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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins SYNGR1, WTAP (from a repository: Sun Jul 28 05:55:21 2019)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)24
The number (and %) of the onco-proteins3 (12.50 %)
The number (and %) of the tumor suppressors3 (12.50 %)
Total number of binary PPIs (saturation %)41 (14.86 %)
The number (and %) of affected PPIs22 (53.66 %)
The number of possible different fusions3
PPI diameter2
PPI radiusinf
The average degree of PPI2.833
Assortativity coefficient-0.3009
The network average Clustering coefficient0.307
The number (and %) of a zero Clustering coefficients14 (58.33 %)
The number (and %) of a zero Betweenness Centrality17 (70.83 %)


List of the fusions

PPI for parental proteins: WTAP,SYNGR1 All fusions
Proteins found in more fusions IKZF1 (see 1 fusions); SH3KBP1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 WTAPparental protein190.070304.667DUF1043 (PF06295, IPR009386): Protein of unknown function (DUF1043)
SOSSC (PF15925, IPR031821): SOSS complex subunit C
Wtap (PF17098, IPR029732): WTAP/Mum2p family
2 SYNGR1parental protein306.000MARVEL (PF01284, IPR008253): Membrane-associating domain
3 CBLL1oncoprotein31.0000Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
4 CENPAinteractor41.0000Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
5 CREB3interactor200bZIP_1 (PF00170, IPR004827): bZIP transcription factor
GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
6 ELAVL1oncoprotein40.6671.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
7 FAM175Ainteractor100DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
SRC-1 (PF08832, IPR014935): Steroid receptor coactivator
HMMR_C (PF15908, IPR031794): Hyaluronan mediated motility receptor C-terminal
8 FATE1interactor100Miff (PF05644, IPR008518): Mitochondrial and peroxisomal fission factor Mff
9 HMOX2interactor100Heme_oxygenase (PF01126, IPR016053): Heme oxygenase
10 IFI16suppressor100HIN (PF02760, IPR004021): HIN-200/IF120x domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
11 IKZF1suppressor200Desulfoferrod_N (PF06397, IPR004462): Desulfoferrodoxin, N-terminal domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-met (PF12874): Zinc-finger of C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
12 KIAA1429interactor60.6004.667Mpp10 (PF04006, IPR007151): Mpp10 protein
Sigma70_ner (PF04546, IPR007631): Sigma-70, non-essential region
INTS5_N (PF14837, IPR029445): Integrator complex subunit 5 N-terminus
VIR_N (PF15912, IPR031801): Virilizer, N-terminal
13 MAGEA11interactor200MAGE (PF01454, IPR002190): MAGE family
MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
14 MED23interactor30.6671.000Med23 (PF11573, IPR021629): Mediator complex subunit 23
15 METTL3interactor100DUF445 (PF04286, IPR007383): Protein of unknown function (DUF445)
MT-A70 (PF05063, IPR007757): MT-A70
16 MMS19interactor100DUF3437 (PF11919, IPR021843): Domain of unknown function (DUF3437)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
17 PMPCBinteractor100Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
18 SH3KBP1protein found in more fusions31.0000Tmemb_cc2 (PF10267, IPR019394): Predicted transmembrane and coiled-coil 2 protein
SH3_9 (PF14604, IPR001452): Variant SH3 domain
19 TAB1interactor100PP2C (PF00481, IPR001932): Protein phosphatase 2C
20 VPS52interactor200Vps52 (PF04129, IPR007258): Vps52 / Sac2 family
COG5 (PF10392, IPR019465): Golgi transport complex subunit 5
Sec3_C (PF09763, IPR019160): Exocyst complex component Sec3
21 WT1suppressor100WT1 (PF02165, IPR000976): Wilm's tumour protein
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
CCAP (PF11105, IPR024276): Arthropod cardioacceleratory peptide 2a
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain
22 YWHAQinteractor40.8330.66714-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
23 ZC3H13interactor60.5336.000FGF-BP1 (PF06473, IPR010510): FGF binding protein 1 (FGF-BP1)
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
PET117 (PF15786, IPR031568): PET assembly of cytochrome c oxidase, mitochondrial
24 ZNF645interactor31.0000HNH (PF01844, IPR002711): HNH endonuclease
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)

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