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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)94
The number (and %) of the onco-proteins30 (31.91 %)
The number (and %) of the tumor suppressors5 (5.32 %)
Total number of binary PPIs (saturation %)313 (7.16 %)
The number (and %) of affected PPIs94 (30.03 %)
The number of possible different fusions11
PPI diameter2
PPI radius1
The average degree of PPI5.957
Assortativity coefficient-0.4685
The network average Clustering coefficient0.529
The number (and %) of a zero Clustering coefficients27 (28.72 %)
The number (and %) of a zero Betweenness Centrality50 (53.19 %)

ACTIVE INTERACTORS


List of the fusions

Proteins found in more fusions APP (see 4 fusions); ACTB (see 3 fusions); TSC22D1 (see 4 fusions); APOE (see 1 fusions); NUDT21 (see 2 fusions); A2M (see 2 fusions); GRB2 (see 1 fusions); B2M (see 9 fusions); CDC37 (see 2 fusions); TGM2 (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 A2Mparental protein940.0447233.731A2M (PF00207, IPR001599): Alpha-2-macroglobulin family
A2M_comp (PF07678, IPR011626): A-macroglobulin complement component
A2M_N (PF01835, IPR002890): MG2 domain
A2M_N_2 (PF07703, IPR011625): Alpha-2-macroglobulin family N-terminal region
A2M_recep (PF07677, IPR009048): A-macroglobulin receptor
MP (PF01107, IPR028919): Viral movement protein (MP)
SVA (PF05326, IPR007990): Seminal vesicle autoantigen (SVA)
Thiol-ester_cl (PF10569, IPR019565): Alpha-macro-globulin thiol-ester bond-forming region
2 ACTBoncoprotein140.21857.667Actin (PF00022, IPR004000, SM00268): Actin
3 ADAMTS1interactor100ADAM_spacer1 (PF05986, IPR010294): ADAM-TS Spacer 1
Pep_M12B_propep (PF01562, IPR002870): Reprolysin family propeptide
Reprolysin (PF01421, IPR001590): Reprolysin (M12B) family zinc metalloprotease
TSP_1 (PF00090, IPR000884, SM00209): Thrombospondin type 1 domain
4 AMBPinteractor31.0000Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
Lipocalin (PF00061, IPR000566): Lipocalin / cytosolic fatty-acid binding protein family
5 ANXA7suppressor21.0000Annexin (PF00191, IPR018502, SM00335): Annexin
6 AP1M2interactor51.0000Adap_comp_sub (PF00928, IPR008968): Adaptor complexes medium subunit family
Clat_adaptor_s (PF01217, IPR022775): Clathrin adaptor complex small chain
7 APOEprotein found in more fusions210.35883.874Apolipoprotein (PF01442, IPR000074): Apolipoprotein A1/A4/E domain
TipAS (PF07739, IPR012925): TipAS antibiotic-recognition domain
8 APPprotein found in more fusions270.197229.217APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
9 ATP1A1interactor21.0000Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
Tetraspannin (PF00335, IPR018499): Tetraspanin family
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
10 B2Moncoprotein40.6670.667C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
11 C11orf58interactor100DUF3408 (PF11888, IPR021823): Protein of unknown function (DUF3408)
SMAP (PF15477, IPR028124): Small acidic protein family
12 CDC37protein found in more fusions260.277138.660CDC37_C (PF08564, IPR013873, SM01069): Cdc37 C terminal domain
CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain
CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding
Rho_Binding (PF08912, IPR015008): Rho Binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
13 CDC42oncoprotein50.5003.000Ras (PF00071, IPR001806, SM00173): Ras family
14 CDK11Aoncoprotein30.6670.500DDHD (PF02862, IPR004177, SM01127): DDHD domain
eIF_4EBP (PF05456, IPR008606): Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)
Pkinase (PF00069, IPR000719): Protein kinase domain
RIO1 (PF01163, IPR018934): RIO1 family
DUF4355 (PF14265, IPR025580): Domain of unknown function (DUF4355)
