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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)44
The number (and %) of the onco-proteins16 (36.36 %)
The number (and %) of the tumor suppressors10 (22.73 %)
Total number of binary PPIs (saturation %)102 (10.78 %)
The number (and %) of affected PPIs42 (41.18 %)
The number of possible different fusions12
PPI diameter5
PPI radius3
The average degree of PPI3.773
Assortativity coefficient-0.1281
The network average Clustering coefficient0.315
The number (and %) of a zero Clustering coefficients19 (43.18 %)
The number (and %) of a zero Betweenness Centrality20 (45.45 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: MRC2,GNA12 All fusions
Proteins found in more fusions PRKCE (see 3 fusions); PRKCD (see 2 fusions); HSP90AA1 (see 2 fusions); GNAS (see 5 fusions); LGALS3 (see 2 fusions); CDH1 (see 3 fusions); APP (see 4 fusions); NDEL1 (see 1 fusions); MAP3K5 (see 1 fusions); ARHGEF12 (see 2 fusions); LRRK2 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 MRC2parental protein160.017511.748Chordopox_A33R (PF05966, IPR009238): Chordopoxvirus A33R protein
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
UL45 (PF05473, IPR008646): UL45 protein, carbohydrate-binding C-type lectin-like
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
DUF4381 (PF14316, IPR025489): Domain of unknown function (DUF4381)
2 GNA12parental protein260.0581018.521G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
3 AKAP13oncoprotein21.0000APG6 (PF04111, IPR007243): Autophagy protein Apg6
Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like
DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
IncA (PF04156, IPR007285): IncA protein
PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SPT16 (PF08644, IPR013953): FACT complex subunit (SPT16/CDC68)
RII_binding_1 (PF10522, IPR018459): RII binding domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
4 AKT1oncoprotein80.381100.005PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
5 APPprotein found in more fusions130.197312.464APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
6 ARAFoncoprotein30.66723.633Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
7 ARHGEF1interactor200RGS-like (PF09128, IPR015212): Regulator of G protein signalling-like domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
Syntaxin_2 (PF14523): Syntaxin-like protein
PH_13 (PF16652, IPR001849): Pleckstrin homology domain
8 ARHGEF11interactor100CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
RGS-like (PF09128, IPR015212): Regulator of G protein signalling-like domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
PH_13 (PF16652, IPR001849): Pleckstrin homology domain
9 ARHGEF12suppressor31.0000PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
RGS-like (PF09128, IPR015212): Regulator of G protein signalling-like domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
Ribonuc_2-5A (PF06479, IPR010513): Ribonuclease 2-5A
PH_13 (PF16652, IPR001849): Pleckstrin homology domain
10 ARHGEF28interactor100APG6 (PF04111, IPR007243): Autophagy protein Apg6
Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
11 BAG4interactor2013.336BAG (PF02179, IPR003103, SM00264): BAG domain
DMP12 (PF16779, IPR031891): DNA-mimic protein
12 BRMS1suppressor40.33329.336Dynactin_p62 (PF05502, IPR008603): Dynactin p62 family
Sds3 (PF08598, IPR013907): Sds3-like
13 CDH1suppressor31.0000Cadherin_C (PF01049, IPR000233): Cadherin cytoplasmic region
Cadherin_pro (PF08758, IPR014868, SM01055): Cadherin prodomain like
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
14 CDH15interactor100Cadherin_C (PF01049, IPR000233): Cadherin cytoplasmic region
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
Cadherin_3 (PF16184): Cadherin-like
15 CDH2interactor100Cadherin_C (PF01049, IPR000233): Cadherin cytoplasmic region
Cadherin_pro (PF08758, IPR014868, SM01055): Cadherin prodomain like
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
Cadherin_3 (PF16184): Cadherin-like
16 DRD5interactor1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
17 ESR2suppressor40.33334.136zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ERbeta_N (PF12497, IPR021064): Estrogen receptor beta
18 F2Rinteractor1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
DUF412 (PF04217, IPR007334): Protein of unknown function, DUF412
19 FBXO6interactor30.33337.802FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
20 GNASoncoprotein40.6671.250G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
21 GNB3interactor100Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
22 HSP90AA1oncoprotein170.200294.640HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
23 IL3RAoncoprotein100IL6Ra-bind (PF09240, IPR015321): Interleukin-6 receptor alpha chain, binding
Tissue_fac (PF01108, IPR003961): Tissue factor
Y_Y_Y (PF07495, IPR011123): Y_Y_Y domain
DUF4812 (PF16071, IPR032084): Domain of unknown function (DUF4812)
24 LGALS3oncoprotein40.33353.619Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
25 LGALS8interactor100Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
26 LGALS9interactor21.0000Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
Peptidase_C62 (PF12380, IPR024348): Gill-associated viral 3C-like peptidase
27 LRRK2oncoprotein40.66713.286Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
DUF1043 (PF06295, IPR009386): Protein of unknown function (DUF1043)
T2SSE (PF00437, IPR001482): Type II/IV secretion system protein
Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
Pkinase (PF00069, IPR000719): Protein kinase domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
PQQ_2 (PF13360, IPR002372): PQQ-like domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
COR (PF16095, IPR032171): C-terminal of Roc, COR, domain
28 MAP3K5oncoprotein80.47689.957Pkinase (PF00069, IPR000719): Protein kinase domain
DUF4071 (PF13281, IPR025136): Domain of unknown function (DUF4071)
29 NDEL1protein found in more fusions3016.000HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
30 PALB2suppressor200IncA (PF04156, IPR007285): IncA protein
PALB2_WD40 (PF16756, IPR031920): Partner and localizer of BRCA2 WD40 domain
31 PAX2oncoprotein100PAX (PF00292, IPR001523, SM00351): 'Paired box' domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
Pax2_C (PF12403, IPR022130): Paired-box protein 2 C terminal
32 PCK1interactor30.6675.619PEPCK (PF00821, IPR008209): Phosphoenolpyruvate carboxykinase
33 PPM1Doncoprotein100PP2C (PF00481, IPR001932): Protein phosphatase 2C
34 PPP5Cinteractor50.70026.300Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
PPP5 (PF08321, IPR013235): PPP5 TPR repeat region
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
35 PRKCBsuppressor50.66714.952C2 (PF00168, IPR000008, SM00239): C2 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
36 PRKCDsuppressor50.8331.700Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
37 PRKCEsuppressor40.66714.836C2 (PF00168, IPR000008, SM00239): C2 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
38 PTPN1suppressor100Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
39 RAF1oncoprotein70.333100.521Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
40 RB1CC1suppressor2012.300Arc_PepC_II (PF06847, IPR009655): Archaeal Peptidase A24 C-terminus Type II
DHC (PF09626, IPR018588): Dihaem cytochrome c
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
ATG11 (PF10377, IPR019460): Autophagy-related protein 11
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
Jag_N (PF14804, IPR032782): Jag N-terminus
NPBW (PF15180, IPR013297): Neuropeptides B and W
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
Goodbye (PF17109, IPR031350): fungal STAND N-terminal Goodbye domain
41 S1PR4oncoprotein1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
42 TBXA2Rinteractor40.33330.0387tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
43 TECinteractor21.0000BTK (PF00779, IPR001562, SM00107): BTK motif
PH (PF00169, IPR001849, SM00233): PH domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
44 XRCC3oncoprotein2016.000Rad51 (PF08423, IPR013632): Rad51
RNA_pol_A_CTD (PF03118, IPR011260): Bacterial RNA polymerase, alpha chain C terminal domain

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