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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)79
The number (and %) of the onco-proteins22 (27.85 %)
The number (and %) of the tumor suppressors6 (7.59 %)
Total number of binary PPIs (saturation %)324 (10.52 %)
The number (and %) of affected PPIs79 (24.38 %)
The number of possible different fusions12
PPI diameter4
PPI radius2
The average degree of PPI7.570
Assortativity coefficient-0.2331
The network average Clustering coefficient0.486
The number (and %) of a zero Clustering coefficients8 (10.13 %)
The number (and %) of a zero Betweenness Centrality14 (17.72 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: SEPTIN11,UBE3C All fusions
Proteins found in more fusions UBE2D2 (see 2 fusions); APP (see 4 fusions); SF1 (see 1 fusions); UBE3C (see 1 fusions); SH3KBP1 (see 1 fusions); TLK1 (see 1 fusions); KDM1A (see 2 fusions); UBC (see 1 fusions); PSMC5 (see 2 fusions); MYC (see 1 fusions); UTRN (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 SEPT11parental protein380.1281470.930Septin (PF00735, IPR000038): Septin
DUF3080 (PF11279, IPR021431): Protein of unknown function (DUF3080)
2 UBE3Cparental protein410.1082075.450IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
3 ANXA7suppressor30.6673.636Annexin (PF00191, IPR018502, SM00335): Annexin
4 APPprotein found in more fusions110.200211.818APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
5 CAND2interactor40.5003.000Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
RIX1 (PF08167, IPR012583): rRNA processing/ribosome biogenesis
TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20)
HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat
CAF1A (PF12253, IPR022043): Chromatin assembly factor 1 subunit A
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
TFCD_C (PF12612, IPR022577): Tubulin folding cofactor D C terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
6 CCNB1oncoprotein21.0000Adeno_E1A (PF02703, IPR003853): Early E1A protein
Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
7 CDC42EP4interactor110.60046.160PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
BORG_CEP (PF14957, IPR029273): Cdc42 effector
8 CFTRsuppressor60.40027.762ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Rotamase_2 (PF13145, IPR000297): PPIC-type PPIASE domain
CFTR_R (PF14396, IPR025837): Cystic fibrosis TM conductance regulator (CFTR), regulator domain
9 CPEB4interactor100RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
CEBP_ZZ (PF16366, IPR032296): Cytoplasmic polyadenylation element-binding protein ZZ domain
RRM_7 (PF16367, IPR000504): RNA recognition motif
10 ECT2suppressor50.10039.614BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
PTCB-BRCT (PF12738, IPR001357): twin BRCT domain
PGBA_C (PF15437, IPR032737): Plasminogen-binding protein pgbA C-terminal
11 EEF2Kinteractor30.6673.331Alpha_kinase (PF02816, IPR004166, SM00811): Alpha-kinase family
Sel1 (PF08238, IPR006597, SM00671): Sel1 repeat
12 EFNB2interactor21.0000Ephrin (PF00812, IPR001799): Ephrin
TMEM132D_C (PF15706, IPR031436): Mature oligodendrocyte transmembrane protein, TMEM132D, C-term
13 ELAVL1oncoprotein200.175691.421RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
14 ESR1suppressor120.255141.440Oest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
15 FAF2interactor90.32184.480DUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682)
UBX (PF00789, IPR001012, SM00166): UBX domain
Thioredoxin_7 (PF13899): Thioredoxin-like
UBA_4 (PF14555): UBA-like domain
16 FERMT2interactor40.5009.599FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
17 FSCN1oncoprotein30.3333.648Fascin (PF06268, IPR022768): Fascin domain
18 GOLGA2interactor40.8330.811ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
GOLGA2L5 (PF15070, IPR024858): Putative golgin subfamily A member 2-like protein 5
19 KDM1Aprotein found in more fusions100.41780.775Amino_oxidase (PF01593, IPR002937): Flavin containing amine oxidoreductase
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
SWIRM (PF04433, IPR007526): SWIRM domain
DUF4298 (PF14131, IPR025384): Domain of unknown function (DUF4298)
20 MAD2L1BPinteractor200p31comet (PF06581, IPR009511): Mad1 and Cdc20-bound-Mad2 binding
21 MPSTinteractor31.0000Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain
22 MTA2interactor60.66712.717BAH (PF01426, IPR001025, SM00439): BAH domain
ELM2 (PF01448, IPR000949): ELM2 domain
Resolvase (PF00239, IPR006119, SM00857): Resolvase, N terminal domain
DDA1 (PF10172, IPR018276): Det1 complexing ubiquitin ligase
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