DHHW (PF14286, IPR025945): DHHW protein
DUF4748 (PF15932, IPR031833): Domain of unknown function (DUF4748)
15 CDK2AP2interactor21.0000CDK2AP (PF09806, IPR019187): Cyclin-dependent kinase 2-associated protein
16 CDK7oncoprotein41.0000Pkinase (PF00069, IPR000719): Protein kinase domain
17 CDKN1Aoncoprotein60.6004.333CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor
18 CFTRsuppressor50.5002.667ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Rotamase_2 (PF13145, IPR000297): PPIC-type PPIASE domain
CFTR_R (PF14396, IPR025837): Cystic fibrosis TM conductance regulator (CFTR), regulator domain
19 CPB2interactor100Peptidase_M14 (PF00246, IPR000834, SM00631): Zinc carboxypeptidase
Propep_M14 (PF02244, IPR003146): Carboxypeptidase activation peptide
20 CYP2C18interactor31.0000p450 (PF00067, IPR001128): Cytochrome P450
21 CYP2C8interactor80.8571.467p450 (PF00067, IPR001128): Cytochrome P450
22 DNAJB1suppressor90.44415.052DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
DnaJ_C (PF01556, IPR002939): DnaJ C terminal domain
23 ECSITinteractor260.340104.398ECSIT (PF06239, IPR010418): Evolutionarily conserved signalling intermediate in Toll pathway
ECSIT_C (PF14784, IPR029342): C-terminal domain of the ECSIT protein
24 EGLN2interactor2002OG-FeII_Oxy_3 (PF13640, IPR005123): 2OG-Fe(II) oxygenase superfamily
25 ELAVL3interactor60.8670.300RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
26 ENO2interactor100Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain
Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
27 EVI5Linteractor100DivIC (PF04977, IPR007060): Septum formation initiator
Nnf1 (PF03980, IPR007128): Nnf1
PAP_central (PF04928, IPR007012): Poly(A) polymerase central domain
RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
28 EXOSC1interactor70.9050.300EXOSC1 (PF10447, IPR019495): Exosome component EXOSC1/CSL4
ECR1_N (PF14382, IPR025721): Exosome complex exonuclease RRP4 N-terminal region
29 FARSAinteractor70.42910.067tRNA-synt_2d (PF01409, IPR002319): tRNA synthetases class II core domain (F)
MarR_2 (PF12802): MarR family
30 FBXL12interactor60.9330.100F-box-like (PF12937, IPR001810): F-box-like
31 FBXO6interactor100.28927.633FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
32 FBXW4oncoprotein50.9000.100WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
F-box-like (PF12937, IPR001810): F-box-like
F-box_4 (PF15966, IPR001810): F-box
33 FIS1interactor31.0000Fis1_TPR_N (PF14852, IPR028058): Fis1 N-terminal tetratricopeptide repeat
Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
34 GCDHinteractor80.7503.367Acyl-CoA_dh_1 (PF00441, IPR009075): Acyl-CoA dehydrogenase, C-terminal domain
Acyl-CoA_dh_M (PF02770, IPR006091): Acyl-CoA dehydrogenase, middle domain
Acyl-CoA_dh_N (PF02771, IPR013786): Acyl-CoA dehydrogenase, N-terminal domain
35 GDPD1interactor100GDPD (PF03009, IPR004129): Glycerophosphoryl diester phosphodiesterase family
PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain
36 GEMinteractor100Ras (PF00071, IPR001806, SM00173): Ras family
AAA_22 (PF13401, IPR003593): AAA domain
37 GRB2oncoprotein80.38112.333SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
38 H2AFXoncoprotein40.6671.667Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
39 HIPK1interactor100Pkinase (PF00069, IPR000719): Protein kinase domain
40 HMOX2interactor100Heme_oxygenase (PF01126, IPR016053): Heme oxygenase
41 HSPA5oncoprotein110.33327.333HSP70 (PF00012, IPR013126): Hsp70 protein
42 HSPB2interactor50.5002.667Crystallin (PF00525, IPR003090): Alpha crystallin A chain, N terminal
HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
