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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)135
The number (and %) of the onco-proteins39 (28.89 %)
The number (and %) of the tumor suppressors17 (12.59 %)
Total number of binary PPIs (saturation %)739 (8.17 %)
The number (and %) of affected PPIs139 (18.81 %)
The number of possible different fusions32
PPI diameter4
PPI radius2
The average degree of PPI9.970
Assortativity coefficient-0.2420
The network average Clustering coefficient0.477
The number (and %) of a zero Clustering coefficients8 (5.93 %)
The number (and %) of a zero Betweenness Centrality20 (14.81 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: MVP,AP1B1 All fusions
Proteins found in more fusions AP2M1 (see 4 fusions); AES (see 3 fusions); VCP (see 4 fusions); CKAP4 (see 5 fusions); EPS15 (see 1 fusions); U2AF2 (see 2 fusions); ATR (see 1 fusions); CUL3 (see 1 fusions); HSP90AB1 (see 3 fusions); LGALS3BP (see 2 fusions); KCTD9 (see 1 fusions); UBA1 (see 2 fusions); PSAP (see 6 fusions); RBPMS (see 1 fusions); VAC14 (see 1 fusions); ARF1 (see 2 fusions); MVP (see 2 fusions); NF2 (see 1 fusions); RNF111 (see 1 fusions); PRKDC (see 2 fusions); BAG3 (see 4 fusions); STAT5B (see 1 fusions); CLINT1 (see 2 fusions); EGFR (see 2 fusions); MCM2 (see 1 fusions); SKI (see 1 fusions); COPS5 (see 1 fusions); TGM2 (see 3 fusions); RPA1 (see 1 fusions); TP53 (see 3 fusions); SNW1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 MVPparental protein810.0507729.590Vault (PF01505, IPR002499): Major Vault Protein repeat
DUF2543 (PF10820, IPR020251): Protein of unknown function (DUF2543)
MVP_shoulder (PF11978, IPR021870): Shoulder domain
2 AP1B1parental protein580.1423317.326Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
Alpha_adaptinC2 (PF02883, IPR008152, SM00809): Adaptin C-terminal domain
B2-adapt-app_C (PF09066, IPR015151, SM01020): Beta2-adaptin appendage, C-terminal sub-domain
3 ABCE1interactor120.34564.252ABC_tran (PF00005, IPR003439): ABC transporter
Fer4 (PF00037, IPR001450): 4Fe-4S binding domain
RLI (PF04068, IPR007209): Possible Fer4-like domain in RNase L inhibitor, RLI
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Fer4_7 (PF12838, IPR001450): 4Fe-4S dicluster domain
AAA_29 (PF13555): P-loop containing region of AAA domain
4 ADAMTSL4interactor50.6004.562ADAM_spacer1 (PF05986, IPR010294): ADAM-TS Spacer 1
PLAC (PF08686, IPR010909, SM00022): PLAC (protease and lacunin) domain
TSP_1 (PF00090, IPR000884, SM00209): Thrombospondin type 1 domain
Zn_ribbon_17 (PF17120): Zinc-ribbon, C4HC2 type
5 AESprotein found in more fusions150.19895.357TLE_N (PF03920, IPR005617): Groucho/TLE N-terminal Q-rich domain
6 AMPHoncoprotein60.60013.991BAR (PF03114, IPR004148, SM00721): BAR domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
PBP_N (PF17093, IPR031375): Penicillin-binding protein N-terminus
7 AP1G1interactor210.329222.864Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
Alpha_adaptinC2 (PF02883, IPR008152, SM00809): Adaptin C-terminal domain
8 AP1M1interactor140.374165.215Adap_comp_sub (PF00928, IPR008968): Adaptor complexes medium subunit family
Clat_adaptor_s (PF01217, IPR022775): Clathrin adaptor complex small chain
9 AP1M2interactor60.7331.241Adap_comp_sub (PF00928, IPR008968): Adaptor complexes medium subunit family
Clat_adaptor_s (PF01217, IPR022775): Clathrin adaptor complex small chain
10 AP1S1interactor90.69411.143Clat_adaptor_s (PF01217, IPR022775): Clathrin adaptor complex small chain
11 AP1S2interactor80.7506.205Clat_adaptor_s (PF01217, IPR022775): Clathrin adaptor complex small chain
12 AP2A1interactor210.443129.557Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
Alpha_adaptin_C (PF02296, IPR003164): Alpha adaptin AP2, C-terminal domain
Alpha_adaptinC2 (PF02883, IPR008152, SM00809): Adaptin C-terminal domain
HEAT_2 (PF13646): HEAT repeats
13 AP2A2interactor200.42191.337Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
Alpha_adaptin_C (PF02296, IPR003164): Alpha adaptin AP2, C-terminal domain
Alpha_adaptinC2 (PF02883, IPR008152, SM00809): Adaptin C-terminal domain
HEAT_2 (PF13646): HEAT repeats
14 AP2M1protein found in more fusions200.47494.843Adap_comp_sub (PF00928, IPR008968): Adaptor complexes medium subunit family
Clat_adaptor_s (PF01217, IPR022775): Clathrin adaptor complex small chain
