Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins PRDX6 (from a repository: Sat Dec 3 19:00:26 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 75 The number (and %) of the onco-proteins 16 (21.33 %) The number (and %) of the tumor suppressors 15 (20.00 %) Total number of binary PPIs (saturation %) 306 (11.03 %) The number (and %) of affected PPIs 75 (24.51 %) The number of possible different fusions 18 PPI diameter 2 PPI radius 1 The average degree of PPI 7.413 Assortativity coefficient -0.2459 The network average Clustering coefficient 0.499 The number (and %) of a zero Clustering coefficients 10 (13.33 %) The number (and %) of a zero Betweenness Centrality 20 (26.67 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: PRDX6	All fusions : CA439640;
Proteins found in more fusions	CD2AP (see 1 fusions); TERF2IP (see 1 fusions); PPARD (see 1 fusions); STAU1 (see 2 fusions); PRDX1 (see 1 fusions); RARA/NPM1 (see 1 fusions); RARA (see 4 fusions); NPM1 (see 1 fusions); HSPB1 (see 4 fusions); CUL7 (see 2 fusions); HUWE1 (see 2 fusions); HDAC5 (see 1 fusions); CUL1 (see 3 fusions); PCNA (see 1 fusions); HINT1 (see 3 fusions); PRDX6 (see 1 fusions); RANGAP1 (see 2 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	PRDX6	parental protein	75	0.076	4114.480	AhpC-TSA (PF00578, IPR000866): AhpC/TSA family 1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
2	AHSA1	interactor	3	1.000	0	Aha1_N (PF09229, IPR015310, SM01000): Activator of Hsp90 ATPase, N-terminal AHSA1 (PF08327, IPR013538): Activator of Hsp90 ATPase homolog 1-like protein
3	AKR1B1	suppressor	8	0.393	14.167	Aldo_ket_red (PF00248, IPR023210): Aldo/keto reductase family
4	APEX1	interactor	6	0.533	4.341	Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family
5	ASB12	interactor	2	1.000	0	Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_3 (PF13606, IPR002110): Ankyrin repeat SOCS_box (PF07525, IPR001496): SOCS box
6	ASB3	interactor	1	0	0	Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) SOCS_box (PF07525, IPR001496): SOCS box
7	ASS1	suppressor	9	0.536	7.389	Arginosuc_synth (PF00764, IPR001518): Arginosuccinate synthase
8	ATP6V1A	interactor	6	0.333	7.250	ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain ATP-synt_ab_Xtn (PF16886, IPR031686): ATPsynthase alpha/beta subunit N-term extension
9	C11orf54	interactor	5	0.500	3.333	DUF1907 (PF08925, IPR015021, SM01168): Domain of Unknown Function (DUF1907)
10	C11orf58	interactor	4	0.667	1.333	DUF3408 (PF11888, IPR021823): Protein of unknown function (DUF3408) SMAP (PF15477, IPR028124): Small acidic protein family
11	CAPG	suppressor	1	0	0	Gelsolin (PF00626, IPR007123): Gelsolin repeat
12	CASP10	interactor	4	1.000	0	DED (PF01335, IPR001875, SM00031): Death effector domain Peptidase_C14 (PF00656, IPR011600): Caspase domain
13	CASP8	suppressor	5	0.833	0.667	DED (PF01335, IPR001875, SM00031): Death effector domain Peptidase_C14 (PF00656, IPR011600): Caspase domain
14	CD2AP	protein found in more fusions	7	0.400	7.900	SH3_1 (PF00018, IPR001452, SM00326): SH3 domain SH3_9 (PF14604, IPR001452): Variant SH3 domain betaPIX_CC (PF16523, IPR032409): betaPIX coiled coil
15	CDK2	suppressor	13	0.500	18.880	Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase (PF00069, IPR000719): Protein kinase domain
16	CUL1	suppressor	12	0.545	11.813	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
17	CUL7	protein found in more fusions	13	0.318	27.111	ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10) Cullin (PF00888, IPR001373, SM00182): Cullin family DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918) Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
18	ECI1	interactor	1	0	0	ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
19	ENOPH1	interactor	1	0	0	Hydrolase (PF00702, IPR023214): haloacid dehalogenase-like hydrolase
20	FN1	oncoprotein	11	0.418	19.594	fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
21	GLO1	interactor	6	0.400	7.833	Glyoxalase (PF00903, IPR004360): Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
22	GPI	interactor	11	0.455	18.738	PGI (PF00342, IPR001672): Phosphoglucose isomerase
23	GPX4	interactor	4	0.833	0.500	GSHPx (PF00255, IPR000889): Glutathione peroxidase