GATA (PF00320, IPR000679, SM00401): GATA zinc finger
23 MYConcoprotein170.242233.187HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
24 NABP2interactor203.094tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
25 NDUFS6interactor100Thiolase_C (PF02803, IPR020617): Thiolase, C-terminal domain
zf-CHCC (PF10276, IPR019401, SM00400): Zinc-finger domain
26 NTRK1oncoprotein280.137855.553I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
27 OXCT1interactor80.28678.648CoA_trans (PF01144, IPR004165, SM00882): Coenzyme A transferase
28 PANK4interactor30.6674.010DUF89 (PF01937, IPR002791): Protein of unknown function DUF89
Fumble (PF03630, IPR004567): Fumble
29 PHKA2interactor100Glyco_hydro_15 (PF00723, IPR011613): Glycosyl hydrolases family 15
30 PSMA2interactor100.8067.757Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
31 PSMC5protein found in more fusions120.60029.046AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
Laminin_II (PF06009, IPR010307): Laminin Domain II
RILP (PF11461, IPR021563): Rab interacting lysosomal protein
AAA_16 (PF13191): AAA ATPase domain
32 PSMD14interactor80.8933.136JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
33 PSMD2oncoprotein130.397105.659PC_rep (PF01851, IPR002015): Proteasome/cyclosome repeat
THAP (PF05485, IPR006612, SM00980): THAP domain
HEAT_2 (PF13646): HEAT repeats
34 PSMD6interactor70.9521.763RPN7 (PF10602, IPR019585): 26S proteasome subunit RPN7
PCI (PF01399, IPR000717, SM00088): PCI domain
35 RAD21oncoprotein60.60021.706Rad21_Rec8 (PF04824, IPR006909): Conserved region of Rad21 / Rec8 like protein
Rad21_Rec8_N (PF04825, IPR006910): N terminus of Rad21 / Rec8 like protein
FAM176 (PF14851): FAM176 family
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
36 RBM15oncoprotein41.0000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SPOC (PF07744, IPR012921): SPOC domain
Apt1 (PF10351, IPR019443): Golgi-body localisation protein domain
37 SCN2Binteractor21.0000DUF1191 (PF06697, IPR010605): Protein of unknown function (DUF1191)
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
38 SEC22Binteractor120.212129.858Synaptobrevin (PF00957, IPR001388): Synaptobrevin
Longin (PF13774, IPR010908): Regulated-SNARE-like domain
39 SEC23IPinteractor203.021DDHD (PF02862, IPR004177, SM01127): DDHD domain
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
WWE (PF02825, IPR004170, SM00678): WWE domain
40 SEPT1interactor140.526132.574Pet20 (PF08692, IPR014804): Mitochondrial protein Pet20
Septin (PF00735, IPR000038): Septin
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
41 SEPT12interactor100.75616.520Septin (PF00735, IPR000038): Septin
42 SEPT2oncoprotein130.60368.727FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger
Septin (PF00735, IPR000038): Septin
43 SEPT3interactor120.8183.745Septin (PF00735, IPR000038): Septin
44 SEPT4suppressor60.8670.609Septin (PF00735, IPR000038): Septin
45 SEPT5oncoprotein110.82211.164Septin (PF00735, IPR000038): Septin
46 SEPT6oncoprotein140.57157.815Septin (PF00735, IPR000038): Septin
DUF2959 (PF11172, IPR021342): Protein of unknown function (DUF2959)
47 SEPT7interactor120.72728.247Fez1 (PF06818): Fez1
Septin (PF00735, IPR000038): Septin
48 SEPT8interactor110.70920.454IMD (PF08397, IPR013606): IRSp53/MIM homology domain
Septin (PF00735, IPR000038): Septin
DUF3987 (PF13148, IPR025048): Protein of unknown function (DUF3987)
49 SEPT9oncoprotein140.37489.171Septin (PF00735, IPR000038): Septin
DUF3306 (PF11748, IPR021735): Protein of unknown function (DUF3306)
50 SF1protein found in more fusions80.23869.368UPF0181 (PF03701, IPR005371): Uncharacterised protein family (UPF0181)
zf-CCHC (PF00098, IPR001878): Zinc knuckle
KH_1 (PF00013, IPR004088, SM00322): KH domain
RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
PRIMA1 (PF16101): Proline-rich membrane anchor 1
SF1-HH (PF16275, IPR032570): Splicing factor 1 helix-hairpin domain
51 SH3KBP1protein found in more fusions100.47246.600Tmemb_cc2 (PF10267, IPR019394): Predicted transmembrane and coiled-coil 2 protein
SH3_9 (PF14604, IPR001452): Variant SH3 domain
52 SHFM1interactor80.67922.708CLLAC (PF15675, IPR031379): CLLAC-motif containing domain
53 SIN3Aoncoprotein100.289121.468Sin3_corepress (PF08295, IPR013194, SM00761): Sin3 family co-repressor
PAH (PF02671, IPR003822, SM00309): Paired amphipathic helix repeat
Sin3a_C (PF16879, IPR031693): C-terminal domain of Sin3a protein
54 SLC9A3R2interactor60.40014.928EBP50_C (PF09007, IPR015098): EBP50, C-terminal
GRASP55_65 (PF04495, IPR024958): GRASP55/65 PDZ-like domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