43 IFIT3interactor120.8003.129TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_10 (PF13374, IPR011990): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
44 IFIT5interactor110.7279.374TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
Sec16_C (PF12931, IPR024298): Sec23-binding domain of Sec16
TPR_6 (PF13174, IPR019734): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_15 (PF13429): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
45 IGSF8oncoprotein31.0000V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
46 IL10interactor200IL10 (PF00726, IPR020443, SM00188): Interleukin 10
47 IL1Boncoprotein21.0000IL1 (PF00340, IPR000975, SM00125): Interleukin-1 / 18
IL1_propep (PF02394, IPR003502): Interleukin-1 propeptide
48 IL4interactor100IL4 (PF00727, IPR002354): Interleukin 4
49 KLK13interactor100Trypsin (PF00089, IPR001254, SM00020): Trypsin
50 KLK3interactor21.0000Trypsin (PF00089, IPR001254, SM00020): Trypsin
51 KRASoncoprotein40.6670.667Ras (PF00071, IPR001806, SM00173): Ras family
52 LCATinteractor21.0000LCAT (PF02450, IPR003386): Lecithin:cholesterol acyltransferase
53 LEPinteractor100Leptin (PF02024, IPR000065): Leptin
54 LONP1interactor90.9170.671AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
AAA_PrkA (PF08298, IPR013153, SM00763): PrkA AAA domain
LON_substr_bdg (PF02190, IPR003111, SM00464): ATP-dependent protease La (LON) substrate-binding domain
Lon_C (PF05362, IPR008269): Lon protease (S16) C-terminal proteolytic domain
RuvB_N (PF05496, IPR008824): Holliday junction DNA helicase ruvB N-terminus
AAA_23 (PF13476): AAA domain
55 LRP1interactor40.5001.100EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
SGL (PF08450, IPR013658): SMP-30/Gluconolaconase/LRE-like region
TadE (PF07811, IPR012495): TadE-like protein
Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A
Ldl_recept_b (PF00058, IPR000033, SM00135): Low-density lipoprotein receptor repeat class B
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
EGF_3 (PF12947, IPR024731): EGF domain
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
DUF5050 (PF16472, IPR032485): Domain of unknown function (DUF5050)
56 MAPK6oncoprotein200Pkinase (PF00069, IPR000719): Protein kinase domain
57 MAST1interactor240.34180.312DUF1908 (PF08926, IPR015022): Domain of unknown function (DUF1908)
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Pkinase (PF00069, IPR000719): Protein kinase domain
58 MED4interactor50.4004.400Med4 (PF10018, IPR019258): Vitamin-D-receptor interacting Mediator subunit 4
59 MGEA5oncoprotein50.8000.433NAGidase (PF07555, IPR011496): beta-N-acetylglucosaminidase
60 MLST8interactor100Hira (PF07569, IPR011494): TUP1-like enhancer of split
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
61 MMP2interactor100Peptidase_M10 (PF00413, IPR001818): Matrixin
PG_binding_1 (PF01471, IPR002477): Putative peptidoglycan binding domain
Hemopexin (PF00045, IPR018487, SM00120): Hemopexin
62 MYOCinteractor31.0000IncA (PF04156, IPR007285): IncA protein
OLF (PF02191, IPR003112, SM00284): Olfactomedin-like domain
63 NCDNinteractor100Neurochondrin (PF05536, IPR008709): Neurochondrin
64 NGFinteractor100NGF (PF00243, IPR002072, SM00140): Nerve growth factor family
65 NOS3interactor140.44931.333FAD_binding_1 (PF00667, IPR003097): FAD binding domain
Flavodoxin_1 (PF00258, IPR008254): Flavodoxin
NAD_binding_1 (PF00175, IPR001433): Oxidoreductase NAD-binding domain
NO_synthase (PF02898, IPR004030): Nitric oxide synthase, oxygenase domain
HTH_15 (PF12324, IPR024259): Helix-turn-helix domain of alkylmercury lyase
66 NUDT21protein found in more fusions200NUDIX_2 (PF13869, IPR016706): Nucleotide hydrolase
67 PAEPoncoprotein21.0000Lipocalin (PF00061, IPR000566): Lipocalin / cytosolic fatty-acid binding protein family
