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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins ACAT2 (from a repository: Sun Nov 13 01:07:27 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)39
The number (and %) of the onco-proteins10 (25.64 %)
The number (and %) of the tumor suppressors1 (2.56 %)
Total number of binary PPIs (saturation %)110 (14.84 %)
The number (and %) of affected PPIs39 (35.45 %)
The number of possible different fusions7
PPI diameter2
PPI radius1
The average degree of PPI4.872
Assortativity coefficient-0.2328
The network average Clustering coefficient0.587
The number (and %) of a zero Clustering coefficients5 (12.82 %)
The number (and %) of a zero Betweenness Centrality18 (46.15 %)

ACTIVE INTERACTORS


List of the fusions

Proteins found in more fusions TRAPPC8 (see 1 fusions); PCBP2 (see 3 fusions); ACAT2 (see 1 fusions); PABPC1 (see 2 fusions); UBA3 (see 1 fusions); BAG3 (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 ACAT2parental protein390.0811096.133Thiolase_C (PF02803, IPR020617): Thiolase, C-terminal domain
Thiolase_N (PF00108, IPR020616): Thiolase, N-terminal domain
2 ACAT1interactor31.0000Thiolase_C (PF02803, IPR020617): Thiolase, C-terminal domain
Thiolase_N (PF00108, IPR020616): Thiolase, N-terminal domain
3 AHCYinteractor80.4299.567AdoHcyase (PF05221, IPR000043, SM00996): S-adenosyl-L-homocysteine hydrolase
AdoHcyase_NAD (PF00670, IPR015878, SM00997): S-adenosyl-L-homocysteine hydrolase, NAD binding domain
4 AKT1oncoprotein31.0000PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
5 ALDH9A1interactor100Aldedh (PF00171, IPR015590): Aldehyde dehydrogenase family
6 BAG3oncoprotein80.28612.167BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
7 FHsuppressor60.4007.000Lyase_1 (PF00206, IPR022761): Lyase
FumaraseC_C (PF10415, IPR018951): Fumarase C C-terminus
8 HADHinteractor31.00003HCDH (PF00725, IPR006108): 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
3HCDH_N (PF02737, IPR006176): 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
Pyr_redox_2 (PF07992, IPR023753): Pyridine nucleotide-disulphide oxidoreductase
9 HEXAinteractor21.0000Glyco_hydro_20 (PF00728, IPR015883): Glycosyl hydrolase family 20, catalytic domain
Glyco_hydro_20b (PF02838, IPR015882): Glycosyl hydrolase family 20, domain 2
Glycohydro_20b2 (PF14845, IPR029019): beta-acetyl hexosaminidase like
10 HMGB3interactor40.5002.667HMG_box_2 (PF09011, IPR009071): HMG-box domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
11 HSPE1interactor40.6672.000Cpn10 (PF00166, IPR020818, SM00883): Chaperonin 10 Kd subunit
12 LNX1interactor31.0000PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
13 MED20interactor100Med20 (PF08612, IPR013921): TATA-binding related factor (TRF) of subunit 20 of Mediator complex
14 MLST8interactor21.0000Hira (PF07569, IPR011494): TUP1-like enhancer of split
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
15 MOV10interactor80.28619.333AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
16 NTRK1oncoprotein170.20088.333I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
17 OLA1interactor30.6670.400Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
MMR_HSR1 (PF01926, IPR006073): 50S ribosome-binding GTPase
YchF-GTPase_C (PF06071, IPR013029): Protein of unknown function (DUF933)
18 PABPC1oncoprotein60.7001.900RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PABP (PF00658, IPR002004, SM00517): Poly-adenylate binding protein, unique domain
YflT (PF11181, IPR025889): Heat induced stress protein YflT
19 PAPSS1interactor70.4768.900APS_kinase (PF01583, IPR002891): Adenylylsulphate kinase
ATP-sulfurylase (PF01747, IPR024951): ATP-sulfurylase
DUF258 (PF03193, IPR004881): Protein of unknown function, DUF258
PUA_2 (PF14306, IPR025980): PUA-like domain
20 PCBP1oncoprotein70.5715.333Bac_chlorC (PF02043, IPR001470): Bacteriochlorophyll C binding protein
KH_2 (PF07650, IPR004044): KH domain
KH_1 (PF00013, IPR004088, SM00322): KH domain
21 PCBP2protein found in more fusions51.0000Bac_chlorC (PF02043, IPR001470): Bacteriochlorophyll C binding protein
KH_2 (PF07650, IPR004044): KH domain
KH_1 (PF00013, IPR004088, SM00322): KH domain
22 PFDN4interactor100Prefoldin_2 (PF01920, IPR002777): Prefoldin subunit
23 PIRinteractor40.6672.000Pirin (PF02678, IPR003829): Pirin
Pirin_C (PF05726, IPR008778): Pirin C-terminal cupin domain
24 PKMoncoprotein60.4007.233PK (PF00224, IPR015793): Pyruvate kinase, barrel domain
PK_C (PF02887, IPR015795): Pyruvate kinase, alpha/beta domain
25 PPP4R3Ainteractor21.0000Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
SMK-1 (PF04802, IPR006887): Component of IIS longevity pathway SMK-1
WH1 (PF00568, IPR000697, SM00461): WH1 domain
DUF4611 (PF15387, IPR027893): Domain of unknown function (DUF4611)
26 PRRC1interactor100NTPase_I-T (PF01931, IPR026533): Protein of unknown function DUF84
27 PSAT1interactor50.5002.967Aminotran_5 (PF00266, IPR000192): Aminotransferase class-V
28 SPRinteractor21.0000adh_short (PF00106, IPR002198): short chain dehydrogenase
29 SSU72interactor100Ssu72 (PF04722, IPR006811): Ssu72-like protein
30 TERF1interactor60.4004.667TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
31 TKFCinteractor21.0000Dak1 (PF02733, IPR004006): Dak1 domain
Dak2 (PF02734, IPR004007, SM01120): DAK2 domain
32 TRAPPC8protein found in more fusions31.0000TRAPPC-Trs85 (PF12739, IPR024420): ER-Golgi trafficking TRAPP I complex 85 kDa subunit
SNAP (PF14938): Soluble NSF attachment protein, SNAP
33 TTC39Cinteractor21.0000TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
Deme6 (PF10300, IPR019412): Protein of unknown function (DUF3808)
34 TUBB3interactor40.6671.167Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
35 UBA3protein found in more fusions41.0000E2_bind (PF08825, IPR014929): E2 binding domain
ThiF (PF00899, IPR000594): ThiF family
36 UBE2L3interactor60.5004.667UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
37 UBXN1interactor50.5002.667Selenoprotein_S (PF06936, IPR009703): Selenoprotein S (SelS)
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
UBX (PF00789, IPR001012, SM00166): UBX domain
38 VASPinteractor40.6670.667ASD2 (PF08687, IPR014799): Apx/Shroom domain ASD2
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
VASP_tetra (PF08776, IPR014885): VASP tetramerisation domain
WH1 (PF00568, IPR000697, SM00461): WH1 domain
39 YWHAEoncoprotein70.33312.23314-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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