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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins ABCC1 (from a repository: Wed Mar 22 08:09:11 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)52
The number (and %) of the onco-proteins13 (25.00 %)
The number (and %) of the tumor suppressors6 (11.54 %)
Total number of binary PPIs (saturation %)153 (11.54 %)
The number (and %) of affected PPIs52 (33.99 %)
The number of possible different fusions12
PPI diameter2
PPI radius1
The average degree of PPI5.154
Assortativity coefficient-0.1766
The network average Clustering coefficient0.615
The number (and %) of a zero Clustering coefficients7 (13.46 %)
The number (and %) of a zero Betweenness Centrality20 (38.46 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: ABCC1 All fusions
Proteins found in more fusions CSNK2A1 (see 1 fusions); ECHS1 (see 1 fusions); ABCC1 (see 1 fusions); ATP5A1 (see 1 fusions); VCP (see 4 fusions); FKBP8 (see 1 fusions); PUF60 (see 2 fusions); PSMC5 (see 2 fusions); EEF1A1 (see 1 fusions); HNRNPL (see 2 fusions); NPM1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 ABCC1parental protein520.0652018.167ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
ABC_ATPase (PF09818, IPR019195): Predicted ATPase of the ABC class
DUF2304 (PF10066, IPR019277): Uncharacterized conserved protein (DUF2304)
DUF4131 (PF13567, IPR025405): Domain of unknown function (DUF4131)
2 ATP5A1protein found in more fusions90.5719.333ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_C (PF00306, IPR000793): ATP synthase alpha/beta chain, C terminal domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
3 ATP6V1Finteractor50.5004.667ATP-synt_F (PF01990, IPR008218): ATP synthase (F/14-kDa) subunit
4 ATP6V1Hinteractor40.8330.667V-ATPase_H_N (PF03224, IPR004908): V-ATPase subunit H
V-ATPase_H_C (PF11698, IPR011987): V-ATPase subunit H
5 AZGP1suppressor100MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
6 CANXinteractor50.6002.667Calreticulin (PF00262, IPR001580): Calreticulin family
DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit
7 CAV1suppressor60.4676.500Caveolin (PF01146, IPR001612): Caveolin
8 CLGNinteractor31.0000Calreticulin (PF00262, IPR001580): Calreticulin family
CDC45 (PF02724, IPR003874): CDC45-like protein
S-antigen (PF05756, IPR008825): S-antigen protein
DUF3742 (PF12553, IPR022213): Protein of unknown function (DUF3742)
SieB (PF14163, IPR025982): Super-infection exclusion protein B
9 CSNK2A1oncoprotein90.5368.167Pkinase (PF00069, IPR000719): Protein kinase domain
10 DBTinteractor21.00002-oxoacid_dh (PF00198, IPR001078): 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
Biotin_lipoyl (PF00364, IPR000089): Biotin-requiring enzyme
E3_binding (PF02817, IPR004167): e3 binding domain
HlyD_D23 (PF16576, IPR032317): Barrel-sandwich domain of CusB or HlyD membrane-fusion
11 ECHS1protein found in more fusions40.6671.000ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
12 EEF1A1suppressor60.8001.167GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
13 EIF3Concoprotein50.7003.000eIF-3c_N (PF05470, IPR008905): Eukaryotic translation initiation factor 3 subunit 8 N-terminus
PCI (PF01399, IPR000717, SM00088): PCI domain
14 FASNinteractor41.0000Acyl_transf_1 (PF00698, IPR014043): Acyl transferase domain
ADH_zinc_N (PF00107, IPR013149): Zinc-binding dehydrogenase
ketoacyl-synt (PF00109, IPR014030): Beta-ketoacyl synthase, N-terminal domain
Ketoacyl-synt_C (PF02801, IPR014031): Beta-ketoacyl synthase, C-terminal domain
KR (PF08659, IPR013968, SM00130): KR domain
L27 (PF02828, IPR014775, SM00569): L27 domain
Methyltransf_12 (PF08242, IPR013217): Methyltransferase domain
PP-binding (PF00550, IPR009081): Phosphopantetheine attachment site
Thioesterase (PF00975, IPR001031): Thioesterase domain
YjeF_N (PF03853, IPR004443): YjeF-related protein N-terminus
ADH_zinc_N_2 (PF13602): Zinc-binding dehydrogenase
PS-DH (PF14765, IPR020807): Polyketide synthase dehydratase
KAsynt_C_assoc (PF16197, IPR032821): Ketoacyl-synthetase C-terminal extension
15 FKBP8protein found in more fusions60.6003.667FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
16 FLOT1interactor30.6670.500CrtC (PF07143, IPR010791): CrtC N-terminal lipocalin domain
Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
Flot (PF15975, IPR031905): Flotillin
17 HNRNPLprotein found in more fusions70.6004.833RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Dscam_C (PF12355, IPR021012): Down syndrome cell adhesion molecule C terminal
RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
18 IDH3Ainteractor40.6671.167Iso_dh (PF00180, IPR024084): Isocitrate/isopropylmalate dehydrogenase
19 MCUinteractor100MCU (PF04678, IPR006769): Mitochondrial calcium uniporter
