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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins GAB2 (from a repository: Fri Nov 11 23:11:33 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)33
The number (and %) of the onco-proteins20 (60.61 %)
The number (and %) of the tumor suppressors4 (12.12 %)
Total number of binary PPIs (saturation %)169 (32.01 %)
The number (and %) of affected PPIs33 (19.53 %)
The number of possible different fusions10
PPI diameter2
PPI radius1
The average degree of PPI9.333
Assortativity coefficient-0.2625
The network average Clustering coefficient0.635
The number (and %) of a zero Clustering coefficients0 (0.00 %)
The number (and %) of a zero Betweenness Centrality4 (12.12 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: GAB2 All fusions
Proteins found in more fusions SHC1 (see 1 fusions); PTPN11 (see 1 fusions); ETV6 (see 1 fusions); GRB2 (see 1 fusions); MARK2 (see 2 fusions); GAB2 (see 2 fusions); MAPK1 (see 1 fusions); LYN (see 1 fusions); PIK3R1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 GAB2parental protein330.246389.671PH (PF00169, IPR001849, SM00233): PH domain
Pheromone (PF08015, IPR012597): Fungal mating-type pheromone
2 AKT1oncoprotein70.4674.167PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
3 ARHGAP32oncoprotein110.7275.747PX (PF00787, IPR001683, SM00312): PX domain
RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
RPEL (PF02755, IPR004018, SM00707): RPEL repeat
SH3_9 (PF14604, IPR001452): Variant SH3 domain
4 BCRsuppressor100.6227.689Bcr-Abl_Oligo (PF09036, IPR015123): Bcr-Abl oncoprotein oligomerisation domain
C2 (PF00168, IPR000008, SM00239): C2 domain
PH (PF00169, IPR001849, SM00233): PH domain
RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
IQ_SEC7_PH (PF16453, IPR001849): PH domain
5 CD247interactor31.0000ITAM (PF02189, IPR003110, SM00077): Immunoreceptor tyrosine-based activation motif
TCR_zetazeta (PF11628, IPR021663): T-cell surface glycoprotein CD3 zeta chain
6 CRKoncoprotein140.52717.963SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
7 CRKLoncoprotein110.7097.557SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
8 ETV6suppressor41.0000Ets (PF00178, IPR000418, SM00413): Ets-domain
SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
9 GAB1oncoprotein130.56420.060PH (PF00169, IPR001849, SM00233): PH domain
10 GRAPinteractor21.0000SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
11 GRAP2interactor40.5001.467NADH_dhqG_C (PF09326, IPR015405): NADH-ubiquinone oxidoreductase subunit G, C-terminal
SH2 (PF00017, IPR000980, SM00252): SH2 domain
DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
12 GRB2oncoprotein230.39081.937SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
13 LATinteractor80.46412.033LAT (PF15234, IPR008359): Linker for activation of T-cells
14 LRRK1interactor60.8000.486Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
Pkinase (PF00069, IPR000719): Protein kinase domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
COR (PF16095, IPR032171): C-terminal of Roc, COR, domain
15 LYNoncoprotein80.4297.289Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
16 MAPK1oncoprotein50.6671.333Pkinase (PF00069, IPR000719): Protein kinase domain
17 MAPK3oncoprotein40.6670.500Pkinase (PF00069, IPR000719): Protein kinase domain
18 MARK2protein found in more fusions60.7001.400DUF702 (PF05142, IPR007818): Domain of unknown function (DUF702)
KA1 (PF02149, IPR001772): Kinase associated domain 1
Pkinase (PF00069, IPR000719): Protein kinase domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
19 METoncoprotein60.8670.472Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
PSI (PF01437, IPR002165, SM00423): Plexin repeat
Sema (PF01403, IPR001627, SM00630): Sema domain
TIG (PF01833, IPR002909): IPT/TIG domain
20 NCK1oncoprotein41.0000SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
21 NTRK1oncoprotein190.42549.363I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
22 PIK3CBoncoprotein70.7143.233PI3K_C2 (PF00792, IPR002420, SM00142): Phosphoinositide 3-kinase C2
PI3K_p85B (PF02192, IPR003113, SM00143): PI3-kinase family, p85-binding domain
PI3K_rbd (PF00794, IPR000341, SM00144): PI3-kinase family, ras-binding domain
PI3Ka (PF00613, IPR001263, SM00145): Phosphoinositide 3-kinase family, accessory domain (PIK domain)
RWD (PF05773, IPR006575, SM00591): RWD domain
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
Tom37_C (PF11801, IPR019564): Tom37 C-terminal domain
DUF4381 (PF14316, IPR025489): Domain of unknown function (DUF4381)
23 PIK3R1oncoprotein180.47834.383RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
24 PIK3R2oncoprotein100.8002.591RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
25 PLCG1oncoprotein110.52713.606C2 (PF00168, IPR000008, SM00239): C2 domain
PH (PF00169, IPR001849, SM00233): PH domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain
PI-PLC-Y (PF00387, IPR001711, SM00149): Phosphatidylinositol-specific phospholipase C, Y domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
PH_12 (PF16457, IPR001849): Pleckstrin homology domain
26 PLCG2interactor60.6002.200C2 (PF00168, IPR000008, SM00239): C2 domain
EF-hand_like (PF09279, IPR015359): Phosphoinositide-specific phospholipase C, efhand-like
PH (PF00169, IPR001849, SM00233): PH domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain
PI-PLC-Y (PF00387, IPR001711, SM00149): Phosphatidylinositol-specific phospholipase C, Y domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
PH_12 (PF16457, IPR001849): Pleckstrin homology domain
27 PTPN11suppressor110.6446.539SH2 (PF00017, IPR000980, SM00252): SH2 domain
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
28 PTPN6suppressor60.6002.550SH2 (PF00017, IPR000980, SM00252): SH2 domain
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
PolyA_pol_arg_C (PF12626, IPR025866): Polymerase A arginine-rich C-terminus
29 SHC1oncoprotein190.43846.760PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
SH2 (PF00017, IPR000980, SM00252): SH2 domain
30 SRConcoprotein110.5569.819Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
31 XPO1interactor60.7331.833CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
32 YWHAEoncoprotein70.4767.06714-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
33 ZAP70interactor100.6118.286Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain

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