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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins SPTLC2, HERPUD1 (from a repository: Mon Dec 9 11:39:27 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)40
The number (and %) of the onco-proteins17 (42.50 %)
The number (and %) of the tumor suppressors3 (7.50 %)
Total number of binary PPIs (saturation %)131 (16.79 %)
The number (and %) of affected PPIs38 (29.01 %)
The number of possible different fusions11
PPI diameter5
PPI radius3
The average degree of PPI5.450
Assortativity coefficient-0.0790
The network average Clustering coefficient0.434
The number (and %) of a zero Clustering coefficients11 (27.50 %)
The number (and %) of a zero Betweenness Centrality12 (30.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: SPTLC2,HERPUD1 All fusions
Proteins found in more fusions UBQLN1 (see 2 fusions); APP (see 4 fusions); EWSR1 (see 2 fusions); BCL6 (see 2 fusions); UBC (see 1 fusions); SIAH1 (see 4 fusions); SH3RF1 (see 1 fusions); VCP (see 4 fusions); SNCAIP (see 1 fusions); UBQLN2 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 SPTLC2parental protein100.022291.063Aminotran_1_2 (PF00155, IPR004839): Aminotransferase class I and II
2 HERPUD1parental protein280.140668.205Neisseria_TspB (PF05616, IPR008708): Neisseria meningitidis TspB protein
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
3 AMFRoncoprotein90.67924.230CUE (PF02845, IPR003892, SM00546): CUE domain
UbiA (PF01040, IPR000537): UbiA prenyltransferase family
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
4 APPprotein found in more fusions100.25088.055APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
5 ARHGDIAinteractor40.6674.764Rho_GDI (PF02115, IPR000406): RHO protein GDP dissociation inhibitor
6 BCL6oncoprotein4044.891BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
DZR (PF12773, IPR025874): Double zinc ribbon
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2HE (PF16278, IPR032566): C2HE / C2H2 / C2HC zinc-binding finger
7 CAPN15interactor2015.045Zn-ribbon_8 (PF09723, IPR013429, SM00834): Zinc ribbon domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Rubredoxin (PF00301, IPR024935): Rubredoxin
Peptidase_C2 (PF00648, IPR001300, SM00230): Calpain family cysteine protease
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
Synthase_beta (PF11421, IPR020971): ATP synthase F1 beta subunit
MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
PHD_2 (PF13831): PHD-finger
8 CD58interactor21.0000Botulinum_HA-17 (PF05588, IPR008903): Clostridium botulinum HA-17 domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
YjgP_YjgQ (PF03739, IPR005495): Predicted permease YjgP/YjgQ family
9 DERL1interactor80.8104.733DER1 (PF04511, IPR007599): Der1-like family
10 DERL2interactor61.0000DER1 (PF04511, IPR007599): Der1-like family
11 EVA1Cinteractor100Gal_Lectin (PF02140, IPR000922): Galactose binding lectin domain
FAM176 (PF14851): FAM176 family
12 EWSR1oncoprotein60.6008.630RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
13 FAM189A2interactor3026.224CD20 (PF04103, IPR007237): CD20-like family
14 HERC2interactor3015.431ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cyt-b5 (PF00173, IPR001199, SM01117): Cytochrome b5-like Heme/Steroid binding domain
MIB_HERC2 (PF06701, IPR010606): Mib_herc2
RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box)
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
Med3 (PF11593, IPR020998): Mediator complex subunit 3 fungal
RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
15 IL1R1interactor21.0000TIR (PF01582, IPR000157, SM00255): TIR domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
16 IL23Aoncoprotein100IL23 (PF16649, IPR010831): Interleukin 23 subunit alpha
17 NOTCH3suppressor21.0000Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
NOD (PF06816, IPR010660): NOTCH protein
NODP (PF07684, IPR011656): NOTCH protein
Notch (PF00066, IPR000800, SM00004): LNR domain
DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454)
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
18 NRG1interactor100EGF (PF00008, IPR000742, SM00181): EGF-like domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Neuregulin (PF02158, IPR002154): Neuregulin family
19 NTRK1oncoprotein130.182220.222I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
20 P2RX4interactor100P2X_receptor (PF00864, IPR001429): ATP P2X receptor
21 PSEN1oncoprotein50.8331.019Presenilin (PF01080, IPR001108): Presenilin
LRRC37AB_C (PF14914, IPR029423): LRRC37A/B like protein 1 C-terminal domain
22 PSMD2oncoprotein50.50011.164PC_rep (PF01851, IPR002015): Proteasome/cyclosome repeat
THAP (PF05485, IPR006612, SM00980): THAP domain
HEAT_2 (PF13646): HEAT repeats
23 RPA2oncoprotein70.42912.886RPA_C (PF08784, IPR014892): Replication protein A C terminal
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
RMI2 (PF16100, IPR032245): RecQ-mediated genome instability protein 2
24 SELENOSinteractor61.0000Selenoprotein_S (PF06936, IPR009703): Selenoprotein S (SelS)
DUF3326 (PF11805, IPR021763): Protein of unknown function (DUF3326)
25 SH3RF1protein found in more fusions31.0000zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
26 SIAH1suppressor70.33348.427Sina (PF03145, IPR018121): Seven in absentia protein family
27 SNCAinteractor60.5008.677Synuclein (PF01387, IPR001058): Synuclein
28 SNCAIPprotein found in more fusions41.0000Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
SNCAIP_SNCA_bd (PF16700, IPR032027): Synphilin-1 alpha-Synuclein-binding domain
29 SPINT2suppressor2026.245Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
30 STARD9interactor100START (PF01852, IPR002913, SM00234): START domain
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
Kinesin_assoc (PF16183, IPR032405): Kinesin-associated
Yop-YscD_cpl (PF16697, IPR032030): Inner membrane component of T3SS, cytoplasmic domain
31 SYVN1interactor110.42277.345Alpha_GJ (PF03229, IPR004913): Alphavirus glycoprotein J
zf-DHHC (PF01529, IPR001594): DHHC palmitoyltransferase
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
32 TOLLIPinteractor50.5006.540C2 (PF00168, IPR000008, SM00239): C2 domain
CUE (PF02845, IPR003892, SM00546): CUE domain
33 UBCprotein found in more fusions140.295125.073ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
34 UBQLN1protein found in more fusions110.40069.543Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B
FAM199X (PF15814, IPR029672): Protein family FAM199X
35 UBQLN2protein found in more fusions70.66710.464Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
SUZ (PF12752, IPR024771): SUZ domain
Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B
36 UBQLN4interactor60.8001.400CRF (PF00473, IPR000187, SM00039): Corticotropin-releasing factor family
DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
Arm_2 (PF04826, IPR006911): Armadillo-like
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B
partial_CstF (PF15861, IPR031721): Partial cleavage stimulation factor domain
37 USP7oncoprotein80.38146.152MATH (PF00917, IPR002083, SM00061): MATH domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
USP7_ICP0_bdg (PF12436, IPR024729): ICP0-binding domain of Ubiquitin-specific protease 7
USP7_C2 (PF14533, IPR029346): Ubiquitin-specific protease C-terminal
38 VCPprotein found in more fusions100.61130.730AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
39 WBP1interactor2018.278WBP-1 (PF11669, IPR021684): WW domain-binding protein 1
40 XRCC6oncoprotein40.3336.564Ku (PF02735, IPR006164, SM00559): Ku70/Ku80 beta-barrel domain
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Ku_N (PF03731, IPR005161): Ku70/Ku80 N-terminal alpha/beta domain
SAP (PF02037, IPR003034, SM00513): SAP domain

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