Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins NPTN, RNF7 (from a repository: Sun Sep 8 13:37:33 2019)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)63
The number (and %) of the onco-proteins17 (26.98 %)
The number (and %) of the tumor suppressors12 (19.05 %)
Total number of binary PPIs (saturation %)297 (15.21 %)
The number (and %) of affected PPIs62 (20.88 %)
The number of possible different fusions12
PPI diameter5
PPI radius3
The average degree of PPI8.603
Assortativity coefficient-0.2918
The network average Clustering coefficient0.548
The number (and %) of a zero Clustering coefficients8 (12.70 %)
The number (and %) of a zero Betweenness Centrality20 (31.75 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: NPTN,RNF7 All fusions
Proteins found in more fusions NEDD4L (see 4 fusions); UBE2D2 (see 1 fusions); LGALS3 (see 2 fusions); CUL4A (see 4 fusions); VCP (see 4 fusions); NPTN/NDUFV2 (see 1 fusions); CSNK2A1 (see 2 fusions); CUL1 (see 3 fusions); CUL3 (see 1 fusions); VHL (see 1 fusions); NEDD4 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 NPTNparental protein80.071481.093C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Ig_3 (PF13927): Immunoglobulin domain
Ig_5 (PF16681): Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
2 RNF7parental protein540.1411733.808zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
Prok-RING_1 (PF14446): Prokaryotic RING finger family 1
3 ASB1interactor41.0000Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
SOCS_box (PF07525, IPR001496): SOCS box
4 ASB10interactor50.70018.339Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
SOCS_box (PF07525, IPR001496): SOCS box
5 ASB12interactor41.0000Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_3 (PF13606, IPR002110): Ankyrin repeat
SOCS_box (PF07525, IPR001496): SOCS box
6 ASB13interactor41.0000Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
SOCS_box (PF07525, IPR001496): SOCS box
7 ASB2interactor90.6793.345Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
SOCS_box (PF07525, IPR001496): SOCS box
8 ASB4interactor70.6193.827Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
SOCS_box (PF07525, IPR001496): SOCS box
9 ASB6interactor60.66719.025Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
SOCS_box (PF07525, IPR001496): SOCS box
10 ASB7interactor50.9000.400Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
SOCS_box (PF07525, IPR001496): SOCS box
11 BTRConcoprotein140.35938.471WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
12 CBFBsuppressor41.0000CBF_beta (PF02312, IPR003417): Core binding factor beta subunit
13 CDC34oncoprotein100.47216.028UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
14 CHFRsuppressor60.5002.071FHA (PF00498, IPR000253, SM00240): FHA domain
Glyco_hydro_92 (PF07971, IPR012939): Glycosyl hydrolase family 92
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
LAX (PF15681, IPR031393): Lymphocyte activation family X
15 CSNK2A1oncoprotein50.5002.333Pkinase (PF00069, IPR000719): Protein kinase domain
16 CSNK2Binteractor60.6004.719CK_II_beta (PF01214, IPR000704, SM01085): Casein kinase II regulatory subunit
17 CUL1suppressor230.312266.245Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
18 CUL2suppressor210.352168.894Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
19 CUL3protein found in more fusions210.416149.647Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
20 CUL4Aprotein found in more fusions160.46754.620Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
21 CUL4Boncoprotein110.65525.561Cullin (PF00888, IPR001373, SM00182): Cullin family
EBP50_C (PF09007, IPR015098): EBP50, C-terminal
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
PG_binding_4 (PF12229, IPR022029): Putative peptidoglycan binding domain
MDFI (PF15316, IPR026134): MyoD family inhibitor
22 CUL5suppressor350.240505.194Cullin (PF00888, IPR001373, SM00182): Cullin family
GlutR_dimer (PF00745, IPR015896): Glutamyl-tRNAGlu reductase, dimerisation domain
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
23 DCUN1D2interactor100.6674.549Cullin_binding (PF03556, IPR005176): Cullin binding
UBA_4 (PF14555): UBA-like domain
24 DCUN1D3suppressor100.6674.549Cullin_binding (PF03556, IPR005176): Cullin binding
25 DCUN1D4interactor80.8210.982Cullin_binding (PF03556, IPR005176): Cullin binding
26 DCUN1D5interactor90.7222.686Cullin_binding (PF03556, IPR005176): Cullin binding
27 FBXO6interactor40.50058.176FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
28 GEMinteractor100Ras (PF00071, IPR001806, SM00173): Ras family
AAA_22 (PF13401, IPR003593): AAA domain
29 GHRoncoprotein90.6797.126EpoR_lig-bind (PF09067, IPR015152): Erythropoietin receptor, ligand binding