24	GRHPR	interactor	4	0.667	1.500	2-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
25	GSTO1	interactor	5	0.600	2.786	GST_N_3 (PF13417, IPR004045): Glutathione S-transferase, N-terminal domain GST_C_3 (PF14497, IPR004046): Glutathione S-transferase, C-terminal domain
26	GSTZ1	interactor	2	0	0	Tom37 (PF10568, IPR019564): Outer mitochondrial membrane transport complex protein GST_N_3 (PF13417, IPR004045): Glutathione S-transferase, N-terminal domain GST_C_3 (PF14497, IPR004046): Glutathione S-transferase, C-terminal domain
27	H2AFX	suppressor	4	0.667	1.333	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4 Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
28	HDAC5	protein found in more fusions	7	0.733	1.006	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain NOA36 (PF06524, IPR010531): NOA36 protein Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3 HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
29	HINT1	suppressor	9	0.464	11.233	HIT (PF01230, IPR001310): HIT domain
30	HNF4G	interactor	1	0	0	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
31	HSPB1	oncoprotein	14	0.410	29.057	HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
32	HUWE1	oncoprotein	12	0.436	19.272	BUD22 (PF09073, IPR015158): BUD22 DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908) DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913) FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM) Mucin (PF01456, IPR000458): Mucin-like glycoprotein Nop14 (PF04147, IPR007276): Nop14-like family PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32 RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4 TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain WWE (PF02825, IPR004170, SM00678): WWE domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54 U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
33	ISG15	suppressor	8	0.321	9.852	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
34	ITGA4	interactor	12	0.491	16.907	FG-GAP (PF01839, IPR013517): FG-GAP repeat Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
35	LYPLA1	interactor	6	0.600	2.286	Abhydrolase_2 (PF02230, IPR003140): Phospholipase/Carboxylesterase
36	MDH1	interactor	9	0.389	14.738	Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
37	NCF2	interactor	1	0	0	PB1 (PF00564, IPR000270, SM00666): PB1 domain TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat SH3_1 (PF00018, IPR001452, SM00326): SH3 domain TPR_16 (PF13432): Tetratricopeptide repeat
38	NIT2	suppressor	7	0.333	12.000	CN_hydrolase (PF00795, IPR003010): Carbon-nitrogen hydrolase
39	NPM1	suppressor	17	0.358	47.076	Nucleoplasmin (PF03066): Nucleoplasmin SDA1 (PF05285, IPR007949): SDA1 NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
40	NR4A1	suppressor	2	1.000	0	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
41	NTRK1	oncoprotein	26	0.237	172.063	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
42	ORM2	interactor	1	0	0	Lipocalin (PF00061, IPR000566): Lipocalin / cytosolic fatty-acid binding protein family
43	OXCT1	interactor	12	0.273	33.300	CoA_trans (PF01144, IPR004165, SM00882): Coenzyme A transferase
44	PAXIP1	interactor	4	0.500	2.167	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain IPT (PF01745, IPR002648, SM00429): Isopentenyl transferase SURF6 (PF04935, IPR007019): Surfeit locus protein 6 DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052) CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance PTCB-BRCT (PF12738, IPR001357): twin BRCT domain BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT (PF16759, IPR031916): DNA ligase 3 BRCT domain RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
45	PCNA	oncoprotein	12	0.473	13.357	PCNA_C (PF02747, IPR022649): Proliferating cell nuclear antigen, C-terminal domain PCNA_N (PF00705, IPR022648): Proliferating cell nuclear antigen, N-terminal domain
46	PFAS	interactor	2	1.000	0	AIRS_C (PF02769, IPR010918): AIR synthase related protein, C-terminal domain GATase_5 (PF13507): CobB/CobQ-like glutamine amidotransferase domain
47	PGM1	interactor	10	0.400	21.686	PGM_PMM_I (PF02878, IPR005844): Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II (PF02879, IPR005845): Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III (PF02880, IPR005846): Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_IV (PF00408, IPR005843): Phosphoglucomutase/phosphomannomutase, C-terminal domain
