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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins PLEKHO1, PUM1 (from a repository: Sun Jul 14 00:45:35 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)51
The number (and %) of the onco-proteins20 (39.22 %)
The number (and %) of the tumor suppressors2 (3.92 %)
Total number of binary PPIs (saturation %)193 (15.14 %)
The number (and %) of affected PPIs50 (25.91 %)
The number of possible different fusions10
PPI diameter5
PPI radius3
The average degree of PPI6.588
Assortativity coefficient-0.2090
The network average Clustering coefficient0.362
The number (and %) of a zero Clustering coefficients8 (15.69 %)
The number (and %) of a zero Betweenness Centrality12 (23.53 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: PLEKHO1,PUM1 All fusions
Proteins found in more fusions HSPB1 (see 1 fusions); CSNK2A1 (see 2 fusions); RBFOX2 (see 3 fusions); TRAF6 (see 1 fusions); ATXN1 (see 3 fusions); MATR3 (see 4 fusions); PSMC5 (see 2 fusions); VPS26A (see 1 fusions); EGFR (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 PLEKHO1parental protein160.105394.270PH (PF00169, IPR001849, SM00233): PH domain
DUF3055 (PF11256, IPR021415): Protein of unknown function (DUF3055)
2 PUM1parental protein340.119992.773K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
PUF (PF00806, IPR001313, SM00025): Pumilio-family RNA binding repeat
YppG (PF14179, IPR025555): YppG-like protein
3 AKT1oncoprotein90.25036.492PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
4 AKT2oncoprotein309.561PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
5 AKT3oncoprotein100PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
6 ANXA5oncoprotein31.0000Annexin (PF00191, IPR018502, SM00335): Annexin
7 ATXN1protein found in more fusions40.3336.291AXH (PF08517, IPR013723, SM00536): Ataxin-1 and HBP1 module (AXH)
Spt20 (PF12090, IPR021950): Spt20 family
ATXN-1_C (PF12547, IPR020997): Capicua transcriptional repressor modulator
Cnd1_N (PF12922, IPR024324): non-SMC mitotic condensation complex subunit 1, N-term
8 AURKBinteractor41.0000Pkinase (PF00069, IPR000719): Protein kinase domain
9 BMI1oncoprotein50.5007.639zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
10 C10orf88interactor200DUF4506 (PF14958, IPR028043): Domain of unknown function (DUF4506)
11 CAND1interactor90.42946.277Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981)
HEAT (PF02985, IPR000357): HEAT repeat
TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20)
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
12 CAPZA2interactor60.33339.043F-actin_cap_A (PF01267, IPR002189): F-actin capping protein alpha subunit
13 CCDC8interactor100.41740.297Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
14 CDKN1Asuppressor40.16733.236CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor
15 CLNS1Ainteractor60.33321.399Voldacs (PF03517): Regulator of volume decrease after cellular swelling
16 CSNK2A1oncoprotein100.36167.749Pkinase (PF00069, IPR000719): Protein kinase domain
17 DNAJB1suppressor30.3337.799DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
DnaJ_C (PF01556, IPR002939): DnaJ C terminal domain
18 DSTNinteractor100Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
19 EGFRoncoprotein110.37875.129Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
20 EIF5interactor41.0000CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Hist_rich_Ca-bd (PF10529, IPR019552): Histidine-rich Calcium-binding repeat region
eIF-5_eIF-2B (PF01873, IPR002735, SM00653): Domain found in IF2B/IF5
W2 (PF02020, IPR003307, SM00515): eIF4-gamma/eIF5/eIF2-epsilon
21 ELAVL1oncoprotein170.242148.183RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
22 FBXO6interactor50.20021.800FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
23 FBXW11interactor60.5004.608WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
24 FLNBoncoprotein60.20033.641CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Filamin (PF00630, IPR017868): Filamin/ABP280 repeat
PapC_N (PF13954, IPR025885): PapC N-terminal domain
25 FOXG1oncoprotein40.33313.242SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
SPX (PF03105, IPR004331): SPX domain
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
26 FOXI2interactor100Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
27 FOXQ1interactor100Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
28 HSPB1oncoprotein120.38260.380HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
29 IFI35interactor100IFP_35_N (PF07334, IPR009938): Interferon-induced 35 kDa protein (IFP 35) N-terminus
NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID)
30 ITGA4interactor80.33333.702FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
31 KIAA0753interactor21.0000MNR (PF15718, IPR031447): Protein moonraker
32 LAGE3interactor21.0000Pcc1 (PF09341, IPR015419): Transcription factor Pcc1
33 MATR3protein found in more fusions90.39317.025DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
zf-U1 (PF06220, IPR013085, SM00451): U1 zinc finger
Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
FAM60A (PF15396, IPR026065): Protein Family FAM60A
34 NTRK1oncoprotein210.216258.538I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
35 PAICSinteractor60.5009.239AIRC (PF00731, IPR000031, SM01001): AIR carboxylase
SAICAR_synt (PF01259, IPR028923): SAICAR synthetase
36 PRR12interactor204.958CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
DUF4211 (PF13926, IPR025451): Domain of unknown function (DUF4211)
37 PSMC5protein found in more fusions90.14347.702AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
Laminin_II (PF06009, IPR010307): Laminin Domain II
RILP (PF11461, IPR021563): Rab interacting lysosomal protein
AAA_16 (PF13191): AAA ATPase domain
38 RBFOX2protein found in more fusions80.47611.997RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Fox-1_C (PF12414, IPR025670): Calcitonin gene-related peptide regulator C terminal
39 RPS20interactor50.10038.837Ribosomal_S10 (PF00338, IPR027486): Ribosomal protein S10p/S20e
40 SAV1oncoprotein40.5004.511WW (PF00397, IPR001202, SM00456): WW domain
41 SEC16Ainteractor80.42924.639APC_r (PF05923): APC repeat
Sec16_C (PF12931, IPR024298): Sec23-binding domain of Sec16
Sec16 (PF12932, IPR024340): Vesicle coat trafficking protein Sec16 mid-region
42 SEPHS1interactor50.8330.400AIRS (PF00586, IPR000728): AIR synthase related protein, N-terminal domain
AIRS_C (PF02769, IPR010918): AIR synthase related protein, C-terminal domain
43 SIRT7interactor90.22248.042DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563)
SIR2 (PF02146, IPR003000): Sir2 family
44 SMAD1interactor60.50018.290MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
45 SMAD5interactor50.50028.021MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
46 SMURF1interactor90.25047.657C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
47 TRAF6protein found in more fusions80.23851.887SlyX (PF04102, IPR007236): SlyX
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
48 USP7oncoprotein80.09570.766MATH (PF00917, IPR002083, SM00061): MATH domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
USP7_ICP0_bdg (PF12436, IPR024729): ICP0-binding domain of Ubiquitin-specific protease 7
USP7_C2 (PF14533, IPR029346): Ubiquitin-specific protease C-terminal
49 VPS26Aprotein found in more fusions41.0000Vps26 (PF03643, IPR005377): Vacuolar protein sorting-associated protein 26
50 XPO1interactor170.272151.666CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
51 YWHABinteractor80.53616.31414-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
Virulence_fact (PF13769, IPR025989): Virulence factor

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