15 ARF1suppressor40.6670.333Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
16 ARHGAP1interactor60.5005.593RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
CRAL_TRIO_2 (PF13716, IPR001251): Divergent CRAL/TRIO domain
17 ARRB2interactor120.51529.666Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
18 ATMsuppressor110.60053.777FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
HEAT (PF02985, IPR000357): HEAT repeat
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
TAN (PF11640, IPR021668): Telomere-length maintenance and DNA damage repair
ANAPC5 (PF12862, IPR026000): Anaphase-promoting complex subunit 5
19 ATRsuppressor120.65511.794FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
HEAT (PF02985, IPR000357): HEAT repeat
Mad3_BUB1_I (PF08311, IPR013212, SM00777): Mad3/BUB1 homology region 1
THP2 (PF09432, IPR018557): Tho complex subunit THP2
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
UME (PF08064, IPR012993, SM00802): UME (NUC010) domain
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
HEAT_EZ (PF13513): HEAT-like repeat
SgrT (PF15894, IPR031767): Inhibitor of glucose uptake transporter SgrT
20 BAG3oncoprotein70.46729.065BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
21 BANPsuppressor90.32155.412DUF1845 (PF08900, IPR014996): Domain of unknown function (DUF1845)
BEN (PF10523, IPR018379, SM01025): BEN domain
22 BARD1suppressor100.30633.881BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
zf-RING_6 (PF14835): zf-RING of BARD1-type protein
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
23 C1orf94interactor50.8330.618DUF4688 (PF15752, IPR031496): Domain of unknown function (DUF4688)
24 CABIN1interactor21.0000FAT (PF02259, IPR003151): FAT domain
MEF2_binding (PF09047, IPR015134): MEF2 binding
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
25 CALCOCO2interactor80.33337.646bZIP_1 (PF00170, IPR004827): bZIP transcription factor
CALCOCO1 (PF07888, IPR012852): Calcium binding and coiled-coil domain (CALCOCO1) like
DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
zf-C2H2_4 (PF13894): C2H2-type zinc finger
26 CAMK2Boncoprotein31.0000CaMKII_AD (PF08332, IPR013543): Calcium/calmodulin dependent protein kinase II association domain
Pkinase (PF00069, IPR000719): Protein kinase domain
27 CBSinteractor50.50012.475CBS (PF00571, IPR000644, SM00116): CBS domain
DUF1414 (PF07208, IPR009857): Protein of unknown function (DUF1414)
PALP (PF00291, IPR001926): Pyridoxal-phosphate dependent enzyme
28 CCDC183interactor100MRP-63 (PF14978, IPR016576): Mitochondrial ribosome protein 63
29 CCDC36interactor21.0000DUF4700 (PF15771, IPR031529): Domain of unknown function (DUF4700)
30 CCNL2interactor209.518Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
31 CDC5Linteractor230.381347.675OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component
Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
32 CDK2suppressor230.320271.367Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
33 CHMP4Binteractor60.50012.413Snf7 (PF03357, IPR005024): Snf7
34 CKAP4protein found in more fusions80.33360.569DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
FPP (PF05911, IPR008587): Filament-like plant protein, long coiled-coil
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
35 CLINT1protein found in more fusions170.52547.958ENTH (PF01417, IPR001026, SM00273): ENTH domain
36 CLTConcoprotein290.296781.182Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
Clathrin_propel (PF01394, IPR022365): Clathrin propeller repeat
Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS
Clathrin_H_link (PF13838): Clathrin-H-link
37 COPS5protein found in more fusions240.273328.929JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
38 CUL3protein found in more fusions290.286327.959Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
39 CYTBinteractor21.0000NA
40 DDX19Binteractor70.28647.320DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
41 DHX9oncoprotein140.60456.307DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold
T2SSE (PF00437, IPR001482): Type II/IV secretion system protein
HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2)
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