20 MRPL17interactor100Ribosomal_L17 (PF01196, IPR000456): Ribosomal protein L17
COMP (PF11598, IPR024665): Cartilage oligomeric matrix protein
21 NDUFAF3interactor21.0000DUF498 (PF04430, IPR007523): Protein of unknown function (DUF498/DUF598)
22 NDUFB9interactor30.6671.000Complex1_LYR (PF05347, IPR008011): Complex 1 protein (LYR family)
23 NFS1interactor100Aminotran_5 (PF00266, IPR000192): Aminotransferase class-V
24 NPM1suppressor100.50011.500Nucleoplasmin (PF03066): Nucleoplasmin
SDA1 (PF05285, IPR007949): SDA1
NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
25 NTRK1oncoprotein270.163250.167I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
26 PAICSinteractor31.0000AIRC (PF00731, IPR000031, SM01001): AIR carboxylase
SAICAR_synt (PF01259, IPR028923): SAICAR synthetase
27 PDCD6IPinteractor31.0000BRO1 (PF03097, IPR004328, SM01041): BRO1-like domain
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
ALIX_LYPXL_bnd (PF13949, IPR025304): ALIX V-shaped domain binding to HIV
28 PDHXinteractor21.00002-oxoacid_dh (PF00198, IPR001078): 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
Biotin_lipoyl (PF00364, IPR000089): Biotin-requiring enzyme
E3_binding (PF02817, IPR004167): e3 binding domain
29 PGRMC2suppressor30.6670.500Cyt-b5 (PF00173, IPR001199, SM01117): Cytochrome b5-like Heme/Steroid binding domain
30 PSMC5protein found in more fusions80.5716.500AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
Laminin_II (PF06009, IPR010307): Laminin Domain II
RILP (PF11461, IPR021563): Rab interacting lysosomal protein
AAA_16 (PF13191): AAA ATPase domain
31 PSMD2oncoprotein50.7001.833PC_rep (PF01851, IPR002015): Proteasome/cyclosome repeat
THAP (PF05485, IPR006612, SM00980): THAP domain
HEAT_2 (PF13646): HEAT repeats
32 PTGES3interactor50.6671.667CS (PF04969, IPR007052): CS domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
33 PUF60protein found in more fusions51.0000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Titin_Z (PF09042, IPR015129): Titin Z
TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence
34 RAVER1interactor100RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
35 RPS7interactor100Ribosomal_S7e (PF01251, IPR000554): Ribosomal protein S7e
36 SAFBsuppressor40.6672.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SAP (PF02037, IPR003034, SM00513): SAP domain
Ferlin_C (PF16165, IPR032362): Ferlin C-terminus
37 SEC63interactor30.6670.500DNA_pol_phi (PF04931, IPR007015): DNA polymerase phi
DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
Afi1 (PF07792, IPR012860): Docking domain of Afi1 for Arf3 in vesicle trafficking
Nucleo_P87 (PF07267, IPR009893): Nucleopolyhedrovirus capsid protein P87
Sec63 (PF02889, IPR004179, SM00973): Sec63 Brl domain
38 STT3Binteractor40.5003.000STT3 (PF02516, IPR003674): Oligosaccharyl transferase STT3 subunit
39 STX4oncoprotein31.0000Syntaxin (PF00804, IPR006011, SM00503): Syntaxin
SNARE (PF05739, IPR000727, SM00397): SNARE domain
DUF4006 (PF13179, IPR025065): Family of unknown function (DUF4006)
40 SURF1interactor40.6672.000SURF1 (PF02104, IPR002994): SURF1 family
41 TMCO1interactor21.0000DUF106 (PF01956, IPR002809): Integral membrane protein DUF106
42 TMEM17interactor50.4005.000Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
DUF3043 (PF11241, IPR021403): Protein of unknown function (DUF3043)
43 TMEM173interactor40.6671.000TMEM173 (PF15009, IPR029158): Transmembrane protein 173
44 TMEM33interactor31.0000UPF0121 (PF03661, IPR005344): Uncharacterised protein family (UPF0121)
45 TMOD2interactor21.0000Ribosomal_S13 (PF00416, IPR001892): Ribosomal protein S13/S18
Tropomodulin (PF03250, IPR004934): Tropomodulin
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
46 TMX2interactor100Thioredoxin (PF00085, IPR013766): Thioredoxin
47 TRAF3oncoprotein31.0000ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
S-AdoMet_synt_M (PF02772, IPR022629): S-adenosylmethionine synthetase, central domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
MPS2 (PF17060, IPR031433): Monopolar spindle protein 2
Spc29 (PF17082, IPR031392): Spindle Pole Component 29
48 UNC93B1interactor30.6671.000UNC-93 (PF05978, IPR010291): Ion channel regulatory protein UNC-93
Ndc1_Nup (PF09531, IPR019049): Nucleoporin protein Ndc1-Nup
DUF4131 (PF13567, IPR025405): Domain of unknown function (DUF4131)
49 VCPprotein found in more fusions100.41715.667AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
50 VDAC1interactor60.8001.833Porin_3 (PF01459, IPR027246): Eukaryotic porin
51 VDAC2interactor80.53611.333Porin_3 (PF01459, IPR027246): Eukaryotic porin
52 VDAC3interactor60.8002.000Porin_3 (PF01459, IPR027246): Eukaryotic porin

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