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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins PITPNC1, HELZ (from a repository: Thu May 18 22:00:40 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)27
The number (and %) of the onco-proteins10 (37.04 %)
The number (and %) of the tumor suppressors3 (11.11 %)
Total number of binary PPIs (saturation %)66 (18.80 %)
The number (and %) of affected PPIs25 (37.88 %)
The number of possible different fusions6
PPI diameter5
PPI radius3
The average degree of PPI3.852
Assortativity coefficient-0.3884
The network average Clustering coefficient0.379
The number (and %) of a zero Clustering coefficients11 (40.74 %)
The number (and %) of a zero Betweenness Centrality12 (44.44 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: PITPNC1,HELZ All fusions
Proteins found in more fusions TUBG1 (see 1 fusions); RBFOX2 (see 2 fusions); GAN (see 1 fusions); MYC (see 1 fusions); RACK1 (see 3 fusions); GRB2 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 PITPNC1parental protein2050.000IP_trans (PF02121, IPR001666): Phosphatidylinositol transfer protein
2 HELZparental protein230.103473.333PAM2 (PF07145, IPR009818): Ataxin-2 C-terminal region
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
AAA_11 (PF13086): AAA domain
AAA_12 (PF13087): AAA domain
TetR_C_8 (PF14278): Transcriptional regulator C-terminal region
3 AGTRAPinteractor3096.000AGTRAP (PF06396, IPR009436, SM00805): Angiotensin II, type I receptor-associated protein (AGTRAP)
4 BCAT1interactor100Aminotran_4 (PF01063, IPR001544): Amino-transferase class IV
5 BMI1oncoprotein70.6676.833zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
6 CCNJLinteractor100Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
7 CHIAinteractor100Glyco_hydro_18 (PF00704, IPR001223): Glycosyl hydrolases family 18
Serglycin (PF04360, IPR007455): Serglycin
CBM_14 (PF01607, IPR002557, SM00494): Chitin binding Peritrophin-A domain
8 CLTConcoprotein60.4676.667Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
Clathrin_propel (PF01394, IPR022365): Clathrin propeller repeat
Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS
Clathrin_H_link (PF13838): Clathrin-H-link
9 CMTM5suppressor100MARVEL (PF01284, IPR008253): Membrane-associating domain
DUF2207 (PF09972, IPR018702): Predicted membrane protein (DUF2207)
10 ELAVL1oncoprotein110.31142.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
11 FBXW11interactor40.6670.500WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
12 GANprotein found in more fusions31.0000BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_5 (PF13854): Kelch motif
13 GRB2oncoprotein40.6670.500SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
14 KLHL20interactor200BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
15 MYConcoprotein40.6671.000HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
16 NXF1interactor60.6003.000NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
17 RACK1suppressor80.429143.000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
18 RBFOX2protein found in more fusions41.0000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Fox-1_C (PF12414, IPR025670): Calcitonin gene-related peptide regulator C terminal
19 RCBTB1interactor100BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
20 SAV1oncoprotein30.6670.667WW (PF00397, IPR001202, SM00456): WW domain
21 SEC16Ainteractor40.6671.667APC_r (PF05923): APC repeat
Sec16_C (PF12931, IPR024298): Sec23-binding domain of Sec16
Sec16 (PF12932, IPR024340): Vesicle coat trafficking protein Sec16 mid-region
22 SH3YL1interactor100Ysc84 (PF04366, IPR007461): Las17-binding protein actin regulator
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
23 SIRT7interactor60.53312.333DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563)
SIR2 (PF02146, IPR003000): Sir2 family
24 SMYD3oncoprotein100SET (PF00856, IPR001214, SM00317): SET domain
25 STAT5Asuppressor200SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
26 TARDBPinteractor60.8002.500RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
27 TUBG1protein found in more fusions31.0000Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain

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