_10 (PF10058, IPR019273): Predicted integral membrane zinc-ribbon metal-binding protein DUF4749 (PF15936, IPR031847): Domain of unknown function (DUF4749)
87	PFN2	interactor	5	0.500	2.733	Profilin (PF00235, IPR005455, SM00392): Profilin
88	PLD1	suppressor	1	0	0	PH (PF00169, IPR001849, SM00233): PH domain PLDc (PF00614, IPR001736, SM00155): Phospholipase D Active site motif PX (PF00787, IPR001683, SM00312): PX domain PLDc_2 (PF13091, IPR025202): PLD-like domain
89	POU5F1	oncoprotein	9	0.393	9.233	Pou (PF00157, IPR000327, SM00352): Pou domain - N-terminal to homeobox domain Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
90	PPP1CB	interactor	27	0.538	52.856	Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
91	PPP1CC	oncoprotein	17	0.574	21.864	Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
92	PRSS23	interactor	2	1.000	0	Trypsin (PF00089, IPR001254, SM00020): Trypsin
93	PSEN2	oncoprotein	3	1.000	0	Herpes_LMP1 (PF05297, IPR007961): Herpesvirus latent membrane protein 1 (LMP1) Presenilin (PF01080, IPR001108): Presenilin
94	RAN	oncoprotein	10	0.356	13.158	Ras (PF00071, IPR001806, SM00173): Ras family
95	RBX1	oncoprotein	7	0.400	4.567	zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
96	RNF2	interactor	18	0.294	60.117	zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
97	RPS6KA5	interactor	5	0.500	1.786	Choline_kinase (PF01633): Choline/ethanolamine kinase Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
98	RPS6KB2	interactor	14	0.495	10.089	Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
99	RUVBL1	oncoprotein	24	0.352	71.101	TIP49 (PF06068, IPR010339): TIP49 C-terminus
100	RUVBL2	oncoprotein	33	0.274	194.958	TIP49 (PF06068, IPR010339): TIP49 C-terminus
101	SFN	suppressor	11	0.400	14.991	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
102	SGF29	interactor	1	0	0	DUF1325 (PF07039, IPR010750): SGF29 tudor-like domain Filament (PF00038, IPR001664): Intermediate filament protein
103	SH3GL2	oncoprotein	3	1.000	0	BAR (PF03114, IPR004148, SM00721): BAR domain SH3_2 (PF07653, IPR011511): Variant SH3 domain
104	SHC1	oncoprotein	19	0.477	30.330	PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID) SH2 (PF00017, IPR000980, SM00252): SH2 domain
105	SP1	protein found in more fusions	11	0.622	5.264	zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type Miga (PF10265, IPR019392): Mitoguardin zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
106	SRPK2	oncoprotein	8	0.381	11.033	DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387) Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator Pkinase (PF00069, IPR000719): Protein kinase domain S-antigen (PF05756, IPR008825): S-antigen protein DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
107	ST3GAL3	interactor	1	0	0	Glyco_transf_29 (PF00777, IPR001675): Glycosyltransferase family 29 (sialyltransferase)
108	SUZ12	suppressor	14	0.462	18.640	DUF2070 (PF09843, IPR019204): Predicted membrane protein (DUF2070) VEFS-Box (PF09733, IPR019135): VEFS-Box of polycomb protein
109	TMSB4X	interactor	3	0.667	0.667	Thymosin (PF01290, IPR001152, SM00152): Thymosin beta-4 family
110	TNIK	interactor	3	0.667	1.000	CNH (PF00780, IPR001180, SM00036): CNH domain Pkinase (PF00069, IPR000719): Protein kinase domain Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family DUF3499 (PF12005, IPR021888): Protein of unknown function (DUF3499) CNDH2_M (PF16869): PF16858 AIM3 (PF17096, IPR031370): Altered inheritance of mitochondria protein 3
111	TOPBP1	protein found in more fusions	5	0.667	0.667	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain PTCB-BRCT (PF12738, IPR001357): twin BRCT domain RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
112	TRAF2	interactor	9	0.357	12.633	MATH (PF00917, IPR002083, SM00061): MATH domain Sina (PF03145, IPR018121): Seven in absentia protein family SlyX (PF04102, IPR007236): SlyX zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
113	TRAF3IP1	interactor	8	0.500	6.254	MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
114	TSGA10	interactor	4	1.000	0	Bcr-Abl_Oligo (PF09036, IPR015123): Bcr-Abl oncoprotein oligomerisation domain SKA1 (PF07160, IPR009829): Spindle and kinetochore-associated protein 1 DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) Pox_A3L (PF05288, IPR007952): Poxvirus A3L Protein DUF4201 (PF13870, IPR025254): Domain of unknown function (DUF4201) PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
115	UBASH3B	interactor	12	0.764	3.577	His_Phos_1 (PF00300, IPR013078, SM00855): Histidine phosphatase superfamily (branch 1) UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain 2_5_RNA_ligase2 (PF13563): 2'-5' RNA ligase superfamily SH3_9 (PF14604, IPR001452): Variant SH3 domain
116	UBE2Q2	interactor	4	1.000	0	Josephin (PF02099, IPR006155): Josephin RWD (PF05773, IPR006575, SM00591): RWD domain UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme DUF2890 (PF11081, IPR021304): Protein of unknown function (DUF2890)
117	UBL4A	interactor	12	0.333	18.705	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
118	UCHL5	oncoprotein	9	0.536	6.333	Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
119	VASP	interactor	8	0.667	3.515	ASD2 (PF08687, IPR014799): Apx/Shroom domain ASD2 CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal VASP_tetra (PF08776, IPR014885): VASP tetramerisation domain WH1 (PF00568, IPR000697, SM00461): WH1 domain
120	VCL	oncoprotein	12	0.455	13.063	Vinculin (PF01044, IPR006077): Vinculin family
121	WASL	interactor	7	0.714	2.173	Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain WH1 (PF00568, IPR000697, SM00461): WH1 domain WH2 (PF02205, IPR003124, SM00246): WH2 motif RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein Caskin-Pro-rich (PF16907): Proline rich region of Caskin proteins
122	WDYHV1	interactor	3	0.667	0.333	Nt_Gln_amidase (PF09764, IPR023128): N-terminal glutamine amidase
123	WIPF1	interactor	5	0.700	1.567	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal GRP (PF07172, IPR010800): Glycine rich protein family WH2 (PF02205, IPR003124, SM00246): WH2 motif
124	YARS	interactor	8	0.679	3.593	tRNA-synt_1b (PF00579, IPR002305): tRNA synthetases class I (W and Y) tRNA_bind (PF01588, IPR002547): Putative tRNA binding domain
125	YWHAQ	interactor	23	0.356	82.903	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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