Find Fusion Network

Enter

Fusion ID: Protein names:	ACO1 SERPINA1
Level of PPIs:	or Upload text file:	Update repository

Visible interactions:

all

affected

independent (normal)

nothing (blank)

Visualization interactions

Cytoscape Web for: parental proteins SERPINA1, ACO1 (from a repository: Wed Jan 20 19:05:40 2021)

Examples	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
Layout Tree Circle Radial Force Directed Preset
Export graph PDF file SVG file SIF file XML file GraphML file

Statistics and Network structure information

Statistic of PPI	Value(s)
The number of interactors (fusion and proteins)	49
The number (and %) of the onco-proteins	13 (26.53 %)
The number (and %) of the tumor suppressors	3 (6.12 %)
Total number of binary PPIs (saturation %)	132 (11.22 %)
The number (and %) of affected PPIs	47 (35.61 %)
The number of possible different fusions	8
PPI diameter	5
PPI radius	3
The average degree of PPI	4.735
Assortativity coefficient	-0.2091
The network average Clustering coefficient	0.306
The number (and %) of a zero Clustering coefficients	19 (38.78 %)
The number (and %) of a zero Betweenness Centrality	18 (36.73 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: ACO1,SERPINA1	All fusions
Proteins found in more fusions	APP (see 4 fusions); ECHS1 (see 1 fusions); OS9 (see 2 fusions); SMAD4 (see 2 fusions); VCP (see 4 fusions); SDC2 (see 2 fusions); STRAP (see 2 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	ACO1	parental protein	17	0.103	570.763	Aconitase (PF00330, IPR001030): Aconitase family (aconitate hydratase) Aconitase_C (PF00694, IPR000573): Aconitase C-terminal domain
2	SERPINA1	parental protein	30	0.051	1118.419	Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
3	ALDH2	oncoprotein	3	0	20.709	Aldedh (PF00171, IPR015590): Aldehyde dehydrogenase family DUF1235 (PF06822, IPR009641): Protein of unknown function (DUF1235)
4	APP	protein found in more fusions	9	0.036	134.989	APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP) BUD22 (PF09073, IPR015158): BUD22 IncA (PF04156, IPR007285): IncA protein Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
5	ATP5C1	interactor	5	0.300	28.128	ATP-synt (PF00231, IPR000131): ATP synthase ACT_4 (PF13291, IPR002912): ACT domain
6	C12orf57	interactor	1	0	0	P_C10 (PF14974, IPR026317): Protein C10
7	CA8	interactor	1	0	0	Carb_anhydrase (PF00194, IPR001148, SM01057): Eukaryotic-type carbonic anhydrase
8	CANX	interactor	3	0.667	10.707	Calreticulin (PF00262, IPR001580): Calreticulin family DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510) TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit
9	CTPS1	interactor	4	1.000	0	CTP_synth_N (PF06418, IPR017456): CTP synthase N-terminus GATase (PF00117, IPR017926): Glutamine amidotransferase class-I
10	DCPS	interactor	5	0.500	20.533	DcpS (PF05652, IPR008594): Scavenger mRNA decapping enzyme (DcpS) N-terminal DcpS_C (PF11969): Scavenger mRNA decapping enzyme C-term binding
11	DDX19B	interactor	3	0	23.214	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
12	DERL1	interactor	5	0.500	20.108	DER1 (PF04511, IPR007599): Der1-like family
13	DERL2	interactor	5	0.700	2.639	DER1 (PF04511, IPR007599): Der1-like family
14	ECHS1	protein found in more fusions	6	0.200	52.141	ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
15	ELANE	interactor	1	0	0	Trypsin (PF00089, IPR001254, SM00020): Trypsin
16	ENO1	oncoprotein	4	0.500	17.800	Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
17	ERLEC1	interactor	4	0.833	1.877	PRKCSH (PF07915, IPR012913): Glucosidase II beta subunit-like protein PRKCSH_1 (PF13015, IPR009011): Glucosidase II beta subunit-like protein
18	FBXL5	interactor	2	0	0	Hemerythrin (PF01814, IPR012312): Hemerythrin HHE cation binding domain LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) F-box-like (PF12937, IPR001810): F-box-like LRR_6 (PF13516, IPR001611): Leucine Rich repeat
19	FBXO2	interactor	2	1.000	0	FBA (PF04300, IPR007397): F-box associated region F-box (PF00646, IPR001810, SM00256): F-box domain
20	FN1	oncoprotein	11	0.200	203.577	fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
21	FUBP1	oncoprotein	4	0.500	17.276	DUF1897 (PF09005, IPR015096): Domain of unknown function (DUF1897) KH_1 (PF00013, IPR004088, SM00322): KH domain CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