42 DIABLOsuppressor40.3337.719Smac_DIABLO (PF09057, IPR015142): Second Mitochondria-derived Activator of Caspases
43 DISC1interactor30.6674.203HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
Mnd1 (PF03962, IPR005647): Mnd1 family
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
Tropomyosin (PF00261, IPR000533): Tropomyosin
UVR (PF02151, IPR001943): UvrB/uvrC motif
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
44 DLX2interactor31.0000Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
SelK_SelG (PF10961, IPR024491): Selenoprotein SelK_SelG
DLL_N (PF12413, IPR022135): Homeobox protein distal-less-like N terminal
45 EGFRoncoprotein320.230645.507Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
46 EPHX2interactor200Abhydrolase_1 (PF00561, IPR000073): alpha/beta hydrolase fold
HAD_2 (PF13419, IPR023214): Haloacid dehalogenase-like hydrolase
47 EPN1interactor120.65226.194ENTH (PF01417, IPR001026, SM00273): ENTH domain
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
48 EPS15oncoprotein170.55067.355Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
49 ESR1suppressor210.311246.513Oest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
50 FAM46Cinteractor30.6671.131NTP_transf_7 (PF07984, IPR012937, SM01153): Nucleotidyltransferase
51 FLNBoncoprotein90.38942.982CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Filamin (PF00630, IPR017868): Filamin/ABP280 repeat
PapC_N (PF13954, IPR025885): PapC N-terminal domain
52 GIT2interactor31.0000ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf
Sen15 (PF09631, IPR018593): Sen15 protein
GIT_SHD (PF08518, IPR013724, SM00555): Spa2 homology domain (SHD) of GIT
GIT1_C (PF12205, IPR022018): G protein-coupled receptor kinase-interacting protein 1 C term
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
DUF4482 (PF14818, IPR027882): Domain of unknown function (DUF4482)
GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
53 GOLGA2interactor120.303132.124ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
GOLGA2L5 (PF15070, IPR024858): Putative golgin subfamily A member 2-like protein 5
54 GTSE1interactor150.486327.795GTSE1_N (PF15259, IPR032768): G-2 and S-phase expressed 1
55 HPinteractor30.6671.000Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
Trypsin (PF00089, IPR001254, SM00020): Trypsin
56 HSP90AB1oncoprotein240.308264.913HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
57 INTS9interactor31.0000Beta-Casp (PF10996, IPR022712, SM01027): Beta-Casp domain
Lactamase_B_6 (PF16661, IPR001279): Metallo-beta-lactamase superfamily domain
58 KCTD9protein found in more fusions70.267113.305BTB_2 (PF02214, IPR003131): BTB/POZ domain
Pentapeptide (PF00805, IPR001646): Pentapeptide repeats (8 copies)
KHA (PF11834, IPR021789): KHA, dimerisation domain of potassium ion channel
59 KIF13Ainteractor40.8330.389FHA (PF00498, IPR000253, SM00240): FHA domain
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
KIF1B (PF12423, IPR022140): Kinesin protein 1B
DUF3694 (PF12473, IPR022164): Kinesin protein
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
FAM184 (PF15665): Family with sequence similarity 184, A and B
Kinesin_assoc (PF16183, IPR032405): Kinesin-associated
60 KPNA2interactor140.396108.123Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
IBB (PF01749, IPR002652): Importin beta binding domain
Arm_3 (PF16186, IPR032413): Atypical Arm repeat
61 KPNA3interactor70.47638.289Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
IBB (PF01749, IPR002652): Importin beta binding domain
Arm_3 (PF16186, IPR032413): Atypical Arm repeat
62 KRASoncoprotein110.133131.426Ras (PF00071, IPR001806, SM00173): Ras family
63 LGALS3BPoncoprotein70.60010.893BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
SRCR (PF00530, IPR001190): Scavenger receptor cysteine-rich domain
SRCR_2 (PF15494, IPR017448): Scavenger receptor cysteine-rich domain
64 LRFN4interactor40.50055.120fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
LRRCT (PF01463, IPR000483, SM00082): Leucine rich repeat C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
65 MCM2oncoprotein240.300300.812AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
66 MDFIinteractor50.5003.502MDFI (PF15316, IPR026134): MyoD family inhibitor
67 MEOX1interactor21.0000Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