68 PAXIP1interactor90.55612.067BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
IPT (PF01745, IPR002648, SM00429): Isopentenyl transferase
SURF6 (PF04935, IPR007019): Surfeit locus protein 6
DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052)
CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
PTCB-BRCT (PF12738, IPR001357): twin BRCT domain
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
LIG3_BRCT (PF16759, IPR031916): DNA ligase 3 BRCT domain
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
69 PRAM1interactor60.8670.300hSH3 (PF14603, IPR029294): Helically-extended SH3 domain
70 PRDX2interactor80.8930.586AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
71 RAB3Aoncoprotein60.9330.400G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
Ras (PF00071, IPR001806, SM00173): Ras family
DUF2757 (PF10955, IPR020115): Protein of unknown function (DUF2757)
72 RAD23Aoncoprotein80.9520.100UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
73 RAP1Boncoprotein30.6671.000Ras (PF00071, IPR001806, SM00173): Ras family
74 RETNinteractor200Resistin (PF06954, IPR009714): Resistin
75 RHEBoncoprotein31.0000Ras (PF00071, IPR001806, SM00173): Ras family
76 RNF32interactor250.38873.264IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
77 RPP14interactor100RNase_P_Rpp14 (PF01900, IPR002759): Rpp14/Pop5 family
78 SEPT8interactor100IMD (PF08397, IPR013606): IRSp53/MIM homology domain
Septin (PF00735, IPR000038): Septin
DUF3987 (PF13148, IPR025048): Protein of unknown function (DUF3987)
79 SHBGoncoprotein41.0000Laminin_G_1 (PF00054, IPR001791): Laminin G domain
Laminin_G_2 (PF02210, IPR001791): Laminin G domain
80 SMN1interactor31.0000SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
81 STAMBPL1interactor50.9000.100CHDCT2 (PF08074, IPR012957): CHDCT2 (NUC038) domain
USP8_dimer (PF08969, IPR015063): USP8 dimerisation domain
JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
82 SWSAP1interactor100NACHT (PF05729): NACHT domain
83 TGIF1oncoprotein21.0000Homeobox_KN (PF05920, IPR008422): Homeobox KN domain
LRS4 (PF10422, IPR018479): Monopolin complex subunit LRS4
84 TGM2protein found in more fusions40.6670.500Transglut_C (PF00927, IPR008958): Transglutaminase family, C-terminal ig like domain
Transglut_N (PF00868, IPR001102): Transglutaminase family
Transglut_core (PF01841, IPR002931, SM00460): Transglutaminase-like superfamily
85 TK1oncoprotein50.8330.500TK (PF00265, IPR001267, SM00203): Thymidine kinase
86 TNFRSF14oncoprotein21.0000Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like
Hum_adeno_E3A (PF05393, IPR008652): Human adenovirus early E3A glycoprotein
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
87 TP63suppressor41.0000Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
88 TRAPPC5interactor100TRAPP (PF04051, IPR007194): Transport protein particle (TRAPP) component
89 TSC22D1suppressor200SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
90 TTRinteractor31.0000Transthyretin (PF00576, IPR023416, SM00095): HIUase/Transthyretin family
91 TUBA1Binteractor40.8330.667Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
92 TYRO3oncoprotein21.0000fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ig_3 (PF13927): Immunoglobulin domain
DUF4229 (PF14012, IPR025323): Protein of unknown function (DUF4229)
93 UFD1Linteractor100UFD1 (PF03152, IPR004854): Ubiquitin fusion degradation protein UFD1
94 UMPSinteractor31.0000OMPdecase (PF00215, IPR001754, SM00934): Orotidine 5'-phosphate decarboxylase / HUMPS family
Pribosyltran (PF00156, IPR000836): Phosphoribosyl transferase domain

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