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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)29
The number (and %) of the onco-proteins5 (17.24 %)
The number (and %) of the tumor suppressors4 (13.79 %)
Total number of binary PPIs (saturation %)67 (16.50 %)
The number (and %) of affected PPIs27 (40.30 %)
The number of possible different fusions2
PPI diameter5
PPI radius3
The average degree of PPI4.138
Assortativity coefficient-0.0394
The network average Clustering coefficient0.489
The number (and %) of a zero Clustering coefficients7 (24.14 %)
The number (and %) of a zero Betweenness Centrality14 (48.28 %)


List of the fusions

PPI for parental proteins: CD63,VARS2 All fusions
Proteins found in more fusions LGALS3 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 CD63parental protein200.158494.833Tetraspannin (PF00335, IPR018499): Tetraspanin family
DUF4282 (PF14110, IPR025557): Domain of unknown function (DUF4282)
2 VARS2parental protein70.048207.000Anticodon_1 (PF08264, IPR013155): Anticodon-binding domain of tRNA
tRNA-synt_1 (PF00133, IPR002300): tRNA synthetases class I (I, L, M and V)
tRNA-synt_1g (PF09334, IPR015413): tRNA synthetases class I (M)
FimP (PF09766, IPR019163): Fms-interacting protein
3 ABI2suppressor40.333147.000Abi_HHR (PF07815, IPR012849): Abl-interactor HHR
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
SH3_9 (PF14604, IPR001452): Variant SH3 domain
TMEM171 (PF15471, IPR029173): Transmembrane protein family 171
ATP-synt_ab_Xtn (PF16886, IPR031686): ATPsynthase alpha/beta subunit N-term extension
4 ATP6V1B1interactor21.0000ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
DUF3533 (PF12051, IPR022703): Protein of unknown function (DUF3533)
5 CD81interactor80.5715.667Tetraspannin (PF00335, IPR018499): Tetraspanin family
6 CD82suppressor70.47611.000Tetraspannin (PF00335, IPR018499): Tetraspanin family
7 CD9oncoprotein80.46411.667Tetraspannin (PF00335, IPR018499): Tetraspanin family
8 CMTM5suppressor20105.000MARVEL (PF01284, IPR008253): Membrane-associating domain
DUF2207 (PF09972, IPR018702): Predicted membrane protein (DUF2207)
9 FAM134Cinteractor100Reticulon (PF02453, IPR003388): Reticulon
10 HLA-DMBinteractor31.0000MHC_II_beta (PF00969, IPR000353, SM00921): Class II histocompatibility antigen, beta domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
11 HLA-DOBinteractor21.0000MHC_II_beta (PF00969, IPR000353, SM00921): Class II histocompatibility antigen, beta domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
12 HLA-DRAinteractor31.0000MHC_II_alpha (PF00993, IPR001003, SM00920): Class II histocompatibility antigen, alpha domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
C1-set_C (PF16196, IPR032431): C1-set C-terminal domain
13 ITGB1suppressor60.4675.167EGF_2 (PF07974, IPR013111): EGF-like domain
Integrin_b_cyt (PF08725, IPR014836): Integrin beta cytoplasmic domain
Integrin_B_tail (PF07965, IPR012896): Integrin beta tail domain
Integrin_beta (PF00362, IPR002369, SM00187): Integrin, beta chain
PSI_integrin (PF17205): Integrin plexin domain
14 KIToncoprotein31.0000ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
15 LGALS3oncoprotein50.8330.333Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
16 LGALS8interactor50.40025.667Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
17 LGALS9interactor50.6002.667Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
Peptidase_C62 (PF12380, IPR024348): Gill-associated viral 3C-like peptidase
18 MAL2interactor100MARVEL (PF01284, IPR008253): Membrane-associating domain
19 MRPL58interactor100RF-1 (PF00472, IPR000352): RF-1 domain
20 NCK2interactor31.0000SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
21 PIK3CAoncoprotein100PI3K_C2 (PF00792, IPR002420, SM00142): Phosphoinositide 3-kinase C2
PI3K_p85B (PF02192, IPR003113, SM00143): PI3-kinase family, p85-binding domain
PI3K_rbd (PF00794, IPR000341, SM00144): PI3-kinase family, ras-binding domain
PI3Ka (PF00613, IPR001263, SM00145): Phosphoinositide 3-kinase family, accessory domain (PIK domain)
DUF2321 (PF10083, IPR016891): Uncharacterized protein conserved in bacteria (DUF2321)
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
22 PTGFRNinteractor70.4768.167V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
23 RNF13interactor40.5002.167DNA_ligase_ZBD (PF03119, IPR004149): NAD-dependent DNA ligase C4 zinc finger domain
PA (PF02225, IPR003137): PA domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
FAM176 (PF14851): FAM176 family
STAC2_u1 (PF16664): Unstructured on SH3 and cysteine-rich domain-containing protein 2
24 SDC1oncoprotein21.0000Herpes_TAF50 (PF03326, IPR004998): Herpesvirus transcription activation factor (transactivator)
Syndecan (PF01034, IPR027789): Syndecan domain
DUF3592 (PF12158, IPR021994): Protein of unknown function (DUF3592)
AJAP1_PANP_C (PF15298, IPR029198): AJAP1/PANP C-terminus
25 SDCBPinteractor60.200323.667PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
26 SORBS3interactor200Sorb (PF02208, IPR003127, SM00459): Sorbin homologous domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
27 SRFinteractor200SRF-TF (PF00319, IPR002100, SM00432): SRF-type transcription factor (DNA-binding and dimerisation domain)
28 TSPAN3interactor30.6676.000Hum_adeno_E3A (PF05393, IPR008652): Human adenovirus early E3A glycoprotein
Tetraspannin (PF00335, IPR018499): Tetraspanin family
29 VKORC1interactor41.0000VKOR (PF07884, IPR012932, SM00756): Vitamin K epoxide reductase family

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