22	GBE1	interactor	1	0	0	Alpha-amylase (PF00128, IPR006047): Alpha amylase, catalytic domain CBM_48 (PF02922, IPR004193): Carbohydrate-binding module 48 (Isoamylase N-terminal domain) Alpha-amylase_C (PF02806, IPR006048, SM00632): Alpha amylase, C-terminal all-beta domain
23	GDPD1	interactor	1	0	0	GDPD (PF03009, IPR004129): Glycerophosphoryl diester phosphodiesterase family PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain
24	GSDMB	interactor	2	0	8.660	Gasdermin (PF04598, IPR007677): Gasdermin family
25	HIST1H2AB	interactor	1	0	0	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4 Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
26	HSPA5	oncoprotein	15	0.209	231.612	HSP70 (PF00012, IPR013126): Hsp70 protein
27	ICE2	interactor	1	0	0	NARG2_C (PF10505, IPR019535): NMDA receptor-regulated gene protein 2 C-terminus CLAMP (PF14769, IPR032727): Flagellar C1a complex subunit C1a-32
28	KLK3	interactor	3	1.000	0	Trypsin (PF00089, IPR001254, SM00020): Trypsin
29	LAMTOR5	interactor	4	0.500	21.795	LAMTOR5 (PF16672, IPR024135): Ragulator complex protein LAMTOR5
30	LGALS1	interactor	6	0.333	50.377	Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
31	MIS12	interactor	1	0	0	DUF349 (PF03993, IPR007139): Domain of Unknown Function (DUF349) Mis12 (PF05859, IPR008685): Mis12 protein
32	MOV10	interactor	8	0.214	78.264	AAA_12 (PF13087): AAA domain AAA_30 (PF13604): AAA domain
33	NTRK1	oncoprotein	16	0.181	273.662	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
34	NXF1	interactor	8	0.095	70.396	NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain LRR_8 (PF13855, IPR001611): Leucine rich repeat
35	OS9	protein found in more fusions	6	0.800	2.377	DNA_pol_phi (PF04931, IPR007015): DNA polymerase phi Nucleo_P87 (PF07267, IPR009893): Nucleopolyhedrovirus capsid protein P87 PRKCSH (PF07915, IPR012913): Glucosidase II beta subunit-like protein Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein PRKCSH_1 (PF13015, IPR009011): Glucosidase II beta subunit-like protein
36	PLK2	suppressor	2	0	8.660	Pkinase (PF00069, IPR000719): Protein kinase domain POLO_box (PF00659, IPR000959): POLO box duplicated region G_path_suppress (PF15991, IPR026094): G-protein pathway suppressor
37	PRTN3	interactor	1	0	0	Trypsin (PF00089, IPR001254, SM00020): Trypsin
38	PSMG1	interactor	4	0.667	14.270	PAC1 (PF16094, IPR016565): Proteasome assembly chaperone 4
39	RAP2A	oncoprotein	4	0	38.020	Ras (PF00071, IPR001806, SM00173): Ras family
40	RCHY1	suppressor	2	0	0	C1_2 (PF03107, IPR004146): C1 domain zf-CHY (PF05495, IPR008913): CHY zinc finger zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain Prok-RING_4 (PF14447): Prokaryotic RING finger family 4 zinc_ribbon_6 (PF14599): Zinc-ribbon
41	SDC2	protein found in more fusions	3	1.000	0	Glycophorin_A (PF01102, IPR001195): Glycophorin A Syndecan (PF01034, IPR027789): Syndecan domain DUF3275 (PF11679, IPR021693): Protein of unknown function (DUF3275)
42	SHMT2	interactor	5	0.300	28.596	SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
43	SMAD4	suppressor	3	1.000	0	MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain
44	SSR1	interactor	4	0.667	11.374	TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit
45	STRAP	protein found in more fusions	6	0.600	5.057	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
46	TXNDC17	interactor	1	0	0	DUF953 (PF06110, IPR010357): Eukaryotic protein of unknown function (DUF953) Glutaredoxin (PF00462, IPR002109): Glutaredoxin
47	VCP	protein found in more fusions	10	0.361	88.207	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2 CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain TniB (PF05621, IPR008868): Bacterial TniB protein Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
48	VKORC1	interactor	2	0	0	VKOR (PF07884, IPR012932, SM00756): Vitamin K epoxide reductase family
49	ZNF558	interactor	3	0	21.795	KRAB (PF01352, IPR001909, SM00349): KRAB box zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain

B a c k t o T o p ⇑

Find Fusion Network

Visualization interactions

Statistics and Network structure information

List of the fusions

List of active interactors