Find Fusion Network

Fusion ID:
Protein names:

Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins A2M (from a repository: Thu Nov 10 14:59:26 2016)

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Force Directed
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)94
The number (and %) of the onco-proteins30 (31.91 %)
The number (and %) of the tumor suppressors5 (5.32 %)
Total number of binary PPIs (saturation %)313 (7.16 %)
The number (and %) of affected PPIs94 (30.03 %)
The number of possible different fusions11
PPI diameter2
PPI radius1
The average degree of PPI5.957
Assortativity coefficient-0.4685
The network average Clustering coefficient0.529
The number (and %) of a zero Clustering coefficients27 (28.72 %)
The number (and %) of a zero Betweenness Centrality50 (53.19 %)


List of the fusions

Proteins found in more fusions APP (see 4 fusions); ACTB (see 3 fusions); TSC22D1 (see 4 fusions); APOE (see 1 fusions); NUDT21 (see 2 fusions); A2M (see 2 fusions); GRB2 (see 1 fusions); B2M (see 9 fusions); CDC37 (see 2 fusions); TGM2 (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 A2Mparental protein940.0447233.731A2M (PF00207, IPR001599): Alpha-2-macroglobulin family
A2M_comp (PF07678, IPR011626): A-macroglobulin complement component
A2M_N (PF01835, IPR002890): MG2 domain
A2M_N_2 (PF07703, IPR011625): Alpha-2-macroglobulin family N-terminal region
A2M_recep (PF07677, IPR009048): A-macroglobulin receptor
MP (PF01107, IPR028919): Viral movement protein (MP)
SVA (PF05326, IPR007990): Seminal vesicle autoantigen (SVA)
Thiol-ester_cl (PF10569, IPR019565): Alpha-macro-globulin thiol-ester bond-forming region
2 ACTBoncoprotein140.21857.667Actin (PF00022, IPR004000, SM00268): Actin
3 ADAMTS1interactor100ADAM_spacer1 (PF05986, IPR010294): ADAM-TS Spacer 1
Pep_M12B_propep (PF01562, IPR002870): Reprolysin family propeptide
Reprolysin (PF01421, IPR001590): Reprolysin (M12B) family zinc metalloprotease
TSP_1 (PF00090, IPR000884, SM00209): Thrombospondin type 1 domain
4 AMBPinteractor31.0000Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
Lipocalin (PF00061, IPR000566): Lipocalin / cytosolic fatty-acid binding protein family
5 ANXA7suppressor21.0000Annexin (PF00191, IPR018502, SM00335): Annexin
6 AP1M2interactor51.0000Adap_comp_sub (PF00928, IPR008968): Adaptor complexes medium subunit family
Clat_adaptor_s (PF01217, IPR022775): Clathrin adaptor complex small chain
7 APOEprotein found in more fusions210.35883.874Apolipoprotein (PF01442, IPR000074): Apolipoprotein A1/A4/E domain
TipAS (PF07739, IPR012925): TipAS antibiotic-recognition domain
8 APPprotein found in more fusions270.197229.217APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
9 ATP1A1interactor21.0000Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
Tetraspannin (PF00335, IPR018499): Tetraspanin family
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
10 B2Moncoprotein40.6670.667C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
11 C11orf58interactor100DUF3408 (PF11888, IPR021823): Protein of unknown function (DUF3408)
SMAP (PF15477, IPR028124): Small acidic protein family
12 CDC37protein found in more fusions260.277138.660CDC37_C (PF08564, IPR013873, SM01069): Cdc37 C terminal domain
CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain
CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding
Rho_Binding (PF08912, IPR015008): Rho Binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
13 CDC42oncoprotein50.5003.000Ras (PF00071, IPR001806, SM00173): Ras family
14 CDK11Aoncoprotein30.6670.500DDHD (PF02862, IPR004177, SM01127): DDHD domain
eIF_4EBP (PF05456, IPR008606): Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)