68 MEOX2interactor30.6671.000Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
69 MID2interactor70.5335.934fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
CEBP_ZZ (PF16366, IPR032296): Cytoplasmic polyadenylation element-binding protein ZZ domain
APC_u15 (PF16636): Unstructured region on APC between APC_crr regions 5 and 6
70 MKL1oncoprotein204.084RPEL (PF02755, IPR004018, SM00707): RPEL repeat
SAP (PF02037, IPR003034, SM00513): SAP domain
Troponin-I_N (PF11636, IPR021666): Troponin I residues 1-32
71 NCBP1interactor140.341131.459MIF4G (PF02854, IPR003890, SM00543): MIF4G domain
MIF4G_like (PF09088, IPR015172): MIF4G like
MIF4G_like_2 (PF09090, IPR015174): MIF4G like
SlyX (PF04102, IPR007236): SlyX
72 NECAP2interactor90.44447.587DUF1681 (PF07933, IPR012466): Protein of unknown function (DUF1681)
73 NF2suppressor90.143186.374ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
74 NNTinteractor30.3332.327AlaDh_PNT_C (PF01262, IPR007698, SM01002): Alanine dehydrogenase/PNT, C-terminal domain
AlaDh_PNT_N (PF05222, IPR007886, SM01003): Alanine dehydrogenase/PNT, N-terminal domain
PNTB (PF02233, IPR012136): NAD(P) transhydrogenase beta subunit
PNTB_4TM (PF12769, IPR024605): 4TM region of pyridine nucleotide transhydrogenase, mitoch
75 NOTCH2NLinteractor50.50084.528EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
76 NTRK1oncoprotein420.218877.421I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
77 NTRK2oncoprotein30.6676.202I-set (PF07679, IPR013098): Immunoglobulin I-set domain
LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
78 PARP4interactor50.40010.908BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
PARP (PF00644, IPR012317): Poly(ADP-ribose) polymerase catalytic domain
PARP_reg (PF02877, IPR004102): Poly(ADP-ribose) polymerase, regulatory domain
VIT (PF08487, IPR013694, SM00609): Vault protein inter-alpha-trypsin domain
VWA (PF00092, IPR002035, SM00327): von Willebrand factor type A domain
79 PIH1D2interactor40.6671.000PIH1 (PF08190, IPR012981): pre-RNA processing PIH1/Nop17
80 PLSCR1interactor50.30074.699Scramblase (PF03803, IPR005552): Scramblase
81 PNKDinteractor2020.892Lactamase_B (PF00753, IPR001279, SM00849): Metallo-beta-lactamase superfamily
HAGH_C (PF16123, IPR032282): Hydroxyacylglutathione hydrolase C-terminus
82 POT1interactor80.333130.696POT1 (PF02765, IPR011564, SM00976): Telomeric single stranded DNA binding POT1/CDC13
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
POT1PC (PF16686, IPR032042): ssDNA-binding domain of telomere protection protein
83 PPP6R3interactor80.6076.898SAPS (PF04499, IPR007587): SIT4 phosphatase-associated protein
84 PRKAB1oncoprotein31.0000AMPKBI (PF04739, IPR006828, SM01010): 5'-AMP-activated protein kinase beta subunit, interaction domain
AMPK1_CBM (PF16561, IPR032640): Glycogen recognition site of AMP-activated protein kinase
85 PRKDCprotein found in more fusions250.388202.263FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
NUC194 (PF08163, IPR012582): NUC194 domain
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
86 PSAPoncoprotein40.33326.859SapA (PF02199, IPR003119, SM00162): Saposin A-type domain
SapB_1 (PF05184, IPR007856): Saposin-like type B, region 1
SapB_2 (PF03489, IPR008138): Saposin-like type B, region 2
zf-DBF (PF07535, IPR006572, SM00586): DBF zinc finger
87 PSTPIP1interactor2082.101ABATE (PF07336, IPR010852): Putative stress-induced transcription regulator
FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain
WXG100 (PF06013, IPR010310): Proteins of 100 residues with WXG
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
88 PTENsuppressor50.60019.954DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein
89 PTPN1suppressor80.250148.869Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
90 RAB3IPinteractor21.0000Sec2p (PF06428, IPR009449): GDP/GTP exchange factor Sec2p
91 RBPMSprotein found in more fusions120.27352.306RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
92 RELoncoprotein60.20068.383RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
93 RFWD2suppressor70.33316.393Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
IncA (PF04156, IPR007285): IncA protein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
WD40_like (PF17005, IPR031544): WD40-like domain
94 RHOXF2interactor80.42913.903DUF367 (PF04034, IPR007177): Domain of unknown function (DUF367)
