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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins DEPDC5, TXN2 (from a repository: Sun Aug 11 22:26:26 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)67
The number (and %) of the onco-proteins14 (20.90 %)
The number (and %) of the tumor suppressors6 (8.96 %)
Total number of binary PPIs (saturation %)173 (7.82 %)
The number (and %) of affected PPIs65 (37.57 %)
The number of possible different fusions10
PPI diameter5
PPI radius3
The average degree of PPI4.209
Assortativity coefficient-0.3866
The network average Clustering coefficient0.552
The number (and %) of a zero Clustering coefficients17 (25.37 %)
The number (and %) of a zero Betweenness Centrality39 (58.21 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: TXN2,DEPDC5 All fusions
Proteins found in more fusions DCTD (see 1 fusions); MAP3K5 (see 1 fusions); MAPRE2 (see 1 fusions); VCP (see 4 fusions); SSNA1 (see 2 fusions); UBR5 (see 4 fusions); VIM (see 1 fusions); NR3C1 (see 8 fusions); PSME3 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 TXN2parental protein580.0393606.833Thioredoxin (PF00085, IPR013766): Thioredoxin
2 DEPDC5parental protein70.524108.500DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
FGGY_N (PF00370, IPR018484): FGGY family of carbohydrate kinases, N-terminal domain
IML1 (PF12257, IPR027244): Vacuolar membrane-associated protein Iml1
3 AGTRAPinteractor200AGTRAP (PF06396, IPR009436, SM00805): Angiotensin II, type I receptor-associated protein (AGTRAP)
4 ALDOBoncoprotein100Glycolytic (PF00274, IPR000741): Fructose-bisphosphate aldolase class-I
5 ANXA6interactor21.0000Annexin (PF00191, IPR018502, SM00335): Annexin
6 AP2B1interactor30.6671.000Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
Alpha_adaptinC2 (PF02883, IPR008152, SM00809): Adaptin C-terminal domain
B2-adapt-app_C (PF09066, IPR015151, SM01020): Beta2-adaptin appendage, C-terminal sub-domain
7 CCDC114interactor100FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
Histone_HNS (PF00816, IPR001801): H-NS histone family
Hydantoinase_B (PF02538, IPR003692): Hydantoinase B/oxoprolinase
DUF2353 (PF09789, IPR019179): Uncharacterized coiled-coil protein (DUF2353)
PLAC9 (PF15205, IPR027941): Placenta-specific protein 9
8 DCTDprotein found in more fusions200dCMP_cyt_deam_1 (PF00383, IPR002125): Cytidine and deoxycytidylate deaminase zinc-binding region
9 FAM98Binteractor21.0000DUF2465 (PF10239, IPR018797): Protein of unknown function (DUF2465)
10 FAM9Binteractor31.0000Cor1 (PF04803, IPR006888): Cor1/Xlr/Xmr conserved region
Spore_coat_CotO (PF14153, IPR025439): Spore coat protein CotO
11 GOLIM4interactor100Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
DDRGK (PF09756, IPR019153, SM01128): DDRGK domain
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
DUF3410 (PF11890, IPR024531): Domain of unknown function (DUF3410)
DUF3584 (PF12128, IPR021979): Protein of unknown function (DUF3584)
DUF4525 (PF15027, IPR027833): Domain of unknown function (DUF4525)
12 GPRASP2interactor21.0000Arm_2 (PF04826, IPR006911): Armadillo-like
DUF3020 (PF11223, IPR021386): Protein of unknown function (DUF3020)
PH_4 (PF15404): Pleckstrin homology domain
13 HSPA1Linteractor40.6672.000HSP70 (PF00012, IPR013126): Hsp70 protein
14 ILF2interactor100.48942.500DZF (PF07528, IPR006561, SM00572): DZF domain
15 ILF3oncoprotein130.35984.000dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
DZF (PF07528, IPR006561, SM00572): DZF domain
16 KRT18interactor200Filament (PF00038, IPR001664): Intermediate filament protein
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
17 KRT40interactor100Filament (PF00038, IPR001664): Intermediate filament protein