55 SMARCA2suppressor60.46725.128DUF1168 (PF06658, IPR009548): Protein of unknown function (DUF1168)
DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840)
HSA (PF07529, IPR014012, SM00573): HSA
QLQ (PF08880, IPR014978, SM00951): QLQ
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
YL1 (PF05764, IPR008895): YL1 nuclear protein
BRK (PF07533, IPR006576, SM00592): BRK domain
DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052)
EPL1 (PF10513, IPR019542): Enhancer of polycomb-like
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
SnAC (PF14619, IPR029295): Snf2-ATP coupling, chromatin remodelling complex
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
56 STIM1interactor30.6670.667APG6 (PF04111, IPR007243): Autophagy protein Apg6
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
SSP160 (PF06933, IPR009701): Special lobe-specific silk protein SSP160
DUF4446 (PF14584, IPR027981): Protein of unknown function (DUF4446)
SOAR (PF16533, IPR032393): STIM1 Orai1-activating region
57 SUCLG1interactor50.20023.501CoA_binding (PF02629, IPR003781, SM00881): CoA binding domain
Ligase_CoA (PF00549, IPR005811): CoA-ligase
CoA_binding_2 (PF13380, IPR003781): CoA binding domain
58 TCOF1interactor60.20035.852CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755)
Gal-3-0_sulfotr (PF06990, IPR009729): Galactose-3-O-sulfotransferase
Treacle (PF03546, IPR003993): Treacher Collins syndrome protein Treacle
IMUP (PF15761, IPR026621): Immortalisation up-regulated protein
AP3D1 (PF06375): AP-3 complex subunit delta-1
59 THOC2interactor50.30043.987Sec62 (PF03839, IPR004728): Translocation protein Sec62
Tho2 (PF11262, IPR021418): Transcription factor/nuclear export subunit protein 2
Thoc2 (PF11732, IPR021726): Transcription- and export-related complex subunit
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
THOC2_N (PF16134, IPR032302): THO complex subunit 2 N-terminus
60 THOC7interactor30.6671.000EcoEI_R_C (PF08463, IPR013670): EcoEI R protein C-terminal
THOC7 (PF05615, IPR008501): Tho complex subunit 7
UPF0193 (PF05250, IPR007914): Uncharacterised protein family (UPF0193)
61 TLK1protein found in more fusions31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
Vir_act_alpha_C (PF10400, IPR018309): Virulence activator alpha C-term
62 TMEM177interactor21.0000NA
63 TMEM189interactor60.40059.497MARVEL (PF01284, IPR008253): Membrane-associating domain
TMEM189_B_dmain (PF10520, IPR019547): B domain of TMEM189, localisation domain
64 TMEM9interactor30.6670.500Tmemb_9 (PF05434, IPR008853): TMEM9
65 TOMM40interactor50.40028.225Porin_3 (PF01459, IPR027246): Eukaryotic porin
66 TSTinteractor30.6670.500Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain
67 UBCprotein found in more fusions180.206312.543ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
68 UBE2D1interactor80.38121.440UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
69 UBE2D2oncoprotein60.6008.152UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
70 UBE2D3interactor40.6670.319UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
71 UBE2L3interactor90.32154.358UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
72 USP13interactor40.6675.681UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
73 UTRNprotein found in more fusions40.6671.000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1
EF-hand_2 (PF09068, IPR015153): EF hand
EF-hand_3 (PF09069, IPR015154): EF-hand
Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Spectrin (PF00435, IPR002017): Spectrin repeat
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
WW (PF00397, IPR001202, SM00456): WW domain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
CCDC-167 (PF15188, IPR028194): Coiled-coil domain-containing protein 167
ABC_tran_CTD (PF16326, IPR032524): ABC transporter C-terminal domain
74 VCAM1interactor90.194104.069C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
75 VDAC2interactor90.22280.373Porin_3 (PF01459, IPR027246): Eukaryotic porin
76 VSIG4interactor21.0000EMP70 (PF02990, IPR004240): Endomembrane protein 70
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
77 WDR74interactor100WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
78 WDR92interactor100WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
Itfg2 (PF15907, IPR031793): Integrin-alpha FG-GAP repeat-containing protein 2
79 XRCC1interactor30.3336.080BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
SPX (PF03105, IPR004331): SPX domain
XRCC1_N (PF01834, IPR002706): XRCC1 N terminal domain
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain

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