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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)28
The number (and %) of the onco-proteins2 (7.14 %)
The number (and %) of the tumor suppressors1 (3.57 %)
Total number of binary PPIs (saturation %)48 (12.70 %)
The number (and %) of affected PPIs26 (54.17 %)
The number of possible different fusions2
PPI diameter5
PPI radius3
The average degree of PPI2.929
Assortativity coefficient-0.3212
The network average Clustering coefficient0.340
The number (and %) of a zero Clustering coefficients13 (46.43 %)
The number (and %) of a zero Betweenness Centrality17 (60.71 %)


List of the fusions

PPI for parental proteins: KNTC1,N4BP2L2 All fusions
Proteins found in more fusions VHL (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 KNTC1parental protein140.110326.733DUF2240 (PF09999, IPR018716): Uncharacterized protein conserved in archaea (DUF2240)
MRP-S22 (PF10245, IPR019374): Mitochondrial 28S ribosomal protein S22
Rod_C (PF10493, IPR019527): Rough deal protein C-terminal region
2 N4BP2L2parental protein120.030368.000DUF2897 (PF11446, IPR021550): Protein of unknown function (DUF2897)
AAA_33 (PF13671): AAA domain
DUF4519 (PF15012, IPR027960): Domain of unknown function (DUF4519)
3 ACTR5interactor100Actin (PF00022, IPR004000, SM00268): Actin
DUF1542 (PF07564, IPR011439): Domain of Unknown Function (DUF1542)
UPF0449 (PF15136, IPR028227): Uncharacterised protein family UPF0449
4 BSGinteractor40.66711.867Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
5 CA14interactor100Carb_anhydrase (PF00194, IPR001148, SM01057): Eukaryotic-type carbonic anhydrase
NicO (PF03824, IPR011541): High-affinity nickel-transport protein
6 CGRRF1interactor100zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
7 HOXA1interactor31.0000Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
8 LGR4interactor2007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
9 LMO2oncoprotein200CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
LIM (PF00412, IPR001781, SM00132): LIM domain
10 LPAR6interactor1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
MscS_TM (PF12794, IPR025692): Mechanosensitive ion channel inner membrane domain 1
11 NAA38interactor100LSM (PF01423, IPR001163): LSM domain
12 NIPSNAP1interactor21.0000NIPSNAP (PF07978, IPR012577): NIPSNAP
13 NTRK1oncoprotein90.214284.200I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
14 PIAS4interactor30.6670.667CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
SAP (PF02037, IPR003034, SM00513): SAP domain
zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger
PINIT (PF14324, IPR023321): PINIT domain
15 PPIAinteractor20102.600Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
16 PPIHinteractor31.0000Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
17 PPP6R1interactor30.33374.800CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
SAPS (PF04499, IPR007587): SIT4 phosphatase-associated protein
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
18 PRG2interactor2065.800Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
DUF4628 (PF15429, IPR027851): Domain of unknown function (DUF4628)
19 PRMT6interactor21.0000Methyltransf_25 (PF13649): Methyltransferase domain
20 PRPF4interactor40.333131.600PRP4 (PF08799, IPR014906): pre-mRNA processing factor 4 (PRP4) like
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
WD40_like (PF17005, IPR031544): WD40-like domain
21 RP2interactor100NDK (PF00334, IPR001564, SM00562): Nucleoside diphosphate kinase
TBCC (PF07986, IPR012945): Tubulin binding cofactor C
22 SCN2Binteractor21.0000DUF1191 (PF06697, IPR010605): Protein of unknown function (DUF1191)
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
23 TMEM171interactor100TMEM171 (PF15471, IPR029173): Transmembrane protein family 171
24 TMPRSS5interactor100Trypsin (PF00089, IPR001254, SM00020): Trypsin
SRCR_2 (PF15494, IPR017448): Scavenger receptor cysteine-rich domain
25 VARSinteractor21.0000Anticodon_1 (PF08264, IPR013155): Anticodon-binding domain of tRNA
GST_C (PF00043, IPR004046): Glutathione S-transferase, C-terminal domain
tRNA-synt_1 (PF00133, IPR002300): tRNA synthetases class I (I, L, M and V)
Val_tRNA-synt_C (PF10458, IPR019499): Valyl tRNA synthetase tRNA binding arm
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
26 VHLsuppressor40.6670.667Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
VHL (PF01847, IPR022772): VHL beta domain
VHL_C (PF17211): VHL box domain
27 WNT4interactor100MEF2_binding (PF09047, IPR015134): MEF2 binding
wnt (PF00110, IPR005817, SM00097): wnt family
28 ZW10interactor50.50025.067Zw10 (PF06248, IPR009361): Centromere/kinetochore Zw10
DUF2203 (PF09969, IPR018699): Uncharacterized conserved protein (DUF2203)

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