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
GHBP (PF12772, IPR025871): Growth hormone receptor binding
30 GLMNoncoprotein50.8000.287Kinetochor_Ybp2 (PF08568, IPR013877): Uncharacterised protein family, YAP/Alf4/glomulin
31 IKBKGinteractor41.0000CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725)
NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO
LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
32 ITM2Cinteractor100BRICHOS (PF04089, IPR007084, SM01039): BRICHOS domain
33 LGALS3oncoprotein31.0000Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
34 MKRN3oncoprotein80.5247.071zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
MKRN1_C (PF15815, IPR031644): E3 ubiquitin-protein ligase makorin-1, C-terminal
Torus (PF16131, IPR032297): Torus domain
zf-3CxxC_2 (PF17180): Zinc-binding domain
35 MNAT1oncoprotein21.0000MAT1 (PF06391, IPR015877): CDK-activating kinase assembly factor MAT1
Mu-like_Com (PF10122, IPR019294): Mu-like prophage protein Com
zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
36 NDUFV2protein found in more fusions1002Fe-2S_thioredx (PF01257, IPR002023): Thioredoxin-like [2Fe-2S] ferredoxin
37 NEDD4suppressor90.5719.059Rota_NS26 (PF01525, IPR002512): Rotavirus NS26
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
38 NEDD4Lsuppressor60.5001.971WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
39 NIT2suppressor100CN_hydrolase (PF00795, IPR003010): Carbon-nitrogen hydrolase
40 RAB40Concoprotein51.0000Ras (PF00071, IPR001806, SM00173): Ras family
SOCS_box (PF07525, IPR001496): SOCS box
41 SKP2suppressor100.6227.314LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRR_2 (PF07723, IPR013101): Leucine Rich Repeat
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
F-box-like (PF12937, IPR001810): F-box-like
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
LRR_8 (PF13855, IPR001611): Leucine rich repeat
42 SLC25A5interactor110.327484.346Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
43 SOCS2oncoprotein61.0000SH2 (PF00017, IPR000980, SM00252): SH2 domain
SOCS_box (PF07525, IPR001496): SOCS box
44 SOCS3suppressor70.9050.800SH2 (PF00017, IPR000980, SM00252): SH2 domain
SOCS_box (PF07525, IPR001496): SOCS box
45 SPSB1interactor41.0000SPRY (PF00622, IPR003877, SM00449): SPRY domain
SOCS_box (PF07525, IPR001496): SOCS box
46 SPSB2interactor41.0000SPRY (PF00622, IPR003877, SM00449): SPRY domain
47 SPSB4interactor41.0000SPRY (PF00622, IPR003877, SM00449): SPRY domain
SOCS_box (PF07525, IPR001496): SOCS box
48 SURF2interactor100SURF2 (PF05477, IPR008833): Surfeit locus protein 2 (SURF2)
49 TCEB1oncoprotein220.29984.647Skp1_POZ (PF03931, IPR016073): Skp1 family, tetramerisation domain
50 TCEB2interactor240.275106.928ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
51 TRIM46interactor100FlgN (PF05130, IPR007809): FlgN protein
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
zf-AN1 (PF01428, IPR000058, SM00154): AN1-like Zinc finger
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
CEBP_ZZ (PF16366, IPR032296): Cytoplasmic polyadenylation element-binding protein ZZ domain
52 TRIM8interactor70.6672.071dCache_2 (PF08269, IPR004010, SM01049): Cache domain
CASP_C (PF08172, IPR012955): CASP C terminal
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
Zn_ribbon_recom (PF13408, IPR025827): Recombinase zinc beta ribbon domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
53 UBE2D1interactor140.33344.323UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
54 UBE2D2oncoprotein130.34831.848UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
55 UBE2D3interactor90.32111.867UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
56 UBE2D4interactor50.6670.800UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
57 UBE2Finteractor70.6192.993UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
58 UBE2Minteractor130.60610.001UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
59 UBE2Q1interactor100Josephin (PF02099, IPR006155): Josephin
RWD (PF05773, IPR006575, SM00591): RWD domain
UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
KIAA1430 (PF13879, IPR029488): KIAA1430 homologue
60 UBXN1interactor60.500130.031Selenoprotein_S (PF06936, IPR009703): Selenoprotein S (SelS)
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
UBX (PF00789, IPR001012, SM00166): UBX domain
61 VCPprotein found in more fusions120.49188.077AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
62 VHLsuppressor120.47321.874Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
VHL (PF01847, IPR022772): VHL beta domain
VHL_C (PF17211): VHL box domain
63 VMA21interactor100VMA21 (PF09446, IPR019013): VMA21-like domain

B a c k    t o    T o p ⇑