Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins VARS2, CD63 (from a repository: Wed Jan 20 18:09:41 2021)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 29 The number (and %) of the onco-proteins 5 (17.24 %) The number (and %) of the tumor suppressors 4 (13.79 %) Total number of binary PPIs (saturation %) 67 (16.50 %) The number (and %) of affected PPIs 27 (40.30 %) The number of possible different fusions 2 PPI diameter 5 PPI radius 3 The average degree of PPI 4.138 Assortativity coefficient -0.0394 The network average Clustering coefficient 0.489 The number (and %) of a zero Clustering coefficients 7 (24.14 %) The number (and %) of a zero Betweenness Centrality 14 (48.28 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: CD63,VARS2	All fusions
Proteins found in more fusions	LGALS3 (see 2 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	CD63	parental protein	20	0.158	494.833	Tetraspannin (PF00335, IPR018499): Tetraspanin family DUF4282 (PF14110, IPR025557): Domain of unknown function (DUF4282)
2	VARS2	parental protein	7	0.048	207.000	Anticodon_1 (PF08264, IPR013155): Anticodon-binding domain of tRNA tRNA-synt_1 (PF00133, IPR002300): tRNA synthetases class I (I, L, M and V) tRNA-synt_1g (PF09334, IPR015413): tRNA synthetases class I (M) FimP (PF09766, IPR019163): Fms-interacting protein
3	ABI2	suppressor	4	0.333	147.000	Abi_HHR (PF07815, IPR012849): Abl-interactor HHR NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region SH3_9 (PF14604, IPR001452): Variant SH3 domain TMEM171 (PF15471, IPR029173): Transmembrane protein family 171 ATP-synt_ab_Xtn (PF16886, IPR031686): ATPsynthase alpha/beta subunit N-term extension
4	ATP6V1B1	interactor	2	1.000	0	ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain DUF3533 (PF12051, IPR022703): Protein of unknown function (DUF3533)
5	CD81	interactor	8	0.571	5.667	Tetraspannin (PF00335, IPR018499): Tetraspanin family
6	CD82	suppressor	7	0.476	11.000	Tetraspannin (PF00335, IPR018499): Tetraspanin family
7	CD9	oncoprotein	8	0.464	11.667	Tetraspannin (PF00335, IPR018499): Tetraspanin family
8	CMTM5	suppressor	2	0	105.000	MARVEL (PF01284, IPR008253): Membrane-associating domain DUF2207 (PF09972, IPR018702): Predicted membrane protein (DUF2207)
9	FAM134C	interactor	1	0	0	Reticulon (PF02453, IPR003388): Reticulon
10	HLA-DMB	interactor	3	1.000	0	MHC_II_beta (PF00969, IPR000353, SM00921): Class II histocompatibility antigen, beta domain C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
11	HLA-DOB	interactor	2	1.000	0	MHC_II_beta (PF00969, IPR000353, SM00921): Class II histocompatibility antigen, beta domain C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
12	HLA-DRA	interactor	3	1.000	0	MHC_II_alpha (PF00993, IPR001003, SM00920): Class II histocompatibility antigen, alpha domain C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain C1-set_C (PF16196, IPR032431): C1-set C-terminal domain
13	ITGB1	suppressor	6	0.467	5.167	EGF_2 (PF07974, IPR013111): EGF-like domain Integrin_b_cyt (PF08725, IPR014836): Integrin beta cytoplasmic domain Integrin_B_tail (PF07965, IPR012896): Integrin beta tail domain Integrin_beta (PF00362, IPR002369, SM00187): Integrin, beta chain PSI_integrin (PF17205): Integrin plexin domain
14	KIT	oncoprotein	3	1.000	0	ig (PF00047, IPR013151, SM00409): Immunoglobulin domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Ig_2 (PF13895, IPR007110): Immunoglobulin domain Ig_3 (PF13927): Immunoglobulin domain
15	LGALS3	oncoprotein	5	0.833	0.333	Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
16	LGALS8	interactor	5	0.400	25.667	Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
17	LGALS9	interactor	5	0.600	2.667	Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin Peptidase_C62 (PF12380, IPR024348): Gill-associated viral 3C-like peptidase
18	MAL2	interactor	1	0	0	MARVEL (PF01284, IPR008253): Membrane-associating domain
19	MRPL58	interactor	1	0	0	RF-1 (PF00472, IPR000352): RF-1 domain
20	NCK2	interactor	3	1.000	0	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain SH3_9 (PF14604, IPR001452): Variant SH3 domain
21	PIK3CA	oncoprotein	1	0	0	PI3K_C2 (PF00792, IPR002420, SM00142): Phosphoinositide 3-kinase C2 PI3K_p85B (PF02192, IPR003113, SM00143): PI3-kinase family, p85-binding domain PI3K_rbd (PF00794, IPR000341, SM00144): PI3-kinase family, ras-binding domain PI3Ka (PF00613, IPR001263, SM00145): Phosphoinositide 3-kinase family, accessory domain (PIK domain) DUF2321 (PF10083, IPR016891): Uncharacterized protein conserved in bacteria (DUF2321) PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
22	PTGFRN	interactor	7	0.476	8.167	V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_2 (PF13895, IPR007110): Immunoglobulin domain Ig_3 (PF13927): Immunoglobulin domain
23	RNF13	interactor	4	0.500	2.167	DNA_ligase_ZBD (PF03119, IPR004149): NAD-dependent DNA ligase C4 zinc finger domain PA (PF02225, IPR003137): PA domain zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain FAM176 (PF14851): FAM176 family STAC2_u1 (PF16664): Unstructured on SH3 and cysteine-rich domain-containing protein 2
24	SDC1	oncoprotein	2	1.000	0	Herpes_TAF50 (PF03326, IPR004998): Herpesvirus transcription activation factor (transactivator) Syndecan (PF01034, IPR027789): Syndecan domain DUF3592 (PF12158, IPR021994): Protein of unknown function (DUF3592) AJAP1_PANP_C (PF15298, IPR029198): AJAP1/PANP C-terminus
25	SDCBP	interactor	6	0.200	323.667	PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
26	SORBS3	interactor	2	0	0	Sorb (PF02208, IPR003127, SM00459): Sorbin homologous domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain SH3_9 (PF14604, IPR001452): Variant SH3 domain
27	SRF	interactor	2	0	0	SRF-TF (PF00319, IPR002100, SM00432): SRF-type transcription factor (DNA-binding and dimerisation domain)
28	TSPAN3	interactor	3	0.667	6.000	Hum_adeno_E3A (PF05393, IPR008652): Human adenovirus early E3A glycoprotein Tetraspannin (PF00335, IPR018499): Tetraspanin family
29	VKORC1	interactor	4	1.000	0	VKOR (PF07884, IPR012932, SM00756): Vitamin K epoxide reductase family

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