48	PITRM1	interactor	2	1.000	0	M16C_assoc (PF08367, IPR013578): Peptidase M16C associated Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16) Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
49	PKM	oncoprotein	18	0.340	56.831	PK (PF00224, IPR015793): Pyruvate kinase, barrel domain PK_C (PF02887, IPR015795): Pyruvate kinase, alpha/beta domain
50	PPARD	oncoprotein	2	0	0	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
51	PRDX1	oncoprotein	16	0.305	38.198	AhpC-TSA (PF00578, IPR000866): AhpC/TSA family 1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
52	PRDX2	interactor	16	0.350	52.575	AhpC-TSA (PF00578, IPR000866): AhpC/TSA family 1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
53	PRDX5	interactor	8	0.500	9.900	Redoxin (PF08534, IPR013740): Redoxin NAD_binding_10 (PF13460, IPR016040): NAD(P)H-binding
54	PTGR1	interactor	5	0.500	2.900	ADH_zinc_N (PF00107, IPR013149): Zinc-binding dehydrogenase ADH_N_2 (PF16884): N-terminal domain of oxidoreductase
55	RANGAP1	protein found in more fusions	6	0.500	3.033	RanGAP1_C (PF07834, IPR009109): RanGAP1 C-terminal domain SDA1 (PF05285, IPR007949): SDA1 LRR_6 (PF13516, IPR001611): Leucine Rich repeat LRR_8 (PF13855, IPR001611): Leucine rich repeat
56	RARA	oncoprotein	4	1.000	0	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
57	RDX	interactor	3	1.000	0	ERM (PF00769, IPR011259): Ezrin/radixin/moesin family FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain FERM_M (PF00373, IPR019748): FERM central domain FERM_N (PF09379, IPR018979): FERM N-terminal domain
58	RHOA	suppressor	4	0.833	0.667	Ras (PF00071, IPR001806, SM00173): Ras family
59	SCPEP1	interactor	2	1.000	0	Peptidase_S10 (PF00450, IPR001563): Serine carboxypeptidase
60	SDHB	suppressor	4	0.500	1.667	Fer2_3 (PF13085, IPR025192): 2Fe-2S iron-sulfur cluster binding domain Fer4_8 (PF13183, IPR017896): 4Fe-4S dicluster domain Fer4_17 (PF13534): 4Fe-4S dicluster domain
61	SERPINB5	suppressor	7	0.429	10.400	Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
62	SPR	interactor	7	0.667	3.567	adh_short (PF00106, IPR002198): short chain dehydrogenase
63	SSU72	interactor	2	1.000	0	Ssu72 (PF04722, IPR006811): Ssu72-like protein
64	STAU1	protein found in more fusions	8	0.667	4.486	dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif Staufen_C (PF16482, IPR032478): Staufen C-terminal domain
65	STH	interactor	1	0	0	NA
66	SUCLG2	interactor	3	0.667	1.000	ATP-grasp_2 (PF08442, IPR013650): ATP-grasp domain Ligase_CoA (PF00549, IPR005811): CoA-ligase
67	TERF1	interactor	10	0.444	11.822	TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF) Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
68	TERF2IP	protein found in more fusions	6	0.800	1.000	BRF1 (PF07741, IPR011665): Brf1-like TBP-binding domain Histone_HNS (PF00816, IPR001801): H-NS histone family Myb_DNA-bind_2 (PF08914, IPR015010): Rap1 Myb domain Rap1_C (PF11626, IPR021661): TRF2-interacting telomeric protein/Rap1 - C terminal domain DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391) BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
69	TIMM9	interactor	3	0.667	0.500	zf-Tim10_DDP (PF02953, IPR004217): Tim10/DDP family zinc finger
70	TMED10	interactor	3	0.667	0.667	EMP24_GP25L (PF01105, IPR009038): emp24/gp25L/p24 family/GOLD
71	TMEM189	interactor	3	0.667	0.500	MARVEL (PF01284, IPR008253): Membrane-associating domain TMEM189_B_dmain (PF10520, IPR019547): B domain of TMEM189, localisation domain
72	TPI1	interactor	20	0.263	93.407	TIM (PF00121, IPR000652): Triosephosphate isomerase
73	UCHL5	oncoprotein	10	0.556	8.025	Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
74	VCAM1	interactor	8	0.536	6.055	C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain ig (PF00047, IPR013151, SM00409): Immunoglobulin domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain
75	WDR1	interactor	8	0.464	9.852	eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A PQQ (PF01011, IPR002372, SM00564): PQQ enzyme repeat WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain

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