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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins TATDN2, CCDC47 (from a repository: Tue Jul 23 23:52:08 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)43
The number (and %) of the onco-proteins12 (27.91 %)
The number (and %) of the tumor suppressors4 (9.30 %)
Total number of binary PPIs (saturation %)133 (14.73 %)
The number (and %) of affected PPIs41 (30.83 %)
The number of possible different fusions7
PPI diameter5
PPI radius3
The average degree of PPI5.535
Assortativity coefficient-0.1604
The network average Clustering coefficient0.508
The number (and %) of a zero Clustering coefficients6 (13.95 %)
The number (and %) of a zero Betweenness Centrality15 (34.88 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: CCDC47,TATDN2 All fusions
Proteins found in more fusions COPS5 (see 1 fusions); ILK (see 2 fusions); CUL3 (see 1 fusions); LMNA (see 4 fusions); EGFR (see 2 fusions); IRF7 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 CCDC47parental protein330.104912.551DUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682)
STAC2_u1 (PF16664): Unstructured on SH3 and cysteine-rich domain-containing protein 2
2 TATDN2parental protein80.071260.557TatD_DNase (PF01026, IPR001130): TatD related DNase
3 AMFRoncoprotein50.6671.654CUE (PF02845, IPR003892, SM00546): CUE domain
UbiA (PF01040, IPR000537): UbiA prenyltransferase family
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
4 BRCA1suppressor3019.213BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
5 CCNJLinteractor100Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
6 CLN3interactor40.5002.595CLN3 (PF02487, IPR003492): CLN3 protein
7 CLTConcoprotein90.44453.345Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
Clathrin_propel (PF01394, IPR022365): Clathrin propeller repeat
Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS
Clathrin_H_link (PF13838): Clathrin-H-link
8 COPS5protein found in more fusions100.58337.599JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
9 CUL3protein found in more fusions120.41898.021Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
10 CYB5Binteractor60.33330.438Cyt-b5 (PF00173, IPR001199, SM01117): Cytochrome b5-like Heme/Steroid binding domain
MIP (PF00230, IPR000425): Major intrinsic protein
11 ECT2suppressor30.6671.000BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
PTCB-BRCT (PF12738, IPR001357): twin BRCT domain
PGBA_C (PF15437, IPR032737): Plasminogen-binding protein pgbA C-terminal
12 EGFRoncoprotein50.6671.321Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
13 ERLIN2interactor50.5004.507Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
DUF4346 (PF14251, IPR025595): Domain of unknown function (DUF4346)
14 EVC2interactor21.0000HBS1_N (PF08938, IPR015033): HBS1 N-terminus
DUF342 (PF03961, IPR005646): Protein of unknown function (DUF342)
Histone_HNS (PF00816, IPR001801): H-NS histone family
EVC2_like (PF12297, IPR022076): Ellis van Creveld protein 2 like protein
15 FBXW11interactor70.26758.018WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
16 ILKsuppressor80.61918.296Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
17 IRAK1interactor120.200111.766Death (PF00531, IPR000488, SM00005): Death domain
Pkinase (PF00069, IPR000719): Protein kinase domain
18 IRF7protein found in more fusions31.0000IRF (PF00605, IPR001346, SM00348): Interferon regulatory factor transcription factor
IRF-3 (PF10401, IPR019471): Interferon-regulatory factor 3
19 LMNAprotein found in more fusions70.46714.786Filament (PF00038, IPR001664): Intermediate filament protein
LTD (PF00932, IPR001322): Lamin Tail Domain
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
20 MOV10interactor90.278117.064AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
21 MRPL4interactor30.3339.919Ribosomal_L4 (PF00573, IPR002136): Ribosomal protein L4/L1 family
22 NTRK1oncoprotein140.308101.813I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
23 NXF1interactor110.244125.952NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
24 PHB2interactor60.33373.682DUF2605 (PF10792, IPR019728): Protein of unknown function (DUF2605)
Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
25 PHLDA3suppressor100PH (PF00169, IPR001849, SM00233): PH domain
26 PLAURoncoprotein100Toxin_1 (PF00087, IPR003571): Snake toxin
UPAR_LY6 (PF00021, IPR001526): u-PAR/Ly-6 domain
27 PYCR1interactor31.0000ApbA (PF02558, IPR013332): Ketopantoate reductase PanE/ApbA
F420_oxidored (PF03807, IPR028939): NADP oxidoreductase coenzyme F420-dependent
P5CR_dimer (PF14748, IPR029036): Pyrroline-5-carboxylate reductase dimerisation
28 RAB1Aoncoprotein50.7003.463Ras (PF00071, IPR001806, SM00173): Ras family
29 RAB1Boncoprotein31.0000Ras (PF00071, IPR001806, SM00173): Ras family
30 RPN1oncoprotein150.248104.032Ribophorin_I (PF04597, IPR007676): Ribophorin I
CtIP_N (PF10482, IPR019518): Tumour-suppressor protein CtIP N-terminal domain
31 SARM1interactor30.6670.500Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Carb_kinase (PF01256, IPR000631): Carbohydrate kinase
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
HEAT_2 (PF13646): HEAT repeats
TIR_2 (PF13676, IPR000157): TIR domain
32 SPACA1interactor100DUF912 (PF06024, IPR009261): Nucleopolyhedrovirus protein of unknown function (DUF912)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
33 TCTN2interactor31.0000DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
34 TCTN3interactor70.38137.159DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
35 TIRAPinteractor31.0000TIR_2 (PF13676, IPR000157): TIR domain
36 TMBIM4interactor100Presenilin (PF01080, IPR001108): Presenilin
Bax1-I (PF01027, IPR006214): Inhibitor of apoptosis-promoting Bax1
37 TMEM17interactor21.0000Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
DUF3043 (PF11241, IPR021403): Protein of unknown function (DUF3043)
38 TMEM173interactor31.0000TMEM173 (PF15009, IPR029158): Transmembrane protein 173
39 TMEM216interactor21.0000Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
40 TMEM237interactor21.0000TMEM237 (PF15383, IPR029409): Transmembrane protein 237
41 TMEM67interactor30.6670.500Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like
NCD3G (PF07562, IPR011500): Nine Cysteines Domain of family 3 GPCR
Tme5_EGF_like (PF09064, IPR015149): Thrombomodulin like fifth domain, EGF-like
Meckelin (PF09773, IPR019170): Meckelin (Transmembrane protein 67)
hEGF (PF12661, IPR013032): Human growth factor-like EGF
42 TOM1L1interactor40.5002.589GAT (PF03127, IPR004152): GAT domain
VHS (PF00790, IPR002014, SM00288): VHS domain
43 UNC93B1interactor40.6675.659UNC-93 (PF05978, IPR010291): Ion channel regulatory protein UNC-93
Ndc1_Nup (PF09531, IPR019049): Nucleoporin protein Ndc1-Nup
DUF4131 (PF13567, IPR025405): Domain of unknown function (DUF4131)

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