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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins OXSR1, LOC105375153 (from a repository: Thu Aug 15 23:44:06 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)30
The number (and %) of the onco-proteins10 (33.33 %)
The number (and %) of the tumor suppressors2 (6.67 %)
Total number of binary PPIs (saturation %)83 (19.08 %)
The number (and %) of affected PPIs28 (33.73 %)
The number of possible different fusions5
PPI diameter2
PPI radiusinf
The average degree of PPI4.933
Assortativity coefficient-0.2616
The network average Clustering coefficient0.593
The number (and %) of a zero Clustering coefficients5 (16.67 %)
The number (and %) of a zero Betweenness Centrality12 (40.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: OXSR1,LOC105375153 All fusions
Proteins found in more fusions APP (see 5 fusions); EGFR (see 2 fusions); SNW1 (see 1 fusions); CDK9 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 OXSR1parental protein280.122533.967Pkinase (PF00069, IPR000719): Protein kinase domain
OSR1_C (PF12202, IPR024678): Oxidative-stress-responsive kinase 1 C terminal
DUF4423 (PF14394, IPR025537): Domain of unknown function (DUF4423)
2 LOC105375153interactor000NA
3 ACAD10interactor21.0000Acyl-CoA_dh_1 (PF00441, IPR009075): Acyl-CoA dehydrogenase, C-terminal domain
Acyl-CoA_dh_M (PF02770, IPR006091): Acyl-CoA dehydrogenase, middle domain
Acyl-CoA_dh_N (PF02771, IPR013786): Acyl-CoA dehydrogenase, N-terminal domain
APH (PF01636, IPR002575): Phosphotransferase enzyme family
HAD_2 (PF13419, IPR023214): Haloacid dehalogenase-like hydrolase
4 ADSLinteractor40.6671.333DUF1331 (PF07048, IPR009762): Protein of unknown function (DUF1331)
Lyase_1 (PF00206, IPR022761): Lyase
ADSL_C (PF10397, IPR019468, SM00998): Adenylosuccinate lyase C-terminus
HTH_Tnp_Tc5 (PF03221, IPR006600, SM00674): Tc5 transposase DNA-binding domain
DUF4089 (PF13318, IPR025148): Protein of unknown function (DUF4089)
5 AIFM1oncoprotein40.8330.667Pyr_redox_2 (PF07992, IPR023753): Pyridine nucleotide-disulphide oxidoreductase
AIF_C (PF14721, IPR029324): Apoptosis-inducing factor, mitochondrion-associated, C-term
AIF-MLS (PF14962, IPR032773): Mitochondria Localisation Sequence
6 ANP32Asuppressor31.0000SDA1 (PF05285, IPR007949): SDA1
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_9 (PF14580): Leucine-rich repeat
7 API5interactor60.8001.833API5 (PF05918, IPR008383): Apoptosis inhibitory protein 5 (API5)
8 APPprotein found in more fusions80.28614.667APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
9 BAG6interactor41.0000DUF1179 (PF06678, IPR009564): Protein of unknown function (DUF1179)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
DUF2939 (PF11159, IPR021330): Protein of unknown function (DUF2939)
DUF3538 (PF12057, IPR021925): Domain of unknown function (DUF3538)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
10 BTF3L4interactor30.6670.500NAC (PF01849, IPR002715): NAC domain
11 CDC5Linteractor80.7622.467OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component
Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
12 CDK9protein found in more fusions60.7002.000Pkinase (PF00069, IPR000719): Protein kinase domain
13 EGFRoncoprotein80.4768.667Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
14 ELAVL1oncoprotein110.42221.567RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
15 MAD2L1oncoprotein31.0000HORMA (PF02301, IPR003511): HORMA domain
16 MARSoncoprotein40.6671.400Anticodon_1 (PF08264, IPR013155): Anticodon-binding domain of tRNA
DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
GST_C (PF00043, IPR004046): Glutathione S-transferase, C-terminal domain
tRNA-synt_1g (PF09334, IPR015413): tRNA synthetases class I (M)
WHEP-TRS (PF00458, IPR000738, SM00991): WHEP-TRS domain
GST_N_2 (PF13409, IPR004045): Glutathione S-transferase, N-terminal domain
17 NTRK1oncoprotein160.29564.400I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
18 OARD1interactor21.00003HCDH_N (PF02737, IPR006176): 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
Macro (PF01661, IPR002589, SM00506): Macro domain
19 PFKPinteractor60.6673.000PFK (PF00365, IPR000023): Phosphofructokinase
Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate
20 RELL2interactor100RELT (PF12606, IPR022248): Tumour necrosis factor receptor superfamily member 19
21 RELTinteractor21.0000Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
RELT (PF12606, IPR022248): Tumour necrosis factor receptor superfamily member 19
22 RNASEH2Cinteractor100RNase_H2_suC (PF08615, IPR013924): Ribonuclease H2 non-catalytic subunit (Ylr154p-like)
23 RPL17interactor31.0000Ribosomal_L22 (PF00237, IPR001063): Ribosomal protein L22p/L17e
24 SLFN5interactor100AlbA_2 (PF04326, IPR007421): Putative DNA-binding domain
DUF2075 (PF09848, IPR018647): Uncharacterized conserved protein (DUF2075)
UvrD_C_2 (PF13538, IPR027785): UvrD-like helicase C-terminal domain
25 SNW1protein found in more fusions80.7622.467SKIP_SNW (PF02731, IPR004015): SKIP/SNW domain
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
SIR4_SID (PF16991, IPR031556): Sir4 SID domain
26 TGFBR1oncoprotein30.6671.000Activin_recp (PF01064, IPR000472): Activin types I and II receptor domain
Pkinase (PF00069, IPR000719): Protein kinase domain
TGF_beta_GS (PF08515, IPR003605, SM00467): Transforming growth factor beta type I GS-motif
27 TGFBR2suppressor40.5003.000ecTbetaR2 (PF08917, IPR015013): Transforming growth factor beta receptor 2 ectodomain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
28 THUMPD1interactor100THUMP (PF02926, IPR004114, SM00981): THUMP domain
29 UBA6interactor40.8330.400ThiF (PF00899, IPR000594): ThiF family
E1_UFD (PF09358, IPR018965, SM00985): Ubiquitin fold domain
UBA_e1_thiolCys (PF10585, IPR019572): Ubiquitin-activating enzyme active site
30 USP5interactor30.6670.667UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein

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