Pkinase (PF00069, IPR000719): Protein kinase domain
RIO1 (PF01163, IPR018934): RIO1 family
DUF4355 (PF14265, IPR025580): Domain of unknown function (DUF4355)
DHHW (PF14286, IPR025945): DHHW protein
DUF4748 (PF15932, IPR031833): Domain of unknown function (DUF4748)
15 CDK2AP2interactor21.0000CDK2AP (PF09806, IPR019187): Cyclin-dependent kinase 2-associated protein
16 CDK7oncoprotein41.0000Pkinase (PF00069, IPR000719): Protein kinase domain
17 CDKN1Aoncoprotein60.6004.333CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor
18 CFTRsuppressor50.5002.667ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Rotamase_2 (PF13145, IPR000297): PPIC-type PPIASE domain
CFTR_R (PF14396, IPR025837): Cystic fibrosis TM conductance regulator (CFTR), regulator domain
19 CPB2interactor100Peptidase_M14 (PF00246, IPR000834, SM00631): Zinc carboxypeptidase
Propep_M14 (PF02244, IPR003146): Carboxypeptidase activation peptide
20 CYP2C18interactor31.0000p450 (PF00067, IPR001128): Cytochrome P450
21 CYP2C8interactor80.8571.467p450 (PF00067, IPR001128): Cytochrome P450
22 DNAJB1suppressor90.44415.052DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
DnaJ_C (PF01556, IPR002939): DnaJ C terminal domain
23 ECSITinteractor260.340104.398ECSIT (PF06239, IPR010418): Evolutionarily conserved signalling intermediate in Toll pathway
ECSIT_C (PF14784, IPR029342): C-terminal domain of the ECSIT protein
24 EGLN2interactor2002OG-FeII_Oxy_3 (PF13640, IPR005123): 2OG-Fe(II) oxygenase superfamily
25 ELAVL3interactor60.8670.300RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
26 ENO2interactor100Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain
Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
27 EVI5Linteractor100DivIC (PF04977, IPR007060): Septum formation initiator
Nnf1 (PF03980, IPR007128): Nnf1
PAP_central (PF04928, IPR007012): Poly(A) polymerase central domain
RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
28 EXOSC1interactor70.9050.300EXOSC1 (PF10447, IPR019495): Exosome component EXOSC1/CSL4
ECR1_N (PF14382, IPR025721): Exosome complex exonuclease RRP4 N-terminal region
29 FARSAinteractor70.42910.067tRNA-synt_2d (PF01409, IPR002319): tRNA synthetases class II core domain (F)
MarR_2 (PF12802): MarR family
30 FBXL12interactor60.9330.100F-box-like (PF12937, IPR001810): F-box-like
31 FBXO6interactor100.28927.633FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
32 FBXW4oncoprotein50.9000.100WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
F-box-like (PF12937, IPR001810): F-box-like
F-box_4 (PF15966, IPR001810): F-box
33 FIS1interactor31.0000Fis1_TPR_N (PF14852, IPR028058): Fis1 N-terminal tetratricopeptide repeat
Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
34 GCDHinteractor80.7503.367Acyl-CoA_dh_1 (PF00441, IPR009075): Acyl-CoA dehydrogenase, C-terminal domain
Acyl-CoA_dh_M (PF02770, IPR006091): Acyl-CoA dehydrogenase, middle domain
Acyl-CoA_dh_N (PF02771, IPR013786): Acyl-CoA dehydrogenase, N-terminal domain
35 GDPD1interactor100GDPD (PF03009, IPR004129): Glycerophosphoryl diester phosphodiesterase family
PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain
36 GEMinteractor100Ras (PF00071, IPR001806, SM00173): Ras family
AAA_22 (PF13401, IPR003593): AAA domain
37 GRB2oncoprotein80.38112.333SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
38 H2AFXoncoprotein40.6671.667Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
39 HIPK1interactor100Pkinase (PF00069, IPR000719): Protein kinase domain
40 HMOX2interactor100Heme_oxygenase (PF01126, IPR016053): Heme oxygenase
41 HSPA5oncoprotein110.33327.333HSP70 (PF00012, IPR013126): Hsp70 protein
42 HSPB2interactor50.5002.667Crystallin (PF00525, IPR003090): Alpha crystallin A chain, N terminal
HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
43 IFIT3interactor120.8003.129TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_10 (PF13374, IPR011990): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
44 IFIT5interactor110.7279.374TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
Sec16_C (PF12931, IPR024298): Sec23-binding domain of Sec16
TPR_6 (PF13174, IPR019734): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_15 (PF13429): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
45 IGSF8oncoprotein31.0000V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
46 IL10interactor200IL10 (PF00726, IPR020443, SM00188): Interleukin 10
47 IL1Boncoprotein21.0000IL1 (PF00340, IPR000975, SM00125): Interleukin-1 / 18
IL1_propep (PF02394, IPR003502): Interleukin-1 propeptide
48 IL4interactor100IL4 (PF00727, IPR002354): Interleukin 4
49 KLK13interactor100Trypsin (PF00089, IPR001254, SM00020): Trypsin
50 KLK3interactor21.0000Trypsin (PF00089, IPR001254, SM00020): Trypsin
51 KRASoncoprotein40.6670.667Ras (PF00071, IPR001806, SM00173): Ras family
52 LCATinteractor21.0000LCAT (PF02450, IPR003386): Lecithin:cholesterol acyltransferase
53 LEPinteractor100Leptin (PF02024, IPR000065): Leptin
54 LONP1interactor90.9170.671AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
AAA_PrkA (PF08298, IPR013153, SM00763): PrkA AAA domain
LON_substr_bdg (PF02190, IPR003111, SM00464): ATP-dependent protease La (LON) substrate-binding domain
Lon_C (PF05362, IPR008269): Lon protease (S16) C-terminal proteolytic domain
RuvB_N (PF05496, IPR008824): Holliday junction DNA helicase ruvB N-terminus
AAA_23 (PF13476): AAA domain
55 LRP1interactor40.5001.100EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
SGL (PF08450, IPR013658): SMP-30/Gluconolaconase/LRE-like region
TadE (PF07811, IPR012495): TadE-like protein
Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A
Ldl_recept_b (PF00058, IPR000033, SM00135): Low-density lipoprotein receptor repeat class B
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
EGF_3 (PF12947, IPR024731): EGF domain
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
DUF5050 (PF16472, IPR032485): Domain of unknown function (DUF5050)
56 MAPK6oncoprotein200Pkinase (PF00069, IPR000719): Protein kinase domain
57 MAST1interactor240.34180.312DUF1908 (PF08926, IPR015022): Domain of unknown function (DUF1908)
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Pkinase (PF00069, IPR000719): Protein kinase domain
58 MED4interactor50.4004.400Med4 (PF10018, IPR019258): Vitamin-D-receptor interacting Mediator subunit 4
59 MGEA5oncoprotein50.8000.433NAGidase (PF07555, IPR011496): beta-N-acetylglucosaminidase
60 MLST8interactor100Hira (PF07569, IPR011494): TUP1-like enhancer of split
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
61 MMP2interactor100Peptidase_M10 (PF00413, IPR001818): Matrixin
PG_binding_1 (PF01471, IPR002477): Putative peptidoglycan binding domain
Hemopexin (PF00045, IPR018487, SM00120): Hemopexin
62 MYOCinteractor31.0000IncA (PF04156, IPR007285): IncA protein
OLF (PF02191, IPR003112, SM00284): Olfactomedin-like domain
63 NCDNinteractor100Neurochondrin (PF05536, IPR008709): Neurochondrin
64 NGFinteractor100NGF (PF00243, IPR002072, SM00140): Nerve growth factor family
65 NOS3interactor140.44931.333FAD_binding_1 (PF00667, IPR003097): FAD binding domain
Flavodoxin_1 (PF00258, IPR008254): Flavodoxin
NAD_binding_1 (PF00175, IPR001433): Oxidoreductase NAD-binding domain
NO_synthase (PF02898, IPR004030): Nitric oxide synthase, oxygenase domain
HTH_15 (PF12324, IPR024259): Helix-turn-helix domain of alkylmercury lyase
66 NUDT21protein found in more fusions200NUDIX_2 (PF13869, IPR016706): Nucleotide hydrolase