GRP (PF07172, IPR010800): Glycine rich protein family
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
95 RIMBP3interactor21.0000fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
tRNA-synt_1c (PF00749, IPR020058): tRNA synthetases class I (E and Q), catalytic domain
G-gamma (PF00631, IPR015898, SM00224): GGL domain
Alanine_zipper (PF11839, IPR021793): Alanine-zipper, major outer membrane lipoprotein
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
SH3_9 (PF14604, IPR001452): Variant SH3 domain
GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
96 RNF111suppressor41.0000zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
Prok-RING_1 (PF14446): Prokaryotic RING finger family 1
RNF111_N (PF15303, IPR029306): E3 ubiquitin-protein ligase Arkadia N-terminus
97 RPA1suppressor210.50081.881Rep-A_N (PF04057, IPR007199): Replication factor-A protein 1, N-terminal domain
Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
REPA_OB_2 (PF16900, IPR031657): Replication protein A OB domain
98 RPA2oncoprotein190.415166.593RPA_C (PF08784, IPR014892): Replication protein A C terminal
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
RMI2 (PF16100, IPR032245): RecQ-mediated genome instability protein 2
99 RPA3interactor150.64816.572Rep_fac-A_3 (PF08661, IPR013970): Replication factor A protein 3
100 SAXO1interactor21.0000STOP (PF05217, IPR024963): STOP protein
DUF4572 (PF15139, IPR027905): Domain of unknown function (DUF4572)
101 SERTAD1interactor40.5004.444CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
SERTA (PF06031, IPR009263): SERTA motif
102 SHBGoncoprotein40.33351.665Laminin_G_1 (PF00054, IPR001791): Laminin G domain
Laminin_G_2 (PF02210, IPR001791): Laminin G domain
103 SIRT7interactor160.325234.441DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563)
SIR2 (PF02146, IPR003000): Sir2 family
104 SKIoncoprotein90.60727.491c-SKI_SMAD_bind (PF08782, IPR014890, SM01046): c-SKI Smad4 binding domain
Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family
SlyX (PF04102, IPR007236): SlyX
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
105 SKILsuppressor70.53311.271c-SKI_SMAD_bind (PF08782, IPR014890, SM01046): c-SKI Smad4 binding domain
DUF489 (PF04356, IPR007451): Protein of unknown function (DUF489)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family
DUF2115 (PF09888, IPR019215): Uncharacterized protein conserved in archaea (DUF2115)
106 SLC2A4interactor2027.162Sugar_tr (PF00083, IPR005828): Sugar (and other) transporter
107 SNAP91interactor31.0000ANTH (PF07651, IPR011417): ANTH domain
MGC-24 (PF05283, IPR007947): Multi-glycosylated core protein 24 (MGC-24), sialomucin
Mucin (PF01456, IPR000458): Mucin-like glycoprotein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
DUF3275 (PF11679, IPR021693): Protein of unknown function (DUF3275)
108 SNCAinteractor60.20059.902Synuclein (PF01387, IPR001058): Synuclein
109 SNW1protein found in more fusions240.332329.644SKIP_SNW (PF02731, IPR004015): SKIP/SNW domain
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
SIR4_SID (PF16991, IPR031556): Sir4 SID domain
110 STAT5Boncoprotein60.50038.394SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
111 STN1interactor204.084STN1_2 (PF09170, IPR015253): CST, Suppressor of cdc thirteen homolog, complex subunit STN1
RUN (PF02759, IPR004012, SM00593): RUN domain
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
Stn1 (PF10451, IPR018856): Telomere regulation protein Stn1
112 TBC1D2interactor31.0000DivIC (PF04977, IPR007060): Septum formation initiator
ZapB (PF06005, IPR009252): Cell division protein ZapB
IncA (PF04156, IPR007285): IncA protein
PH (PF00169, IPR001849, SM00233): PH domain
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain
DUF4795 (PF16043, IPR032013): Domain of unknown function (DUF4795)
113 TCF4suppressor50.30021.070CDC45 (PF02724, IPR003874): CDC45-like protein
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
114 TEP1interactor30.6670.960NACHT (PF05729): NACHT domain
TEP1_N (PF05386, IPR008850): TEP1 N-terminal domain
TROVE (PF05731, IPR008858): TROVE domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Mcl1_mid (PF12341, IPR022100): Minichromosome loss protein, Mcl1, middle region
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
