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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins LOC339166, CD63 (from a repository: Fri May 19 09:06:43 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)22
The number (and %) of the onco-proteins4 (18.18 %)
The number (and %) of the tumor suppressors2 (9.09 %)
Total number of binary PPIs (saturation %)54 (23.38 %)
The number (and %) of affected PPIs20 (37.04 %)
The number of possible different fusions2
PPI diameter2
PPI radiusinf
The average degree of PPI4.545
Assortativity coefficient-0.2126
The network average Clustering coefficient0.596
The number (and %) of a zero Clustering coefficients3 (13.64 %)
The number (and %) of a zero Betweenness Centrality10 (45.45 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: CD63,LOC339166 All fusions
Proteins found in more fusions LGALS3 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 CD63parental protein200.158265.500Tetraspannin (PF00335, IPR018499): Tetraspanin family
DUF4282 (PF14110, IPR025557): Domain of unknown function (DUF4282)
2 LOC339166interactor000Sulfotransfer_1 (PF00685, IPR000863): Sulfotransferase domain
WSC (PF01822, IPR002889, SM00321): WSC domain
3 ATP6V1B1interactor21.0000ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
DUF3533 (PF12051, IPR022703): Protein of unknown function (DUF3533)
4 CD81interactor80.5715.667Tetraspannin (PF00335, IPR018499): Tetraspanin family
5 CD82suppressor70.47611.000Tetraspannin (PF00335, IPR018499): Tetraspanin family
6 CD9oncoprotein80.46411.667Tetraspannin (PF00335, IPR018499): Tetraspanin family
7 FAM134Cinteractor100Reticulon (PF02453, IPR003388): Reticulon
8 HLA-DMBinteractor31.0000MHC_II_beta (PF00969, IPR000353, SM00921): Class II histocompatibility antigen, beta domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
9 HLA-DOBinteractor21.0000MHC_II_beta (PF00969, IPR000353, SM00921): Class II histocompatibility antigen, beta domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
10 HLA-DRAinteractor31.0000MHC_II_alpha (PF00993, IPR001003, SM00920): Class II histocompatibility antigen, alpha domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
C1-set_C (PF16196, IPR032431): C1-set C-terminal domain
11 ITGB1suppressor60.4675.167EGF_2 (PF07974, IPR013111): EGF-like domain
Integrin_b_cyt (PF08725, IPR014836): Integrin beta cytoplasmic domain
Integrin_B_tail (PF07965, IPR012896): Integrin beta tail domain
Integrin_beta (PF00362, IPR002369, SM00187): Integrin, beta chain
PSI_integrin (PF17205): Integrin plexin domain
12 KIToncoprotein31.0000ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
13 LGALS3oncoprotein50.8330.333Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
14 LGALS8interactor50.4004.333Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
15 LGALS9interactor50.6002.667Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
Peptidase_C62 (PF12380, IPR024348): Gill-associated viral 3C-like peptidase
16 PTGFRNinteractor70.4768.167V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
17 RNF13interactor40.5002.167DNA_ligase_ZBD (PF03119, IPR004149): NAD-dependent DNA ligase C4 zinc finger domain
PA (PF02225, IPR003137): PA domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
FAM176 (PF14851): FAM176 family
STAC2_u1 (PF16664): Unstructured on SH3 and cysteine-rich domain-containing protein 2
18 SDC1oncoprotein21.0000Herpes_TAF50 (PF03326, IPR004998): Herpesvirus transcription activation factor (transactivator)
Syndecan (PF01034, IPR027789): Syndecan domain
DUF3592 (PF12158, IPR021994): Protein of unknown function (DUF3592)
AJAP1_PANP_C (PF15298, IPR029198): AJAP1/PANP C-terminus
19 SDCBPinteractor40.5002.667PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
20 SRFinteractor200SRF-TF (PF00319, IPR002100, SM00432): SRF-type transcription factor (DNA-binding and dimerisation domain)
21 TSPAN3interactor30.6670.667Hum_adeno_E3A (PF05393, IPR008652): Human adenovirus early E3A glycoprotein
Tetraspannin (PF00335, IPR018499): Tetraspanin family
22 VKORC1interactor41.0000VKOR (PF07884, IPR012932, SM00756): Vitamin K epoxide reductase family

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