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Visible interactions: all affected independent (normal) missing (in fusions) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins VGLL4 (from a repository: Wed Feb 15 20:15:19 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)12
The number (and %) of the onco-proteins5 (41.67 %)
The number (and %) of the tumor suppressors1 (8.33 %)
Total number of binary PPIs (saturation %)20 (30.30 %)
The number (and %) of affected PPIs11 (55.00 %)
The number of possible different fusions4
PPI diameter2
PPI radius1
The average degree of PPI2.667
Assortativity coefficient-0.5366
The network average Clustering coefficient0.480
The number (and %) of a zero Clustering coefficients5 (41.67 %)
The number (and %) of a zero Betweenness Centrality10 (83.33 %)

ACTIVE INTERACTORS
MISSING INTERACTORS (in fusions)


List of the fusions

PPI for parental proteins: VGLL4 All fusions
Proteins found in more fusions TERF2IP (see 1 fusions); CDK6 (see 1 fusions); USP11 (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 VGLL4parental protein110.09198.000Vg_Tdu (PF07545, IPR011520): Vestigial/Tondu family
VGLL4 (PF15245, IPR028184): Transcription cofactor vestigial-like protein 4
2 CDK6suppressor31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
3 ELAVL1oncoprotein50.6672.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
4 IRF2BP1interactor100zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
IRF-2BP1_2 (PF11261, IPR022750): Interferon regulatory factor 2-binding protein zinc finger
5 IRF2BP2oncoprotein31.0000zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
IRF-2BP1_2 (PF11261, IPR022750): Interferon regulatory factor 2-binding protein zinc finger
DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729)
Bd3614_N (PF14442, IPR025854): Bd3614-like deaminase N-terminal
6 IRF2BPLinteractor31.0000Calpain_inhib (PF00748, IPR001259): Calpain inhibitor
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
DUF2722 (PF10846, IPR021216): Protein of unknown function (DUF2722)
IRF-2BP1_2 (PF11261, IPR022750): Interferon regulatory factor 2-binding protein zinc finger
Ribosomal_L12_N (PF16320, IPR008932): Ribosomal protein L7/L12 dimerisation domain
AIM3 (PF17096, IPR031370): Altered inheritance of mitochondria protein 3
7 MEF2Aoncoprotein100TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
SRF-TF (PF00319, IPR002100, SM00432): SRF-type transcription factor (DNA-binding and dimerisation domain)
HJURP_C (PF12347, IPR022102): Holliday junction regulator protein family C-terminal repeat
8 TEAD1interactor21.0000TEA (PF01285, IPR000818, SM00426): TEA/ATTS domain family
9 TEAD3interactor100TEA (PF01285, IPR000818, SM00426): TEA/ATTS domain family
10 TEAD4interactor21.0000TEA (PF01285, IPR000818, SM00426): TEA/ATTS domain family
11 TERF2IPprotein found in more fusions200BRF1 (PF07741, IPR011665): Brf1-like TBP-binding domain
Histone_HNS (PF00816, IPR001801): H-NS histone family
Myb_DNA-bind_2 (PF08914, IPR015010): Rap1 Myb domain
Rap1_C (PF11626, IPR021661): TRF2-interacting telomeric protein/Rap1 - C terminal domain
DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
12 USP11protein found in more fusions200Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
DUSP (PF06337, IPR006615, SM00695): DUSP domain
Ubiquitin_3 (PF14836, IPR028135): Ubiquitin-like domain

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List of missing interactors (in fusions)

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 VGLL4parental proteinVg_Tdu (PF07545, IPR011520): Vestigial/Tondu family
VGLL4 (PF15245, IPR028184): Transcription cofactor vestigial-like protein 4
AI202435

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