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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins DONSON, ARHGAP32 (from a repository: Mon May 27 12:11:39 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)42
The number (and %) of the onco-proteins19 (45.24 %)
The number (and %) of the tumor suppressors5 (11.90 %)
Total number of binary PPIs (saturation %)171 (19.86 %)
The number (and %) of affected PPIs41 (23.98 %)
The number of possible different fusions11
PPI diameter3
PPI radius2
The average degree of PPI7.048
Assortativity coefficient-0.2027
The network average Clustering coefficient0.553
The number (and %) of a zero Clustering coefficients6 (14.29 %)
The number (and %) of a zero Betweenness Centrality10 (23.81 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: ARHGAP32,DONSON All fusions
Proteins found in more fusions HNRNPD (see 1 fusions); SHC1 (see 1 fusions); AES (see 3 fusions); ATXN1 (see 3 fusions); GRB2 (see 1 fusions); RAC1 (see 1 fusions); GAB2 (see 3 fusions); FYN (see 1 fusions); EGFR (see 2 fusions); PIK3R1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 ARHGAP32parental protein380.149978.591PX (PF00787, IPR001683, SM00312): PX domain
RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
RPEL (PF02755, IPR004018, SM00707): RPEL repeat
SH3_9 (PF14604, IPR001452): Variant SH3 domain
2 DONSONparental protein307.000NA
3 ABI2suppressor60.4009.333Abi_HHR (PF07815, IPR012849): Abl-interactor HHR
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
SH3_9 (PF14604, IPR001452): Variant SH3 domain
TMEM171 (PF15471, IPR029173): Transmembrane protein family 171
ATP-synt_ab_Xtn (PF16886, IPR031686): ATPsynthase alpha/beta subunit N-term extension
4 AESprotein found in more fusions40.6670.667TLE_N (PF03920, IPR005617): Groucho/TLE N-terminal Q-rich domain
5 ARRB1interactor40.6671.167Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
6 ATXN1protein found in more fusions50.5002.400AXH (PF08517, IPR013723, SM00536): Ataxin-1 and HBP1 module (AXH)
Spt20 (PF12090, IPR021950): Spt20 family
ATXN-1_C (PF12547, IPR020997): Capicua transcriptional repressor modulator
Cnd1_N (PF12922, IPR024324): non-SMC mitotic condensation complex subunit 1, N-term
7 BCAR1oncoprotein110.43621.236Serine_rich (PF08824, IPR014928): Serine rich protein interaction domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF3513 (PF12026, IPR021901): Domain of unknown function (DUF3513)
Caskin1-CID (PF16600): Caskin1 CASK-interaction domain
8 CDC42oncoprotein50.6671.167Ras (PF00071, IPR001806, SM00173): Ras family
9 CRKoncoprotein110.60012.818SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
10 CRKLoncoprotein100.7119.103SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
11 DZIP3interactor40.6672.000DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
SlyX (PF04102, IPR007236): SlyX
zf-RING-like (PF08746, IPR014857): RING-like domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
12 EGFRoncoprotein170.41755.955Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
13 FYNoncoprotein70.5336.000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
14 FZR1suppressor21.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
15 GAB1oncoprotein100.8671.884PH (PF00169, IPR001849, SM00233): PH domain
16 GAB2oncoprotein120.7275.988PH (PF00169, IPR001849, SM00233): PH domain
Pheromone (PF08015, IPR012597): Fungal mating-type pheromone
17 GRB2oncoprotein190.43169.072SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
18 GRIN2Binteractor21.0000ANF_receptor (PF01094, IPR001828): Receptor family ligand binding region
Lig_chan (PF00060, IPR001320): Ligand-gated ion channel
Lig_chan-Glu_bd (PF10613, IPR019594, SM00918): Ligated ion channel L-glutamate- and glycine-binding site
NMDAR2_C (PF10565, IPR018884): N-methyl D-aspartate receptor 2B3 C-terminus
19 HNRNPDoncoprotein80.52410.252CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain
NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Keratin_2_head (PF16208, IPR032444): Keratin type II head
20 LZTS2suppressor40.5002.500CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
DUF1127 (PF06568, IPR009506): Domain of unknown function (DUF1127)
Fez1 (PF06818): Fez1
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
DUF4250 (PF14056, IPR025346): Domain of unknown function (DUF4250)
21 MDFIinteractor200MDFI (PF15316, IPR026134): MyoD family inhibitor
22 NASPinteractor205.419Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
SlyX (PF04102, IPR007236): SlyX
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TraV (PF09676, IPR014118): Type IV conjugative transfer system lipoprotein (TraV)
SHNi-TPR (PF10516, IPR019544): SHNi-TPR
XhlA (PF10779, IPR019715): Haemolysin XhlA
TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat
CCSAP (PF15748, IPR029774): Centriole, cilia and spindle-associated
MAP17 (PF15807, IPR031627): Membrane-associated protein 117 kDa, PDZK1-interacting protein 1
23 NCK1oncoprotein70.6673.884SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
24 NCK2interactor60.5004.000SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
25 NPHP1interactor31.0000SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
FAM176 (PF14851): FAM176 family
Speriolin_N (PF15058, IPR029385): Speriolin N terminus
DUF4746 (PF15928, IPR031827): Domain of unknown function (DUF4746)
26 NTRK1oncoprotein190.346201.672I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
27 NXF1interactor90.28676.479NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
28 PIK3R1oncoprotein140.66714.787RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
29 PLCG1oncoprotein110.56420.934C2 (PF00168, IPR000008, SM00239): C2 domain
PH (PF00169, IPR001849, SM00233): PH domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain
PI-PLC-Y (PF00387, IPR001711, SM00149): Phosphatidylinositol-specific phospholipase C, Y domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
PH_12 (PF16457, IPR001849): Pleckstrin homology domain
30 PSMA3interactor305.419Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
31 RAC1oncoprotein31.0000Ras (PF00071, IPR001806, SM00173): Ras family
32 RHOAsuppressor30.6670.667Ras (PF00071, IPR001806, SM00173): Ras family
33 SFNsuppressor70.6003.75014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
34 SGTBinteractor100TOM20_plant (PF06552, IPR010547): Plant specific mitochondrial import receptor subunit TOM20
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
XPC-binding (PF09280, IPR015360): XPC-binding domain
TPR_11 (PF13414, IPR011990): TPR repeat
SGTA_dimer (PF16546, IPR032374): Homodimerisation domain of SGTA
35 SHC1oncoprotein120.7648.470PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
SH2 (PF00017, IPR000980, SM00252): SH2 domain
36 SHC2interactor21.0000PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
SH2 (PF00017, IPR000980, SM00252): SH2 domain
37 SHC3interactor31.0000PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
SH2 (PF00017, IPR000980, SM00252): SH2 domain
38 SMURF1interactor60.5004.667C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
39 SORT1interactor31.0000Sortilin_C (PF15901, IPR031777): Sortilin, neurotensin receptor 3, C-terminal
Sortilin-Vps10 (PF15902, IPR031778): Sortilin, neurotensin receptor 3
40 SRConcoprotein120.60015.987Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
41 SYNCRIPinteractor70.6196.733RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Limkain-b1 (PF11608, IPR024582): Limkain b1
42 ZWINTinteractor200Zwint (PF15556, IPR029092): ZW10 interactor

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