67 PAEPoncoprotein21.0000Lipocalin (PF00061, IPR000566): Lipocalin / cytosolic fatty-acid binding protein family
68 PAXIP1interactor90.55612.067BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
IPT (PF01745, IPR002648, SM00429): Isopentenyl transferase
SURF6 (PF04935, IPR007019): Surfeit locus protein 6
DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052)
CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
PTCB-BRCT (PF12738, IPR001357): twin BRCT domain
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
LIG3_BRCT (PF16759, IPR031916): DNA ligase 3 BRCT domain
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
69 PRAM1interactor60.8670.300hSH3 (PF14603, IPR029294): Helically-extended SH3 domain
70 PRDX2interactor80.8930.586AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
71 RAB3Aoncoprotein60.9330.400G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
Ras (PF00071, IPR001806, SM00173): Ras family
DUF2757 (PF10955, IPR020115): Protein of unknown function (DUF2757)
72 RAD23Aoncoprotein80.9520.100UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
73 RAP1Boncoprotein30.6671.000Ras (PF00071, IPR001806, SM00173): Ras family
74 RETNinteractor200Resistin (PF06954, IPR009714): Resistin
75 RHEBoncoprotein31.0000Ras (PF00071, IPR001806, SM00173): Ras family
76 RNF32interactor250.38873.264IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
77 RPP14interactor100RNase_P_Rpp14 (PF01900, IPR002759): Rpp14/Pop5 family
78 SEPT8interactor100IMD (PF08397, IPR013606): IRSp53/MIM homology domain
Septin (PF00735, IPR000038): Septin
DUF3987 (PF13148, IPR025048): Protein of unknown function (DUF3987)
79 SHBGoncoprotein41.0000Laminin_G_1 (PF00054, IPR001791): Laminin G domain
Laminin_G_2 (PF02210, IPR001791): Laminin G domain
80 SMN1interactor31.0000SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
81 STAMBPL1interactor50.9000.100CHDCT2 (PF08074, IPR012957): CHDCT2 (NUC038) domain
USP8_dimer (PF08969, IPR015063): USP8 dimerisation domain
JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
82 SWSAP1interactor100NACHT (PF05729): NACHT domain
83 TGIF1oncoprotein21.0000Homeobox_KN (PF05920, IPR008422): Homeobox KN domain
LRS4 (PF10422, IPR018479): Monopolin complex subunit LRS4
84 TGM2protein found in more fusions40.6670.500Transglut_C (PF00927, IPR008958): Transglutaminase family, C-terminal ig like domain
Transglut_N (PF00868, IPR001102): Transglutaminase family
Transglut_core (PF01841, IPR002931, SM00460): Transglutaminase-like superfamily
85 TK1oncoprotein50.8330.500TK (PF00265, IPR001267, SM00203): Thymidine kinase
86 TNFRSF14oncoprotein21.0000Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like
Hum_adeno_E3A (PF05393, IPR008652): Human adenovirus early E3A glycoprotein
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
87 TP63suppressor41.0000Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
88 TRAPPC5interactor100TRAPP (PF04051, IPR007194): Transport protein particle (TRAPP) component
89 TSC22D1suppressor200SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
90 TTRinteractor31.0000Transthyretin (PF00576, IPR023416, SM00095): HIUase/Transthyretin family
91 TUBA1Binteractor40.8330.667Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
92 TYRO3oncoprotein21.0000fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ig_3 (PF13927): Immunoglobulin domain
DUF4229 (PF14012, IPR025323): Protein of unknown function (DUF4229)
93 UFD1Linteractor100UFD1 (PF03152, IPR004854): Ubiquitin fusion degradation protein UFD1
94 UMPSinteractor31.0000OMPdecase (PF00215, IPR001754, SM00934): Orotidine 5'-phosphate decarboxylase / HUMPS family
Pribosyltran (PF00156, IPR000836): Phosphoribosyl transferase domain

B a c k    t o    T o p ⇑