DUF4062 (PF13271, IPR025139): Domain of unknown function (DUF4062)
WD40_like (PF17005, IPR031544): WD40-like domain
115 TFCP2interactor30.3337.654CP2 (PF04516, IPR007604): CP2 transcription factor
DUF2967 (PF11179, IPR021349): Protein of unknown function (DUF2967)
116 TGM2protein found in more fusions60.40015.576Transglut_C (PF00927, IPR008958): Transglutaminase family, C-terminal ig like domain
Transglut_N (PF00868, IPR001102): Transglutaminase family
Transglut_core (PF01841, IPR002931, SM00460): Transglutaminase-like superfamily
117 TMEM17interactor80.25030.225Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
DUF3043 (PF11241, IPR021403): Protein of unknown function (DUF3043)
118 TP53suppressor300.190633.445DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
119 TRAF2interactor120.164263.842MATH (PF00917, IPR002083, SM00061): MATH domain
Sina (PF03145, IPR018121): Seven in absentia protein family
SlyX (PF04102, IPR007236): SlyX
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
120 TRIM27oncoprotein80.47617.592IncA (PF04156, IPR007285): IncA protein
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
121 TRIM42interactor120.29163.788CHDCT2 (PF08074, IPR012957): CHDCT2 (NUC038) domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
122 TRIP10interactor60.40046.899Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
Lzipper-MIP1 (PF14389, IPR025757): Leucine-zipper of ternary complex factor MIP1
123 TRIP13interactor100.44485.077AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
124 TRIP6interactor60.20074.752DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
LIM (PF00412, IPR001781, SM00132): LIM domain
125 TRMT61Ainteractor21.0000GCD14 (PF08704, IPR014816): tRNA methyltransferase complex GCD14 subunit
GCD14_N (PF14801): tRNA methyltransferase complex GCD14 subunit N-term
126 TSPOAP1oncoprotein60.4006.355bZIP_1 (PF00170, IPR004827): bZIP transcription factor
CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
ZapB (PF06005, IPR009252): Cell division protein ZapB
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SlyX (PF04102, IPR007236): SlyX
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
SH3_9 (PF14604, IPR001452): Variant SH3 domain
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
127 TTC37interactor80.60713.061DUF982 (PF06169, IPR010385): Protein of unknown function (DUF982)
Sel1 (PF08238, IPR006597, SM00671): Sel1 repeat
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_3 (PF07720, IPR011716): Tetratricopeptide repeat
Vps39_1 (PF10366, IPR019452): Vacuolar sorting protein 39 domain 1
Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_6 (PF13174, IPR019734): Tetratricopeptide repeat
TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_15 (PF13429): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
Retrotran_gag_2 (PF14223): gag-polypeptide of LTR copia-type
TPR_19 (PF14559): Tetratricopeptide repeat
128 U2AF2protein found in more fusions200.415138.033RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Transformer (PF06495, IPR010519): Fruit fly transformer protein
129 UBA1protein found in more fusions150.319129.117ThiF (PF00899, IPR000594): ThiF family
E1_UFD (PF09358, IPR018965, SM00985): Ubiquitin fold domain
UBA_e1_thiolCys (PF10585, IPR019572): Ubiquitin-activating enzyme active site
130 VAC14oncoprotein60.40042.563TAF6_C (PF07571, IPR011442): TAF6 C-terminal HEAT repeat domain
HEAT (PF02985, IPR000357): HEAT repeat
Vac14_Fig4_bd (PF11916, IPR021841): Vacuolar protein 14 C-terminal Fig4p binding
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
131 VAT1interactor50.5009.473ADH_N (PF08240, IPR013154): Alcohol dehydrogenase GroES-like domain
ADH_zinc_N (PF00107, IPR013149): Zinc-binding dehydrogenase
ADH_zinc_N_2 (PF13602): Zinc-binding dehydrogenase
132 VCPprotein found in more fusions160.42959.514AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
133 XPO1interactor310.187822.184CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
134 ZBTB32interactor31.0000BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-met (PF12874): Zinc-finger of C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
135 ZMIZ2interactor31.0000zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger

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