UPF0184 (PF03670, IPR022788): Uncharacterised protein family (UPF0184)
18 MAGEA11interactor40.6671.000MAGE (PF01454, IPR002190): MAGE family
MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
19 MAP3K5oncoprotein40.6670.500Pkinase (PF00069, IPR000719): Protein kinase domain
DUF4071 (PF13281, IPR025136): Domain of unknown function (DUF4071)
20 MAPRE2protein found in more fusions31.0000ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
EB1 (PF03271, IPR004953): EB1-like C-terminal motif
21 MAPRE3interactor21.0000CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
EB1 (PF03271, IPR004953): EB1-like C-terminal motif
22 MLH1suppressor40.5003.000DNA_mis_repair (PF01119, IPR013507): DNA mismatch repair protein, C-terminal domain
HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
Mlh1_C (PF16413, IPR032189): DNA mismatch repair protein Mlh1 C-terminus
23 MOV10interactor100.267950.833AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
24 MRFAP1L1interactor200MRFAP1 (PF15155, IPR029254): MORF4 family-associated protein1
25 MRPL23interactor41.0000Ribosomal_L23 (PF00276, IPR013025): Ribosomal protein L23
26 MTUS2suppressor31.0000DUF496 (PF04363, IPR007458): Protein of unknown function (DUF496)
RNA_pol_Rpb1_R (PF05001, IPR000684): RNA polymerase Rpb1 C-terminal repeat
FAM184 (PF15665): Family with sequence similarity 184, A and B
27 NPRL2suppressor60.467827.833NPR2 (PF06218, IPR009348): Nitrogen permease regulator 2
28 NPRL3interactor50.7001.833NPR3 (PF03666, IPR005365): Nitrogen Permease regulator of amino acid transport activity 3
29 NR3C1protein found in more fusions60.5004.500GCR (PF02155, IPR001409): Glucocorticoid receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
30 PPCDCinteractor200Flavoprotein (PF02441, IPR003382): Flavoprotein
31 PSME3protein found in more fusions31.0000PA28_alpha (PF02251, IPR003185): Proteasome activator pa28 alpha subunit
PA28_beta (PF02252, IPR003186): Proteasome activator pa28 beta subunit
32 PTBP3interactor31.0000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
33 RABAC1interactor31.0000PRA1 (PF03208, IPR004895): PRA1 family protein
34 RABGEF1interactor200Rho_Binding (PF08912, IPR015008): Rho Binding
VPS9 (PF02204, IPR003123, SM00167): Vacuolar sorting protein 9 (VPS9) domain
zf-A20 (PF01754, IPR002653, SM00259): A20-like zinc finger
GIT1_C (PF12205, IPR022018): G protein-coupled receptor kinase-interacting protein 1 C term
SSTK-IP (PF15836, IPR031679): SSTK-interacting protein, TSSK6-activating co-chaperone protein
35 RBM45interactor200RNA_bind (PF08675, IPR014789): RNA binding domain
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
36 REEP6interactor200TB2_DP1_HVA22 (PF03134, IPR004345): TB2/DP1, HVA22 family
37 RELAoncoprotein60.6003.667DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
38 RPIAinteractor31.0000Rib_5-P_isom_A (PF06026, IPR004788): Ribose 5-phosphate isomerase A (phosphoriboisomerase A)
Sugar-bind (PF04198, IPR007324): Putative sugar-binding domain
39 RPL8interactor60.8671.000Ribosomal_L2 (PF00181, IPR022666): Ribosomal Proteins L2, RNA binding domain
Ribosomal_L2_C (PF03947, IPR022669): Ribosomal Proteins L2, C-terminal domain
40 RPL9interactor110.32781.000Ribosomal_L6 (PF00347, IPR020040): Ribosomal protein L6
41 RPS16interactor51.0000Ribosomal_S9 (PF00380, IPR000754): Ribosomal protein S9/S16
42 RRAGAinteractor40.66740.667Gtr1_RagA (PF04670, IPR006762): Gtr1/RagA G protein conserved region
DUF5099 (PF17025, IPR031503): Domain of unknown function (DUF5099)
43 RRAGBinteractor31.0000Gtr1_RagA (PF04670, IPR006762): Gtr1/RagA G protein conserved region
44 RRAGCinteractor40.6671.500Gtr1_RagA (PF04670, IPR006762): Gtr1/RagA G protein conserved region
