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Visible interactions: all affected independent (normal) nothing (blank)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)28
The number (and %) of the onco-proteins5 (17.86 %)
The number (and %) of the tumor suppressors3 (10.71 %)
Total number of binary PPIs (saturation %)54 (14.29 %)
The number (and %) of affected PPIs28 (51.85 %)
The number of possible different fusions4
PPI diameter2
PPI radius1
The average degree of PPI3.000
Assortativity coefficient-0.4058
The network average Clustering coefficient0.429
The number (and %) of a zero Clustering coefficients12 (42.86 %)
The number (and %) of a zero Betweenness Centrality20 (71.43 %)


List of the fusions

PPI for parental proteins: ACADVL All fusions
: BI013807;
Proteins found in more fusions CDH1 (see 3 fusions); MCM2 (see 1 fusions); ACADVL (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 ACADVLparental protein280.043651.500Acyl-CoA_dh_1 (PF00441, IPR009075): Acyl-CoA dehydrogenase, C-terminal domain
Acyl-CoA_dh_M (PF02770, IPR006091): Acyl-CoA dehydrogenase, middle domain
Acyl-CoA_dh_N (PF02771, IPR013786): Acyl-CoA dehydrogenase, N-terminal domain
2 ATF2oncoprotein200bZIP_1 (PF00170, IPR004827): bZIP transcription factor
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
3 ATP5Linteractor21.0000ATP-synt_G (PF04718, IPR006808): Mitochondrial ATP synthase g subunit
4 C17orf105interactor100KIAA1430 (PF13879, IPR029488): KIAA1430 homologue
5 CCDC8interactor40.6670.500Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
6 CDH1suppressor200Cadherin_C (PF01049, IPR000233): Cadherin cytoplasmic region
Cadherin_pro (PF08758, IPR014868, SM01055): Cadherin prodomain like
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
7 CKAP5interactor60.4005.000HEAT (PF02985, IPR000357): HEAT repeat
PAS_6 (PF08348, IPR013559): YheO-like PAS domain
UME (PF08064, IPR012993, SM00802): UME (NUC010) domain
CLASP_N (PF12348, IPR024395): CLASP N terminal
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
8 COQ9interactor200COQ9 (PF08511, IPR013718): COQ9
9 CYP1A1oncoprotein30.6670.500p450 (PF00067, IPR001128): Cytochrome P450
10 DCUN1D5interactor100Cullin_binding (PF03556, IPR005176): Cullin binding
11 ECSITinteractor200ECSIT (PF06239, IPR010418): Evolutionarily conserved signalling intermediate in Toll pathway
ECSIT_C (PF14784, IPR029342): C-terminal domain of the ECSIT protein
12 EEF2Kinteractor100Alpha_kinase (PF02816, IPR004166, SM00811): Alpha-kinase family
Sel1 (PF08238, IPR006597, SM00671): Sel1 repeat
13 GPHNoncoprotein31.0000MoCF_biosynth (PF00994, IPR001453, SM00852): Probable molybdopterin binding domain
MoeA_C (PF03454, IPR005111): MoeA C-terminal region (domain IV)
MoeA_N (PF03453, IPR005110): MoeA N-terminal region (domain I and II)
Tubulin-binding (PF00418, IPR001084): Tau and MAP protein, tubulin-binding repeat
14 HIBCHinteractor30.6671.000ECH_2 (PF16113, IPR032259): Enoyl-CoA hydratase/isomerase
15 HMGCLinteractor100HMGL-like (PF00682, IPR000891): HMGL-like
16 IFI16suppressor21.0000HIN (PF02760, IPR004021): HIN-200/IF120x domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
17 INTS9interactor100Beta-Casp (PF10996, IPR022712, SM01027): Beta-Casp domain
Lactamase_B_6 (PF16661, IPR001279): Metallo-beta-lactamase superfamily domain
18 KIF2Ainteractor31.0000Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
AAA_23 (PF13476): AAA domain
CREPT (PF16566, IPR032337): Cell-cycle alteration and expression-elevated protein in tumour
19 MCM2oncoprotein60.5004.000AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
20 MRM1interactor21.0000SpoU_methylase (PF00588, IPR001537): SpoU rRNA Methylase family
SpoU_sub_bind (PF08032, IPR013123, SM00967): RNA 2'-O ribose methyltransferase substrate binding
21 MRPL58interactor30.6671.000RF-1 (PF00472, IPR000352): RF-1 domain
22 NDUFA4interactor200B12D (PF06522, IPR010530): NADH-ubiquinone reductase complex 1 MLRQ subunit
23 NTRK1oncoprotein70.4008.500I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
24 OXLD1interactor21.0000Oxidored-like (PF09791, IPR019180): Oxidoreductase-like protein, N-terminal
25 PPA2interactor21.0000Pyrophosphatase (PF00719, IPR008162): Inorganic pyrophosphatase
26 RPSAinteractor31.0000Ribosomal_S2 (PF00318, IPR001865): Ribosomal protein S2
40S_SA_C (PF16122, IPR032281): 40S ribosomal protein SA C-terminus
27 SOCS3suppressor100SH2 (PF00017, IPR000980, SM00252): SH2 domain
SOCS_box (PF07525, IPR001496): SOCS box
28 SURF1interactor100SURF1 (PF02104, IPR002994): SURF1 family

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