45 SCYL3interactor100Pkinase (PF00069, IPR000719): Protein kinase domain
46 SHARPINinteractor200DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518)
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
Sharpin_PH (PF16764, IPR031912): Sharpin PH domain
47 SNRNP70interactor40.6672.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
48 SOD1interactor50.5002.500Sod_Cu (PF00080, IPR001424): Copper/zinc superoxide dismutase (SODC)
49 SPTBN1suppressor21.0000CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
COG2 (PF06148, IPR024602): COG (conserved oligomeric Golgi) complex component, COG2
DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
Spectrin (PF00435, IPR002017): Spectrin repeat
PH_9 (PF15410): Pleckstrin homology domain
50 SSNA1protein found in more fusions200APG6 (PF04111, IPR007243): Autophagy protein Apg6
Fzo_mitofusin (PF04799, IPR006884): fzo-like conserved region
51 STUB1suppressor90.32162.667U-box (PF04564, IPR003613, SM00504): U-box domain
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_20 (PF14561): Tetratricopeptide repeat
52 THAP1interactor31.0000THAP (PF05485, IPR006612, SM00980): THAP domain
Tho2 (PF11262, IPR021418): Transcription factor/nuclear export subunit protein 2
Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
53 TIFAinteractor31.0000FHA (PF00498, IPR000253, SM00240): FHA domain
54 TOMM22interactor40.6672.000Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Tom22 (PF04281, IPR005683): Mitochondrial import receptor subunit Tom22
55 TPM4oncoprotein50.7001.833Tropomyosin (PF00261, IPR000533): Tropomyosin
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
56 TRIM21interactor31.0000DUF313 (PF03754, IPR005508): Domain of unknown function (DUF313)
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
Prok-RING_1 (PF14446): Prokaryotic RING finger family 1
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
57 TRIP6interactor40.8334.500DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
LIM (PF00412, IPR001781, SM00132): LIM domain
58 TXNoncoprotein80.25020.000Thioredoxin (PF00085, IPR013766): Thioredoxin
59 UBR5protein found in more fusions31.0000CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
SDA1 (PF05285, IPR007949): SDA1
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
PABP (PF00658, IPR002004, SM00517): Poly-adenylate binding protein, unique domain
E3_UbLigase_EDD (PF11547, IPR024725): E3 ubiquitin ligase EDD
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
60 UCHL5oncoprotein31.0000Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
61 VCPprotein found in more fusions70.3339.667AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
62 VIMsuppressor50.5003.000Filament (PF00038, IPR001664): Intermediate filament protein
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
63 VPS52interactor200Vps52 (PF04129, IPR007258): Vps52 / Sac2 family
COG5 (PF10392, IPR019465): Golgi transport complex subunit 5
Sec3_C (PF09763, IPR019160): Exocyst complex component Sec3
64 WDR12interactor200NLE (PF08154, IPR012972): NLE (NUC135) domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
65 WDR24interactor50.600101.667WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Zn_ribbon_17 (PF17120): Zinc-ribbon, C4HC2 type
66 ZBTB14interactor31.0000BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
67 ZNF414interactor31.0000CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Rib_recp_KP_reg (PF05104, IPR007794): Ribosome receptor lysine/proline rich region
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain
zf-C2H2_8 (PF15909, IPR031799): C2H2-type zinc ribbon

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